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Evaluation of local guideline introduction on surgical antimicrobial prophylaxis prescribing for open reduction internal fixations at an Australian tertiary hospital 对澳大利亚一家三级医院引入开刀复位内固定手术抗菌药预防处方地方指南的评估
IF 2.1 Q2 Health Professions Pub Date : 2023-10-03 DOI: 10.1002/jppr.1886
Sarah Hassan BPharm (Hons), PhD, Vincent Chan BSc (Hons), BPharm, MPH, PhD, GradCertAcadPrac, AACPA, Julie E. Stevens BSc, BPharm (Hons), PhD, Ieva Stupans BPharm (Hons), PhD, Juliette Gentle MBBS, FRACS (Orth)

Background

Guidelines advocate for the use of single-dose prophylaxis in open reduction internal fixation (ORIF) procedures. The presence of local (institutional) guidelines may assist in the uptake of evidence-based recommendations.

Aim

To determine the impact of local guideline introduction on prescribing practice for ORIF procedures at a metropolitan hospital in relation to our previous audit investigating adherence to national guidelines, which found that only 20.4% of ORIF patients received single-dose prophylaxis.

Method

Antibiotic prescribing was audited for patients undergoing ORIF of closed fractures from July–December 2021 at a metropolitan, tertiary hospital following guideline introduction in April 2021. Data on perioperative prescribing regimens were collected, with results compared to recommendations in local guidelines. Descriptive statistics, chi-squared test, and Fisher's exact test were used to report categorical variables. Ethics approval was granted by Northern Health Office of Research, Ethics, and Governance (Reference no: NLR 72459) and registered with the RMIT University College Human Ethics Advisory Network (Reference no: RM 24642).

Results

Data were collected for 165 patients. Almost all patients (93.5%) received cefazolin preoperatively as per guidelines. Only 22.6% of patients received single-dose prophylaxis as per local guideline recommendations, with overall adherence to guidelines only 16.4%.

Conclusion

Little change was observed in the proportion of patients who received single-dose prophylaxis as compared to our previous audit. There is a need to understand why guidelines are not adhered to despite the availability of national and local guidelines. An evaluation of local barriers may assist with informing future implementation strategies.

背景指南提倡在开放复位内固定术(ORIF)中使用单剂量预防疗法。地方(机构)指南的存在可能有助于采纳循证建议。 目的 针对我们之前对国家指南遵守情况的审计发现,仅有 20.4% 的 ORIF 患者接受了单剂量预防治疗,从而确定地方指南的引入对一家都市医院 ORIF 手术处方实践的影响。 方法 在 2021 年 4 月引入指南后,我们于 2021 年 7 月至 12 月对一家大都市三级医院接受闭合性骨折 ORIF 手术的患者的抗生素处方进行了审核。收集了围手术期处方方案的数据,并将结果与当地指南的建议进行了比较。描述性统计、卡方检验和费雪精确检验用于报告分类变量。该研究获得了北部卫生部研究、伦理和管理办公室的伦理批准(编号:NLR 72459),并在皇家墨尔本理工大学学院人类伦理咨询网络注册(编号:RM 24642)。 结果 收集了 165 名患者的数据。几乎所有患者(93.5%)都按照指南在术前接受了头孢唑啉治疗。只有 22.6% 的患者按照当地指南的建议接受了单剂量预防治疗,而遵守指南的总体比例仅为 16.4%。 结论 与我们之前的审计相比,接受单剂量预防的患者比例变化不大。我们有必要了解,尽管有国家和地方指南,但为何仍有人不遵守指南。对当地存在的障碍进行评估有助于为未来的实施策略提供依据。
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引用次数: 0
Management of thyroid disorders in older people 老年人甲状腺疾病的管理
IF 2.1 Q2 Health Professions Pub Date : 2023-10-03 DOI: 10.1002/jppr.1883
Gauri Godbole BPharm, MClinPharm, BCGP, AdvPP(II), AcSHP, CDP, FSHP, Tripti Joshi MBBS, MD, MPH, FRACP, MPhil, Monica Majumder BMed, BSc(Med)Hons

Thyroid disorders are common in older people and cause significant morbidity. There may be fewer symptoms at presentation and increased susceptibility to adverse events, making diagnosis and management more challenging. The approach to management of thyroid disorders in older people differs from that for younger individuals. Factors that need to be considered include frailty, concurrent illness, polypharmacy, drug–drug interactions, and target organ sensitivity to treatment. This review discusses the clinical presentation, pathophysiology, and management of thyroid disorders and the effects of medications on thyroid function in older people.

甲状腺疾病在老年人中很常见,并引起显著的发病率。出现时症状可能较少,对不良事件的易感性增加,使诊断和管理更具挑战性。老年人甲状腺疾病的治疗方法不同于年轻人。需要考虑的因素包括虚弱、并发疾病、多种药物、药物相互作用和靶器官对治疗的敏感性。本文综述了老年人甲状腺疾病的临床表现、病理生理、治疗以及药物对甲状腺功能的影响。
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引用次数: 0
Safety and efficacy comparisons of intravenous trastuzumab biosimilars to the reference product medicine in treatment-naïve and switch-over patients with breast cancer: a systematic and meta-analysis 静脉注射曲妥珠单抗生物仿制药与参比产品药物在乳腺癌新患者和转归患者中的安全性和疗效比较:系统和荟萃分析
IF 2.1 Q2 Health Professions Pub Date : 2023-09-27 DOI: 10.1002/jppr.1882
Nina K. Song BPharm (Hons), Hala Musa BSc (Hons), MSc, MPharm, Michael Soriano BS Pharmacy (PH), Mellissa Batger BSc, MPharm, Bryson Hawkins BPharm (Hons), Iqbal Ramzan Dip Pharmacy (NZ), MSc, PhD, David E. Hibbs BSc (Hons), PhD, Grad Cert Ed (Higher Ed), Jennifer Ong BPharm (Hons), PhD, Grad Cert Ed Studies (Higher Ed)

Aim

To compare the efficacy and safety of trastuzumab biosimilars to reference trastuzumab in patients with breast cancer. Trastuzumab, a biologic pharmaceutical product, has improved survival in hormone-oestrogen receptor 2 positive breast cancer. However, due to its high economic burden, ‘highly similar’ products known as biosimilars have been developed. Yet, concerns remain around the equivalency of efficacy and safety between biosimilars and their reference biologic.

Data Sources

A systematic review with meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE, EMBASE, and Cochrane Central databases were searched from inception to 26 April 2021 to obtain all randomised control trial data reporting on safety and efficacy outcomes of patients with breast cancer treated with trastuzumab biosimilars.

Study Selection

Studies were required to investigate and report on the safety and/or efficacy of trastuzumab. No restrictions were placed on study setting or intervention type and any study which reported at least one efficacy or safety outcome was included. A head-to-head comparison between the biosimilar and its reference biologic was not required for inclusion in the results. Only studies using randomised control trials were included. There was no restriction on the language the study was published in, and all abstracts, raw clinical trial data, and full-text studies were eligible.

Results

Forty-one studies were identified to report on patients treated with trastuzumab. The odds of achieving an overall response rate in patients treated with a trastuzumab biosimilar compared to the reference over at least 24 weeks of treatment was 1.10 (95% confidence interval [CI] 0.94–1.29). The proportion of patients experiencing any treatment emergent adverse events were comparable between the two study arms, 1.07 (95% CI 0.87–1.32). The switching group contained one study with 342 patients in the meta-analysis.

Conclusion

Trastuzumab biosimilars have comparable efficacy and safety to reference trastuzumab in treatment-naïve patients. However, evidence is lacking for switching patients from reference trastuzumab to biosimilars, so further work is required in the switch-over population.

目的 比较曲妥珠单抗生物仿制药与参考曲妥珠单抗对乳腺癌患者的疗效和安全性。曲妥珠单抗是一种生物制药产品,可提高激素-雌激素受体2阳性乳腺癌患者的生存率。然而,由于其经济负担较重,被称为生物仿制药的 "高度相似 "产品已被开发出来。然而,人们对生物仿制药与其参照生物制剂之间的疗效和安全性的等效性仍存在担忧。 数据来源 根据《系统综述和元分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analyses,PRISMA)指南进行了系统综述和元分析。检索了 MEDLINE、EMBASE 和 Cochrane Central 数据库,检索时间从开始到 2021 年 4 月 26 日,以获得所有报告使用曲妥珠单抗生物仿制药治疗乳腺癌患者的安全性和疗效结果的随机对照试验数据。 研究选择 要求对曲妥珠单抗的安全性和/或疗效进行调查和报告。研究环境或干预类型不受限制,任何报告了至少一项疗效或安全性结果的研究均可纳入。生物仿制药与其参照生物制剂之间的正面比较无需纳入结果。只有采用随机对照试验的研究才被纳入。研究发表的语言没有限制,所有摘要、原始临床试验数据和全文研究均符合条件。 结果 41 项研究报告了接受曲妥珠单抗治疗的患者的情况。接受曲妥珠单抗生物类似物治疗的患者在至少24周的治疗中获得总体应答率的几率为1.10(95% 置信区间[CI] 0.94-1.29)。两组研究中出现治疗突发不良事件的患者比例相当,均为1.07(95% 置信区间为0.87-1.32)。在荟萃分析中,转换组包含一项有 342 名患者的研究。 结论 曲妥珠单抗生物仿制药在治疗新药患者方面的疗效和安全性与参考曲妥珠单抗相当。然而,目前还缺乏将患者从参考曲妥珠单抗转为生物仿制药的证据,因此还需要在转换人群中开展进一步的工作。
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引用次数: 0
A retrospective study investigating the management, risk factors, and outcomes of patients diagnosed with Clostridioides difficile infection 一项回顾性研究调查诊断为艰难梭菌感染的患者的管理、危险因素和结局
IF 2.1 Q2 Health Professions Pub Date : 2023-09-12 DOI: 10.1002/jppr.1881
Mitt M. Vongphakdi BPharm(Hons), Nicholas Ah Yui BPharm, GCClinPharm, Kevin OCallaghan MB BCh BAO, MPHTM, FRACP

Background

The rate of clostridioides difficile infection (CDI) in Australia has increased by more than 8% between 2016–2018. This can be attributed to multiple factors including an ageing population, widespread antibiotic and proton-pump-inhibitor usage.

Aim

The aim of this study was to investigate the management, risk factors and outcomes for CDI to identify strategies to reduce its incidence.

Method

A single-centre retrospective audit was completed using medical records for patients admitted to a 250-bed regional Queensland hospital with CDI in 2020–2021. Data surrounding CDI management for each patient was analysed against the Therapeutic Guidelines. This study was approved by The Prince Charles Hospital Human Research Ethics Committee (Reference No: LNR/HREC/QPCH/81287).

Results

There were 72 cases with CDI during the study timeframe. Recent antibiotic prescription, proton-pump-inhibitor (PPI) use and antibiotic allergy labels were common. Thirty-five per cent of cases were treated appropriately. Eight per cent died, and nine per cent had relapsed CDI within 12 weeks of diagnosis. Common gaps found in the results included inappropriate selection of antibiotics based on the severity of disease and lack of documentation surrounding CDI cases left untreated.

Conclusion

There are multiple opportunities for pharmacists to improve the care of patients with CDI which range from promoting guideline adherence, influencing prescriber antibiotic selection based on disease severity, prompting review of PPIs upon CDI diagnosis and prompting provider follow-up of CDI laboratory results pending at the point of patient discharge. The results of this study have prompted antimicrobial stewardship service review of all CDI admissions at the study site and indicates the need for a larger multiple-site study to raise awareness of CDI risk factors and severity criteria.

2016-2018年间,澳大利亚艰难梭菌感染率(CDI)增加了8%以上。这可归因于多种因素,包括人口老龄化,抗生素和质子泵抑制剂的广泛使用。目的本研究的目的是探讨CDI的管理、危险因素和结果,以确定降低其发病率的策略。方法采用单中心回顾性审计方法,对昆士兰州一家拥有250个床位的地区医院2020-2021年收治的CDI患者的医疗记录进行审计。根据治疗指南对每位患者的CDI管理数据进行分析。本研究已获查尔斯王子医院人类研究伦理委员会批准(参考编号:LNR/HREC/QPCH/81287)。结果研究期间共发生72例CDI。最近的抗生素处方、质子泵抑制剂(PPI)使用和抗生素过敏标签是常见的。35%的病例得到了适当的治疗。8%的患者死亡,9%的患者在确诊后的12周内复发。在结果中发现的常见差距包括根据疾病严重程度不适当地选择抗生素,以及缺乏关于未经治疗的CDI病例的记录。结论药师有多种机会改善CDI患者的护理,包括促进指南的遵守,根据疾病严重程度影响处方抗生素的选择,在CDI诊断时提示PPIs的审查,以及在患者出院时提示提供者对CDI实验室结果的随访。这项研究的结果促使对研究地点所有CDI入院的抗菌药物管理服务进行审查,并表明需要进行更大规模的多地点研究,以提高对CDI风险因素和严重程度标准的认识。
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引用次数: 0
Selecting performance indicators for hospital pharmacy practice: A Canadian initiative 选择医院药学实践的绩效指标:加拿大的一项举措
IF 2.1 Q2 Health Professions Pub Date : 2023-08-31 DOI: 10.1002/jppr.1880
France Boucher BPharm, MSc, Benoît Lemire BPharm, MSc, Sylvie Schryve BArch, DEA, Linda Vaillant BPharm, MSc, MBA, FCSHP

Activity-based funding is a method of funding hospitals according to the type and volume of services provided and adjusted to their patient population. Currently, pharmacy practice is mainly evaluated with costs and volumes, which are insufficient to properly measure the contribution of pharmacists. Facing the province of Quebec statewide implementation of activity-based funding, expert committees were set up to develop a set of indicators using a predefined framework to assess pharmacy performance throughout all hospital activities and patient care. Through consultations, partners and stakeholders showed strong support for the initiative, putting more emphasis on the assessment of appropriateness as well as quality and safety. Among the different roles of pharmacists, respondents favoured the assessment of the pharmaceutical care and education of trainees and colleagues. Of the 150 candidate indicators initially identified, 24 were selected, of which 13 were prioritised for experimentation.

基于活动的资助是一种根据医院提供的服务类型和数量并根据患者群体进行调整的资助方法。目前,对药学实践的评价以成本和数量为主,不足以恰当衡量药师的贡献。面对魁北克省在全州范围内实施的基于活动的资金,设立了专家委员会,利用预定义的框架制定一套指标,以评估所有医院活动和患者护理中的药房绩效。通过磋商,合作伙伴和持份者对这一倡议表示大力支持,更加重视评估适当性以及质量和安全。在不同角色的药师中,受访者更倾向于对学员和同事的药学服务和药学教育的评价。在最初确定的150个候选指标中,选择了24个,其中13个优先用于实验。
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引用次数: 0
Vale Amy McRae 好吧,艾米·麦克雷
IF 2.1 Q2 Health Professions Pub Date : 2023-08-29 DOI: 10.1002/jppr.1879
Michael J. Dooley BPharm, GradDipHospPharm, PhD, FSHP, AdvPracPharm

This issue of the Journal includes a paper titled ‘Time for change: Improving neuromuscular blocking agent safety in Australia’.1 The lead author, Amy McRae, sadly passed away last year on 15 December, at home peacefully with her family by her side.

Amy had a passion and determination to improve the safe use of medicines and this influenced the many pharmacists, nurses, doctors, and patients who had the pleasure of interacting with her during her career. This included in her early role as a clinical pharmacist, through to more recently as Senior Medication Safety Pharmacist at Alfred Health. In addition, Amy was also the Senior Pharmacist, Quality Use of Medicines, Western Health and Senior Lecturer, Post-Graduate Studies and Professional Development Unit, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University.

Her contribution to improving the care of patients and reducing the risks associated with medication will be one of her many legacies. Amy was central in Australia-wide improvements to reduce neuromuscular blocking agent (NMBA) administration errors, which can cause unintended paralysis, respiratory arrest, severe permanent harm, and death. These endeavours included the publication of a national report Time for change: proposed improvements to the labelling and packaging of neuromuscular blocking agents in Australia.2 This work, supported by the Victorian Therapeutics Advisory Group and many other national organisations, resulted in the introduction of mandatory warning statements for the labels of NMBAs in Australia. Amy was also pivotal in a range of other initiatives, including reducing potentially fatal errors associated with high doses of insulin, the introduction of Tall Man lettering to reduce medication selection errors, and patient education and empowerment strategies to improve prophylaxis for venous thromboembolism.

We are very saddened that Amy is not here to share in this milestone but know that her impact and legacy will continue. Amy was a wonderful person whose courage and determination to live a full life was inspirational to many of us who knew her. Amy will continue to be missed by many and her impact on making care safer will be felt far into the future.

The author complies with the Journal's authorship policy.

Michael Dooley is the Editor-in-Chief of the Journal of Pharmacy Practice and Research.

Ethics approval was not required for this announcement.

本期《华尔街日报》刊登了一篇题为《是时候改变了:提高澳大利亚神经肌肉阻滞剂的安全性》的论文主要作者艾米·麦克雷于去年12月15日在家中与家人平静地离世。艾米对提高药物安全使用的热情和决心,影响了许多药剂师、护士、医生和在她的职业生涯中有幸与她互动的病人。这包括她早期作为临床药剂师的角色,直到最近作为阿尔弗雷德健康的高级药物安全药剂师。此外,Amy还是莫纳什大学药学和药物科学学院研究生学习和专业发展部门的高级药剂师、西方健康高级药剂师和高级讲师。她对改善患者护理和减少药物相关风险的贡献将成为她的众多遗产之一。Amy是澳大利亚范围内减少神经肌肉阻滞剂(NMBA)给药错误的核心,NMBA可能导致意外瘫痪、呼吸停止、严重的永久性伤害和死亡。这些努力包括一份国家报告的出版:改变的时间:建议改进澳大利亚神经肌肉阻滞剂的标签和包装。这项工作得到了维多利亚治疗咨询小组和许多其他国家组织的支持,导致澳大利亚引入了NMBAs标签的强制性警告声明。Amy在一系列其他倡议中也发挥了关键作用,包括减少与高剂量胰岛素相关的潜在致命错误,引入Tall Man字母以减少药物选择错误,以及患者教育和授权策略以改善静脉血栓栓塞的预防。我们很遗憾艾米不能在这里分享这一里程碑,但我们知道她的影响和遗产将继续下去。艾米是一个很棒的人,她过充实生活的勇气和决心鼓舞了我们许多认识她的人。许多人将继续怀念艾米,她在使护理更安全方面的影响将在遥远的未来被感受到。作者遵守《华尔街日报》的署名政策。迈克尔·杜利(Michael Dooley)是《药学实践与研究》杂志的主编。这项声明不需要伦理审批。
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引用次数: 0
Testing a medicine information needs identification tool (MINI-Q) with hospital inpatients in New Zealand 在新西兰的医院住院患者中测试药物信息需求识别工具(MINI‐Q)
IF 2.1 Q2 Health Professions Pub Date : 2023-08-25 DOI: 10.1002/jppr.1877
Trudi Aspden BPharm(Hons), PhD, Michelle Honey RN, PhD, Sarah Sneyd BA, BHSc, MPH, Kim Brackley DipPharm(Dist), PGDipHighE, MScClinPharm, Alana Cavadino BSc, MSc, PhD, Rosalie Chang BPharm, PGCert, Amy HY Chan BPharm(Hons), PhD

Background

Determining an individual's medicines information preferences and needs could enable health professionals to deliver more effective medicines information and help build patients' health literacy and ability to self-manage their health.

Aim

This descriptive, cross-sectional study aimed to test a new information needs assessment tool, the Medicine Information Needs for Individuals – Questionnaire (MINI-Q), which elicits what individuals want to know about their medicines. This study aimed to explore the face validity, acceptability, and feasibility of using the tool in a hospital inpatient setting.

Method

Ethical approval was obtained from Health and Disability Ethics Committees (Reference no: 18/NTA/137). Following ethical approval, adult hospital inpatients from two service divisions in one large urban hospital in New Zealand were invited to self-assess their medicines information needs using the 23-item MINI-Q via a tablet or on paper. Descriptive statistics were generated from the quantitative data and responses to a free-text question were inductively analysed.

Results

The MINI-Q was completed by 228 inpatients, 137 (60%) of whom used a tablet. Participants requested information on 80.6% of the possible topics. The most common topic that participants wanted information about was possible side effects (92%). No additional topics to include in the MINI-Q were identified from the free-text responses. The median completion time of the tablet version was 9.2 min (interquartile range 6.7–14.6).

Conclusion

The MINI-Q shows promise to efficiently identify an individual's medicines information needs in an inpatient setting. The findings reinforce that most people want to know all the basic information about their medicines, with side effects being particularly important.

确定个人的药物信息偏好和需求可以使卫生专业人员提供更有效的药物信息,并帮助培养患者的健康素养和自我管理健康的能力。这项描述性的横断面研究旨在测试一种新的信息需求评估工具,即个人药物信息需求问卷(MINI‐Q),该工具可以引出个人想要了解的药物信息。本研究旨在探讨在医院住院环境中使用该工具的面部有效性、可接受性和可行性。获得了健康和残疾伦理委员会的伦理批准(参考号:18/NTA/137)。在获得伦理批准后,来自新西兰一家大型城市医院两个服务部门的成年住院患者被邀请通过平板电脑或纸上使用23项MINI‐Q自我评估他们的药物信息需求。从定量数据中生成描述性统计数据,并对自由文本问题的回答进行归纳分析。MINI‐Q由228名住院患者完成,其中137人(60%)使用平板电脑。与会者要求提供80.6%的可能主题的信息。参与者想要了解的最常见的话题是可能的副作用(92%)。从自由文本回复中没有发现需要纳入MINI‐Q的其他主题。平板电脑版本的中位完成时间为9.2 min(四分位间距6.7-14.6)。MINI‐Q有望在住院环境中有效识别个人的药物信息需求。研究结果进一步表明,大多数人都想了解他们药物的所有基本信息,其中副作用尤为重要。
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引用次数: 0
Elective surgery cancellations due to suboptimal medicine management: a retrospective single site study 由于药物管理不理想而取消择期手术:一项回顾性单点研究
IF 2.1 Q2 Health Professions Pub Date : 2023-08-21 DOI: 10.1002/jppr.1876
Kate Elizabeth Doreen Ziser BPharm, GradDdpEd APP[II], MClinPharm, Jessica Barbara King BPharm, Natasha Alkass BPharm, Jane Elizabeth Dunsdon BPharm, BNursing APP[II]

Background

Elective surgery cancellations and delays are associated with negative financial and staffing ramifications, adverse clinical outcomes, and poor patient outcomes. The Princess Alexandra Hospital in Brisbane, Australia, performs approximately 15 000 elective surgeries per year and medication optimisation is pivotal in preparing a patient for surgery to avoid same day of surgery theatre cancellations. Ideally, patients are seen in a multidisciplinary pre-admission clinic for optimisation of their health and medicines, and to provide education regarding their surgery.

Aim

To calculate the incidence of elective surgery cancellations due to medication misadventure over a 12-month period.

Method

A retrospective audit at a tertiary Queensland Hospital was conducted over a 12-month period (April 2021–March 2022), including patients who had their elective surgeries cancelled. The medical records from the hospital's digital databases for patients who were identified by the hospital coding service as ‘unfit for surgery’ were screened to see if the reason for the surgery cancellation was due to medication misadventure. The project was reviewed by the Metro South Human Research Ethics Committee and deemed exempt from further review (Ref No: CM20221651).

Results

The surgery cancellation rate was 50% (n = 6626 cancelled surgeries from 13 255 total surgeries booked). The same day of surgery cancellation rate was 5.5% (n = 734). Medication misadventure resulting from suboptimal medicine management was responsible for 1% (n = 66 out of 6626 surgery cancellations). A total of 41% (n = 27) of patients had their surgery cancelled ahead of time by the pharmacist due to a medication not being withheld for long enough, which prevented a same-day cancellation.

Conclusion

Having a pre-admission clinic pharmacist improves preoperative medication optimisation and has been proven to avoid same-day cancellations.

选择性手术的取消和延误与负面的财务和人员影响、不良的临床结果和不良的患者结果有关。澳大利亚布里斯班的亚历山德拉公主医院演出约15场 000例择期手术,药物优化对于为患者做好手术准备以避免手术当天取消至关重要。理想情况下,患者可以在多学科的入院前诊所就诊,以优化他们的健康和药物,并提供有关他们手术的教育。计算12个月内因药物意外事故而取消择期手术的发生率。昆士兰一家三级医院进行了为期12个月(2021年4月至2022年3月)的回顾性审计,包括取消择期手术的患者。对医院数字数据库中被医院编码服务部门认定为“不适合手术”的患者的医疗记录进行了筛查,以确定取消手术的原因是否是药物意外。该项目由Metro South人类研究伦理委员会审查,并被视为免于进一步审查(参考号:CM20221651)。手术取消率为50%(n = 6626例手术从13例取消 总共预约了255个手术)。当天手术取消率为5.5%(n = 734)。不良药物管理导致的药物意外事故占1%(n = 6626例手术取消中有66例)。总共41%(n = 27)的患者由于药物扣留时间不够长而被药剂师提前取消了手术,这阻止了当天的取消。有一位入院前的诊所药剂师可以改善术前的药物优化,并已被证明可以避免当天取消。
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引用次数: 0
Standard of practice in mental health for pharmacy services 药学服务精神卫生实践标准
IF 2.1 Q2 Health Professions Pub Date : 2023-08-08 DOI: 10.1002/jppr.1874
Helen Lowy BSc (Hons), PGDipClinPharm, MPhil, PGDipCounselling, FSHP, Viandro Borja BPharm (Hons), GradCertPharmPrac, MClinPharm, MSHP, Stewart Bailey BPharm, DipMgt, MPS, MSHP, Cecilia Bjorksten BPharm, MPS, MSHP, FACP, AACPA, Alice Kochman BPharm, MClinPharm, MSHP, Judy Longworth BPharm, MPharm (Clin), FSHP, Alistair Meldrum BPharm (Hons), MClinPharm, MSHP, Amy Sieff BBiomedSc, MPharm, GradCertLShip (HlthHumServ), MSHP, Lesley Smith BPharm, AdvPP (II), BCPP, MSHP, Alice Wisdom BPharm (Hons), MSHP, Yee Mellor BPharm, MCncrSc, GPhC, MSHP
Standard of practice in mental health for pharmacy services Helen Lowy, BSc (Hons), PGDipClinPharm, MPhil, PGDipCounselling, FSHP*, Viandro Borja, BPharm (Hons), GradCertPharmPrac, MClinPharm, MSHP, Stewart Bailey, BPharm, DipMgt, MPS, MSHP, Cecilia Bjorksten, BPharm, MPS, MSHP, FACP, AACPA, Alice Kochman, BPharm, MClinPharm, MSHP, Judy Longworth, BPharm, MPharm (Clin), FSHP, Alistair Meldrum, BPharm (Hons), MClinPharm, MSHP, Amy Sieff, BBiomedSc, MPharm, GradCertLShip (HlthHumServ), MSHP, Lesley Smith, BPharm, AdvPP (II), BCPP, MSHP, Alice Wisdom, BPharm (Hons), MSHP, Yee Mellor, BPharm, MCncrSc, GPhC, MSHP 1 Mental Health Leadership Committee, The Society of Hospital Pharmacists of Australia, Abbotsford, Victoria, Australia 2 Helen Lowy Counselling and Psychotherapy, Frankston South, Victoria, Australia 3 Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia 4 Faculty of Pharmacy and Pharmaceutical Science, Monash University, Parkville, Victoria, Australia 5 Pharmacy Department, Darling Downs Health, Toowoomba, Queensland, Australia 6 Hunter New England Mental Health Service, Waratah, New South Wales, Australia 7 Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia 8 The Children’s Hospital at Westmead, Sydney Children’s Hospital Network, Sydney, NSW, Australia 9 Rockhampton Hospital Pharmacy Department, Central Queensland Hospital and Health Service, Rockhampton, Queensland, Australia 10 South Western Sydney Local Health District, Warwick Farm, New South Wales, Australia 11 Pharmacy Department, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia 12 SA Pharmacy, SA Health, Adelaide, South Australia, Australia 13 The Society of Hospital Pharmacists of Australia, Abbotsford, Victoria, Australia
Helen Lowy, BSc(荣誉),PGDipClinPharm, MPhil, pgdipcounseling, FSHP*, Viandro Borja, BPharm(荣誉),GradCertPharmPrac, MClinPharm, MSHP, Stewart Bailey, BPharm, DipMgt, MPS, MSHP, Cecilia Bjorksten, BPharm, MPS, MSHP, BPharm, MSHP, Judy Longworth, BPharm, MPharm(临床),FSHP, Alistair Meldrum, BPharm(荣誉),MClinPharm, MSHP, Amy Sieff, BBiomedSc, MPharm, GradCertLShip (HlthHumServ), MSHP,Lesley Smith, BPharm, AdvPP (II), BCPP, MSHP, Alice Wisdom, BPharm(荣誉),MSHP, Yee Mellor, BPharm, MCncrSc, GPhC, MSHP 1心理健康领导委员会,澳大利亚维多利亚州阿伯茨福德澳大利亚医院药剂师协会2 Helen Lowy咨询和心理治疗,澳大利亚维多利亚州弗兰克斯顿南部3澳大利亚维多利亚州墨尔本阿尔弗雷德健康药房4维多利亚州帕克维尔莫纳什大学药学和药物科学学院澳大利亚5澳大利亚昆士兰州图沃姆巴达令斯健康药房6澳大利亚新南威尔士州沃拉塔亨特新英格兰精神健康服务7澳大利亚维多利亚州海德堡奥斯汀健康药房8澳大利亚新南威尔士州悉尼韦斯特米德儿童医院悉尼儿童医院网络9罗克汉普顿医院药房昆士兰州罗克汉普顿澳大利亚10澳大利亚新南威尔士州沃里克农场西南悉尼地方卫生区11澳大利亚昆士兰州伍龙加巴亚历山德拉公主医院药房12澳大利亚南澳大利亚阿德莱德SA药房13澳大利亚医院药剂师协会阿伯茨福德澳大利亚维多利亚州
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引用次数: 0
A review of pharmacy-led interventions: identification of facilitators and barriers for the design of a new model of care for asthma 药房主导的干预措施综述:确定哮喘新护理模式设计的促进因素和障碍
IF 2.1 Q2 Health Professions Pub Date : 2023-07-31 DOI: 10.1002/jppr.1870
Neera Rajballi-Naidoo BSC.Pharm, PGDipHS, MHSc, Kyle John Wilby PharmD, PhD, Amber Young BPharm, PGCertPharm, PGCertGPP, PhD, Alesha Smith BSc, MSc, PhD, MBA

The objective of this narrative review was to determine the facilitators and barriers identified in pharmacy-led interventions that improve outcomes in patients with asthma and support the implementation of interventions in practice. EMBASE, Web of Science, Google Scholar, and PubMed were used to identify 17 relevant articles. Seven studies were randomised controlled studies and 10 were one-arm, pre-post evaluations of all participants enrolled. Questionnaires assessing asthma control, medicine adherence, and knowledge about asthma were used, while checklists were used to assess inhaler technique. Studies with planned interventions in a clinic or general practice setting and lasting for 6 months (compared to longer interventions of 48 weeks) were more successful in retaining participation in the program. Education was the key intervention in which inhaler technique training was the most common. Knowledge about the disease, its aetiology, trigger factors, and medication used were covered in 10 of the studies. Fifteen of the articles reported an improvement in the asthma of patients receiving intervention by the pharmacist, measured by their asthma control test scores, emergency department visits, or reduced emergency steroid prescriptions. This review highlights five key requirements for the success of pharmacy-based interventions for asthma management: (a) developing and maintaining a skilled workforce; (b) close proximation of a general practitioner practice or clinic to the pharmacy; (c) patient education on the disease and medicine; (d) structured and standardised intervention and assessment; and (e) length of the intervention suitable to the pharmacist and the patient.

这篇叙述性综述的目的是确定在药物主导的干预措施中发现的促进因素和障碍,这些干预措施可以改善哮喘患者的预后,并支持干预措施在实践中的实施。使用EMBASE、Web of Science、b谷歌Scholar和PubMed识别出17篇相关文章。7项研究是随机对照研究,10项是单臂研究,对所有入组参与者进行前后评估。使用问卷评估哮喘控制、药物依从性和哮喘知识,使用检查表评估吸入器技术。在诊所或一般实践环境中进行计划干预的研究,持续6个月(与48周的较长干预相比),更成功地保留了对该计划的参与。教育是最主要的干预措施,其中吸入器技术培训最为常见。其中10项研究涵盖了对这种疾病的了解、病因、触发因素和使用的药物。其中15篇文章报告了接受药剂师干预的患者哮喘的改善,通过他们的哮喘控制测试分数、急诊科就诊或减少紧急类固醇处方来衡量。本综述强调了以药物为基础的哮喘管理干预措施取得成功的五个关键要求:(a)发展和维持一支熟练的劳动力队伍;(b)全科医生的诊所或诊所靠近药房;(c)对患者进行疾病和药物教育;(d)结构化和标准化的干预和评估;(e)适合药剂师和患者的干预时间长度。
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引用次数: 0
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Journal of Pharmacy Practice and Research
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