Journal of Reproductive Immunology最新文献

英文中文

Shaping Future Leaders in JSIR through YouTube-Driven Education 通过youtube驱动的教育塑造JSIR的未来领导者

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104787

Akitoshi Nakashima, Takashi Nishigori, Shina Sakaguchi, Takuya Majima, Atsushi Furuta, Kiyotaka Yamada, Sayaka Tsuda, Tomoko Shima

引用次数: 0

A Case of Vulvar Giant Condyloma Acuminatum Developing During Long-Term Oral Steroid Therapy and Treated with Etretinate 外阴巨大尖锐湿疣长期口服类固醇治疗并发异维甲酸治疗1例

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104790

Yuji Habu , Hiroshi Ishikawa , Fumiki Mukouyama , Chigusa Hiroka , Yoshiko Saito , Akiko Omoto , Yaei Togawa , Atsuko Tomikawa , Kaori Koga

引用次数: 0

A Novel Pathogenic Mechanism Underlying Placental Dysfunction and Pregnancy Complications: Double-Stranded RNA–Mediated Inhibition of Cytotrophoblast Differentiation 胎盘功能障碍和妊娠并发症的新致病机制：双链rna介导的细胞滋养细胞分化抑制

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104778

Hiromichi Yamamoto , Masato Tamari , Naoko Nagano , Yuka Hayashi , Hironori Takahashi , Seiji Wada , Hiromi Komiya , Hideaki Morita , Kenji Matsumoto , Kenichiro Motomura

引用次数: 0

Comparison of IgG4 and asymmetric IgG and their similar properties as blocking antibodies IgG4与非对称IgG的比较及其作为阻断抗体的相似性质。

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104807

Penghao Li , Yiqun Geng , Xiaomiao Yan , Weifeng Zhang , Sujuan Zhang , Jingliang Xu , Qu Zheng , Qiaoxiu Gu , Ziqi Zhu , Qiaoling Hu , Jiang Gu

Background

Blocking antibody can inhibit immunoreactions. IgG4 and asymmetric (asym) IgG are both referred to as “blocking antibodies”. However, their working mechanisms and effects on maternal-fetal immune tolerance in pregnancy remain unclear.

Methods

To explore the relationship between IgG4 and asym IgG as well as IgG4's role in maternal-fetal immune tolerance, Western blot, immunohistochemistry, protein array, and immune turbidimetric assay were employed to compare the structural and functional properties of the two antibodies. These included their distribution, density, and concentration in maternal sera as well as their interactions with other IgG subtypes.

Results

Significant molecular structural overlap was found between IgG4 and asym IgG. IgG4 exhibited an asym Fab glycosylated pattern. Both IgG4 and asym IgG, unlike symmetric(sym) IgG or IgG1, bound to cross-species IgGs. IgG1 and IgG4 were distributed in the outer layer of placental villi and within the lumens of placental intravascular vessels. In early placental villi, they were localized in the syncytiotrophoblast layer, while in the decidua, there were found mainly in lymphocytes.

IgG4 exhibited Fc-Fc interactions with IgG1, which were enhanced by glutathione (GSH) in a dose - dependent manner. IgG4 levels increased in early pregnancy sera but reduced during the late phase, likely contributing to placental immune tolerance early in pregnancy.

Conclusion

The study indicates that IgG4 and asym IgG are likely the same molecule with different purity but with similar biological properties. The IgG4 Fc-Fc interaction may be a key mechanism for immunotolerance in reproduction helping to establish immune equilibrium between mother and fetus during pregnancy.

背景：阻断抗体可以抑制免疫反应。IgG4和不对称IgG都被称为“阻断抗体”。然而，它们在妊娠期对母胎免疫耐受的作用机制和影响尚不清楚。方法：采用Western blot、免疫组织化学、蛋白阵列、免疫比浊法等方法比较两种抗体的结构和功能特性，探讨IgG4与异型IgG的关系以及IgG4在母胎免疫耐受中的作用。这些包括它们在母体血清中的分布、密度和浓度，以及它们与其他IgG亚型的相互作用。结果：IgG4与对称IgG存在明显的分子结构重叠。IgG4呈非对称Fab糖基化模式。与对称IgG或IgG1不同，IgG4和对称IgG都与跨物种IgG结合。IgG1和IgG4分布于胎盘绒毛外层和胎盘血管内管腔内。在胎盘绒毛早期，它们主要分布在合胞滋养层，而在蜕膜中，它们主要分布在淋巴细胞中。IgG4与IgG1表现出Fc-Fc相互作用，这种相互作用在谷胱甘肽（GSH）作用下呈剂量依赖性增强。IgG4水平在妊娠早期血清中升高，但在妊娠后期降低，可能有助于妊娠早期胎盘免疫耐受。结论：本研究提示IgG4和asym IgG可能是纯度不同但生物学性质相似的同一分子。IgG4 Fc-Fc相互作用可能是生殖免疫耐受的关键机制，有助于在怀孕期间建立母亲和胎儿之间的免疫平衡。

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引用次数: 0

Does administration of pravastatin to advanced maternal age mouse model improve long-term prognosis in hypertensive disorders of pregnancy? 普伐他汀对高龄产妇小鼠模型是否能改善妊娠期高血压疾病的长期预后？

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104774

Kazunari Nemoto , Keiichi Kumasawa , Motoaki Kinugawa , Risa Miyatake , Kei Inaba , Masako Kanda , Kiichiro Furuya , Takayuki Iriyama , Yutaka Osuga , Miyuki Harada , Yasushi Hirota

引用次数: 0

Anti-β2GPⅠ/HLA-DR antibody and pregnancy outcome in our clinic 抗β 2gpⅠ/HLA-DR抗体与妊娠结局的关系

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104770

Nao Hayashi, Hiroaki Shibahara, Eri Okamoto, Shoji Kokeguchi, Masahide Shiotani

引用次数: 0

Environmental Stress Response of TSPAN8 and Glucose Intolerance in the MEM Mouse Model MEM小鼠模型中TSPAN8的环境应激反应与葡萄糖耐受不良

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104783

Keisuke Nakajima , Takeshi Nagamatsu , Mari Ichinose , Masatake Toshimitsu , Seisuke Sayama , Keiichi Kumasawa , Takayuki Iriyama , Miyuki Harada , Yasushi Hirota

引用次数: 0

Unfractionated heparin prevents fetal inflammatory response syndrome and adverse pregnancy outcomes in a murine model 未分离肝素在小鼠模型中预防胎儿炎症反应综合征和不良妊娠结局

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104779

Miwa Ogitsu , Hajime Ino , Yumi Horii , Tomoko Ichikawa , Asako Watanabe , Yuki Kaito , Yasuyuki Negishi , Shunji Suzuki , Rimpei Morita

引用次数: 0

Lipophilic statin simvastatin demonstrates potent and rapid therapeutic efficacy in a murine model of preeclampsia 亲脂性他汀辛伐他汀在小鼠子痫前期模型中显示出有效和快速的治疗效果

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104761

Kei Inaba , Keiichi Kumasawa , Risa Miyatake , Masako Kanda , Sayama Seisuke , Takayuki Iriyama , Takeshi Nagamatsu , Hiroyasu Kidoya , Yutaka Osuga , Tomoyuki Fujii , Miyuki Harada , Yasushi Hirota

引用次数: 0

Metabolome analyses of mouse uteri two to four days post coitum 性交后2 - 4天小鼠子宫代谢组学分析

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology

Pub Date : 2025-12-01 DOI: 10.1016/j.jri.2025.104809

Nana Yang , Meng Li , Jingmei Han , Yiyong Liu , Hang Zhao , Xiangyun Li , Xinglong Wu

To elucidate the temporal and dynamic changes in uterine metabolites in mice, uterine samples were collected on Day 2 (D2; n = 8), Day 3 (D3; n = 6), and Day 4 (D4; n = 7) postcoitum and subjected to an untargeted metabolomic analysis. The results revealed significant metabolic alterations across the time points. Compared to D2, D3 showed 124 differentially expressed metabolites (95 upregulated and 29 downregulated), whereas D4 exhibited 377 (262 upregulated and 115 downregulated). Between D4 and D3, 370 metabolites were altered (242 upregulated and 128 downregulated). K-means clustering identified five metabolite clusters, with Clusters 3 and 5 displaying the most pronounced temporal variations. Metabolites in cluster 3 remained stable from D2 to D3 but sharply increased by D4, whereas those in cluster 5 were stable from D2 to D3 and markedly decreased by D4. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that metabolites in Cluster 3 were primarily enriched in the tricarboxylic acid (TCA) cycle, arachidonic acid metabolism, and cholesterol and linoleic acid metabolism pathways. Cluster 5 metabolites were primarily enriched in pathways related to unsaturated fatty acids (linoleic acid, arachidonic acid, and α-linolenic acid) and amino acid metabolism (vitamin B6, taurine, and hypotaurine). Cluster 3 mainly comprised prostaglandins and related compounds, whereas Cluster 5 consisted largely of long-chain fatty acids. Notably, most lipid and lipid-like metabolites in these clusters were associated with embryonic development. These findings elucidate the dynamic metabolic changes in the uterus during the preimplantation stage and highlight the critical roles of amino acids, unsaturated fatty acids, prostaglandins, and lipid-related metabolites in modulating the uterine environment to support embryo implantation and early development.

为了阐明小鼠子宫代谢物的时间和动态变化，在性交后第2天（D2; n = 8）、第3天（D3; n = 6）和第4天（D4; n = 7）采集子宫样本，进行非靶向代谢组学分析。结果显示，各时间点的代谢发生了显著变化。与D2相比，D3有124个差异表达代谢物（95个上调，29个下调），而D4有377个差异表达代谢物（262个上调，115个下调）。在D4和D3之间，370种代谢物发生改变（242种上调，128种下调）。K-means聚类鉴定出5个代谢物簇，其中簇3和簇5显示出最明显的时间变化。从D2到D3，第3类代谢产物保持稳定，但在D4时急剧增加；而从D2到D3，第5类代谢产物保持稳定，在D4时显著减少。京都基因与基因组百科（KEGG）通路分析表明，簇3代谢产物主要富集于三羧酸（TCA）循环、花生四烯酸代谢、胆固醇和亚油酸代谢途径。簇5代谢物主要富集于与不饱和脂肪酸（亚油酸、花生四烯酸和α-亚麻酸）和氨基酸代谢（维生素B6、牛磺酸和次牛磺酸）相关的途径。簇3主要由前列腺素和相关化合物组成，而簇5主要由长链脂肪酸组成。值得注意的是，这些簇中的大多数脂质和类脂代谢产物与胚胎发育有关。这些发现阐明了着床前子宫内的动态代谢变化，并强调了氨基酸、不饱和脂肪酸、前列腺素和脂质相关代谢物在调节子宫环境以支持胚胎着床和早期发育中的重要作用。

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引用次数: 0

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