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Response - Letter to Editor About the Article: Should Pediatricians be Aware of Cystic Echinococcosis? A Literature Review. 回复-致编辑关于文章的信:儿科医生应该意识到囊性包虫病吗?文献综述。
Pub Date : 2019-10-01 DOI: 10.1097/MPG.0000000000002453
C. Tersigni, L. Galli
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引用次数: 0
Letter to editor about the article: Should Pediatricians be aware of cystic Echinococcosis? A literature review. 致编辑关于文章的信:儿科医生应该意识到囊性包虫病吗?文献综述。
Pub Date : 2019-10-01 DOI: 10.1097/MPG.0000000000002452
Dongmei Huang, Yin Zhou
T o the Editor: We have read a recent report by Tersigni et al (1) with great interest. This review demonstrated that serological tests and different radiological findings are diagnostic tools in cystic echinococcosis (CE) in European children. Meanwhile, watch-andwait, pharmacological treatment, percutaneous treatment, and surgery are 4 available therapy approaches of CE. However, recently more study claimed that endoscopic retrograde cholangiopancreatography (ERCP) and ERCP-associated techniques play a crucial role in diagnosis and treatment biliary tree CE (2–6). ERCP is an important diagnostic and therapeutic tool for biliary disease in child (7,8). Firstly, ERCP can be used to identify the cystobiliary relations if noninvasive tools to explore the biliary tract are unavailable, which attributes to determinate next treatment means (7,9). Secondly, ERCP is another nonsurgical way to treat cystobiliary communications diseases, especially alleviating jaundice and cholangitis of biliary tree obstruction, as a therapeutic alternative to percutaneous transhepatic biliary drainage (PTDC). ERCP is regarded as an interesting alternative to palliative surgery combined with drug treatment, and never impairs further surgical operation (2). Thirdly, ERCP and ERCP-associated techniques are effective ways to detect and treat the postoperative complications after surgery for biliary hydatid diseases, such as biliary fistulas and biliary obstruction by endoscopic nasobiliary drainage and endoscopic sphincterotomy. It avoids surgical reintervention and decreases hospitalazitation time (2,4). Hence, we suggest emphasizing the ERCP role in diagnosis and treatment of CE in European child. It is absolutely benefited to effectively and safely diagnosis and treatment CE in an early stage.
致编辑:我们非常感兴趣地阅读了Tersigni等人(1)最近的一份报告。这篇综述表明血清学检查和不同的放射学表现是诊断欧洲儿童囊性包虫病(CE)的工具。同时,观察等待、药物治疗、经皮治疗和手术治疗是CE的4种治疗方法。然而,最近越来越多的研究表明,内镜逆行胆管胰胆管造影(ERCP)和ERCP相关技术在胆道树CE的诊断和治疗中起着至关重要的作用(2-6)。ERCP是儿童胆道疾病的重要诊断和治疗工具(7,8)。首先,如果没有无创胆道探查工具,ERCP可用于识别胆囊胆关系,这有助于确定下一步的治疗方法(7,9)。其次,ERCP作为经皮经肝胆道引流(PTDC)的一种治疗选择,是治疗胆囊胆道交通疾病的又一种非手术方式,尤其是缓解黄疸和胆道梗阻胆管炎。ERCP被认为是姑息性手术联合药物治疗的一种有趣的替代方案,并且不会影响进一步的外科手术(2)。第三,ERCP及ERCP相关技术是发现和治疗胆道包虫病术后并发症的有效方法,如内镜下鼻胆道引流和内镜下括约肌切开术中的胆道瘘和胆道梗阻。它避免了手术再干预,减少了住院时间(2,4)。因此,我们建议强调ERCP在欧洲儿童CE诊断和治疗中的作用。在早期有效、安全的诊断和治疗CE是绝对有益的。
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引用次数: 0
Integrating Clinical Ultrasound into Screening for Cystic Fibrosis Liver Disease: Approach with Caution and Optimism. 将临床超声纳入囊性纤维化肝病筛查:谨慎和乐观的方法。
Pub Date : 2019-10-01 DOI: 10.1097/MPG.0000000000002441
M. Narkewicz
need to have ‘‘personal equipoise,’’ not favoring a positive outcome over a negative one (13). Studies need to be adequately powered and designed, so that a negative study is as scientifically sound as a positive one. Medical journals need to embrace negative or neutral studies just as much as the positive ones (14). Some progress on this topic has been made, for example with the American Journal of Gastroenterology recently dedicating an entire issue to studies that had no statistically significant superiority of one outcome over another (15). Finally, penalties probably need to be imposed to pharmaceutical companies who keep the less favorable results from being reported in medical journals.
需要保持“个人平衡”,不喜欢积极的结果而不喜欢消极的结果。研究需要有足够的动力和设计,这样消极的研究就像积极的研究一样科学合理。医学期刊需要像接纳积极的研究一样接纳消极或中立的研究(14)。在这个话题上已经取得了一些进展,例如,美国胃肠病学杂志最近专门用一整期的时间来研究没有统计学意义上的显著优势的结果(15)。最后,可能需要对那些不让不太有利的结果发表在医学期刊上的制药公司施加惩罚。
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引用次数: 0
The role of distress and pain catastrophizing on the health-related quality of life of children with inflammatory bowel disease. 焦虑和疼痛对炎症性肠病儿童健康相关生活质量的影响
Pub Date : 2019-10-01 DOI: 10.1097/MPG.0000000000002447
C. De Carlo, M. Bramuzzo, C. Canaletti, C. Udina, G. Cozzi, P. M. Pavanello, Stefania Rampado, S. Martelossi, F. Giudici, G. Di leo, E. Barbi
OBJECTIVESInflammatory bowel disease (IBD) can be particularly challenging during the pediatric age with a relevant impact on patient's health-related quality of life (HRQoL). Disease activity accounts for only a small part of the variability in HRQoL, and psychological factors can play a significant role. We aimed to evaluate the impact of patient's distress and pain catastrophizing on children and adolescents with IBD.METHODSWe prospectively recruited children aged 8-18 with IBD and recorded demographic and disease characteristics. Patients answered questionnaires on HRQoL (IMPACT III), distress (Distress Thermometer, DT), and pain catastrophizing (Pain Catastrophizing Scale - Children, PCS-C). Univariate and multivariate regression models analysis were used to evaluate correlations between patients's characteristics, disease activity, distress, pain catastrophizing and HRQoL.RESULTSSeventy-one patients were enrolled (median age 13.6, 49.3% Crohn's disease, 50.7% ulcerative colitis). Median HRQoL, DT and PCS-C scores were 78.6 (IQR 68.0-87.1), 3.0 (1.0-5.0), and 12.0 (4.0-23.0) respectively. Patient's distress and pain catastrophizing levels significantly correlated with HRQoL. Pain catastrophizing had the strongest impact on HRQoL (Spearman correlation coefficient, ρ 0.73), followed by distress (ρ 0.67), and ulcerative colitis severity (ρ 0.67). The DT and the PCS-C scores were significantly associated (ρ 0.46).CONCLUSIONSDistress and pain catastrophizing have a significative impact on HRQoL in young patients with IBD. Physicians should recognise the role of these psychological factors and consider cognitive-behavioural therapy to optimise the patient's health.
目的:炎症性肠病(IBD)在儿童时期尤其具有挑战性,对患者的健康相关生活质量(HRQoL)有相关影响。疾病活动度仅占HRQoL变异性的一小部分,心理因素可能起重要作用。我们的目的是评估患者的痛苦和痛苦灾难对儿童和青少年IBD的影响。方法前瞻性招募8-18岁IBD患儿,记录人口统计学和疾病特征。患者回答HRQoL (IMPACT III)、窘迫(窘迫温度计,DT)和疼痛灾变(儿童疼痛灾变量表,PCS-C)问卷。采用单因素和多因素回归模型分析评估患者特征、疾病活动性、痛苦、疼痛灾变与HRQoL之间的相关性。结果纳入71例患者(中位年龄13.6岁,克罗恩病49.3%,溃疡性结肠炎50.7%)。HRQoL、DT和PCS-C评分中位数分别为78.6 (IQR 68.0 ~ 87.1)、3.0(1.0 ~ 5.0)和12.0(4.0 ~ 23.0)。患者的苦恼和疼痛灾变水平与HRQoL有显著相关。疼痛灾难化对HRQoL的影响最大(Spearman相关系数,ρ 0.73),其次是焦虑(ρ 0.67)和溃疡性结肠炎严重程度(ρ 0.67)。DT与PCS-C评分显著相关(ρ 0.46)。结论窘迫和疼痛灾难化对年轻IBD患者HRQoL有显著影响。医生应该认识到这些心理因素的作用,并考虑认知行为疗法来优化患者的健康。
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引用次数: 12
Spleen and Liver Stiffness to Detect Esophageal Varices in Children with Biliary Atresia. 脾肝僵硬检测小儿胆道闭锁食管静脉曲张。
Pub Date : 2019-10-01 DOI: 10.1097/MPG.0000000000002430
P. Sintusek, Nipaporn Siriporn, D. Punpanich, V. Chongsrisawat, Y. Poovorawan
OBJECTIVESTo determine the accuracy of non-invasive parameters such as liver (LS) and spleen stiffness (SS) to detect esophageal varices (EV) in children with biliary atresia (BA).METHODSChildren with BA between 2000 and 2015 were recruited. All underwent esophagogastroduodenoscopy and transient elastography. Demographic data, laboratory investigations, alanine transferase-to-platelet ratio index (APRI), and Varices Prediction Rule (VPR) score were collected.RESULTSA total of 51 children (mean age 10.63 years, standard deviation [SD]=6.08 years; 53% males) were enrolled. There were differences in onset and outcome of portoenterostomy, spleen palpablility, platelet count, albumin, LS, SS, and VPR between the varice and varice-free groups (P < 0.05). In the varice group, the median LS was 18.12 [interquartile ratio, IQR 13.15-19.12] and the median SS was 46.85 [IQR 25.95-54.55] kPa. In the varice-free group, the median LS was 7.85 [IQR 5.88-16.75] and the median SS was 16.54 [IQR 11.75-21.75] kPa. Both LS and SS were higher in the varice than the varice-free group (P < 0001). The area under the receiver operating characteristic curve of LS, SS, spleen palpability, platelet count, APRI and VPR were 0.734, 0.870, 0.817, 0.810, 0.751 and 0.794, respectively. Using a cut-off value of 12.5 kPa for LS, the sensitivity and specificity were 80% and 70% respectively. Using a cut-off value of 28.9 kPa for SS, the sensitivity and specificity were 75% and 87% respectively. Combination of LS and SS to diagnose varices increased the specificity to 93%.CONCLUSIONSSS as a single marker had the best diagnostic value to predict esophageal varices in children with BA. The combination of SS and LS furthermore increased the diagnostic yield.
目的探讨肝(LS)、脾硬度(SS)等无创参数检测胆道闭锁(BA)患儿食管静脉曲张(EV)的准确性。方法选取2000 ~ 2015年BA患儿为研究对象。所有患者均行食管胃十二指肠镜检查和瞬时弹性成像。收集患者的人口学资料、实验室调查、丙氨酸转移酶与血小板比值指数(APRI)和静脉曲张预测规则(VPR)评分。结果共51例患儿(平均年龄10.63岁,标准差[SD]=6.08岁;(53%男性)被纳入。静脉曲张组和无静脉曲张组在门肠造口术的起病和转归、脾脏可触性、血小板计数、白蛋白、LS、SS、VPR等方面差异有统计学意义(P < 0.05)。静脉曲张组中位LS为18.12[四分位数比,IQR 13.15 ~ 19.12],中位SS为46.85 [IQR 25.95 ~ 54.55] kPa。无静脉曲张组中位LS为7.85 [IQR 5.88-16.75],中位SS为16.54 [IQR 11.75-21.75] kPa。LS和SS在静脉曲张组均高于无静脉曲张组(P < 0001)。LS、SS、脾脏可触性、血小板计数、APRI、VPR的受试者工作特征曲线下面积分别为0.734、0.870、0.817、0.810、0.751、0.794。LS采用12.5 kPa的临界值,敏感性为80%,特异性为70%。采用28.9 kPa的临界值诊断SS,敏感性和特异性分别为75%和87%。LS和SS联合诊断静脉曲张的特异性提高到93%。结论sss作为单一指标对BA患儿食管静脉曲张的诊断价值最高。SS和LS联合使用进一步提高了诊断率。
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引用次数: 13
European Society for Paediatric Gastroenterology, Hepatology and Nutrition Position Paper on Training in Paediatric Endoscopy. 欧洲儿科胃肠病学、肝病学和营养学学会关于儿科内窥镜检查培训的立场文件。
Pub Date : 2019-09-13 DOI: 10.1097/MPG.0000000000002496
I. Broekaert, C. Tzivinikos, P. Narula, H. Antunes, J. Dias, H. V. D. van der Doef, S. Isoldi, L. Norsa, C. Romano, I. Scheers, A. Silbermintz, M. Tavares, F. Torroni, A. Urs, M. Thomson
Received March 8, 2019; From the University Ch University of Cologn Specialty Hospital, D dren’s Hospital, Sheffi terology, Hepatology of Medicine; Univer Hospitalar S. João, P Gastroenterology Hep Groningen, University #Pediatric Gastroente Rome, the Paediatr Giovanni XXIII, Be Department of Huma Barresi’, University o enterology Unit, Clini de Louvain, Brussels Nutrition, and Liver of Israel, Petach Tik Pediatrica, Centro ma Digestive Endosco Hospital-IRCCS, Rom Address correspondence University Children’s versity of Cologne, C (e-mail: ibroekaert@g Disclaimer: ‘‘ESPGHAN and provides guideline only. Diagnosis and t J.A.D. received grants/res for lectures from Nest ings from Danone an lectures from Abbvie; from Nestle; C.T. rece vie, Merck, Sanofi; A Health Science and p Johnson Nutrition. H.A and F.T. report no con Copyright # 2019 by E Hepatology, and Nut Gastroenterology, He DOI: 10.1097/MPG.0000
2019年3月8日收稿;来自科隆大学专科医院、谢菲儿童医院、肝病学;约翰大学医院,格罗宁根大学消化科,罗马儿科胃肠大学,儿科Giovanni XXIII,巴雷西人类科,鲁汶医院,布鲁塞尔营养和以色列肝脏,Petach Tik儿科,中心消化内窥科医院- irccs,罗马地址通信大学科隆儿童大学(电子邮件:ibroekaert@g)免责声明:“ESPGHAN仅提供指南。Diagnosis和t J.A.D.获得了来自Nest、达能和艾伯维的讲座资助/赞助;从雀巢公司;c.t.r evie,默克,赛诺菲;A健康科学和p约翰逊营养。H.A和F.T.报告没有版权# 2019由E肝病学和坚果胃肠病学,贺DOI: 10.1097/MPG.0000
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引用次数: 14
Gastrointestinal Symptoms in Infants of Mothers with a Psychiatric History and the Role of Depression and Bonding. 有精神病史母亲所生婴儿的胃肠道症状及抑郁和联系的作用
Pub Date : 2019-09-11 DOI: 10.1097/MPG.0000000000002484
Ineke de Kruijff, Vandhana Choenni, Jasja T Groeneweg, A. Vlieger, M. Benninga, R. Kok, A. Kamperman, M. L. D. Berg
OBJECTIVESGastroesophageal reflux (GER), excessive crying, and constipation are common gastrointestinal symptoms in infancy of multifactorial origin in which psychosocial stress factors play an important role. The aims of this observational study were to investigate the presence of gastrointestinal symptoms in infants of mothers with or without a history of a psychiatric disorder, their association with maternal depressive symptoms, and the possible mediating role of bonding.METHODS101 mothers with a history of a psychiatric disorder ("PD mothers") and 60 control mothers were included. Infant gastrointestinal symptoms, maternal depressive symptoms, and mother-infant bonding were assessed using validated questionnaires and diagnostic criteria at 1.5 month postpartum.RESULTSThe mean total score on the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R) reported in infants of PD mothers (13.4 SD 5.4) was significantly higher than in infants of control mothers (10.8 SD 5.4; P = .003). No significant differences were found in the presence of excessive crying (modified Wessel's criteria and subjective experience) and constipation (ROME IV criteria) between both groups. Infant GER was associated with maternal depressive symptoms (P = 0.027) and bonding problems (P = <0.001). Constipation was related to maternal depressive symptoms (P = 0.045), and excessive crying (Wessel and subjective criteria) was associated with bonding problems (respectively P = 0.022 and P = 0.002). The effect of maternal depressive symptomatology on infant GER symptoms and excessive crying was mediated by bonding problems.CONCLUSIONMaternal psychiatric history is associated with infant gastrointestinal symptoms, in which mother-infant bonding is a mediating factor.
目的胃食管反流(GER)、过度哭闹和便秘是婴儿期常见的多因素胃肠道症状,其中心理社会应激因素在其中起重要作用。本观察性研究的目的是调查有或没有精神疾病史的母亲所生的婴儿胃肠道症状的存在,它们与母亲抑郁症状的关系,以及纽带可能的中介作用。方法纳入101名有精神障碍病史的母亲(PD母亲)和60名对照母亲。在产后1.5个月采用有效问卷和诊断标准评估婴儿胃肠道症状、母亲抑郁症状和母婴关系。结果PD组婴儿胃食管反流问卷(I-GERQ-R)平均总分(13.4 SD 5.4)显著高于对照组(10.8 SD 5.4;p = .003)。两组之间在过度哭闹(修改的Wessel标准和主观经验)和便秘(ROME IV标准)方面没有发现显著差异。婴儿GER与母亲抑郁症状(P = 0.027)和亲子关系问题(P = <0.001)相关。便秘与产妇抑郁症状相关(P = 0.045),过度哭闹(Wessel和主观标准)与亲子关系问题相关(P = 0.022和P = 0.002)。母亲抑郁症状对婴儿GER症状和过度哭闹的影响是由结合问题介导的。结论母亲精神病史与婴儿胃肠道症状相关,其中母婴关系是其中的中介因素。
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引用次数: 6
Abstracts: 5th International Symposium on Paediatric Inflammatory Bowel Disease 第五届儿科炎症性肠病国际研讨会
Pub Date : 2019-09-05 DOI: 10.1097/mpg.0000000000002485
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引用次数: 5
Depression Screening in Pediatric IBD Clinics: Recommendations and a Toolkit for Implementation. 儿童IBD诊所抑郁症筛查:建议和实施工具包。
Pub Date : 2019-09-01 DOI: 10.1097/MPG.0000000000002499
L. Mackner, Brandi N. Whitaker, Michele H. Maddux, S. Thompson, Cheyenne L. Hughes-Reid, Megan Drovetta, B. Reed‐Knight
Rates of youth depression are increasing, and approximately 75% of adolescents with depression go unrecognized. Research in pediatric IBD documents increased depression risk, with rates up to 25%, as well as worse adherence and treatment outcomes associated with depressive symptoms. Evidence-based psychological interventions improve the physical and emotional health of these patients, highlighting the importance of detection and treatment. Psychosocial screening has been shown to increase the accurate identification of psychosocial problems and facilitate timely psychosocial intervention. The objective of this article is to establish clinical guidelines for depression screening in youth diagnosed with IBD and to provide resources for implementation. The psychosocial screening task force group comprised of psychologists and social workers in the ImproveCareNow (ICN) learning health system reviewed research and clinical guidelines in other fields, and consulted with physicians, nurses, other psychosocial professionals, patients with IBD, and parents of children with IBD in ICN. It is recommended that adolescents with IBD ages 12 and older be screened for depression annually. Additional practical recommendations for implementation, triage, and treatment within the pediatric gastroenterology clinic are also provided.
青少年抑郁症的发病率正在上升,大约75%的青少年抑郁症患者未被发现。对儿童IBD的研究表明,抑郁风险增加,发生率高达25%,并且与抑郁症状相关的依从性和治疗结果更差。循证心理干预措施改善了这些患者的身心健康,突出了发现和治疗的重要性。社会心理筛查已被证明可以提高对社会心理问题的准确识别,并促进及时的社会心理干预。本文的目的是建立诊断为IBD的青少年抑郁症筛查的临床指南,并为实施提供资源。由improecarenow (ICN)学习卫生系统的心理学家和社会工作者组成的社会心理筛查工作组审查了其他领域的研究和临床指南,并咨询了医生、护士、其他社会心理专业人员、IBD患者以及ICN IBD患儿的父母。建议12岁及以上患有IBD的青少年每年进行抑郁症筛查。额外的实用建议的实施,分流,并在儿科胃肠病学诊所治疗也提供。
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引用次数: 15
Obscure GI Bleeding Secondary to Diffuse Gastric Heterotopia in the Proximal Jejunum. 空肠近端弥漫性胃异位继发的隐蔽性消化道出血。
Pub Date : 2019-09-01 DOI: 10.1097/MPG.0000000000002240
Amit A Shah, A. Kastl, Bridget C. Godwin, P. Mamula, Kristin N. Fiorino
Upper gastrointestinal series with small bowel follow-through, upper endoscopy, and colonoscopy were normal. Magnetic resonance enterography showed proximal jejunal thickening. Capsule endoscopy and push enteroscopy exhibited proximal jejunal edema and ulceration; jejunal biopsies showed normal mucosa intermixed with gastric epithelium (Fig. 1). Meckel’s scan revealed ectopic gastric mucosa throughout midabdomen (Fig. 2). Laparotomy with intraoperative push enteroscopy resulted in 25 cm of jejunal resection 20 cm distal to the ligament of Treitz (Fig. 3). Pathology illustrated multifocal polypoid gastric heterotopia with reactive gastropathy and focal hemorrhage.
上消化道检查、小肠随访、上消化道内镜检查和结肠镜检查均正常。磁共振肠造影显示空肠近端增厚。胶囊内镜和推式肠镜检查显示空肠近端水肿和溃疡;空肠活检显示正常粘膜与胃上皮混杂(图1)。Meckel扫描显示胃粘膜异位贯穿中腹(图2)。开腹术中推肠镜导致空肠切除25厘米,距离Treitz韧带远20厘米(图3)。病理显示多灶性息肉样胃异位伴反应性胃病和局灶性出血。
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引用次数: 0
期刊
Journal of Pediatric Gastroenterology & Nutrition
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