Pub Date : 2025-01-15DOI: 10.1016/j.jneuroim.2024.578404
Jonathan Reed Komisar , Sohag Sanghani , Grace Thrall , Leonardo V. Lopez , Khyati Brahmbhatt , Stanley Brewer , Jacob Feigal , James Luccarelli , Nasuh Malas , Dennis Popeo , Joshua Ryan Smith , Chase Samsel , D. Catherine Fuchs , GenaLynne C. Mooneyham
{"title":"Correspondence: Electroconvulsive therapy in N-methyl-D-aspartate receptor encephalitis","authors":"Jonathan Reed Komisar , Sohag Sanghani , Grace Thrall , Leonardo V. Lopez , Khyati Brahmbhatt , Stanley Brewer , Jacob Feigal , James Luccarelli , Nasuh Malas , Dennis Popeo , Joshua Ryan Smith , Chase Samsel , D. Catherine Fuchs , GenaLynne C. Mooneyham","doi":"10.1016/j.jneuroim.2024.578404","DOIUrl":"10.1016/j.jneuroim.2024.578404","url":null,"abstract":"","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578404"},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent literature describes a condition similar to multiple sclerosis (MS) but with demyelinating lesions limited to the spinal cord. This condition, referred to as “pure spinal” MS, might benefit from disease-modifying treatment (DMT).
Methods
We screened the medical records of approximately 8000 patients with demyelinating diseases at the Isfahan MS clinic in Iran. Criteria for inclusion in the case series were adults with a demyelinating disease limited to the spinal cord, positive oligoclonal IgG bands in cerebrospinal fluid (CSF), and negative results for other potential diagnoses.
Results
Seven people with pure spinal MS were identified (all women, mean age [SD]: 40.14 [6.17] years at the first visit, mean follow-up duration [SD]: 98 [39.41] months). Two had a family history of conventional MS in their siblings. All patients exhibited lower limb weakness and tested negative for anti-MOG and anti-AQP4 antibodies. They experienced relapsing-remitting partial myelitis, with new spinal cord lesions on MRI but no extraspinal CNS lesions. DMT significantly reduced relapse rates in all patients, and two showed no increase in EDSS scores.
Conclusion
Pure spinal MS might be an atypical form of MS. Those affected may benefit from DMT; therefore, further investigation and consideration in the upcoming revisions of the McDonald criteria are recommended.
{"title":"Pure spinal multiple sclerosis: A case series of a possible new entity","authors":"Masoud Etemadifar , Seyyed-Ali Alaei , Nahad Sedaghat , Amir Hossein Ghandehari , Ahmadreza Dehghani , Zahra-sadat Mirian , Mahdi Norouzi , Mohammadreza Etemadifar , Mehri Salari","doi":"10.1016/j.jneuroim.2024.578429","DOIUrl":"10.1016/j.jneuroim.2024.578429","url":null,"abstract":"<div><h3>Background</h3><div>Recent literature describes a condition similar to multiple sclerosis (MS) but with demyelinating lesions limited to the spinal cord. This condition, referred to as “pure spinal” MS, might benefit from disease-modifying treatment (DMT).</div></div><div><h3>Methods</h3><div>We screened the medical records of approximately 8000 patients with demyelinating diseases at the Isfahan MS clinic in Iran. Criteria for inclusion in the case series were adults with a demyelinating disease limited to the spinal cord, positive oligoclonal IgG bands in cerebrospinal fluid (CSF), and negative results for other potential diagnoses.</div></div><div><h3>Results</h3><div>Seven people with pure spinal MS were identified (all women, mean age [SD]: 40.14 [6.17] years at the first visit, mean follow-up duration [SD]: 98 [39.41] months). Two had a family history of conventional MS in their siblings. All patients exhibited lower limb weakness and tested negative for anti-MOG and anti-AQP4 antibodies. They experienced relapsing-remitting partial myelitis, with new spinal cord lesions on MRI but no extraspinal CNS lesions. DMT significantly reduced relapse rates in all patients, and two showed no increase in EDSS scores.</div></div><div><h3>Conclusion</h3><div>Pure spinal MS might be an atypical form of MS. Those affected may benefit from DMT; therefore, further investigation and consideration in the upcoming revisions of the McDonald criteria are recommended.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578429"},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.jneuroim.2025.578524
Silvia Falso , Pietro Zara , Sofia Marini , Mariangela Puci , Eleonora Sabatelli , Giovanni Sotgiu , Martina Marini , Gregorio Spagni , Amelia Evoli , Paolo Solla , Raffaele Iorio , Elia Sechi
Introduction
Environmental factors may contribute to myasthenia gravis (MG) development, sometimes with seasonal patterns of exposure. However, whether seasonality has an impact on MG incidence remains unclear. We aimed to investigate the association between seasonality and MG onset.
Methods
We reviewed data of MG patients with acetylcholine receptor (AChR)-IgG and disease onset between January 2010–December 2019, from two Italian cohorts: 1) an hospital-based cohort and 2) a population-based cohort. MG cases were assigned to four season-trimesters based on month of onset to determine seasonal association with MG incidence.
Results
We enrolled 316 patients:214 in the hospital-based and 102 in the population-based cohort. Median age at onset was 66 years (range, 8–92); Female accounted for 41.1 %. The median number of new MG cases per season-trimester was significantly higher in summer than other trimesters (p=0.009), and associated with higher environmental temperatures.
Discussion
Our findings suggest that MG onset may be more common in summer and at higher environmental temperatures. Identifying the determinants of this association may improve our understanding of disease pathophysiology.
{"title":"Seasonal variation in myasthenia gravis incidence","authors":"Silvia Falso , Pietro Zara , Sofia Marini , Mariangela Puci , Eleonora Sabatelli , Giovanni Sotgiu , Martina Marini , Gregorio Spagni , Amelia Evoli , Paolo Solla , Raffaele Iorio , Elia Sechi","doi":"10.1016/j.jneuroim.2025.578524","DOIUrl":"10.1016/j.jneuroim.2025.578524","url":null,"abstract":"<div><h3>Introduction</h3><div>Environmental factors may contribute to myasthenia gravis (MG) development, sometimes with seasonal patterns of exposure. However, whether seasonality has an impact on MG incidence remains unclear. We aimed to investigate the association between seasonality and MG onset.</div></div><div><h3>Methods</h3><div>We reviewed data of MG patients with acetylcholine receptor (AChR)-IgG and disease onset between January 2010–December 2019, from two Italian cohorts: 1) an hospital-based cohort and 2) a population-based cohort. MG cases were assigned to four season-trimesters based on month of onset to determine seasonal association with MG incidence.</div></div><div><h3>Results</h3><div>We enrolled 316 patients:214 in the hospital-based and 102 in the population-based cohort. Median age at onset was 66 years (range, 8–92); Female accounted for 41.1 %. The median number of new MG cases per season-trimester was significantly higher in summer than other trimesters <em>(p</em> <em>=</em> <em>0.009),</em> and associated with higher environmental temperatures.</div></div><div><h3>Discussion</h3><div>Our findings suggest that MG onset may be more common in summer and at higher environmental temperatures. Identifying the determinants of this association may improve our understanding of disease pathophysiology.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578524"},"PeriodicalIF":2.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.jneuroim.2025.578523
Bade Gulec , Elif Everest , Ugur Uygunoglu
{"title":"Letter to the Editor Regarding “Spinocerebellar ataxia masquerading as multiple sclerosis, a case report”","authors":"Bade Gulec , Elif Everest , Ugur Uygunoglu","doi":"10.1016/j.jneuroim.2025.578523","DOIUrl":"10.1016/j.jneuroim.2025.578523","url":null,"abstract":"","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578523"},"PeriodicalIF":2.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare cause of NORSE. We describe the case of a young girl who presented with NORSE associated with MOGAD along with a systematic review of all cases of NORSE associated with MOGAD till date. Seizures associated with MOGAD are usually associated with good outcome but can occasionally be catastrophic and non-responsive to conventional therapies. Early initiation of anti-IL6 therapies might help improve outcomes in such patients.
{"title":"Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) as a cause of new-onset refractory status epilepticus (NORSE): Case report and review of literature","authors":"Abhishek Vaingankar , Ayush Agarwal , Divyani Garg , Pranjal Gupta , Ajay Garg , Divya M. Radhakrishnan , Awadh K. Pandit , Achal Kumar Srivastava","doi":"10.1016/j.jneuroim.2025.578522","DOIUrl":"10.1016/j.jneuroim.2025.578522","url":null,"abstract":"<div><div>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare cause of NORSE. We describe the case of a young girl who presented with NORSE associated with MOGAD along with a systematic review of all cases of NORSE associated with MOGAD till date. Seizures associated with MOGAD are usually associated with good outcome but can occasionally be catastrophic and non-responsive to conventional therapies. Early initiation of anti-IL6 therapies might help improve outcomes in such patients.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578522"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-06DOI: 10.1016/j.jneuroim.2024.578517
Li Zhang , Long Ma , Yi Wang , Xiang Li , Yanjie Yang , Ling Yang , Xiangyou Yu
This study aimed to investigate the effects of MCC950 in a rat model of sepsis-associated encephalopathy (SAE). Adult male rats were randomly assigned to 12 groups according to the surgery or treatment received and evaluation times. The SAE model was established using the cecal ligation and puncture (CLP) method. Intraperitoneal injections of normal saline (10 mL/kg) or MCC950 (10 mg/kg) were administered 30 min pre-surgery and daily post-surgery. Changes in survival rates, weight loss, and heart rate were assessed at four time points, and neurobehavioral changes were evaluated using the composite neural reflex function scores, light/dark box test, and open-field test (OFT). Compared with the SAE group, the SAE + MCC950 group had significantly higher survival rates (P < 0.05), lower postoperative weight loss rates (P < 0.05), and higher neurological function scores (P < 0.05); the SAE + MCC950 group also traveled further and crossed the central area more frequently in the OFT (P < 0.05), spent more time in the light compartment at different time points (P < 0.05), and exhibited a lower heart rate at different time points (P < 0.05). MCC950 treatment significantly improved cognitive function and related indices in the SAE rats.
{"title":"NOD-like receptor protein 3 inhibition by MCC950 improves the cognitive function of rats with sepsis-associated encephalopathy","authors":"Li Zhang , Long Ma , Yi Wang , Xiang Li , Yanjie Yang , Ling Yang , Xiangyou Yu","doi":"10.1016/j.jneuroim.2024.578517","DOIUrl":"10.1016/j.jneuroim.2024.578517","url":null,"abstract":"<div><div>This study aimed to investigate the effects of MCC950 in a rat model of sepsis-associated encephalopathy (SAE). Adult male rats were randomly assigned to 12 groups according to the surgery or treatment received and evaluation times. The SAE model was established using the cecal ligation and puncture (CLP) method. Intraperitoneal injections of normal saline (10 mL/kg) or MCC950 (10 mg/kg) were administered 30 min pre-surgery and daily post-surgery. Changes in survival rates, weight loss, and heart rate were assessed at four time points, and neurobehavioral changes were evaluated using the composite neural reflex function scores, light/dark box test, and open-field test (OFT). Compared with the SAE group, the SAE + MCC950 group had significantly higher survival rates (<em>P</em> < 0.05), lower postoperative weight loss rates (P < 0.05), and higher neurological function scores (<em>P</em> < 0.05); the SAE + MCC950 group also traveled further and crossed the central area more frequently in the OFT (<em>P</em> < 0.05), spent more time in the light compartment at different time points (<em>P</em> < 0.05), and exhibited a lower heart rate at different time points (P < 0.05). MCC950 treatment significantly improved cognitive function and related indices in the SAE rats.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"400 ","pages":"Article 578517"},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-06DOI: 10.1016/j.jneuroim.2025.578521
Enrico Ripamonti , Magnus Gisslén , Lars Hagberg , Pradeepthi Bathala , Shraddha Kale , Martin Stengelin , George Sigal , Jacob Wohlstadter , Henrik Zetterberg , Richard Price
Background
A retrospective study was conducted in people with HIV (PWH) to explore potential cerebrospinal fluid (CSF) biomarkers linked to CSF neurofilament light levels (NfL), indicative of neuronal injury.
Methods
A sample of 168 participants was tested, including 43 HIV-negative controls and PWH who were classified into subgroups based on HIV and treatment status. Twenty CSF protein biomarkers were analyzed for their association with CSF NfL concentrations using a linear regression forward selection strategy, adjusted for age and sex. Regression trees were utilized to visualize feature relationships.
Results
Age-adjusted average concentrations of CSF NfL ranged from 427 pg/mL (SD = 190) in HIV- participants to 6456 pg/mL (SD = 46,024) in participants with HIV-associated dementia. Significant associations were found between specific biomarkers and CSF NfL levels in different participant subgroups. Noteworthy findings included correlations between CSF t-tau, CSF MCP-1, CSF TNF-α, and albumin ratio with CSF NfL levels in untreated PWH, and CSF IL-21 with CSF NfL in treated, virally suppressed PWH. Association between age and CSF NfL concentrations was a general finding.
Conclusion
We identified specific CSF biomarkers, including CSF t-tau protein, CSF MCP-1, and CSF TNF-α that associated with CSF NfL concentrations in untreated PWH and CSF IL-21 that associated with CSF NfL in PWH with effective treatment, shedding light on neuroinflammatory processes which may underlie HIV-related neuronal injury and the impact of antiviral therapy. Further investigations are needed to validate if elevated CSF IL-21 concentrations persist during long-term treatment, and if particular drug combinations are optimal for decreasing inflammatory latency.
{"title":"Cerebrospinal fluid biomarkers associated with neurofilament light levels: A study in HIV disease","authors":"Enrico Ripamonti , Magnus Gisslén , Lars Hagberg , Pradeepthi Bathala , Shraddha Kale , Martin Stengelin , George Sigal , Jacob Wohlstadter , Henrik Zetterberg , Richard Price","doi":"10.1016/j.jneuroim.2025.578521","DOIUrl":"10.1016/j.jneuroim.2025.578521","url":null,"abstract":"<div><h3>Background</h3><div>A retrospective study was conducted in people with HIV (PWH) to explore potential cerebrospinal fluid (CSF) biomarkers linked to CSF neurofilament light levels (NfL), indicative of neuronal injury.</div></div><div><h3>Methods</h3><div>A sample of 168 participants was tested, including 43 HIV-negative controls and PWH who were classified into subgroups based on HIV and treatment status. Twenty CSF protein biomarkers were analyzed for their association with CSF NfL concentrations using a linear regression forward selection strategy, adjusted for age and sex. Regression trees were utilized to visualize feature relationships.</div></div><div><h3>Results</h3><div>Age-adjusted average concentrations of CSF NfL ranged from 427 pg/mL (SD = 190) in HIV- participants to 6456 pg/mL (SD = 46,024) in participants with HIV-associated dementia. Significant associations were found between specific biomarkers and CSF NfL levels in different participant subgroups. Noteworthy findings included correlations between CSF t-tau, CSF MCP-1, CSF TNF-α, and albumin ratio with CSF NfL levels in untreated PWH, and CSF IL-21 with CSF NfL in treated, virally suppressed PWH. Association between age and CSF NfL concentrations was a general finding.</div></div><div><h3>Conclusion</h3><div>We identified specific CSF biomarkers, including CSF t-tau protein, CSF MCP-1, and CSF TNF-α that associated with CSF NfL concentrations in untreated PWH and CSF IL-21 that associated with CSF NfL in PWH with effective treatment, shedding light on neuroinflammatory processes which may underlie HIV-related neuronal injury and the impact of antiviral therapy. Further investigations are needed to validate if elevated CSF IL-21 concentrations persist during long-term treatment, and if particular drug combinations are optimal for decreasing inflammatory latency.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"400 ","pages":"Article 578521"},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143305167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-30DOI: 10.1016/j.jneuroim.2024.578520
MaryGlen V. Stanich , Trevor Memmott , Taumoha Ghosh , Melissa A. Wright
Refractory seizures are common in pediatric neurology; consideration of whether seizures are acutely symptomatic of an underlying disease process is critical. In this case, a previously healthy 7-year-old patient presented with intractable focal seizures in the setting of a viral prodrome and headache. This case highlights a comprehensive work up of new-onset refractory seizures in a patient with features of encephalitis and describes a diagnostic quandary that ultimately led to a rare unifying diagnosis.
{"title":"A 7-year-old with new-onset seizures, behavior disturbance, and encephalitis","authors":"MaryGlen V. Stanich , Trevor Memmott , Taumoha Ghosh , Melissa A. Wright","doi":"10.1016/j.jneuroim.2024.578520","DOIUrl":"10.1016/j.jneuroim.2024.578520","url":null,"abstract":"<div><div>Refractory seizures are common in pediatric neurology; consideration of whether seizures are acutely symptomatic of an underlying disease process is critical. In this case, a previously healthy 7-year-old patient presented with intractable focal seizures in the setting of a viral prodrome and headache. This case highlights a comprehensive work up of new-onset refractory seizures in a patient with features of encephalitis and describes a diagnostic quandary that ultimately led to a rare unifying diagnosis.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578520"},"PeriodicalIF":2.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-27DOI: 10.1016/j.jneuroim.2024.578519
Cody J. Gurski , Zivar Hajiyeva , Anthony J. Veltri , Kaylan Fenton , Samantha O'Dell , Ahmed Z. Obeidat , Bonnie N. Dittel
{"title":"Corrigendum to “Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels are B cell depletion with Ocrelizumab” [J. Neuroimmunol. 339:578502 (2024)]","authors":"Cody J. Gurski , Zivar Hajiyeva , Anthony J. Veltri , Kaylan Fenton , Samantha O'Dell , Ahmed Z. Obeidat , Bonnie N. Dittel","doi":"10.1016/j.jneuroim.2024.578519","DOIUrl":"10.1016/j.jneuroim.2024.578519","url":null,"abstract":"","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578519"},"PeriodicalIF":2.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20DOI: 10.1016/j.jneuroim.2024.578518
Kehinde Joshua Ogundeyi , Abayomi Mayowa Ajayi , Ololade Justina Oduyomi , Stella Afolakemi Adeyemo , Mary O. Ologe , Olusegun George Ademowo
This study evaluated the effects of vitamin C and artemether-lumefantrine (AL) on sickness behaviour and oxido-inflammatory response in chronically stressed mice infected with Plasmodium berghei. Sickness behaviour severity was examined with weight and assessment of mice behaviours. Results showed that stress increased parasitaemia in infected mice. Vitamin C co-administration with AL increased parasite clearance over AL alone, and modulated inflammatory cytokines (TNF-α, IL-1β, IL-10, IL-12) and antioxidant parameters in plasma and brain tissue.
Conclusively, stress worsens malaria-induced sickness behaviour and up-regulates the inflammatory and oxidative stress response. Co-administration of vitamin C with AL appears to counteract these detrimental effects.
{"title":"Vitamin C co-administration with artemether-lumefantrine abrogates chronic stress exacerbated Plasmodium berghei-induced sickness behaviour, inflammatory and oxidative stress responses in mice","authors":"Kehinde Joshua Ogundeyi , Abayomi Mayowa Ajayi , Ololade Justina Oduyomi , Stella Afolakemi Adeyemo , Mary O. Ologe , Olusegun George Ademowo","doi":"10.1016/j.jneuroim.2024.578518","DOIUrl":"10.1016/j.jneuroim.2024.578518","url":null,"abstract":"<div><div>This study evaluated the effects of vitamin C and artemether-lumefantrine (AL) on sickness behaviour and oxido-inflammatory response in chronically stressed mice infected with <em>Plasmodium berghei</em>. Sickness behaviour severity was examined with weight and assessment of mice behaviours. Results showed that stress increased parasitaemia in infected mice. Vitamin C co-administration with AL increased parasite clearance over AL alone, and modulated inflammatory cytokines (TNF-α, IL-1β, IL-10, IL-12) and antioxidant parameters in plasma and brain tissue.</div><div>Conclusively, stress worsens malaria-induced sickness behaviour and up-regulates the inflammatory and oxidative stress response. Co-administration of vitamin C with AL appears to counteract these detrimental effects.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578518"},"PeriodicalIF":2.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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