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Oxford Textbook of Social Psychiatry. 牛津社会精神病学教科书》。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1097/PRA.0000000000000753
Michelle B Riba
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引用次数: 0
The Neuropsychiatric Side of Cerebral Venous Thrombosis: A Case of Delirium and Catatonia. 脑静脉血栓形成的神经精神侧:一例谵妄和强直。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000746
Metzli Calva-González, Triana Juliana Tello-Gerez, Fabiola Serrano-Arias, Vanessa Cano-Nigenda, Jesus Ramírez-Bermúdez

We report a patient with cerebral venous thrombosis who initially presented with psychosis and who then progressed to delirium and catatonia within a few days. Upon treatment and resolution of the thrombosis, she presented complete remission of the psychiatric disturbances. This case highlights a specific neuropsychiatric presentation of cerebral venous thrombosis involving psychosis, catatonia, and delirium, which, to our best knowledge, has not been reported in the neurological or psychiatric literature. However, it reminds us of mental status and behavioral abnormalities which are not infrequent features of cerebral venous thrombosis. This leads to a discussion regarding the psychopathology, etiology, and pathophysiology of the case.

我们报告了一名脑静脉血栓形成患者,他最初表现为精神病,然后在几天内发展为谵妄和紧张症。在血栓形成的治疗和解决后,她的精神障碍完全缓解。该病例突出了涉及精神病、紧张症和谵妄的脑静脉血栓形成的特定神经精神表现,据我们所知,这在神经或精神病学文献中尚未报道。然而,它提醒我们精神状态和行为异常,这是脑静脉血栓形成的常见特征。这导致了对该病例的精神病理学、病因和病理生理学的讨论。
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引用次数: 0
Psychotherapy and Artificial Intelligence. 心理治疗和人工智能。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000748
Eric M Plakun

This column explores the challenges involved in providing psychotherapy through artificial intelligence. It reviews artificial intelligence's capacity across schools of therapy to address relevant issues related to privacy, the use of technical interventions, and the therapeutic relationship.

本专栏探讨了通过人工智能提供心理治疗所面临的挑战。它审查了人工智能在治疗学校中解决与隐私、技术干预的使用和治疗关系相关问题的能力。
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引用次数: 0
Psychodynamic Psychopharmacology: Caring for the Treatment-resistant Patient. 精神动力精神药理学:照顾难治患者。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000740
Richard F Summers
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引用次数: 0
Confidentiality and the VIP. 保密和VIP。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000747
John M Oldham
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引用次数: 0
Personalized Medicine in the Treatment of a Patient With Obsessive-Compulsive Disorder With Clomipramine. 克罗米帕明治疗强迫症患者的个性化药物。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000750
Sheldon H Preskorn, Ryan Rode

Clomipramine (CIMI) is an effective treatment for obsessive-compulsive disorder in patients who have failed to respond to trials of selective serotonin transport inhibitors (eg, sertraline). The case presented here illustrates how knowledge of the pharmacodynamics and pharmacokinetics of CIMI in a specific patient can be used to personalize treatment to optimize the likelihood of efficacy (ie, maximum benefit to risk ratio). The approach described in this column considered: (1) the patient's diminished ability to clear CIMI and its major metabolite, desmethlyclomipramine due to a genetic deficiency in cytochrome P450 2D6 enzyme activity, and (2) the patient's ability to extensively convert CIMI to desmethlyclomipramine. That conversion impairs the ability to inhibit the serotonin transporter, the mechanism that is most likely responsible for the efficacy of CIMI in obsessive-compulsive disorder.

克罗米帕明(CIMI)是治疗对选择性血清素转运抑制剂(如舍曲林)试验无效的强迫症患者的有效方法。这里介绍的案例说明了CIMI在特定患者中的药效学和药代动力学知识如何用于个性化治疗,以优化疗效的可能性(即最大获益风险比)。本专栏中描述的方法考虑到:(1)由于细胞色素P450 2D6酶活性的遗传缺陷,患者清除CIMI及其主要代谢产物去甲多胺的能力减弱,以及(2)患者将CIMI广泛转化为去甲多丁胺的能力。这种转化削弱了抑制血清素转运蛋白的能力,血清素转运蛋白很可能是CIMI治疗强迫症疗效的机制。
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引用次数: 0
Methods Used to Control the Reproductive Choices of Women Who Are Sex Trafficked: Considerations for Health Care Providers. 用于控制性交易妇女生殖选择的方法:卫生保健提供者的考虑因素。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000741
Lindsey Limbaugh, Mollie R Gordon, Phuong Thanh Nguyen, Mayrose Porter, John Coverdale

Reproductive control or reproductive coercion has negative health consequences but has not been systematically studied within the context of sex trafficking. Our goal is to identify the range of methods used by sex traffickers and buyers to control the reproductive choices of trafficked women and to provide specific examples of these methods. We searched PubMed, Embase, and PsycInfo using the terms "reproductive control" or "reproductive coercion" and "human trafficking" or "sex trafficking," including papers that contained original, specific examples of reproductive control occurring within the context of sex trafficking. These reports were described and categorized into established domains of reproductive control. Eight articles were located that met our inclusion criteria, of which 6 described outcomes of birth control sabotage, 2 described pressuring into pregnancy, 5 described controlling the outcome of a pregnancy, and 2 described forced birth control or sterilization. Our findings have implications for how to take sexual histories and for identifying and assisting trafficked persons.

生殖控制或生殖胁迫会对健康产生负面影响,但尚未在性交易的背景下进行系统研究。我们的目标是确定性贩运者和购买者用来控制被贩运妇女生育选择的一系列方法,并提供这些方法的具体例子。我们使用“生殖控制”或“生殖胁迫”、“人口贩运”或“性贩运”等术语搜索PubMed、Embase和PsycInfo,包括包含在性贩运背景下发生的生殖控制的原始、具体例子的论文。对这些报告进行了描述,并将其分类为生殖控制的既定领域。找到了8篇符合我们纳入标准的文章,其中6篇描述了破坏节育的结果,2篇描述了强迫怀孕,5篇描述了控制怀孕的结果,还有2篇描述强制节育或绝育。我们的研究结果对如何记录性史以及识别和协助被贩运者具有启示意义。
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引用次数: 0
Psychiatric Treatment of Medical Colleagues and Their Families: Potential Risks. 医务人员及其家属的精神病治疗:潜在风险。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000745
Eduardo Constantino, Thomas Spina

Clinicians treating "very important persons" face potential problems that can negatively impact the quality of care they provide. Mental health professionals face similar pressures, particularly when asked to treat a particular kind of patient who is a very important person: medical colleagues or their family members. The authors present 3 cases that exemplify possible risks associated with the psychiatric treatment of these individuals, including negative effects on the physician-patient relationship, lapses in patient confidentiality, and violations of medical ethics. Preventive and mitigative steps to avoid these pitfalls are discussed. Awareness of these issues when treating fellow physicians or their family members is an important consideration for any mental health clinician.

治疗“非常重要的人”的临床医生面临着潜在的问题,这些问题可能会对他们提供的护理质量产生负面影响。心理健康专业人员也面临着类似的压力,尤其是当被要求治疗一种非常重要的患者时:医疗同事或他们的家人。作者提出了3个案例,举例说明了这些人的精神治疗可能存在的风险,包括对医患关系的负面影响、患者保密失误和违反医疗道德。讨论了避免这些陷阱的预防和缓解措施。在治疗同事或其家人时,意识到这些问题是任何心理健康临床医生的重要考虑因素。
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引用次数: 0
A Cardiovascular Risk Optimization Program in People With Schizophrenia: A Pilot Randomized Controlled Clinical Trial. 精神分裂症患者心血管风险优化计划:一项随机对照临床试验。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000743
Núria Riera-Molist, Montse Assens-Tauste, Pere Roura-Poch, Marta Guimerà-Gallent, Josep Manel Santos-López, Montserrat Serra-Millas, Neus Frau-Rosselló, Estefania Gallego-Peña, Quintí Foguet-Boreu

Background: Cardiovascular disease is one of the leading causes of premature death in people with schizophrenia. Some modifiable factors that have been implicated include unhealthy lifestyle, medication side effects, and physical comorbidities. The goal of this study was to assess the efficacy of a 6-month, multifactorial cardiovascular risk intervention to reduce cardiovascular risk (CVR) in people with schizophrenia.

Methods: We conducted a 2-arm, parallel, randomized clinical trial in a regional mental health center. Participants with at least 1 poorly controlled cardiovascular risk factor (CVRF) (hypertension, diabetes mellitus, hypercholesterolemia, or tobacco smoking) were randomly assigned to the intervention group or to a control group. The subjects in the intervention group received a patient-centered approach that included promoting a healthy lifestyle, pharmacological management of CVRFs, psychotropic drug optimization, and motivational follow-up [Programa d'optimització del RISc CArdiovascular (PRISCA)]. The main outcome was change in CVR as assessed using the Framingham-REGICOR function, after 6 months compared with the baseline in both groups.

Results: Forty-six participants were randomly assigned to the PRISCA group (n=23) or the control group (n=23). The most prevalent CVRFs at baseline were hypercholesterolemia (84.8%) and tobacco smoking (39.1%). The PRISCA group showed a significant reduction in the REGICOR score (-0.96%; 95% CI: -1.60 to -0.32, P=0.011) after 6 months (relative risk reduction of 20.9%), with no significant changes in the control group (0.21%; 95% CI: -0.47 to 0.89, P=0.706). In the PRISCA group, low-density lipoprotein cholesterol also decreased significantly (-27.14 mg/dL; 95% CI: -46.28 to -8.00, P=0.008).

Conclusion: A patient-centered, multifactorial cardiovascular risk intervention improved CVR in people with schizophrenia after 6 months, which was achieved mainly by improving the lipid profile.

背景:心血管疾病是精神分裂症患者过早死亡的主要原因之一。一些可改变的因素包括不健康的生活方式、药物副作用和身体合并症。本研究的目的是评估为期6个月的多因素心血管风险干预对降低精神分裂症患者心血管风险(CVR)的疗效。方法:我们在一个地区心理健康中心进行了一项2臂、平行、随机的临床试验。至少有1种控制不良心血管危险因素(CVRF)(高血压、糖尿病、高胆固醇血症或吸烟)的参与者被随机分配到干预组或对照组。干预组的受试者接受了以患者为中心的方法,包括促进健康的生活方式、CVRF的药物管理、精神药物优化和动机随访[心血管RISc优化计划(PRISCA)]。主要结果是使用Framingham REGICOR函数评估的两组6个月后CVR与基线相比的变化。结果:46名参与者被随机分配到PRISCA组(n=23)或对照组(n=24)。基线时最常见的CVRF是高胆固醇血症(84.8%)和吸烟(39.1%)。PRISCA组在6个月后REGICOR评分显著降低(-0.96%;95%CI:-1.60至-0.32,P=0.011)(相对风险降低20.9%),对照组没有显著变化(0.21%;95%CI:-0.47至0.89,P=0.006),低密度脂蛋白胆固醇也显著降低(-27.14mg/dL;95%可信区间:-46.28至-8.00,P=0.008)。结论:以患者为中心的多因素心血管风险干预改善了精神分裂症患者6个月后的CVR,这主要是通过改善脂质状况来实现的。
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引用次数: 0
Catatonia as the Presentation of Encephalopathy Associated With Autoimmune Thyroiditis: A Case Report and Literature Review. 以强直为表现的与自身免疫性甲状腺炎相关的脑病:一例报告和文献复习。
IF 1.9 4区 医学 Q3 PSYCHIATRY Pub Date : 2023-11-01 DOI: 10.1097/PRA.0000000000000751
Hossam Tharwat Ali, Farah Riyad Mohamed, Ahmed Khaled Al-Ghannami, Ana Leticia Fornari Caprara, Jamir Pitton Rissardo

Encephalopathy can be associated with autoimmune disorders such as autoimmune thyroiditis, and it can present with a wide range of neuropsychiatric manifestations. However, it rarely presents with catatonia. We present the case of a middle-aged female with Hashimoto's thyroiditis presenting with catatonia. A literature review of previous similar cases highlighting significant points is also included. A 48-year-old female presented to the emergency department with catatonic symptoms that had worsened over the previous 5 days. A similar condition was reported to have occurred and resolved spontaneously 3 months earlier. On examination, the patient appeared uncooperative and unresponsive. She showed typical symptoms of catatonia, with a score of 21 points on the Bush-Francis Catatonia Rating Scale. Routine tests were within normal ranges except for an elevated level of C-reactive protein and an elevated erythrocyte sedimentation rate. Computed tomography, magnetic resonance imaging, and cerebrospinal fluid analysis were all normal. An electroencephalogram showed diffuse delta-theta range slowing with no epileptiform discharges. Lorazepam was initiated but did not control the catatonic symptoms. Re-evaluation revealed thyroid swelling and elevated levels of thyroperoxidase antibodies. IV methylprednisolone was therefore initiated and produced complete resolution of the catatonic symptoms in 4 hours. The patient was discharged and prescribed prednisone 1 mg/kg daily. At follow-up, the patient continued to show complete resolution of the catatonic symptoms. It is noteworthy that the patient developed hypothyroidism 6 months after this catatonic episode for which levothyroxine 50 mcg/d was prescribed. Encephalopathy associated with autoimmune thyroiditis can initially present with catatonic symptoms in euthyroid cases. The mainstay of treatment is steroids which result in complete resolution of the catatonic symptoms.

脑病可与自身免疫性疾病相关,如自身免疫性甲状腺炎,并可表现为广泛的神经精神表现。然而,它很少表现为紧张症。我们报告一例中年女性桥本甲状腺炎伴紧张症。还包括对以前类似案例的文献综述,突出了重要的观点。一名48岁的女性因紧张症状在前5天恶化而被送往急诊科。据报道,类似的情况在3个月前发生并自行缓解。检查时,患者表现出不配合和无反应。她表现出典型的紧张症症状,在布什-弗朗西斯紧张症评定量表上得了21分。常规检查在正常范围内,除了C反应蛋白水平升高和红细胞沉降率升高。计算机断层扫描、磁共振成像和脑脊液分析均正常。脑电图显示弥漫性Δθ范围减慢,无癫痫样放电。服用洛拉西泮,但并未控制紧张症状。重新评估显示甲状腺肿胀,甲状腺过氧化物酶抗体水平升高。因此,开始静脉注射甲基强的松龙,并在4小时内完全缓解紧张症状。患者出院后,每天服用1 mg/kg的泼尼松。在随访中,患者继续表现出紧张症状的完全缓解。值得注意的是,该患者在该紧张性发作6个月后出现甲状腺功能减退,为此开具了50mcg/d的左旋甲状腺素处方。与自身免疫性甲状腺炎相关的脑病在甲状腺功能正常的病例中最初可表现为紧张性症状。主要的治疗方法是类固醇,它可以完全缓解紧张症状。
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Journal of Psychiatric Practice
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