Pub Date : 2022-03-10DOI: 10.1007/s40005-022-00563-1
Dang-Khoa Vo, Thi-Thao-Linh Nguyen, H. Maeng
{"title":"Effects of 1α,25-dihydroxyvitamin D3 on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats","authors":"Dang-Khoa Vo, Thi-Thao-Linh Nguyen, H. Maeng","doi":"10.1007/s40005-022-00563-1","DOIUrl":"https://doi.org/10.1007/s40005-022-00563-1","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"341 - 351"},"PeriodicalIF":5.5,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47732166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.1007/s40005-022-00561-3
Ji Hoon Kim, Kyeong-Lim Kim, Hyo-Eon Jin
{"title":"Three-Dimensional Printing for Oral Pharmaceutical Dosage Forms","authors":"Ji Hoon Kim, Kyeong-Lim Kim, Hyo-Eon Jin","doi":"10.1007/s40005-022-00561-3","DOIUrl":"https://doi.org/10.1007/s40005-022-00561-3","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"293 - 317"},"PeriodicalIF":5.5,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48582871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.1007/s40005-022-00564-0
Haesoo Lee, Minki Jin, W. Jeon, Haeun Kim, M. Jung, Hyelim Yoo, Jong-Hee Won, C. Cho
{"title":"Regulatory and safe-use considerations related to stability after opening of nonsterile dosage forms","authors":"Haesoo Lee, Minki Jin, W. Jeon, Haeun Kim, M. Jung, Hyelim Yoo, Jong-Hee Won, C. Cho","doi":"10.1007/s40005-022-00564-0","DOIUrl":"https://doi.org/10.1007/s40005-022-00564-0","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"319 - 329"},"PeriodicalIF":5.5,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44736117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.1007/s40005-022-00566-y
Reeju Amatya, K. Min, M. Shin
{"title":"A review of glucoregulatory hormones potentially applicable to the treatment of Alzheimer’s disease: mechanism and brain delivery","authors":"Reeju Amatya, K. Min, M. Shin","doi":"10.1007/s40005-022-00566-y","DOIUrl":"https://doi.org/10.1007/s40005-022-00566-y","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"195 - 216"},"PeriodicalIF":5.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45679014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-14DOI: 10.1007/s40005-022-00562-2
Ae-Gyeoing Im, Go-Wun Choi, D. Kang, Seok-jin Cho, Jaehee Kim, Kyu Yeon Kim, Hea‐Young Cho
{"title":"Population pharmacokinetic modeling and simulation of choline in healthy Korean subjects after oral administration of choline alfoscerate","authors":"Ae-Gyeoing Im, Go-Wun Choi, D. Kang, Seok-jin Cho, Jaehee Kim, Kyu Yeon Kim, Hea‐Young Cho","doi":"10.1007/s40005-022-00562-2","DOIUrl":"https://doi.org/10.1007/s40005-022-00562-2","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"331 - 339"},"PeriodicalIF":5.5,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41538027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-06DOI: 10.1007/s40005-021-00555-7
Shreya Kaul, N. Jain, Upendra Nagaich
{"title":"Ultra deformable vesicles for boosting transdermal delivery of 2-arylpropionic acid class drug for management of musculoskeletal pain","authors":"Shreya Kaul, N. Jain, Upendra Nagaich","doi":"10.1007/s40005-021-00555-7","DOIUrl":"https://doi.org/10.1007/s40005-021-00555-7","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"217 - 231"},"PeriodicalIF":5.5,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48600830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-05DOI: 10.1007/s40005-022-00560-4
HyeogJin Park, Su Hyun Seok, Kyu‐Mok Hwang, Juyoung Kim, Chun-Woong Park, E. Park
{"title":"Formulation of sustained-release orodispersible film containing drug–resin complexes of donepezil hydrochloride","authors":"HyeogJin Park, Su Hyun Seok, Kyu‐Mok Hwang, Juyoung Kim, Chun-Woong Park, E. Park","doi":"10.1007/s40005-022-00560-4","DOIUrl":"https://doi.org/10.1007/s40005-022-00560-4","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"259 - 272"},"PeriodicalIF":5.5,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48887597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-27DOI: 10.1007/s40005-021-00554-8
Jaemin Lee, Yun-Seok Rhee
{"title":"Ophthalmic dosage forms for drug delivery to posterior segment","authors":"Jaemin Lee, Yun-Seok Rhee","doi":"10.1007/s40005-021-00554-8","DOIUrl":"https://doi.org/10.1007/s40005-021-00554-8","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"161 - 173"},"PeriodicalIF":5.5,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45066098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-25DOI: 10.1007/s40005-022-00559-x
Athirah Bakhtiar, Qing Xin Liew, K. Ng, E. Chowdhury
{"title":"Active targeting via ligand-anchored pH-responsive strontium nanoparticles for efficient nucleic acid delivery into breast cancer cells","authors":"Athirah Bakhtiar, Qing Xin Liew, K. Ng, E. Chowdhury","doi":"10.1007/s40005-022-00559-x","DOIUrl":"https://doi.org/10.1007/s40005-022-00559-x","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 1","pages":"243 - 257"},"PeriodicalIF":5.5,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45298034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-04DOI: 10.1007/s40005-021-00558-4
Inhwan Noh, Kyuri Lee, Yun-Seok Rhee
Background: Nucleic acid-based gene therapy is a promising technology that has been used in various applications such as novel vaccination platforms for infectious/cancer diseases and cellular reprogramming because of its fast, specific, and effective properties. Despite its potential, the parenteral nucleic acid drug formulation exhibits instability and low efficacy due to various barriers, such as stability concerns related to its liquid state formulation, skin barriers, and endogenous nuclease degradation. As promising alternatives, many attempts have been made to perform nucleic acid delivery using a microneedle system. With its minimal invasiveness, microneedle can deliver nucleic acid drugs with enhanced efficacy and improved stability.
Area covered: This review describes nucleic acid medicines' current state and features and their delivery systems utilizing non-viral vectors and physical delivery systems. In addition, different types of microneedle delivery systems and their properties are briefly reviewed. Furthermore, recent advances of microneedle-based nucleic acid drugs, including featured vaccination applications, are described.
Expert opinion: Nucleic acid drugs have shown significant potential beyond the limitation of conventional small molecules, and the current COVID-19 pandemic highlights the importance of nucleic acid therapies as a novel vaccination platform. Microneedle-mediated nucleic acid drug delivery is a potential platform for less invasive nucleic acid drug delivery. Microneedle system can show enhanced efficacy, stability, and improved patient convenience through self-administration with less pain.
{"title":"Microneedle systems for delivering nucleic acid drugs.","authors":"Inhwan Noh, Kyuri Lee, Yun-Seok Rhee","doi":"10.1007/s40005-021-00558-4","DOIUrl":"https://doi.org/10.1007/s40005-021-00558-4","url":null,"abstract":"<p><strong>Background: </strong>Nucleic acid-based gene therapy is a promising technology that has been used in various applications such as novel vaccination platforms for infectious/cancer diseases and cellular reprogramming because of its fast, specific, and effective properties. Despite its potential, the parenteral nucleic acid drug formulation exhibits instability and low efficacy due to various barriers, such as stability concerns related to its liquid state formulation, skin barriers, and endogenous nuclease degradation. As promising alternatives, many attempts have been made to perform nucleic acid delivery using a microneedle system. With its minimal invasiveness, microneedle can deliver nucleic acid drugs with enhanced efficacy and improved stability.</p><p><strong>Area covered: </strong>This review describes nucleic acid medicines' current state and features and their delivery systems utilizing non-viral vectors and physical delivery systems. In addition, different types of microneedle delivery systems and their properties are briefly reviewed. Furthermore, recent advances of microneedle-based nucleic acid drugs, including featured vaccination applications, are described.</p><p><strong>Expert opinion: </strong>Nucleic acid drugs have shown significant potential beyond the limitation of conventional small molecules, and the current COVID-19 pandemic highlights the importance of nucleic acid therapies as a novel vaccination platform. Microneedle-mediated nucleic acid drug delivery is a potential platform for less invasive nucleic acid drug delivery. Microneedle system can show enhanced efficacy, stability, and improved patient convenience through self-administration with less pain.</p>","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 3","pages":"273-292"},"PeriodicalIF":5.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39662371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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