Salivary circular RNAs, particularly hsa_circ_0003563 (circRUNX2) and hsa_circ_0001161 (circMMP9), show strong potential as non-invasive biomarkers for diagnosing periodontitis and distinguishing the rate of disease progression, offering promising tools for improved periodontal diagnostics.
This study shows that using subepithelial connective tissue graft (SeCTG) with either the coronally-advanced flap (CAF) or the tunnel technique (TT) results in similar outcomes for root coverage and patient-reported measures, offering effective treatment options for localized type-1 gingival recessions.
The primary objective was to evaluate the 3-year outcomes of a coronally advanced flap with connective tissue graft (CAF + CTG) for treating gingival recession defects affecting lower incisors. Additionally, the study aimed to investigate whether anatomical factors related to mandibular incisors influence gingival margin stability 3 years post-surgery.
A prospective study was conducted on 30 patients with single gingival recession affecting mandibular incisors, treated with a trapezoidal CAF + CTG at San Raffaele Hospital (Milan, Italy) between January and May 2021. Clinical parameters, including recession depth (REC), keratinized tissue width (KTW), and marginal tissue thickness (MTT), were recorded at baseline and at the 1-year and 3-year follow-ups. Cone Beam Computed Tomography (CBCT) scans were also utilized to assess bucco-lingual inclination, apical root position, vestibular bone dehiscence, and root prominence.
At the 3-year follow-up, complete root coverage (CRC) was achieved in 52% of treated sites. A statistically significant reduction in REC was observed over the evaluation period. However, no significant differences were found in clinical parameters (REC, KTW, and MTT) between the 1-year and 3-year follow-ups. REC at 3 years was significantly and positively correlated with baseline REC, whereas it was inversely correlated with apical root position. Factors associated with mRC at 3 years were KTW baseline, root prominence, and apical root position.
The findings of this study highlight key site-specific anatomical factors that may negatively influence root coverage outcomes in mandibular incisors, providing valuable insights for predicting treatment success.
To (i) assess the prevalence, incidence, and burden of lip and oral cavity cancer, untreated caries, and “other oral conditions” (a group that includes temporomandibular disorders, malocclusion, and dental trauma, among others) in 2021; and (ii) forecast their estimates in 2050. Aggregate estimates for overall oral conditions (comprising caries, periodontitis, and edentulism, but excluding cancer) were also evaluated.
Prevalence, incidence, Years Lived with Disability (YLDs), Years of Life Lost (YLLs), Disability-Adjusted Life Years (DALYs), and deaths were reported for lip and oral cavity cancer. Untreated caries and “other oral conditions” were described as prevalence and YLDs, with incidence included only for caries. Aggregate estimates for overall oral conditions encompassed prevalence, incidence, and YLDs. Data were gathered globally, covering 204 countries, seven super-regions, and 21 regions from the Global Burden of Disease (GBD) study in 2021, with projections up to 2050 using mixed-effects models.
In 2021, over 1.54 million (95% UI 1.44; 1.63) people worldwide were affected by lip and oral cavity cancer, with a global age-standardized prevalence of 0.02%. The burden included 1.28 YLDs per 100 000 (0.97; 1.59), 65.86 YLLs per 100 000 (59.53; 71.00), 67.71 DALYs per 100 000 (61.32; 73.17), and 2.42 deaths per 100 000 (2.21; 2.60). By 2050, prevalence and incidence are projected to increase by +68.7% and + 82.6%, respectively. By that time, lip and oral cavity cancer is expected to rank 119th in terms of YLDs. In 2021, 7.55% (6.29–8.78) of children had untreated caries in deciduous teeth, 27.54% (23.98–32.02) of the adult population had caries in permanent teeth, and 1.86% (1.78–1.93) were affected by “other oral conditions”, with 45.91% (42.26–49.78) of the global population experiencing at least one oral condition. By 2050, the prevalence of deciduous caries is projected to decrease by −15.80%, while permanent caries is predicted to rise by +23.77%, and “other oral conditions” will increase by +22.28%. Overall oral conditions (including periodontitis and edentulism, but excluding cancer) are projected to affect 46.17% (42.52–49.95) of the global population in 2050, ranking as the 10th leading cause of YLDs, surpassing conditions such as stroke and Alzheimer's disease.
Lip and oral cavity cancer, along with oral conditions aggregated (caries, periodontitis, edentulism,
Implant dentistry and periodontology have shown an increasing demand for regenerative procedures associated with biomaterials targeting successful clinical outcomes and predictable long-term results. Membranes applied in oral regeneration have proved to be essential in regenerative procedures, increasing the quality, volume, and stability of the regenerated tissues. This review depicts and explores the past, present, and future of membranes used in periodontal and bone regeneration. Historical concepts and early studies using pioneering membranes are reviewed; physio-chemical and biological membrane properties (e.g., wettability, roughness, biocompatibility, porosity, and mechanical characteristics) are discussed, as well as, the future directions of innovative membranes in the developing stage; and as a central focus, a summary of the clinical techniques and scientific evidence in which membrane application is significantly relevant is exposed. Today, a wide option of membranes is available on the market for clinicians to select and use in regenerative procedures according to the surgical level and desired tissue to be regenerated. For instance, non-resorbable membranes (d-PTFE, e-PTFE, and Ti-reinforced PTFE); resorbable membranes (synthetic and collagen-based); and autologous membranes. Clinical and preclinical results in regenerative procedures using membranes such as horizontal and vertical bone augmentation, sinus lift, immediate implant placement, have shown strong positive evidence compared to spontaneous healing, meanwhile, the current use of membranes in periodontal regeneration, periimplantitis treatment, and alveolar ridge preservation has revealed reduced scientific data, suggesting the need for further investigation. Concluding, the use of membranes is predictable and relevant in oral regeneration. Nevertheless, still there is space for evolution and clinical progress in the use of membranes in oral regeneration aiming to surpass current limitations, eliminate possible contaminations, and promote faster regeneration.
Periodontitis, a chronic inflammatory condition, affects approximately 20%-50% of the world's population. It is usually characterized by progressive destruction of the periodontal soft and hard tissues, clinically manifested as gingival inflammation combined with attachment loss (CAL), radiographically detectable alveolar bone resorption, periodontal pockets, and bleeding on probing, as well as tooth mobility and potential tooth loss in advanced stages. These processes are moderated by the interplay between a dysbiotic microbiota and aberrant immune reactions within the gingival and periodontal tissues and can be modified by numerous internal or external influences. A number of studies discovered the importance of a variety of these impacting factors in periodontitis, including systemic, lifestyle, and environmental factors. Regarding the evidence level, these factors can be classified as predisposing factors, risk indicators, or risk factors. Predisposing factors include age, physical activity, dietary habits, alcohol consumption, and socioeconomic status. As risk indicators, obesity, osteoporosis, cardiovascular diseases, mental health disorders, poor diet, stress, and sleep disorders can be regarded Well-known risk factors for periodontitis are smoking/tobacco use and diabetes mellitus. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long-standing knowledge of the progression of the disease.
This clinical narrative review aimed to comprehensively evaluate the effects of platelet-rich fibrin (PRF) on clinically related and patient-reported outcomes during palatal wound healing following autologous palatal graft harvesting. To gather all available evidence, a comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar, along with a manual search of reference lists from eligible studies, up to November 22, 2024. A total of 28 clinical comparative studies were identified, including 21 randomized clinical trials (RCTs), two non-RCTs, and five case series. Most studies investigated the application of PRF following free gingival grafts (FGG) rather than subepithelial connective tissue grafts (SCTG), with the majority also using solid PRF as opposed to liquid PRF. For FGG harvesting sites, PRF demonstrated positive outcomes in enhancing wound healing-related outcomes, reducing postoperative pain and other complications, lowering analgesic consumption, and improving quality of life (QoL). For SCTG harvesting sites, PRF also showed beneficial effects in promoting wound healing, reducing postoperative pain, and eliminating the need for analgesics. Based on the current findings, PRF application following either FGG and SCTG harvesting appears to be a promising approach for enhancing wound healing, minimizing postoperative complications, reducing analgesic consumption, and improving patient satisfaction. Clinical recommendations, along with step-by-step protocols, are also provided in this review article to guide clinicians in optimized efficiency for use of PRF for palatal wound healing following FGG and SCTG harvesting. A recommended simplified use of solid PRF prepared using horizontal centrifugation, in combination with a palatal stent, is suggested. The addition of sutures alongside the stent may provide enhanced stabilization of PRF in place for larger graft sites. Nevertheless, further well-designed RCTs with standardized methods and larger sample sizes are needed to strengthen the evidence base and confirm the therapeutic advantages of PRF in palatal wound healing.
This is the first study to examine induced periodontitis under simulated microgravity in vivo. Microgravity significantly increased alveolar bone loss, elevated GCF alkaline phosphatase levels, and caused severe periodontal destruction with notable immune cell infiltration. Understanding the underlying molecular pathways may guide future treatments for periodontitis in space and on Earth.
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