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Effect of activity restrictions on pectus bar displacement following minimally invasive repair of pectus excavatum - A Western Pediatric Surgery Research Consortium 活动限制对漏斗胸微创修复后胸棒移位的影响——一项西方儿科外科研究联盟研究。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162520
R. Scott Eldredge , Benjamin E. Padilla , Anastasia M. Kahan , Lauren Nicassio , Stephanie D. Chao , Marisa Schwab , Jose Diaz-Miron , Ana Ibarra , Samir Pandya , Mark Ryan , Lauren Gillory , Justin Lee , Romeo C. Ignacio , Ben A. Keller , Jack H. Scaife , Christopher E. Clinker , Lucas A. McDuffie , Emily Byrd , David Rothstein , Lorraine I. Kelley-Quon , Katie W. Russell

Introduction

Activity restrictions following the minimally invasive repair of pectus excavatum (MIRPE) are often given with the intention of reducing pectus bar displacement (PBD). We aimed to assess the effect of activity restrictions on PBD following MIPRE.

Methods

A ten-center retrospective review was conducted among patients <21 years undergoing MIRPE between 7/1/2022-10/31/2023. Postoperative activity restrictions were categorized into two groups: no restrictions versus any activity restrictions. PBD was defined as bar migration requiring reoperation within 90 days of MIRPE. We compared the incidence of PBD and postoperative outcomes between cohorts.

Results

A total of 532 patients were included (mean age - 15.9 ± 2.0 years, male – 86 %, median Haller index - 4.5 [IQR:3.8–5.8]). Postoperatively, 24 % of patients (127/532) were not given activity restrictions. Patients with activity restriction had a higher proportion of pericostal suture use (78 % vs 43 %, p < 0.001) and subpectoral tunneling (58 % vs 36 %, P < 0.001), and a lower proportion of sternal elevation (63 % vs 80 %, p < 0.001) and cryoanalgesia (88 % vs 100 %, p < 0.001) during MIRPE. Overall, PBD occurred in 1.6 % of patients, with no difference in the incidence of PBD between those patients with and without activity restrictions (1.7 % vs 0.8 %, p = 0.468). Additionally, there were no significant differences in other postoperative complications between these groups.

Conclusion

Ad libitum physical activity after MIRPE was not associated with an increased risk of pectus bar displacement. Activity restrictions may be unnecessary, and consideration should be given to their elimination to accelerate recovery.
导语:微创漏斗胸修复术(MIRPE)后的活动限制通常是为了减少胸棒移位(PBD)。我们的目的是评估MIPRE后活动限制对PBD的影响。方法:对2022年7月1日至2023年10月31日期间接受MIRPE治疗的< 21岁患者进行十中心回顾性研究。术后活动限制分为两组:无活动限制和有活动限制。PBD被定义为MIRPE后90天内需要再次手术的条状偏移。我们比较了队列间PBD的发生率和术后结果。结果:共纳入532例患者(平均年龄- 15.9±2.0岁,男性- 86%,中位Haller指数- 4.5 [IQR:3.8-5.8])。术后,24%的患者(127/532)未给予活动限制。活动受限的患者使用骨周缝合的比例更高(78%对43%)。结论:MIRPE术后自由活动与胸肌杆移位的风险增加无关。活动限制可能是不必要的,应考虑取消这些限制以加速恢复。
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引用次数: 0
Reduction of prophylactic antibiotics for elective pediatric cholecystectomy: A QI initiative to promote antimicrobial stewardship 选择性儿童胆囊切除术减少预防性抗生素:一项促进抗菌药物管理的QI倡议。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162542
Colton D. Wayne , Wendy Jo Svetanoff , Taylor H. Jacobs , Cindy L. McManaway , Sara A. Mansfield , Elizabeth Schneider , Brian D. Kenney , Joshua R. Watson , Gail E. Besner

Purpose

Antibiotic prophylaxis minimizes the risk of infection, but overtreatment leads to antimicrobial resistance. Adult studies suggest antibiotic prophylaxis for elective cholecystectomy may not be needed. Our quality improvement project aimed to decrease prophylactic antibiotic use for elective cholecystectomies from 100 % to ≤50 % and maintain that rate for one year.

Methods

Prior to initiation, the pre-operative orderset was modified, education was provided, and surgeon consensus was achieved. All patients undergoing elective minimally invasive (laparoscopic and robotic) cholecystectomy were included. Exclusion criteria included acute cholecystitis, immunocompromised state, or performance of a combined procedure. Compliance was measured by chart review, with feedback provided for noncompliance. The project was initiated January 2024. Data were collected for twelve months prior (1/23–12/23) and after initiation (1/24–12/24). The balancing measure was surgical site infection (SSI).

Results

Ninety patients met inclusion criteria (40 pre-protocol and 50 post-protocol). Median age at surgery was 16 years (IQR 14, 17.2). Seventy-seven (86 %) patients were female. Prior to implementation, all patients (n = 40) received prophylactic antibiotics. In the first three months post-implementation, 3/16 (19 %) received antibiotic prophylaxis (due to inadequate communication with anesthesia providers). In the subsequent nine months, 0/34 (0 %) received antibiotic prophylaxis. One (2.5 %) patient in the pre-implementation group was noted to have an SSI requiring antibiotics vs. 3 (6 %) patients in the post-implementation group (p = 0.43).

Conclusion

Use of prophylactic antibiotics for elective minimally invasive cholecystectomy decreased from 100 % to 6 % without significantly increasing the rate of SSI. Appropriately decreasing use of prophylactic antibiotics can improve antibiotic stewardship efforts.

Level of evidence

Level III.
目的:抗生素预防可将感染风险降至最低,但过度治疗会导致抗菌素耐药性。成人研究表明选择性胆囊切除术可能不需要抗生素预防。我们的质量改进项目旨在将选择性胆囊切除术预防性抗生素的使用从100%降低到≤50%,并保持该比例一年。方法:在手术开始前,修改术前医嘱,提供教育,并取得外科医生的一致意见。所有接受选择性微创(腹腔镜和机器人)胆囊切除术的患者均被纳入研究。排除标准包括急性胆囊炎、免疫功能低下或联合手术。依从性是通过图表审查来衡量的,并对不依从性提供反馈。该项目于2024年1月启动。数据收集于起始前(1月23日-12月23日)和起始后(1月24日-12月24日)12个月。平衡指标为手术部位感染(SSI)。结果:90例患者符合纳入标准(方案前40例,方案后50例)。手术年龄中位数为16岁(IQR 14,17.2)。77例(86%)为女性。在实施之前,所有患者(n=40)均接受预防性抗生素治疗。在实施后的前三个月,3/16(19%)接受了抗生素预防(由于与麻醉提供者沟通不足)。在随后的9个月中,0/34(0%)接受了抗生素预防。实施前组有1例(2.5%)患者有SSI需要抗生素治疗,而实施后组有3例(6%)患者(p=0.43)。结论:选择性微创胆囊切除术预防性抗生素的使用从100%下降到6%,未显著增加SSI发生率。适当减少预防性抗生素的使用可以改善抗生素管理工作。证据等级:三级。
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引用次数: 0
Risk of missed diagnoses when choosing non-operative management of pediatric uncomplicated appendicitis 小儿无并发症阑尾炎选择非手术治疗的漏诊风险。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162543
Mary Elizabeth Guerra , Brian T. Hickner , Celia D. Flores , Mary E. Fang , Charlene A. Barclay , Gabriella L. Graybill , Timothy C. Lee , Sanjeev A. Vasudevan , Sundeep G. Keswani , J. Ruben Rodriguez

Purpose

An antibiotic-only approach to managing uncomplicated appendicitis in children confers the risk of missed diagnoses of alternate pathologies. We aimed to quantify this risk in patients presenting with uncomplicated acute appendicitis at a large tertiary children's hospital and to assess contemporary perioperative clinical outcomes.

Methods

A retrospective review of patients who underwent appendectomy for uncomplicated appendicitis between January 1, 2019 and December 31, 2023 was conducted. Pathology reports and perioperative outcomes were analyzed.

Results

Among 5341 patients, 1.1 % had notable alternative pathologies including 31 occult malignancies (0.6 %) and 24 atypical infections (0.5 %). A subgroup analysis demonstrated that patients who underwent interval appendectomy were more likely to have neoplasms (5/128) than those who underwent uncomplicated acute appendectomies (3.9 % vs 0.6 %, respectively; p < 0.001). The median postoperative length of stay was 2.6 h (IQR 2.0–12.5 h). There were 182 (3.4 %) surgery-related emergency center visits post-discharge and 57 (1.1 %) surgery-related readmissions. Seventeen patients (0.3 %) required additional procedures. The negative appendectomy rate was 1.8 %.

Conclusion

A notable number of patients had alternative diagnoses made by pathologic examination, including occult malignancies and atypical infections which required further treatment. The perioperative outcomes of appendectomy were favorable, with low morbidity and a low rate of negative appendectomy. These findings underscore the diagnostic value of surgical specimen evaluation and quantify the added risk of missing alternate pathologies when offering non-operative management.
目的:仅使用抗生素治疗儿童无并发症的阑尾炎会增加其他病理漏诊的风险。我们的目的是量化一家大型三级儿童医院无并发症急性阑尾炎患者的这种风险,并评估当代围手术期临床结果。方法:回顾性分析2019年1月1日至2023年12月31日因无并发症阑尾炎行阑尾切除术的患者。分析病理报告和围手术期结果。结果:5341例患者中,有明显病变的占1.1%,其中隐匿性恶性肿瘤31例(0.6%),非典型感染24例(0.5%)。亚组分析显示,间隔期阑尾切除术患者比无并发症的急性阑尾切除术患者更容易发生肿瘤(5/128)(分别为3.9%和0.6%;P < 0.001)。术后中位住院时间为2.6小时(IQR 2.0 - 12.5小时)。出院后与手术相关的急诊中心就诊182例(3.4%),与手术相关的再入院57例(1.1%)。17名患者(0.3%)需要额外的手术。阑尾切除术阴性率为1.8%。结论:有相当一部分患者在病理检查中出现了其他诊断,包括隐匿性恶性肿瘤和非典型感染,需要进一步治疗。阑尾切除术围手术期预后良好,发病率低,阴性率低。这些发现强调了手术标本评估的诊断价值,并量化了在提供非手术治疗时遗漏替代病理的附加风险。
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引用次数: 0
Sustained early postnatal humoral and cellular immunity against human cytomegalovirus after transamniotic fetal mRNA vaccination in a rodent model 在啮齿类动物模型中,经羊水胎mRNA疫苗接种后对人巨细胞病毒持续的早期出生后体液和细胞免疫
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162544
Emily M. Scire, Alex L. Huang, Thais Boccia, Kamila Moskowitzova, Ina Kycia, Tanya T. Dang, Melody Tai, Eva Zacharakis, Ayaka Aihara, Beatriz S. Bechara, David Zurakowski, Dario O. Fauza

Purpose

We sought to examine the humoral and cellular immune responses to transamniotic fetal mRNA vaccination against a human cytomegalovirus (hCMV) antigen over time in early postnatal life in a rodent model.

Methods

Seven pregnant Sprague Dawley dams underwent volume-matched intra-amniotic injections in all their fetuses (n = 82) of a custom-made mRNA encoding for hCMV envelope glycoprotein-B (hCMV-gB) antigen encapsulated by a lipid-polymer composite on gestational day 17 (E17; term = E21-22). At three time points between 1 and 3 months after birth, serum levels of antigen-specific hCMV-gB IgG antibodies were measured by ELISA. In addition, host spleen lymphocytes were incubated with or without challenge with the hCMV-gB antigen, followed by flow cytometry of culture supernatants to assess T-cell response.

Results

Overall neonatal survival was 44 % (36/82), with no significant differences between the groups. Antigen-specific hCMV-gB antibodies were present in the serum at all time points, albeit decreasing significantly from 1 to 3 months postnatally (p = 0.029). Spleen lymphocytes from vaccinated pups showed significantly increased production of IFN-γ, IL-2, TNF-α, GM-CSF, and IL-6 following antigen-specific challenge (p = 0.021 to <0.001 vs. non-challenged cells). Cellular response increased significantly over time (p = 0.043 to <0.001), indicating a maturing Th1 response.

Conclusions

Transamniotic fetal mRNA delivery of a human cytomegalovirus antigen can induce a lasting adaptive cell-mediated immune response, while also exhibiting continued antigen-specific immunoglobulin production extending into the early neonatal period in a healthy rat model. Fetal mRNA vaccination via the minimally invasive transamniotic route may become a practical strategy for the prevention of perinatal infections.

Level of evidence

N/A.

Type of study

Animal and laboratory study.
目的:在啮齿动物模型中,我们试图研究在出生后早期,经羊膜胎儿mRNA疫苗接种对人巨细胞病毒(hCMV)抗原的体液和细胞免疫反应。方法:在妊娠第17天(E17),对7只怀孕的Sprague Dawley母母(n=82)胎儿进行羊膜内等量注射,注射一种定制的mRNA,该mRNA编码hCMV包膜糖蛋白- b (hCMV- gb)抗原,该抗原被脂质-聚合物复合物包裹。词= E21-22)。在出生后1 ~ 3个月的3个时间点,采用ELISA法检测血清抗原特异性hCMV-gB IgG抗体水平。此外,用hCMV-gB抗原孵育或不孵育宿主脾淋巴细胞,然后用流式细胞术检测培养上清,以评估t细胞反应。结果:新生儿总生存率为44%(36/82),两组间无显著差异。抗原特异性hCMV-gB抗体在所有时间点均存在于血清中,尽管在出生后1至3个月显著下降(p=0.029)。免疫幼鼠的脾脏淋巴细胞在抗原特异性攻击后显著增加IFN-γ、IL-2、TNF-α、GM-CSF和IL-6的产生(p=0.021)。结论:在健康大鼠模型中,经羊膜胎儿mRNA递送人巨细胞病毒抗原可以诱导持久的适应性细胞介导的免疫应答,同时也表现出持续的抗原特异性免疫球蛋白的产生,并延伸至新生儿早期。通过微创羊膜途径接种胎儿mRNA可能成为预防围产期感染的实用策略。证据水平:无(动物和实验室研究)研究类型:动物和实验室研究。
{"title":"Sustained early postnatal humoral and cellular immunity against human cytomegalovirus after transamniotic fetal mRNA vaccination in a rodent model","authors":"Emily M. Scire,&nbsp;Alex L. Huang,&nbsp;Thais Boccia,&nbsp;Kamila Moskowitzova,&nbsp;Ina Kycia,&nbsp;Tanya T. Dang,&nbsp;Melody Tai,&nbsp;Eva Zacharakis,&nbsp;Ayaka Aihara,&nbsp;Beatriz S. Bechara,&nbsp;David Zurakowski,&nbsp;Dario O. Fauza","doi":"10.1016/j.jpedsurg.2025.162544","DOIUrl":"10.1016/j.jpedsurg.2025.162544","url":null,"abstract":"<div><h3>Purpose</h3><div>We sought to examine the humoral and cellular immune responses to transamniotic fetal mRNA vaccination against a human cytomegalovirus (hCMV) antigen over time in early postnatal life in a rodent model.</div></div><div><h3>Methods</h3><div>Seven pregnant Sprague Dawley dams underwent volume-matched intra-amniotic injections in all their fetuses (n = 82) of a custom-made mRNA encoding for hCMV envelope glycoprotein-B (hCMV-gB) antigen encapsulated by a lipid-polymer composite on gestational day 17 (E17; term = E21-22). At three time points between 1 and 3 months after birth, serum levels of antigen-specific hCMV-gB IgG antibodies were measured by ELISA. In addition, host spleen lymphocytes were incubated with or without challenge with the hCMV-gB antigen, followed by flow cytometry of culture supernatants to assess T-cell response.</div></div><div><h3>Results</h3><div>Overall neonatal survival was 44 % (36/82), with no significant differences between the groups. Antigen-specific hCMV-gB antibodies were present in the serum at all time points, albeit decreasing significantly from 1 to 3 months postnatally (p = 0.029). Spleen lymphocytes from vaccinated pups showed significantly increased production of IFN-γ, IL-2, TNF-α, GM-CSF, and IL-6 following antigen-specific challenge (p = 0.021 to &lt;0.001 vs. non-challenged cells). Cellular response increased significantly over time (p = 0.043 to &lt;0.001), indicating a maturing Th1 response.</div></div><div><h3>Conclusions</h3><div>Transamniotic fetal mRNA delivery of a human cytomegalovirus antigen can induce a lasting adaptive cell-mediated immune response, while also exhibiting continued antigen-specific immunoglobulin production extending into the early neonatal period in a healthy rat model. Fetal mRNA vaccination via the minimally invasive transamniotic route may become a practical strategy for the prevention of perinatal infections.</div></div><div><h3>Level of evidence</h3><div>N/A.</div></div><div><h3>Type of study</h3><div>Animal and laboratory study.</div></div>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":"61 1","pages":"Article 162544"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantifying recovery time after common pediatric surgical procedures 量化普通儿科外科手术后的恢复时间。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162593
Elizabeth Reynolds, Jonathan E. Kohler, Minna M. Wieck

Purpose

Parents need to plan for patients’ recovery after pediatric operations. Standard guidance for pain medication use and time off school is not evidence based, for lack of data. This study aims to quantify recovery time and pain medication usage after common pediatric operations to improve the post-operative experience for families.

Methods

We performed a single-center retrospective survey at an academic tertiary care center. By protocol, patients who are discharged after routine outpatient surgeries are called 2–4 weeks later for follow up. We modified the post-operative call template to include asking when the patient returned to school and baseline behavior, when parent(s) returned to work, and how many days patients required pain medications. We abstracted encounters from December 2022–August 2024.

Results

Follow-up data from the postoperative phone call was available for 192 patients who underwent laparoscopic appendectomy (uncomplicated appendicitis) (n = 65), umbilical hernia repair (n = 41), laparoscopic inguinal hernia repair (n = 40), out-patient laparoscopic cholecystectomy (n = 14), miscellaneous laparoscopy (n = 5), miscellaneous skin and soft tissue cases (n = 22), and pilonidal cyst excision (n = 5). On average patients used non-narcotic pain medications for 2–3 days, but parents did not think they were at baseline until post-operative day (POD) 5–6 and patients did not return to school until POD 6–8. On average, parents returned to work on POD 1–2.

Conclusion

Children miss a predictable number of school days after common pediatric surgeries, which may be more than pediatric surgeons anticipate. Data driven pre-operative counseling can improve families’ trust in their health care team and facilitate anticipation of discharge needs.
目的:家长需要为儿童手术后患者的康复做好计划。由于缺乏数据,关于止痛药使用和休学时间的标准指导没有证据依据。本研究旨在量化普通儿科手术后的恢复时间和止痛药使用情况,以改善家庭的术后体验。方法:我们在一家学术三级保健中心进行了一项单中心回顾性调查。根据协议,常规门诊手术后出院的患者在2-4周后被叫来随访。我们修改了术后电话模板,包括询问患者何时返回学校和基线行为,父母何时返回工作岗位,以及患者需要多少天的止痛药。我们抽取了2022年12月至2024年8月期间的遭遇战。结果:192例腹腔镜阑尾切除术(无并发症阑尾炎)患者(65例)、脐疝修补术(41例)、腹腔镜腹股沟疝修补术(40例)、门诊腹腔镜胆囊切除术(14例)、杂项腹腔镜(5例)、杂项皮肤软组织手术(22例)、毛鞘囊肿切除术(5例)术后电话随访资料。患者使用非麻醉性止痛药的平均时间为2-3天,但家长直到POD 5-6才认为他们处于基线状态,患者直到POD 6-8才返回学校。平均而言,父母在POD 1-2返回工作岗位。结论:儿童在普通儿科手术后缺课的天数可预测,这可能比儿科医生预期的要多。数据驱动的术前咨询可以提高家庭对医疗团队的信任,促进出院需求的预测。
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引用次数: 0
#CBCLIPS: The international impact of a social media-based pediatric surgery interactive educational program #CBCLIPS:基于社交媒体的儿科外科互动教育计划的国际影响。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162533
Julia Ferreira, Boaz Laor, Elena Guadagno, Sherif Emil

Background

Despite the transformative influence of social media on connectivity, learning, and networking, its role and impact on surgical education remains undefined. In the current study, we evaluated the impact of #CBCLIPS (Case Based Clinical Learning In Pediatric Surgery), a social media-based pediatric surgery educational program.

Methods

A descriptive mixed-methods study evaluated the impact of #CBCLIPS, by analyzing social media engagement metrics (likes, shares, comments) across X, Facebook, and LinkedIn. Additionally, an online survey administered on these platforms assessed participants' perceptions of knowledge gained and satisfaction with the program. Descriptive statistics summarized quantitative data, while thematic analysis was applied to qualitative feedback.

Results

#CBCLIPS was highly relevant and appealing to its viewers in all three social media platforms. On X, the episodes boasted an average engagement rate of 6.9 %, significantly outperforming typical benchmarks for the platform. Visibility for #CBCLIPS was substantial on both X and LinkedIn, achieving up to 13,810 and 8282 impressions, respectively. Facebook emerged as the leading platform for interactive engagement, with medians of 60 likes and 13 comments per post, reinforcing its position as the premier platform for fostering community discussions. The survey was completely answered by 160 people from 71 different countries.

Conclusion

#CBCLIPS is a continuous interactive educational program that significantly engages an international audience, facilitates knowledge acquisition and application, and garners high support among participants. Its reach and success demonstrate the effectiveness of social media-based education in pediatric surgery.
背景:尽管社交媒体在连通性、学习和网络方面产生了变革性的影响,但其在外科教育中的作用和影响仍未明确。在当前的研究中,我们评估了#CBCLIPS(基于病例的儿科外科临床学习)的影响,这是一个基于社交媒体的儿科外科教育项目。方法:一项描述性混合方法研究通过分析X、Facebook和LinkedIn的社交媒体参与指标(喜欢、分享、评论)来评估#CBCLIPS的影响。此外,在这些平台上进行的一项在线调查评估了参与者对所获得知识的看法和对课程的满意度。描述性统计概括了定量数据,而专题分析则用于定性反馈。结果:#CBCLIPS在所有三个社交媒体平台上都具有高度相关性和吸引力。在X平台上,剧集的平均参与率为6.9%,明显优于该平台的典型基准。#CBCLIPS在X和LinkedIn上的曝光率都很高,分别达到13810次和8282次。Facebook成为互动互动的领先平台,平均每篇帖子有60个赞和13条评论,巩固了其作为促进社区讨论的首要平台的地位。来自71个不同国家的160人完整地回答了这项调查。结论:#CBCLIPS是一个持续的互动教育项目,吸引了大量国际观众,促进了知识的获取和应用,并获得了参与者的高度支持。它的覆盖面和成功证明了基于社交媒体的儿科外科教育的有效性。
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引用次数: 0
Transamniotic fetal delivery of recombinant human immunoglobulin monoclonal antibodies: A potential novel strategy for prevention of neonatal Respiratory Syncytial Virus (RSV) disease 重组人免疫球蛋白单克隆抗体经羊膜胎儿分娩:预防新生儿呼吸道合胞病毒(RSV)病的潜在新策略。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162516
Alex L. Huang, Emily M. Scire, Tanya T. Dang, Melody Tai, Eva Zacharakis, Blen Yohannes, Ina Kycia, David Zurakowski, Dario O. Fauza

Purpose

Modified monoclonal class-G immunoglobulins (IgG) have been shown to protect infants from Respiratory Syncytial Virus (RSV), a prevalent disease with particularly high morbidity in newborns. We sought to determine whether a clinically relevant monoclonal IgG against RSV could be delivered to the fetus via transammiotic fetal immunotherapy (TRAFIT) and remain bioavailable after birth.

Methods

Fetuses (n = 75) from five pregnant dams received volume-matched intra-amniotic injections on gestational day 17–18 (E17-18, term = E21-22) of either an FDA approved and commercially available recombinant human immunoglobulin-G1-kappa (IgG1κ) monoclonal antibody against RSV (Nirsevimab®) (n = 30) or of saline (n = 45), the latter to control for possible IgG1κ interspecies homology. Levels of IgG1κ were quantified by ELISA in the serum and lungs at term and on postnatal day of life 7 (P7). Maternal serum samples were also tested. Statistical analyses included two-tailed Fisher's exact test, Wilcoxon rank sum test, and mixed-effects median regression (p < 0.05).

Results

Overall survival was not significantly different between the two groups (p = 0.808). Levels of the IgG1κ monoclonal antibody were significantly higher than that of controls in serum and lung samples at both term and P7 (all p < 0.001). IgG1k levels in maternal serum samples were not significantly different between the groups.

Conclusions

TRAFIT with a clinically relevant recombinant human monoclonal antibody against RSV leads to sustained levels of the antibody in the serum and lungs of the neonate at term and into the early neonatal period in a rat model. TRAFIT could become a viable option for the prevention against RSV in newborns.

Level of evidence

N/A (animal and laboratory study).

Type of study

animal and laboratory study.
目的:修饰的单克隆g类免疫球蛋白(IgG)已被证明可保护婴儿免受呼吸道合胞病毒(RSV)的感染,RSV是一种在新生儿中发病率特别高的流行疾病。我们试图确定临床相关的抗RSV单克隆IgG是否可以通过羊水胎儿免疫治疗(transamotic fetal immunotherapy, TRAFIT)传递给胎儿,并在出生后保持生物利用度。方法:来自5只妊娠母鼠的胎儿(n=75)在妊娠第17-18天(E17-18,足月=E21-22)接受容量匹配的羊膜内注射FDA批准和市售的重组人免疫球蛋白- g1 -kappa (IgG1κ)单克隆抗体(Nirsevimab®)(n=30)或生理盐水(n=45),后者用于控制可能的IgG1κ物种间同源性。用ELISA法测定足月和出生后7天血清和肺中IgG1κ水平(P7)。还检测了母体血清样本。统计分析采用双尾Fisher精确检验、Wilcoxon秩和检验和混合效应中位回归(结果:两组总生存率无显著差异(p=0.808)。在足月和P7期的血清和肺部样本中,IgG1κ单克隆抗体的水平均显著高于对照组(均为P7)。结论:TRAFIT结合临床相关的重组人抗RSV单克隆抗体可导致大鼠模型中足月和早期新生儿血清和肺部中抗体水平持续升高。TRAFIT可能成为预防新生儿呼吸道合胞病毒的可行选择。证据水平:无(动物和实验室研究)。
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引用次数: 0
Untold stories: A qualitative investigation of patient and family experiences with congenital diaphragmatic hernia 不为人知的故事:对先天性膈疝患者和家庭经历的定性调查。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162540
Alexandra Dimmer , Zanib Nafees , Sabrina Beauseigle , Franco A. Carnevale , Elena Guadagno , Dan Poenaru , Pramod Puligandla

Background

Patient and family perspectives on CDH are infrequently explored, impairing clinicians’ understanding of illness impact on functioning and desired support. We investigated the lived experiences of CDH patients and primary caregivers, including those with neurodevelopmental impairment (NDI), regarding the adequacy of clinical and community support.

Methods

Cross-sectional qualitative study convening focus groups (FGs) to explore CDH patient experiences within our CDH follow-up clinic. Participants >4 years were recruited between December 2023–March 2024. FGs were grouped by language preference, presence of NDI, and clinic graduate status. Virtual FG sessions were assessed using inductive thematic analyses.

Results

Twenty-six participants (10 CDH children/12 caregivers/4 clinic graduates) participated among 4 FGs. Thematic analysis revealed 4 themes: experiencing CDH as a caregiver; experiencing CDH as a child; striving for normalcy; and getting the support we need. Caregivers reported shock at CDH diagnosis and during initial hospitalization. Caregiver isolation/distress were common, particularly when physically separated from their newborn. Memories faded with time with parents revealing few long-term effects on their children. While most reported minimal impact, some CDH patients struggled with visible CDH indicators (e.g. scars). Patients expressed a high quality of life despite NDI or co-morbidities. Caregivers were satisfied with clinical support and easy contact but desired interaction with other CDH families for emotional/psychological support.

Conclusion

This first study on CDH lived experiences revealed high quality of life, despite early challenges. Caregivers valued the CDH clinic for easy access to expert care but desired contact with other CDH families for emotional support.

Level of Evidence

Level II (prospectively collected data, retrospective analysis).
背景:很少探讨患者和家庭对CDH的看法,这削弱了临床医生对疾病对功能的影响和所需支持的理解。我们调查了CDH患者和主要照顾者的生活经历,包括神经发育障碍(NDI)患者,关于临床和社区支持的充分性。方法:横断面定性研究召集焦点小组(FGs)探讨CDH患者的经验在我们的CDH随访诊所。在2023年12月至2024年3月期间招募了40岁的参与者。FGs按语言偏好、有无NDI和临床毕业生身份进行分组。使用归纳专题分析对虚拟FG会议进行评估。结果:26名参与者(10名CDH儿童/12名护理人员/4名临床毕业生)参加了4个fg。主题分析揭示了4个主题:作为看护者经历CDH;在儿童时期经历过CDH;争取正常的;并得到我们需要的支持。护理人员报告在CDH诊断和最初住院期间出现休克。照顾者的孤立/痛苦很常见,特别是当他们与新生儿身体分离时。随着时间的推移,记忆逐渐消失,父母对孩子的长期影响很少。虽然大多数报告的影响很小,但一些CDH患者仍存在可见的CDH指标(如疤痕)。尽管有NDI或合并症,患者仍表现出较高的生活质量。护理人员对临床支持和容易接触感到满意,但希望与其他CDH家庭进行情感/心理支持的互动。结论:第一项关于CDH生活经历的研究显示,尽管早期存在挑战,但生活质量很高。护理人员重视CDH诊所,因为它易于获得专家护理,但希望与其他CDH家庭接触,以获得情感支持。证据等级:二级(前瞻性收集数据,回顾性分析)。
{"title":"Untold stories: A qualitative investigation of patient and family experiences with congenital diaphragmatic hernia","authors":"Alexandra Dimmer ,&nbsp;Zanib Nafees ,&nbsp;Sabrina Beauseigle ,&nbsp;Franco A. Carnevale ,&nbsp;Elena Guadagno ,&nbsp;Dan Poenaru ,&nbsp;Pramod Puligandla","doi":"10.1016/j.jpedsurg.2025.162540","DOIUrl":"10.1016/j.jpedsurg.2025.162540","url":null,"abstract":"<div><h3>Background</h3><div>Patient and family perspectives on CDH are infrequently explored, impairing clinicians’ understanding of illness impact on functioning and desired support. We investigated the lived experiences of CDH patients and primary caregivers, including those with neurodevelopmental impairment (NDI), regarding the adequacy of clinical and community support.</div></div><div><h3>Methods</h3><div>Cross-sectional qualitative study convening focus groups (FGs) to explore CDH patient experiences within our CDH follow-up clinic. Participants &gt;4 years were recruited between December 2023–March 2024. FGs were grouped by language preference, presence of NDI, and clinic graduate status. Virtual FG sessions were assessed using inductive thematic analyses.</div></div><div><h3>Results</h3><div>Twenty-six participants (10 CDH children/12 caregivers/4 clinic graduates) participated among 4 FGs. Thematic analysis revealed 4 themes: experiencing CDH as a caregiver; experiencing CDH as a child; striving for normalcy; and getting the support we need. Caregivers reported shock at CDH diagnosis and during initial hospitalization. Caregiver isolation/distress were common, particularly when physically separated from their newborn. Memories faded with time with parents revealing few long-term effects on their children. While most reported minimal impact, some CDH patients struggled with visible CDH indicators (e.g. scars). Patients expressed a high quality of life despite NDI or co-morbidities. Caregivers were satisfied with clinical support and easy contact but desired interaction with other CDH families for emotional/psychological support.</div></div><div><h3>Conclusion</h3><div>This first study on CDH lived experiences revealed high quality of life, despite early challenges. Caregivers valued the CDH clinic for easy access to expert care but desired contact with other CDH families for emotional support.</div></div><div><h3>Level of Evidence</h3><div>Level II (prospectively collected data, retrospective analysis).</div></div>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":"61 1","pages":"Article 162540"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feeling the difference: Long-term sensory outcomes following the minimally invasive repair of pectus excavatum with and without intercostal nerve cryoablation: A multicenter prospective observation study 感受差异:肋间神经冷冻消融和非肋间神经冷冻消融微创修复漏斗胸后的长期感觉结果:一项多中心前瞻性观察研究。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162539
R Scott Eldredge , Brielle Ochoa , Kathleen Heller , Katie W. Russell , Zachary J. Moore , Stephanie D. Chao , Akanksha Sabapaty , Jose Diaz-Miron , Nell T. Weber , Kristin Rassam , Emily Khoury , Chakshu Soni , Romeo C. Ignacio , Benjamin E. Padilla

Introduction

Intercostal nerve cryoablation (INC) during the minimally invasive repair of pectus excavatum (MIRPE) provides effective post-operative analgesia; long-term neurosensory effects of MIRPE/INC remain unclear. The study aimed to compare chest wall sensation at pectus-bar removal in patients who previously had MIRPE with and without INC.

Methods

We conducted a multi-institutional prospective study of patients ≤21 who underwent MIRPE with and without INC between 1/11/2021-8/18/2024. Chest wall sensory testing was performed pre-bar removal, and at 2 weeks and 2 months post-bar removal. Demographics and operative details of MIRPE were reviewed. Chest wall hypoesthesia to stimulation were compared between groups.

Results

166 participants were enrolled (male - 86 %, mean age - 18.3 ± 1.7 years at bar removal, median duration of bar implantation - 3.0 [IQR:2.9–3.1] years) INC was performed in 78 % (n = 130) during MIRPE. Compared to no-INC, INC patients were more likely to have >1 pectus bar (82 % vs 47 %, p < 0.001) and pericostal suture fixation (85 % vs 44 %, p = 0.004). Prior to bar removal, chest wall hypoesthesia in ≥1 dermatome was found in 58 % of INC vs 50 % of no-INC (p = 0.451). At two month follow up 85 % of patients had normal chest wall sensation (85 % INC vs 95 % no-INC, p = 0.460). Hypoesthesia was associated with >1 pectus bar implanted.

Conclusion

Three years following MIRPE, hypoesthesia to 1–2 dermatomes in the region of the pectus bar(s) is present in nearly half of patients and is not associated with intercostal nerve cryoablation. Following bar removal, chest wall sensation is normal in approximately 80 % of all patients.
介绍:肋间神经冷冻消融术(INC)微创修复漏斗胸(MIRPE)提供了有效的术后镇痛;MIRPE/INC的长期神经感觉效应尚不清楚。该研究旨在比较先前MIRPE合并和不合并INC的患者胸壁感觉。方法:我们在2021年11月1日至2024年8月18日期间对≤21岁的患者进行了MIRPE合并和不合并INC的多机构前瞻性研究。取棒前、取棒后2周和2个月分别进行胸壁感觉测试。回顾了MIRPE的人口统计和操作细节。比较两组胸壁对刺激的感觉减退。结果:共纳入166名参与者(86%为男性,拔棒时平均年龄为18.3±1.7岁,植入棒的中位持续时间为3.0年[IQR:2.9-3.1]年),其中78% (n=130)在MIRPE期间进行了INC。与未植入胸棒的患者相比,植入胸棒的患者更有可能植入1个胸棒(82% vs 47%)。结论:MIRPE术后3年,近一半的患者出现胸大肌区1-2个皮节的感觉减退,且与肋间神经冷冻消融无关。除棒后,约80%的患者胸壁感觉正常。
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引用次数: 0
Work relative value units and the association with operative time and surgical complexity: A pediatric NSQIP analysis 工作相对价值单位与手术时间和手术复杂性的关系:一项儿科NSQIP分析。
IF 2.5 2区 医学 Q1 PEDIATRICS Pub Date : 2026-01-01 DOI: 10.1016/j.jpedsurg.2025.162523
Olivia L. Katz , Jeanne Wu , Brian A. Coakley

Purpose

In the United States, physician compensation for surgical procedures is largely based on Current Procedural Terminology (CPT)-specific work Relative Value Units (wRVUs), which are meant to reflect operative time, technical skill and effort, mental effort and judgement, and stress. We sought to determine if operative time and case complexity are appropriately compensated for in pediatric surgical procedures.

Methods

The ACS Pediatric NSQIP database was surveyed for procedures that individually accounted for at least 0.1 % of the database in the year 2022. The median operative time and complication rates for these procedures from 2018 to 2022 were calculated. Major complications were defined as those causing significant deviation from the typical clinical course for the index procedure, as determined by the authors. Complications defined as minor were those that were judged to have little effect on a patient's expected clinical course or outcome. These were utilized as a surrogate for case complexity. 2022 wRVU and median operative time were used to calculate wRVU per hour of operative time (wRVU/h). Linear regression analysis was utilized to investigate the relationship between operative time and wRVU, operative time and wRVU/h, and complication rate and wRVU/h.

Results

Linear regression analysis demonstrated a moderate positive association between median operative time and wRVU (R2 = 0.2259, p < 0.0001). For every additional hour of operative time, however, there was an associated decrease in wRVU/h by 2.01 (or 0.33 for every 10 min, R2 = 0.05568, p = 0.0012). Both major and minor complications are both associated with wRVU but neither are significantly associated with wRVU/h.

Conclusions

Compensation is positively correlated with operative time for pediatric surgical procedures. However, the current wRVU system significantly favors shorter procedures. Case complexity is only weakly correlated with wRVU/h, and below the threshold of statistical significance, which suggests that the wRVU system may not adequately compensate pediatric surgeons for performing lengthy and complex procedures.
目的:在美国,外科手术的医生报酬主要基于当前手术术语(Current procedure Terminology, CPT)-specific work Relative Value Units (wRVUs),它旨在反映手术时间、技术技能和努力、精神努力和判断以及压力。我们试图确定手术时间和病例复杂性是否在儿科外科手术中得到适当补偿。方法:对ACS儿科NSQIP数据库进行调查,寻找在2022年单独占数据库至少0.1%的手术。计算2018-2022年这些手术的中位手术时间和并发症发生率。主要并发症被定义为那些引起明显偏离典型临床过程的指标程序,由作者确定。轻微并发症是指那些被认为对患者预期的临床过程或结果影响不大的并发症。它们被用作案例复杂性的替代。采用2022年wRVU和中位手术时间计算每小时手术时间的wRVU (wRVU/h)。采用线性回归分析探讨手术时间与wRVU、手术时间与wRVU/h、并发症发生率与wRVU/h的关系。结果:线性回归分析显示中位手术时间与wRVU呈正相关(R2 = 0.2259, p < 0.0001)。然而,每增加1小时的手术时间,wRVU/h相关下降2.01(或每10分钟0.33,R2 = 0.05568, p = 0.0012)。主要和次要并发症均与wRVU相关,但均与wRVU/h无关。结论:小儿外科手术补偿与手术时间呈正相关。然而,目前的wRVU系统明显倾向于缩短程序。病例复杂性与wRVU/h仅呈弱相关,且低于统计显著性阈值,这表明wRVU系统可能无法充分补偿儿科外科医生进行的冗长而复杂的手术。
{"title":"Work relative value units and the association with operative time and surgical complexity: A pediatric NSQIP analysis","authors":"Olivia L. Katz ,&nbsp;Jeanne Wu ,&nbsp;Brian A. Coakley","doi":"10.1016/j.jpedsurg.2025.162523","DOIUrl":"10.1016/j.jpedsurg.2025.162523","url":null,"abstract":"<div><h3>Purpose</h3><div>In the United States, physician compensation for surgical procedures is largely based on Current Procedural Terminology (CPT)-specific work Relative Value Units (wRVUs), which are meant to reflect operative time, technical skill and effort, mental effort and judgement, and stress. We sought to determine if operative time and case complexity are appropriately compensated for in pediatric surgical procedures.</div></div><div><h3>Methods</h3><div>The ACS Pediatric NSQIP database was surveyed for procedures that individually accounted for at least 0.1 % of the database in the year 2022. The median operative time and complication rates for these procedures from 2018 to 2022 were calculated. Major complications were defined as those causing significant deviation from the typical clinical course for the index procedure, as determined by the authors. Complications defined as minor were those that were judged to have little effect on a patient's expected clinical course or outcome. These were utilized as a surrogate for case complexity. 2022 wRVU and median operative time were used to calculate wRVU per hour of operative time (wRVU/h). Linear regression analysis was utilized to investigate the relationship between operative time and wRVU, operative time and wRVU/h, and complication rate and wRVU/h.</div></div><div><h3>Results</h3><div>Linear regression analysis demonstrated a moderate positive association between median operative time and wRVU (R<sup>2</sup> = 0.2259, p &lt; 0.0001). For every additional hour of operative time, however, there was an associated decrease in wRVU/h by 2.01 (or 0.33 for every 10 min, R<sup>2</sup> = 0.05568, p = 0.0012). Both major and minor complications are both associated with wRVU but neither are significantly associated with wRVU/h.</div></div><div><h3>Conclusions</h3><div>Compensation is positively correlated with operative time for pediatric surgical procedures. However, the current wRVU system significantly favors shorter procedures. Case complexity is only weakly correlated with wRVU/h, and below the threshold of statistical significance, which suggests that the wRVU system may not adequately compensate pediatric surgeons for performing lengthy and complex procedures.</div></div>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":"61 1","pages":"Article 162523"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of pediatric surgery
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