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Life-threatening Rash Due to Lamotrigine and a Failure to Understand Its Pharmacology: How Forensic Detective Work Uses Medical Knowledge and Clinical Pharmacology to Solve Cases. 拉莫三嗪引起的危及生命的皮疹和对其药理的不了解:法医侦探工作如何利用医学知识和临床药理学来破案。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000791
Sheldon H Preskorn, David D Masolak

This column is the second of a 3-part series describing cases where general medical knowledge, including psychiatric and clinical pharmacology, were instrumental in determining dereliction and direct cause in a malpractice suit. This case summarizes how lamotrigine can cause dangerous consequences if its pharmacology is not properly understood. The case also illustrates how the 4 Ds of a forensic malpractice suit were met in this case. First, there was duty on the part of the prescriber which, if followed, would have prevented or minimized the damages experienced by the patient. Dereliction in the performance of a patient-physician treatment contract was a direct cause of the development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in this patient. An immune-mediated reaction to lamotrigine or one of its metabolites has been extensively reported in the literature, with the risk of this reaction increasing at higher doses and with more rapid titration, fulfilling the elements of direct cause. Dereliction implies a deviation from the standard of care. On the basis of the clinical information from the package insert, more likely than not a deviation from the standard of care occurred in this case when lamotrigine was titrated faster than recommended by the package insert.

本专栏是三部曲系列中的第二部,描述了一些案例,在这些案例中,医学常识(包括精神病学和临床药理学)在确定医疗事故诉讼中的失职和直接原因方面发挥了重要作用。本案例总结了如果不正确理解拉莫三嗪的药理学,它是如何导致危险后果的。该案例还说明了本案如何满足了法医渎职诉讼的 4 D 要求。首先,处方者有责任,如果他履行了这一责任,本可以避免或最大限度地减少患者遭受的损害。在履行患者与医生之间的治疗合同方面的失职是导致该患者发生史蒂文斯-约翰逊综合症/中毒性表皮坏死症(SJS/TEN)的直接原因。文献中广泛报道了拉莫三嗪或其代谢物引起的免疫介导反应,剂量越大、滴注越快,发生这种反应的风险越高,因此符合直接原因的要素。失职意味着偏离了护理标准。根据说明书中的临床信息,在本病例中,拉莫三嗪的滴定速度快于说明书的建议速度,很有可能是偏离了治疗标准。
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引用次数: 0
The Grief Debate, the DSM, and Clinical Practice. 悲伤辩论、DSM 和临床实践。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000792
James Phillips

There has been an ongoing debate regarding grief, whether it may be at times pathological, and whether it is different from depression. This article addresses those questions by tracking the changing course of the Diagnostic and Statistical Manuals of Mental Disorders (DSMs) since DSM-III and by reviewing the debate concerning grief and depression. At the time when DSM-III was being prepared in the late 1970s (it was published in 1980), there was a concern that normal bereavement (or grief) was being diagnosed as major depression. To address this concern, the editors of DSM-III added a category of "uncomplicated bereavement." The fourth edition of the DSM (DSM-IV), published in 1994, then followed by a minor change. However, the editors of DSM-5 decided to eliminate the bereavement exclusion entirely. Their concern was simply whether the individual did or did not suffer from major depression. Since an individual might not warrant a diagnosis of major depression but might still be experiencing grief, the DSM discussion leads directly into the question of whether grief-later called prolonged grief disorder-and depression are separate conditions. Advocates for prolonged grief disorder maintained that grief is different from depression but that patients may present with a mix of grief and depressive symptoms that are clinically difficult to distinguish. Advocates of separate conditions have in fact developed an inventory of symptoms that identify prolonged grief disorder. However, inasmuch as a typical grief presentation will include depressive symptoms, the clinical challenge is to distinguish prolonged grief disorder and major depression, as well as to distinguish both from normal grief. Given the temporal limits of an average consultation, this article argues that making the required distinctions is an unrealistic expectation. Finally, researchers have developed specific treatment programs for prolonged grief disorder, but a conflict between the 2 primary researchers involved and the generalities in which the programs are phrased have led to the suggestion of a different approach to treatment that replaces generalities with a person-centered approach.

关于悲伤、悲伤是否有时是病态的、悲伤与抑郁是否有区别等问题一直存在争论。本文通过追踪《精神疾病诊断与统计手册》(DSMs)自 DSM-III 以来的变化过程,并回顾有关悲伤和抑郁的争论,来探讨这些问题。在 20 世纪 70 年代末编制 DSM-III(1980 年出版)时,人们担心正常的丧亲之痛(或悲伤)会被诊断为重度抑郁症。为了解决这一问题,DSM-III 的编辑们增加了 "非复杂性丧亲 "这一类别。随后,1994 年出版的《 DSM》第四版(DSM-IV)也进行了小幅修改。然而,《DSM-5》的编辑们决定完全取消将丧亲之痛排除在外。他们关注的仅仅是一个人是否患有重度抑郁症。由于一个人可能不需要被诊断为重度抑郁症,但可能仍然在经历悲痛,DSM 的讨论直接引出了一个问题:悲痛(后称长期悲痛症)和抑郁症是否是不同的病症。长期悲伤障碍的倡导者坚持认为,悲伤不同于抑郁,但患者可能会表现出悲伤和抑郁症状的混合,这在临床上很难区分。事实上,主张将悲伤与抑郁症分开的人已经编制了一份症状清单,用以识别长期悲伤障碍。然而,由于典型的悲伤表现会包括抑郁症状,因此临床挑战在于如何区分长期悲伤障碍和重度抑郁症,以及如何将两者与正常悲伤区分开来。考虑到一般咨询的时间限制,本文认为,进行必要的区分是不切实际的期望。最后,研究人员已经针对长期悲伤障碍制定了具体的治疗方案,但两位主要研究人员之间的冲突以及方案措辞的笼统性,导致人们提出了一种不同的治疗方法,即以人为本的方法取代笼统的方法。
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引用次数: 0
You Are Not Alone: The NAMI Guide to Navigating Mental Health. 你并不孤单:NAMI 精神健康导航指南》。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000794
Jai Gandhi, J Wesley Boyd
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引用次数: 0
"What you're born with, you die with." Half a Lifetime of Psychiatric Care for a Traumatized Young Woman With Cystic Fibrosis. "生于忧患,死于安乐"。一位患有囊性纤维化的年轻女性半生的精神创伤护理。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000793
George Bruxner

This case report describes 19 years of psychiatric care of a young female survivor of childhood sexual and physical abuse and neglect who also had the misfortune of having a life-compromising and life-limiting physical disease, cystic fibrosis. It summarizes ~ 100 therapeutic contacts from age 21 to age 40 and spans her journey through lung transplantation to the end of her life. The nature of cystic fibrosis and its treatment is reviewed and there is a discussion of the therapeutic process. The case is enriched by emails from the young woman describing her struggles to maintain personal integrity as her lung function declined. The case is presented with the young woman's consent.

本病例报告描述了对一名童年遭受性虐待、身体虐待和忽视的年轻女性幸存者长达 19 年的心理治疗,她还不幸患有危及生命和限制生命的身体疾病--囊性纤维化。这本书总结了她从 21 岁到 40 岁的约 100 次治疗接触,跨越了从肺移植到生命终结的整个过程。书中回顾了囊性纤维化的性质及其治疗方法,并对治疗过程进行了讨论。该年轻女性在邮件中描述了她在肺功能衰退时为保持人格完整所做的努力,丰富了本病例的内容。本病例是在征得该年轻女性同意后提交的。
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引用次数: 0
Psychoeducation for Pathologic Narcissism and Narcissistic Personality Disorder: A Review and Proposal for a Good Psychiatric Management-based Six-week Group Program. 病理性自恋和自恋型人格障碍的心理教育:基于良好精神管理的六周小组项目回顾与建议》(A Review and Proposal for a Good Psychiatric Management-based Six-week Group Program)。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000797
Martin Blay, Miguel Duarte, Ines Benmakhlouf, Melissa Amate, Nader Perroud, Mario Speranza, Loïs Choi-Kain, Elsa Ronningstam

Pathologic narcissism (PN) and narcissistic personality disorder (NPD) are 2 common and stigmatized clinical constructs that are known to have large consequences for patients' functioning and mental health-related outcomes. To date, no treatment for these conditions has been empirically validated, but there is a relative consensus about the importance of psychoeducation. Here we present a model for a psychoeducational intervention for patients with PN or NPD. We start with a review of the current evidence on the role of psychoeducation in different treatment models for PN, and we discuss several aspects regarding the content and format of this type of intervention. Based on this review, we outline a 6-week Good Psychiatric Management-based psychoeducation group program that we developed. We also describe how such a psychoeducational intervention can be implemented individually, with fewer resources, in general care settings. Finally, we discuss the strengths and limitations of our approach and elaborate on the rationale for our proposal. We believe that this program proposal is a first step in the development of psychoeducational programs for PN and NPD that can be further corrected and enhanced.

病理性自恋(PN)和自恋型人格障碍(NPD)是两种常见的临床病症,也是一种耻辱,已知会对患者的功能和心理健康相关结果造成严重影响。迄今为止,针对这两种疾病的治疗方法尚未得到经验验证,但人们对心理教育的重要性已达成相对共识。在此,我们介绍一种针对 PN 或 NPD 患者的心理教育干预模式。首先,我们回顾了心理教育在不同的 PN 治疗模式中所起作用的现有证据,并讨论了有关此类干预的内容和形式的几个方面。在此基础上,我们概述了我们开发的一个为期 6 周、基于良好精神病管理的心理教育小组项目。我们还介绍了如何在普通护理环境中以较少的资源单独实施这种心理教育干预。最后,我们讨论了我们的方法的优势和局限性,并阐述了我们提出建议的理由。我们相信,这项计划建议是针对 PN 和 NPD 开发心理教育计划的第一步,可以进一步修正和改进。
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引用次数: 0
Addressing the Health Needs of LGBTQ Persons in Medical Curricula: A Review of Educational Programs. 在医学课程中满足 LGBTQ 人士的健康需求:教育计划回顾。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000790
Nasim Khalfe, Matthew Stephens, Dania Albaba, Mollie R Gordon, John Coverdale

Objective: Given the vulnerability of and the importance of caring for the specific health care needs of the growing lesbian, gay, bisexual, transgender, and queer (LGBTQ) population, the authors attempted to identify all educational interventions in psychiatric settings with quantitative outcomes targeting medical students, residents, and physicians in postgraduate settings. To gain insight from other disciplines that have published research in this area, a second objective was to review studies in teaching in those other disciplines. The authors sought to describe the methods of selected studies.

Methods: The authors searched the published English-language literature indexed in PubMed, EMBASE, and PsycINFO using key terms for health care education concerning LGBTQ populations. The authors described and critically appraised studies with quantitative outcomes designed to enhance knowledge, skills, and attitudes in treating the LGBTQ community.

Results: Of the 15 trials identified, 10 included medical students, 4 included internal medicine residents or medical school faculty, and 1 included oncologists. We did not find any randomized controlled trials or controlled nonrandomized trials of curricula dedicated to teaching learners in psychiatry. All of the studies included a presurvey, followed by an educational intervention and then a postsurvey assessment. The educational interventions, outcome measures, and quality of studies varied widely. Four studies enrolled self-identified members of the LGBTQ community as trainers and facilitators of the educational interventions.

Conclusions: The lack of high-quality controlled studies indicates the need to develop evidence-based curricula to support the education of the psychiatric workforce to provide for the special needs of LGBTQ persons.

研究目的鉴于日益增长的女同性恋、男同性恋、双性恋、跨性别者和同性恋者(LGBTQ)群体的脆弱性以及满足其特殊医疗需求的重要性,作者试图找出所有针对医学生、住院医师和研究生中的医生的、具有量化结果的精神病学教育干预措施。为了深入了解在该领域发表过研究成果的其他学科,作者的第二个目标是回顾其他学科的教学研究。作者试图描述所选研究的方法:作者使用有关 LGBTQ 群体的医疗保健教育的关键术语检索了 PubMed、EMBASE 和 PsycINFO 中索引的已发表英文文献。作者描述并严格评估了旨在提高 LGBTQ 群体治疗知识、技能和态度的量化结果的研究:在确定的 15 项试验中,10 项包括医学生,4 项包括内科住院医师或医学院教师,1 项包括肿瘤学家。我们没有发现任何专门针对精神病学学员教学课程的随机对照试验或非随机对照试验。所有研究都包括前期调查、教育干预和后期评估。教育干预、结果测量和研究质量差异很大。有四项研究招募了自我认同的 LGBTQ 群体成员作为教育干预的培训师和促进者:缺乏高质量的对照研究表明,有必要开发以证据为基础的课程,以支持对精神科工作人员的教育,从而满足 LGBTQ 人士的特殊需求。
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引用次数: 0
Good-enough Care? How Patients' Perceptions of Counselors' Professional Skills Relate to Everyday Life in Forensic Long-stay Units. 足够的关怀?病人对心理咨询师专业技能的看法与法医长期住院病房日常生活的关系。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000799
Steven Degrauwe, Kim Dierckx, Vicky Van Bulck, Marie-Céline Gouwy, Lize Verbeke, Jasmine Vergauwe, Barbara De Clercq

The overall goal of long-term forensic care is to strive toward acceptable levels of adaptation and quality of life (QoL) of the forensic patient in the institutional context. While the bulk of the literature has focused on the deleterious consequences of personality pathology in this regard, research investigating the contribution of the quality of the therapeutic relationship has remained rather scant. Assuming that the perceived competence of the direct counselor, as perceived by patients, forms an important aspect in this regard, the central aim of this study was to investigate the relationship between patients' perceptions of their therapist's professional skills, their self-reported maladaptive behavior on the ward, and their experienced QoL. To this end, we recruited patients (N = 60) in long-stay forensic units and investigated their perceptions of 10 specific skills displayed by their therapist, along a "too little-too much" rating scale. The results revealed that patients who had the overall impression that their counselor was equipped with an adequate set of professional skills showed less maladaptive behavior and perceived a higher QoL on the ward. Conversely, at a more specific competence level, only a positive relationship between a counselor's predictability and self-reported QoL was found. Taken together, these results highlight that an overall professional skill evaluation matters in the context of forensic patients' adaptation and QoL in their long-stay units, with the counselor's predictability serving as a crucial aspect in obtaining the most favorable outcomes.

长期法医护理的总体目标是努力使法医病人在机构环境中达到可接受的适应水平和生活质量(QoL)。虽然大部分文献都集中于人格病理学在这方面的有害后果,但有关治疗关系质量的研究仍然很少。本研究的主要目的是调查患者对其治疗师专业技能的看法、他们在病房中自我报告的不良行为以及他们的 QoL 体验之间的关系。为此,我们招募了长期住院法医病房的患者(N = 60),按照 "太少-太多 "的评分量表,调查了他们对治疗师所展示的 10 种特定技能的看法。结果显示,那些对其心理咨询师具备足够的专业技能有总体印象的患者,其不良行为较少,在病房中的生活质量也较高。相反,在更具体的能力水平上,只发现心理咨询师的可预测性与自我报告的 QoL 之间存在正相关。综上所述,这些结果突出表明,整体专业技能评估对法医病人在长期住院期间的适应性和 QoL 很重要,而心理咨询师的可预测性则是获得最有利结果的关键因素。
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引用次数: 0
Dimensionality. 维度
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000798
John M Oldham
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引用次数: 0
Multifaceted, Brief Intensive Home-Based Exposure Treatment in Patients with Obsessive-Compulsive Disorder Who are Nonresponsive to Regular Cognitive Behavior Therapy: An Uncontrolled Pilot Study. 对常规认知行为疗法无效的强迫症患者进行多方面、简短的强化家庭暴露疗法:一项非对照试点研究。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000796
Karin C P Remmerswaal, Neeltje M Batelaan, Patricia van Oppen, Willemijn D Scholten, Anton J L M van Balkom

Objective: To test a multifaceted treatment program for patients with obsessive-compulsive disorder (OCD) who did not respond to regular cognitive behavior therapy (CBT). The treatment addresses several factors that may play a role in maintaining OCD.

Methods: We designed a treatment consisting of a 6-day intensive, individual exposure in vivo with response prevention (ERP) format, with 24 therapist-assisted treatment hours at the patient's home and 12 self-controlled ERP hours, including behavioral activation and family interventions. Next, we investigated the effect (obsessive-compulsive symptoms, comorbidity, functioning, quality of life, OCD-related interaction patterns) and feasibility (dropout, treatment satisfaction, and organization) of this program using pre-post-tests, pre-follow-up tests, and qualitative data from patients, family members, and therapists.

Results: In a sample of 22 participants, obsessive-compulsive symptoms (Y-BOCS pre: 28.7, post: 15.9; Wilcoxon S-R tests P<0.01) improved significantly, as did most other effect measures. Results were largely, but not completely, preserved at 3-month follow-up. There was only 1 dropout. Patients, family members, and therapists were satisfied with the treatment. Implementation of the treatment did not pose difficulties.

Conclusions: In nonresponders with OCD, a multifaceted, brief, intensive home-based ERP program targeting factors maintaining OCD is promising and feasible. Extra care is needed to maintain improvement.

目的测试针对常规认知行为疗法(CBT)无效的强迫症(OCD)患者的多方面治疗方案。该治疗针对可能导致强迫症持续存在的几个因素:我们设计了一种治疗方法,包括为期 6 天的强化个体暴露与反应预防(ERP)模式,其中 24 个小时由治疗师在患者家中协助治疗,12 个小时由患者自行控制ERP,包括行为激活和家庭干预。接下来,我们利用前后测试、随访前测试以及来自患者、家庭成员和治疗师的定性数据,对该计划的效果(强迫症状、合并症、功能、生活质量、与强迫症相关的互动模式)和可行性(辍学率、治疗满意度和组织性)进行了调查:结果:在 22 名参与者的样本中,强迫症状(Y-BOCS 前测:28.7,后测:15.9;Wilcoxon)均有所下降:15.9; Wilcoxon S-R tests PConclusions:对于无应答的强迫症患者,针对维持强迫症因素的多方面、简短、强化的家庭ERP项目是有前景的,也是可行的。但需要格外注意以保持改善。
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引用次数: 0
Sexually Transmitted Diseases and Attention-Deficit/Hyperactivity Disorder: A Systematic Literature Review. 性传播疾病与注意力缺陷/多动症:系统性文献综述。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2024-07-01 DOI: 10.1097/PRA.0000000000000789
Lorenzo Soldati, Marie-Pierre Deiber, Pauline Schockaert, John Köhl, Mylène Bolmont, Roland Hasler, Nader Perroud

Patients with attention-deficit/hyperactivity disorder (ADHD) suffer from inattention, hyperactivity, and impulsivity. Clinicians often assume that the specific difficulties associated with ADHD are bound to affect sexual behaviors, and favor risky sexual behaviors, thereby increasing the frequency of sexually transmitted diseases (STDs). This review provides an up-to-date synthesis of the literature concerning STDs in patients with ADHD. A systematic review of the literature was performed using the PubMed, PsychInfo, and Embase databases, with STDs as the main outcome measure. Patients with ADHD report more STDs than the general population. Results are limited by the small number of existing studies, as well as the heterogeneity of the outcome measures. Findings from this first systematic review of data on STDs in individuals with ADHD suggest that ADHD affects sexual health and sexual behaviors. Clinicians treating patients with ADHD should explore risky sexual behaviors in their patients and raise awareness about the risk of contracting STDs. Further studies are warranted to better evaluate the risk of contracting an STD in patients with ADHD.

注意力缺陷/多动障碍(ADHD)患者注意力不集中、多动和冲动。临床医生通常认为,与多动症相关的特殊困难必然会影响性行为,并倾向于危险的性行为,从而增加性传播疾病(STD)的发病率。本综述提供了有关多动症患者性传播疾病的最新文献综述。我们使用 PubMed、PsychInfo 和 Embase 数据库对文献进行了系统性综述,并将性传播疾病作为主要的结果测量指标。与普通人群相比,多动症患者报告的性传播疾病更多。由于现有研究的数量较少,而且结果测量的异质性较大,因此研究结果受到了限制。这是对多动症患者性传播疾病数据的首次系统性回顾,研究结果表明多动症会影响性健康和性行为。治疗ADHD患者的临床医生应该研究患者的危险性行为,提高他们对感染性病风险的认识。为了更好地评估ADHD患者感染性病的风险,有必要开展进一步的研究。
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引用次数: 0
期刊
Journal of Psychiatric Practice
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