Pub Date : 2023-04-12DOI: 10.1007/s40005-023-00618-x
Sang-wook Woo, Sung-Joo Hwang, C. Cho
{"title":"Liquid-filled hard capsule formulation of choline alfoscerate: preparation and in vitro/in vivo evaluation","authors":"Sang-wook Woo, Sung-Joo Hwang, C. Cho","doi":"10.1007/s40005-023-00618-x","DOIUrl":"https://doi.org/10.1007/s40005-023-00618-x","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"517 - 526"},"PeriodicalIF":5.5,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48073889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.1007/s40005-023-00616-z
Thu Nhan Nguyen, Phuong Tran, Y. Choi, J. Park
{"title":"Solid dispersion of mebendazole via surfactant carrier to improve oral bioavailability and in vitro anticancer efficacy","authors":"Thu Nhan Nguyen, Phuong Tran, Y. Choi, J. Park","doi":"10.1007/s40005-023-00616-z","DOIUrl":"https://doi.org/10.1007/s40005-023-00616-z","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"443-455"},"PeriodicalIF":5.5,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43184965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-11DOI: 10.1007/s40005-023-00615-0
J. Jang, Seung-Hyun Jeong, Yong-Bok Lee
{"title":"Establishment of a fexofenadine population pharmacokinetic (PK)–pharmacodynamic (PD) model and exploration of dosing regimens through simulation","authors":"J. Jang, Seung-Hyun Jeong, Yong-Bok Lee","doi":"10.1007/s40005-023-00615-0","DOIUrl":"https://doi.org/10.1007/s40005-023-00615-0","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"427-441"},"PeriodicalIF":5.5,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42751683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.1007/s40005-023-00614-1
Ae-Ri Cho Lee
{"title":"Size matters: differential property of hyaluronan and its fragments in the skin- relation to pharmacokinetics, immune activity and wound healing","authors":"Ae-Ri Cho Lee","doi":"10.1007/s40005-023-00614-1","DOIUrl":"https://doi.org/10.1007/s40005-023-00614-1","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"357 - 376"},"PeriodicalIF":5.5,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49121129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-21DOI: 10.1007/s40005-023-00613-2
Khanh Van Nguyen, Thu Kim Dang, Linh Thi Dieu Vu, Nhan Thi Ha, Hieu Duy Truong, T. H. Tran
{"title":"Orodispersible film incorporating nanoparticulate loratadine for an enhanced oral bioavailability","authors":"Khanh Van Nguyen, Thu Kim Dang, Linh Thi Dieu Vu, Nhan Thi Ha, Hieu Duy Truong, T. H. Tran","doi":"10.1007/s40005-023-00613-2","DOIUrl":"https://doi.org/10.1007/s40005-023-00613-2","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"417-426"},"PeriodicalIF":5.5,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47143846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-07DOI: 10.1007/s40005-023-00612-3
Vanessa Gonzalez Ferreira Caminha Martins, L. Alencar, P. F. N. Souza, C. Lorentino, Heloisa F. Frota, A. L. D. dos Santos, S. Gemini-Piperni, V. Morandi, Vinicius Gonçalves Rodrigues, Jonathas Xavier Pereira, E. Ricci-Júnior, Aline Oliveira da Silva de Barros, R. Santos-Oliveira
{"title":"Wound dressing using graphene quantum dots: a proof of concept","authors":"Vanessa Gonzalez Ferreira Caminha Martins, L. Alencar, P. F. N. Souza, C. Lorentino, Heloisa F. Frota, A. L. D. dos Santos, S. Gemini-Piperni, V. Morandi, Vinicius Gonçalves Rodrigues, Jonathas Xavier Pereira, E. Ricci-Júnior, Aline Oliveira da Silva de Barros, R. Santos-Oliveira","doi":"10.1007/s40005-023-00612-3","DOIUrl":"https://doi.org/10.1007/s40005-023-00612-3","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"333-342"},"PeriodicalIF":5.5,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49385292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-05DOI: 10.1007/s40005-023-00611-4
S. Jeon, Jin-Hyun Park, Joo-Eun Kim, Young-Joon Park
{"title":"Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation","authors":"S. Jeon, Jin-Hyun Park, Joo-Eun Kim, Young-Joon Park","doi":"10.1007/s40005-023-00611-4","DOIUrl":"https://doi.org/10.1007/s40005-023-00611-4","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"407-416"},"PeriodicalIF":5.5,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44961785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1007/s40005-022-00590-y
Nijaya Mohanto, Young-Joon Park, Jun-Pil Jee
Background: Several circumstances such as accidents, surgery, traumatic hemorrhagic shock, and other causalities cause major blood loss. Allogenic blood transfusion can be resuscitative for such conditions; however, it has numerous ambivalent effects, including supply shortage, needs for more time, cost for blood grouping, the possibility of spreading an infection, and short shelf-life. Hypoxia or ischemia causes heart failure, neurological problems, and organ damage in many patients. To address this emergent medical need for resuscitation and to treat hypoxic conditions as well as to enhance oxygen transportation, researchers aspire to achieve a robust technology aimed to develop safe and feasible red blood cell substitutes for effective oxygen transport.
Area covered: This review article provides an overview of the formulation, storage, shelf-life, clinical application, side effects, and current perspectives of artificial oxygen carriers (AOCs) as red blood cell substitutes. Moreover, the pre-clinical (in vitro and in vivo) assessments for the evaluation of the efficacy and safety of oxygen transport through AOCs are key considerations in this study. With the most significant technologies, hemoglobin- and perfluorocarbon-based oxygen carriers as well as other modern technologies, such as synthetically produced porphyrin-based AOCs and oxygen-carrying micro/nanobubbles, have also been elucidated.
Expert opinion: Both hemoglobin- and perfluorocarbon-based oxygen carriers are significant, despite having the latter acting as safeguards; they are cost-effective, facile formulations which penetrate small blood vessels and remove arterial blockages due to their nano-size. They also show better biocompatibility and longer half-life circulation than other similar technologies.
{"title":"Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments.","authors":"Nijaya Mohanto, Young-Joon Park, Jun-Pil Jee","doi":"10.1007/s40005-022-00590-y","DOIUrl":"https://doi.org/10.1007/s40005-022-00590-y","url":null,"abstract":"<p><strong>Background: </strong>Several circumstances such as accidents, surgery, traumatic hemorrhagic shock, and other causalities cause major blood loss. Allogenic blood transfusion can be resuscitative for such conditions; however, it has numerous ambivalent effects, including supply shortage, needs for more time, cost for blood grouping, the possibility of spreading an infection, and short shelf-life. Hypoxia or ischemia causes heart failure, neurological problems, and organ damage in many patients. To address this emergent medical need for resuscitation and to treat hypoxic conditions as well as to enhance oxygen transportation, researchers aspire to achieve a robust technology aimed to develop safe and feasible red blood cell substitutes for effective oxygen transport.</p><p><strong>Area covered: </strong>This review article provides an overview of the formulation, storage, shelf-life, clinical application, side effects, and current perspectives of artificial oxygen carriers (AOCs) as red blood cell substitutes. Moreover, the pre-clinical (in vitro and in vivo) assessments for the evaluation of the efficacy and safety of oxygen transport through AOCs are key considerations in this study. With the most significant technologies, hemoglobin- and perfluorocarbon-based oxygen carriers as well as other modern technologies, such as synthetically produced porphyrin-based AOCs and oxygen-carrying micro/nanobubbles, have also been elucidated.</p><p><strong>Expert opinion: </strong>Both hemoglobin- and perfluorocarbon-based oxygen carriers are significant, despite having the latter acting as safeguards; they are cost-effective, facile formulations which penetrate small blood vessels and remove arterial blockages due to their nano-size. They also show better biocompatibility and longer half-life circulation than other similar technologies.</p>","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"153-190"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10477329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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