Pub Date : 2022-07-08DOI: 10.1007/s12374-022-09358-1
Sang-Hun Oh, H. Suh, S. Seo, Kyong-Sook Chung, T. Yukawa
{"title":"A New Species of Goodyera (Orchidaceae: Orchidoideae) from Korea and Japan","authors":"Sang-Hun Oh, H. Suh, S. Seo, Kyong-Sook Chung, T. Yukawa","doi":"10.1007/s12374-022-09358-1","DOIUrl":"https://doi.org/10.1007/s12374-022-09358-1","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"65 1","pages":"357 - 363"},"PeriodicalIF":2.9,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41720489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.1007/s12374-022-09357-2
Zaib-un-Nisa, Xue Mi, S. Anwar, Chen Chen, Xiaoxia Jin, Lijie Yu, N. Ali, Chao Chen
{"title":"Strigolactone Enhances Alkaline Tolerance in Soybean Seeds Germination by Altering Expression Profiles of ABA Biosynthetic and Signaling Genes","authors":"Zaib-un-Nisa, Xue Mi, S. Anwar, Chen Chen, Xiaoxia Jin, Lijie Yu, N. Ali, Chao Chen","doi":"10.1007/s12374-022-09357-2","DOIUrl":"https://doi.org/10.1007/s12374-022-09357-2","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46421589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-28DOI: 10.1007/s12374-022-09355-4
K. Ko, E. K. Yoon, Souvik Dhar, J. Oh, Jun Lim
{"title":"A SHORTROOT-Mediated Transcriptional Regulatory Network for Vascular Development in the Arabidopsis Shoot","authors":"K. Ko, E. K. Yoon, Souvik Dhar, J. Oh, Jun Lim","doi":"10.1007/s12374-022-09355-4","DOIUrl":"https://doi.org/10.1007/s12374-022-09355-4","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"65 1","pages":"341 - 355"},"PeriodicalIF":2.9,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53088096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.1007/s12374-022-09354-5
K. Pan, Xiaodan Yu, Shujuan Wang, Jie Hou, Yuchao Luo, Bingmiao Gao
{"title":"Dynamic Changes of Transcriptome and Metabolites During Ripening of Alpinia Oxyphylla Fruit (AOF)","authors":"K. Pan, Xiaodan Yu, Shujuan Wang, Jie Hou, Yuchao Luo, Bingmiao Gao","doi":"10.1007/s12374-022-09354-5","DOIUrl":"https://doi.org/10.1007/s12374-022-09354-5","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"65 1","pages":"445 - 457"},"PeriodicalIF":2.9,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41849725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheri L Deal, Joel Steelman, Elpis Vlachopapadopoulou, Renata Stawerska, Lawrence A Silverman, Moshe Phillip, Ho-Seong Kim, CheolWoo Ko, Oleg Malievskiy, Jose F Cara, Carl L Roland, Carrie Turich Taylor, Srinivas Rao Valluri, Michael P Wajnrajch, Aleksandra Pastrak, Bradley S Miller
Context: Somatrogon is a long-acting recombinant human growth hormone (rhGH) in development for once-weekly treatment of children with growth hormone deficiency (GHD).
Objective: We aimed to compare the efficacy and safety of once-weekly somatrogon with once-daily somatropin in prepubertal children with GHD.
Methods: In this 12-month, open-label, randomized, active-controlled, parallel-group, phase 3 study, participants were randomized 1:1 to receive once-weekly somatrogon (0.66 mg/kg/week) or once-daily somatropin (0.24 mg/kg/week) for 12 months. A total of 228 prepubertal children (boys aged 3-11 years, girls aged 3-10 years) with GHD, impaired height and height velocity (HV), and no prior rhGH treatment were randomized and 224 received ≥1 dose of study treatment (somatrogon: 109; somatropin: 115). The primary endpoint was annualized HV at month 12.
Results: HV at month 12 was 10.10 cm/year for somatrogon-treated subjects and 9.78 cm/year for somatropin-treated subjects, with a treatment difference (somatrogon-somatropin) of 0.33 (95% CI: -0.24, 0.89). The lower bound of the 2-sided 95% CI was higher than the prespecified noninferiority margin (-1.8 cm/year), demonstrating noninferiority of once-weekly somatrogon vs daily somatropin. HV at month 6 and change in height standard deviation score at months 6 and 12 were similar between both treatment groups. Both treatments were well tolerated, with a similar percentage of subjects experiencing mild to moderate treatment-emergent adverse events in both groups (somatrogon: 78.9%, somatropin: 79.1%).
Conclusion: The efficacy of once-weekly somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles. (ClinicalTrials.gov no. NCT02968004).
{"title":"Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study.","authors":"Cheri L Deal, Joel Steelman, Elpis Vlachopapadopoulou, Renata Stawerska, Lawrence A Silverman, Moshe Phillip, Ho-Seong Kim, CheolWoo Ko, Oleg Malievskiy, Jose F Cara, Carl L Roland, Carrie Turich Taylor, Srinivas Rao Valluri, Michael P Wajnrajch, Aleksandra Pastrak, Bradley S Miller","doi":"10.1210/clinem/dgac220","DOIUrl":"10.1210/clinem/dgac220","url":null,"abstract":"<p><strong>Context: </strong>Somatrogon is a long-acting recombinant human growth hormone (rhGH) in development for once-weekly treatment of children with growth hormone deficiency (GHD).</p><p><strong>Objective: </strong>We aimed to compare the efficacy and safety of once-weekly somatrogon with once-daily somatropin in prepubertal children with GHD.</p><p><strong>Methods: </strong>In this 12-month, open-label, randomized, active-controlled, parallel-group, phase 3 study, participants were randomized 1:1 to receive once-weekly somatrogon (0.66 mg/kg/week) or once-daily somatropin (0.24 mg/kg/week) for 12 months. A total of 228 prepubertal children (boys aged 3-11 years, girls aged 3-10 years) with GHD, impaired height and height velocity (HV), and no prior rhGH treatment were randomized and 224 received ≥1 dose of study treatment (somatrogon: 109; somatropin: 115). The primary endpoint was annualized HV at month 12.</p><p><strong>Results: </strong>HV at month 12 was 10.10 cm/year for somatrogon-treated subjects and 9.78 cm/year for somatropin-treated subjects, with a treatment difference (somatrogon-somatropin) of 0.33 (95% CI: -0.24, 0.89). The lower bound of the 2-sided 95% CI was higher than the prespecified noninferiority margin (-1.8 cm/year), demonstrating noninferiority of once-weekly somatrogon vs daily somatropin. HV at month 6 and change in height standard deviation score at months 6 and 12 were similar between both treatment groups. Both treatments were well tolerated, with a similar percentage of subjects experiencing mild to moderate treatment-emergent adverse events in both groups (somatrogon: 78.9%, somatropin: 79.1%).</p><p><strong>Conclusion: </strong>The efficacy of once-weekly somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles. (ClinicalTrials.gov no. NCT02968004).</p>","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"41 1","pages":"e2717-e2728"},"PeriodicalIF":5.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73367629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-25DOI: 10.1007/s12374-022-09353-6
S. Oh, S. J. Lee, J. Kim, D. Twell, Soon-Ki Park
{"title":"Overexpression of TWO-IN-ONE Domains Inhibits Cytokinesis in Arabidopsis","authors":"S. Oh, S. J. Lee, J. Kim, D. Twell, Soon-Ki Park","doi":"10.1007/s12374-022-09353-6","DOIUrl":"https://doi.org/10.1007/s12374-022-09353-6","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"65 1","pages":"331 - 340"},"PeriodicalIF":2.9,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44157000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-02DOI: 10.1007/s12374-022-09352-7
Jie Li, Zai-hua Wang
{"title":"Integrative Metabolomic and Transcriptome Analysis Reveal the Differential Mechanisms of Spot Color in the Lips of Dendrobium chrysotoxum","authors":"Jie Li, Zai-hua Wang","doi":"10.1007/s12374-022-09352-7","DOIUrl":"https://doi.org/10.1007/s12374-022-09352-7","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42162665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-19DOI: 10.1007/s12374-022-09351-8
T. Huong, Zhengmei Yang, Le My Tieu Ngoc, Hunseung Kang
{"title":"ALKBH8B, a Putative RNA Demethylase, Plays a Role in the Response of Arabidopsis to Salt Stress and Abscisic Acid","authors":"T. Huong, Zhengmei Yang, Le My Tieu Ngoc, Hunseung Kang","doi":"10.1007/s12374-022-09351-8","DOIUrl":"https://doi.org/10.1007/s12374-022-09351-8","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"65 1","pages":"319 - 330"},"PeriodicalIF":2.9,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45259125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.1007/s12374-022-09349-2
Hyeon Jin Jeong, J. Kim
{"title":"Populations of Asarum mandshuricum are Strongly Differentiated Despite a High Outcrossing Rate","authors":"Hyeon Jin Jeong, J. Kim","doi":"10.1007/s12374-022-09349-2","DOIUrl":"https://doi.org/10.1007/s12374-022-09349-2","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"65 1","pages":"241 - 251"},"PeriodicalIF":2.9,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45105789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.1007/s12374-022-09348-3
Eun Seon Lee, K. A. Phan, Sang Eun Jun, Joung Hun Park, Seol Ki Paeng, H. Chae, Seong Dong Wi, Su Bin Bae, K. Kang, Gyung-Tae Kim, Sang Yeol Lee
{"title":"Universal Stress Protein (USP) Enhances Plant Growth and Development by Promoting Cell Expansion","authors":"Eun Seon Lee, K. A. Phan, Sang Eun Jun, Joung Hun Park, Seol Ki Paeng, H. Chae, Seong Dong Wi, Su Bin Bae, K. Kang, Gyung-Tae Kim, Sang Yeol Lee","doi":"10.1007/s12374-022-09348-3","DOIUrl":"https://doi.org/10.1007/s12374-022-09348-3","url":null,"abstract":"","PeriodicalId":16762,"journal":{"name":"Journal of Plant Biology","volume":"65 1","pages":"231 - 239"},"PeriodicalIF":2.9,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47902950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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