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Long-Term Follow-Up of Patients with Brugada Syndrome: Foremost Risk Factors Associated with Arrhythmic Events Brugada 综合征患者的长期随访:与心律失常事件相关的首要风险因素
Pub Date : 2023-12-31 DOI: 10.23937/2643-3966/1710060
Camkiran Volkan, Ozden Ozge, Atar Ilyas
Background: Brugada syndrome (BS) is characterized by ST segment elevation in right precordial leads (V1-3), ventricular tachycardia (VT), ventricular fibrillation (VF) and sudden cardiac death (SCD) in individuals without structural heart disease. The aim of this study was to assess parameters associated with in patients with BS. Methods: A total of 68 patients diagnosed with BS or had Brugada Type ECG Change (BTEC) between January 1997 and July 2012 at the Department of Cardiology of Başkent University Faculty of Medicine, Ankara, Turkey were included. Patients were screened every 6 months for arrhythmia-related syncope, SCD, appropriate and inappropriate defibrillation (shock), AF development and death; collectively defined as “arrhythmic events” and were the primary endpoints. Patients with and without arrhythmic events were compared. Results: The mean age was 34.9 ± 12.2 years (9-71 years), and 52 (76.5%) patients were male. Mean follow-up was 49.6 ± 37.6 months (4-188 months). Univariate analysis showed that male sex (p = 0.004), Type 1 electrocardiographic pattern (p = 0.008), SCD (p = 0.036), VT/VF history (p = 0.046), requirement for electrophysiological studies (p = 0.034), implantable cardioverter-defibrillator (ICD) placement (p = 0.014) was found to demonstrate significant differences in patients with and without arrhythmic events. In multivariable analyzes, spontaneous Type 1 ECG presence (HR = 8.54, 95% CI: 0.38-26.37; p = 0.003) and VT/VF history (HR = 9.21, 95% CI: 0.004-1.88; p = 0.002) were found to be independently associated with arrhythmic events. Conclusion: We found the presence of spontaneous type 1 ECG and a history of VT/VF to be associated with increased likelihood of arrhythmic events in BS. Comprehensive studies investigating factors that could be used for risk assessment are necessary.
背景:Brugada 综合征(BS)的特征是右心前导联(V1-3)ST 段抬高、室性心动过速(VT)、心室颤动(VF)和无结构性心脏病患者的心脏性猝死(SCD)。本研究旨在评估与 BS 患者相关的参数。方法:共纳入土耳其安卡拉巴什肯特大学医学院心脏病学系 1997 年 1 月至 2012 年 7 月期间确诊为 BS 或有 Brugada 型心电图变化 (BTEC) 的 68 名患者。每 6 个月对患者进行一次心律失常相关晕厥、SCD、适当和不适当除颤(电击)、房颤发展和死亡筛查,这些统称为 "心律失常事件",是主要终点。对发生和未发生心律失常事件的患者进行比较。结果平均年龄为(34.9 ± 12.2)岁(9-71 岁),52 名(76.5%)患者为男性。平均随访时间为 49.6 ± 37.6 个月(4-188 个月)。单变量分析显示,男性性别(p = 0.004)、1型心电图模式(p = 0.008)、SCD(p = 0.036)、VT/VF病史(p = 0.046)、电生理研究要求(p = 0.034)、植入式心律转复除颤器(ICD)安置(p = 0.014)在发生和未发生心律失常事件的患者中存在显著差异。在多变量分析中,发现存在自发性 1 型心电图(HR = 8.54,95% CI:0.38-26.37;p = 0.003)和 VT/VF 史(HR = 9.21,95% CI:0.004-1.88;p = 0.002)与心律失常事件独立相关。结论我们发现自发性 1 型心电图和 VT/VF 病史与 BS 发生心律失常事件的可能性增加有关。有必要对可用于风险评估的因素进行全面研究。
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引用次数: 0
Medical and Day-to-Day Burden on Families of Children with Hypoplastic Left Heart Syndrome Who Have Undergone Single Ventricle Surgical Palliation over a Decade 十年来接受单心室手术姑息治疗的左心发育不全综合征患儿家庭的医疗和日常负担
Pub Date : 2023-12-31 DOI: 10.23937/2643-3966/1710059
Hanft Erin, Abascal Elena, Ferris Anne, Parravicini Elvira
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引用次数: 0
Cardiovascular Diseases Risk Assessment among South and South-East Asian Migrants Living in Greater Sydney, Australia: A Cross-Sectional Study 生活在澳大利亚大悉尼的南亚和东南亚移民的心血管疾病风险评估:一项横断面研究
Pub Date : 2022-12-31 DOI: 10.23937/2643-3966/1710052
W. Sachini, Paudel Grish, Yadav Uday Narayan, I. Shariful, Rawal Lal
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引用次数: 0
Persistence of Stress Related Left Ventricular Filling Abnormality in Treated Hypertensive Patients 高血压患者压力相关左心室充盈异常的持续存在
Pub Date : 2022-12-31 DOI: 10.23937/2643-3966/1710053
Kapuku Gaston K, Brown Michelle L, Suzuki Shin, Coughlin Stephen
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引用次数: 0
A Case Series: Long-Term Follow-Up of Four Patients with Kawasaki Disease who Developed Coronary Artery Disease 4例川崎病并发冠状动脉疾病的长期随访研究
Pub Date : 2022-06-30 DOI: 10.23937/2643-3966/1710050
G. Zagarese, A. Varriale, G. Puntel, G. Pesarini, A. Cristofaletti, C. Sandrini, F. Ribichini, M. Prioli
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引用次数: 0
External Multicenter Validation of the Mehran Risk Score for Contrast Induced Acute Kidney Injury 造影剂引起的急性肾损伤的Mehran风险评分的外部多中心验证
Pub Date : 2021-12-31 DOI: 10.23937/2643-3966/1710048
A. Nashwa
Background: Contrast induced acute kidney injury (CIAKI) is a known complication of percutaneous coronary intervention (PCI). Mehran Risk Score (MR score) has been previously shown to predict CIAKI, renal replacement therapy (RRT), and one-year mortality in patients undergoing PCI. The purpose of our study was to externally validate the MR score. Methods: To examine the utility of the MR score we reviewed records of 931 adult patients who underwent PCI in 2005 at 3 academic medical centers. Patients with acute myocardial infarction, end stage renal disease and contrast exposure within one week of PCI were excluded. MR score was calculated for each patient and stratified into 4 groups: MR score 0-5 (group 1), 6-10 (group 2), 11-15 (group 3), ≥ 16 (group 4). CIAKI was defined as an increase in serum creatinine of 25% or 0.5 mg/dl over baseline 48 hours post PCI. Need for hemodialysis was assessed within 1 month after PCI. All-cause mortality was assessed 1 year after PCI. Likelihood ratio was calculated to assess the MR score discrimination for our data as well as Mehran, et al. Results: The overall incidence of CIAKI, hemodialysis and mortality were 12.2%, 0.4%, and 9.0% respectively. A higher MR score was strongly associated with development of CIAKI and mortality (p < 0.01 for trend). There was no difference in the rate of CIAKI overall or in each MR score group when the 2 populations were compared, however, the risk of death was higher in our population (RR 1.58, CI 1.371.89, p < 0.001). Conclusion: In conclusion, we were able to externally validate the MR score as a useful tool to predict CIAKI and one-year all-cause mortality post PCI.
背景:造影剂引起的急性肾损伤(CIAKI)是经皮冠状动脉介入治疗(PCI)的一种已知并发症。Mehran风险评分(MR评分)先前已被证明可预测PCI患者的CIAKI、肾脏替代治疗(RRT)和一年死亡率。我们研究的目的是外部验证MR评分。方法:为了检验MR评分的实用性,我们回顾了2005年在3个学术医疗中心接受PCI治疗的931名成年患者的记录。排除急性心肌梗死、终末期肾脏疾病和PCI治疗一周内造影剂暴露的患者。计算每位患者的MR评分,并将其分为4组:MR评分0-5分(1组)、6-10分(2组)、11-15分(3组)、≥16分(4组)。CIAKI定义为PCI后48小时血清肌酐比基线升高25%或0.5 mg/dl。PCI术后1个月内评估血液透析需求。PCI术后1年评估全因死亡率。计算似然比来评估我们的数据以及Mehran等人的MR评分歧视。结果:CIAKI、血液透析和死亡率的总发生率分别为12.2%、0.4%和9.0%。较高的MR评分与CIAKI的发展和死亡率密切相关(趋势p < 0.01)。在比较两组人群时,CIAKI的总体发生率和各MR评分组没有差异,但是,我们的人群的死亡风险更高(RR 1.58, CI 1.371.89, p < 0.001)。结论:总之,我们能够从外部验证MR评分作为预测PCI术后CIAKI和一年全因死亡率的有用工具。
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引用次数: 1
Surviving the Death Roll; Unveiling the Undiagnosed: Case of Hispanic Man with Covid-19 Pneumonia 从死亡名单中幸存;揭开未确诊的面纱:西班牙裔男子Covid-19肺炎病例
Pub Date : 2021-12-31 DOI: 10.23937/2643-3966/1710044
Khorsandi Michael, M. Nirmala, Ebrahimihoor Elnaz, Muganlinskaya Nargiz
Brugada syndrome (BrS) is an inherited electrophysiological abnormality which typically manifests in patients with diverse ethnicities as ventricular arrhythmias or sudden cardiac death. The onset is frequently unmasked by various precipitating factors including but not limited to febrile diseases. Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection and associated COVID-19 illness continues to evolve. We are reporting a severe case of Covid-19 infection unveiling the undiagnosed Brugada syndrome, and the complicated course requiring mechanical ventilation and rounds of Cardiopulmonary resuscitation. A 57-years-old Hispanic man with no known prior cardiac history presented to the emergency department with fever and altered mental status. Initial investigations revealed mild leukocytosis, and positive SARS-CoV-2 PCR. The patient was transferred to intensive care unit (ICU) due to hemodynamic instability and electrolyte derangements. On day 2 of ICU stay, patient became febrile, hypotensive, tachycardic, and his hypoxemia worsened with increased supplemental oxygen requirement. His electrocardiogram (ECG) was consistent with atrial fibrillation and covedtyped Brugada pattern. At the early hours of the subsequent day, patient developed first episode of asystolic cardiac arrest requiring cardiopulmonary resuscitations (CPR) and intubation leading to return of spontaneous circulation (ROSC) after 10 mins. Only 3 days after the initial cardiac arrest episode, patient suffered from another episode of asystolic cardiac arrest requiring CPR leading to return of normal sinus rhythm and ROSC. Patient had a successful recovery from COVID-19 pneumonia with no additional cardiac events during his hospitalization, and was subsequently extubated and discharged from hospital with close follow up monitoring. Reported cases of Brugada syndrome in Hispanic population are scarce. Covid-19 positive patients have a guarded prognosis when they require intubation with mechanical ventilation with no chances of survival when they suffer cardiac arrest requiring cardiopulmonary resuscitation. This stimulated us to report a case of Brugada syndrome presented in Hispanic man who recovered a deadly course of Covid-19 infection despite requiring intubation and complicated course by two rounds of cardiopulmonary resuscitation (CPR).
Brugada综合征(BrS)是一种遗传性电生理异常,通常在不同种族的患者中表现为室性心律失常或心脏性猝死。发病常被各种促发因素所掩盖,包括但不限于发热性疾病。严重急性呼吸综合征(SARS)冠状病毒2型(SARS- cov -2)感染和相关的COVID-19疾病继续发展。我们报告了一例严重的Covid-19感染病例,揭示了未确诊的布鲁加达综合征,以及需要机械通气和心肺复苏的复杂过程。57岁西班牙裔男性,既往无心脏病史,以发热和精神状态改变就诊于急诊科。初步调查显示轻度白细胞增多,SARS-CoV-2 PCR阳性。由于血流动力学不稳定和电解质紊乱,患者被转移到重症监护病房(ICU)。入住ICU第2天,患者出现发热、低血压、心动过速,低氧血症加重,补充需氧量增加。他的心电图(ECG)符合心房颤动和codtype Brugada型。次日凌晨,患者出现第一次心脏停搏,需要心肺复苏术(CPR)和插管,10分钟后恢复自然循环(ROSC)。初次心脏骤停后仅3天,患者再次出现心脏骤停,需要心肺复苏术,导致窦性心律和ROSC恢复正常。患者成功从COVID-19肺炎中恢复,住院期间无其他心脏事件,随后拔管出院,并进行了密切随访监测。西班牙裔人群中Brugada综合征的报道病例很少。Covid-19阳性患者在需要插管机械通气时预后有保障,在心脏骤停需要心肺复苏时没有生存机会。这促使我们报告了一例Brugada综合征,该病例发生在西班牙裔男性中,尽管需要插管,但仍恢复了致命的Covid-19感染过程,并通过两轮心肺复苏(CPR)进行了复杂的过程。
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引用次数: 0
A Rare Association: Apical Hypertrophic Cardiomyopathy with Multiple Coronary Artery-Left Ventricular Fistulae 根尖肥厚性心肌病与多发冠状动脉-左心室瘘的罕见关联
Pub Date : 2021-12-31 DOI: 10.23937/2643-3966/1710045
Monedero-Sánchez Isabel, Robles-Velasco Pablo, Rubio-Caballero Amador, González-Doforno Yago, Marco-Quirós Cecilia, Espejo-Bares Victoria, Artiaga-de-la-Barrera Verónica, Jiménez-Martínez Carla
A 59-year-old woman was referred for evaluation of chest pain and she was diagnosed of acute coronary syndrome. Coronary arteriography showed a severe stenosis of left anterior descending artery but also the presence of multiple coronary artery-left ventricle micro-fistulae. Echocardiographic findings were consistent with apical hypertrophic cardiomyopathy and the fistulae were also patent by colour Doppler echocardiography. Little is known about clinical features of micro-fistulae arising from both coronary arteries and emptying into left ventricle, especially when they are associated with apical hypertrophic cardiomyopathy.
一名59岁女性因胸痛被诊断为急性冠状动脉综合征。冠状动脉造影显示左前降支严重狭窄,同时存在多发冠状动脉-左心室微瘘。超声心动图结果与心尖肥厚性心肌病一致,彩色多普勒超声心动图显示瘘管也很明显。目前对冠状动脉和左心室微瘘的临床特征知之甚少,特别是当它们与心尖肥厚性心肌病有关时。
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引用次数: 0
Cardiac Arrhythmia Associated with Remdesivir in COVID-19 新冠肺炎患者与瑞德西韦相关的心律失常
Pub Date : 2021-12-31 DOI: 10.23937/2643-3966/1710046
Niraula Sristee, Oli Shital, L. Janette
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引用次数: 0
Clinical Characteristics and Clinical Outcomes of Patients with Heart Failure Who Receive Public Assistance in Japan 日本接受公共援助的心力衰竭患者的临床特征和临床结果
Pub Date : 2021-11-25 DOI: 10.23937/2643-3966/1710047
Watanabe Shingo
Background: The number of patients with heart failure (HF) is increasing, which is a socio-economic problem. Past overseas studies have reported that low-income patients with HF do not receive adequate treatment for financial reasons and have poor clinical outcomes. In Japan, medical expenses are free if they receive public assistance called Seikatsu hogo (PA), and there is no disadvantage to low-income patients regarding medical expenses. The purpose of this study is to investigate the clinical characteristics of patients with HF who receive PA in Japan. Methods: We enrolled 301 patients who were admitted to our hospital for the congestive HF. We divided patients into groups of patients receiving PA (PA group, N = 51) and groups of patients not receiving PA (Non-WPA group, N = 250). We compared patient clinical characteristics at admission, and the incidence of one-year cardiovascular events (cardiac death, readmission for HF) in both groups. Results: The PA group was significantly younger (71.1y ± 12.7 vs. 79.9y ± 12.4 P < 0.001) and more smokers (62.7% vs. 35.6% P < 0.001) than the Non-PA group. The left ventricular ejection fraction was significantly lower in the PA group than in the Non-PA group (34.6% ± 17.9 vs. 43.0% ± 18.7 P = 0.04). There was no significant difference in mortality between the two groups. The incidence of readmissions for HF was significantly higher in the PA group than in the Non-PA group (33.3% vs. 18.2% P = 0.02). Conclusion: Patients with HF who received public assistance had a poor cardiac function, and the incidence of readmission due to HF was high.
背景:心力衰竭(HF)患者数量不断增加,这是一个社会经济问题。国外既往研究报道,低收入心衰患者因经济原因得不到充分治疗,临床预后较差。在日本,如果接受公共援助(PA),医疗费用是免费的,而且低收入患者在医疗费用方面没有任何劣势。本研究的目的是探讨日本接受PA治疗的心衰患者的临床特征。方法:选取我院收治的301例充血性心力衰竭患者。我们将患者分为接受PA治疗组(PA组,N = 51)和未接受PA治疗组(Non-WPA组,N = 250)。我们比较了两组患者入院时的临床特征和一年内心血管事件(心源性死亡、心衰再入院)的发生率。结果:与非PA组相比,PA组明显更年轻(71.1y±12.7比79.9y±12.4 P < 0.001),吸烟者更多(62.7%比35.6% P < 0.001)。PA组左室射血分数明显低于非PA组(34.6%±17.9∶43.0%±18.7 P = 0.04)。两组患者的死亡率无显著差异。PA组HF再入院率明显高于非PA组(33.3% vs. 18.2% P = 0.02)。结论:接受公共救助的心衰患者心功能差,心衰再入院发生率高。
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引用次数: 0
期刊
International Archives of Cardiovascular Diseases
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