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Strategies for testing the "irritation-signaling" model for chronic lung effects of fine acid particles. 细酸颗粒慢性肺效应“刺激信号”模型的测试策略。
IF 2.7 4区 环境科学与生态学 Pub Date : 1990-03-01 DOI: 10.1080/10473289.1990.10466689
D Hattis, S Abdollahzadeh, C A Franklin

The "irritation signaling" model proposed that a long term contribution to chronic bronchitis might result from the repeated delivery of "signals" resulting from temporary localized acidification of the bronchial epithelium by the action of individual particles. This led to a prediction that the effectiveness of particles in inducing changes in mucus secreting cell numbers/types should depend on the number of particles deposited that contained a particular amount of acid--implying that particles below a certain size cutoff (and therefore lacking a minimum amount of acid) should be ineffective; and that particle potency per unit weight should be greatest at the cutoff and decline strongly above the cutoff. Since the development of this hypothesis both epidemiological observations and some experimental studies have tended to reinforce the notion that acid particles can make a contribution to relatively long lasting bronchitic-like changes, and enhance the desirability of more direct testing of the model. In this paper we develop a general theoretical framework for the contributions of environmental agents to chronic obstructive lung disease, and a series of alternative hypotheses against which the predictions of the "irritant signaling" model can be compared. Based on this, we suggest a research program that could be used to further develop and test the model and reasonable alternatives.

“刺激信号”模型提出,慢性支气管炎的长期贡献可能是由于单个颗粒作用下支气管上皮暂时局部酸化引起的“信号”的反复传递。这导致了一种预测,即颗粒在诱导粘液分泌细胞数量/类型变化方面的有效性应取决于沉积的含有特定数量酸的颗粒的数量——这意味着低于一定大小临界值(因此缺乏最少量的酸)的颗粒应该是无效的;在截止点处,每单位重量的粒子效力最大,在截止点以上,粒子效力急剧下降。由于这一假设的发展,流行病学观察和一些实验研究都倾向于加强酸颗粒可以对相对持久的支气管炎样变化做出贡献的概念,并增强了对该模型进行更直接测试的必要性。在本文中,我们为环境因子对慢性阻塞性肺疾病的贡献建立了一个一般的理论框架,并提出了一系列替代假设,与“刺激信号”模型的预测相比较。在此基础上,我们提出了一个研究方案,可用于进一步开发和测试模型和合理的替代方案。
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引用次数: 8
Fugitive emissions of NO2 from vented gas appliances in residences--a pilot study. 住宅内燃气设备的逸散性二氧化氮排放——一项试点研究。
IF 2.7 4区 环境科学与生态学 Pub Date : 1990-03-01 DOI: 10.1080/10473289.1990.10466695
D J Moschandreas, S M Relwani, E H Luebcke
(1990). Fugitive Emissions of NO2 from Vented Gas Appliances in Residences—A Pilot Study. Journal of the Air & Waste Management Association: Vol. 40, No. 3, pp. 359-361.
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引用次数: 3
Passive sampling for ozone. 臭氧被动采样。
IF 2.7 4区 环境科学与生态学 Pub Date : 1990-03-01 DOI: 10.1080/10473289.1990.10466694
C Monn, M Hangartner
Description des possibilites d'utilisation et des limites d'un tube echantillonneur passif d'ozone pour controler la qualite de l'air ambiant. L'ozone absorbee reagit avec le di-(pyridyl-4)-1,2 ethylene pour donner un aldehyde detecte par spectrometrie UV. Evaluation en laboratoire et sur le terrain de l'appareil de mesure
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引用次数: 47
An examination of the intra-SMSA distribution of carbon monoxide exposure. 一氧化碳暴露的smsa内分布的检查。
IF 2.7 4区 环境科学与生态学 Pub Date : 1990-03-01 DOI: 10.1080/10473289.1990.10466690
M Schwab

Although fixed-site monitoring data have been used to estimate the spatial pattern of human exposure, the intra-urban distribution of actual exposure has not been documented. This paper used the data collected during the Environmental Protection Agency's (EPA) field investigation of personal exposure to carbon monoxide (CO) to investigate the nature of the distribution of CO with respect to residential location in the Washington, D.C. SMSA. Dot-distribution maps and analysis of variance were used to document the spatial pattern of individual-level in-home CO concentrations. The results show sampled individuals living in the SMSA center are exposed to statistically significantly higher levels of CO than are those living in the suburbs. The most important implications of this work are for exposure modeling. Further investigation is needed to determine whether incorporation of a geographic component will improve exposure prediction.

虽然已使用固定地点监测数据来估计人类接触的空间格局,但尚未记录实际接触的城市内分布情况。本文利用环境保护署(EPA)在个人一氧化碳暴露(CO)实地调查期间收集的数据,调查华盛顿特区SMSA住宅区CO分布的性质。使用点分布图和方差分析来记录个人水平家庭CO浓度的空间格局。结果显示,生活在SMSA中心的样本个体暴露于CO的水平在统计上显著高于生活在郊区的个体。这项工作最重要的意义是暴露建模。需要进一步调查以确定纳入地理因素是否会改善暴露预测。
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引用次数: 10
Impact of heating and air conditioning system operation and leakage on ventilation and intercompartment transport: studies in unoccupied and occupied Tennessee Valley homes. 供暖和空调系统的运行和泄漏对通风和车厢间运输的影响:在田纳西州山谷无人居住和有人居住的住宅中进行的研究。
IF 2.7 4区 环境科学与生态学 Pub Date : 1990-02-01 DOI: 10.1080/10473289.1990.10466676
T G Matthews, D L Wilson, C V Thompson, K P Monar, C S Dudney

Forced-air heating and air conditioning (HAC) systems caused an average and maximum increase in air infiltration rates of 1.8- and 4.3-fold, respectively, during brief whole-house studies of tracer gas decay in 39 occupied houses. An average increase in air infiltration rate of 0.33 +/- 0.37 h-1 corresponded to an incremental air leak of 240 m3/h, based on approximate house volume. More detailed tracer gas decay studies were performed in basement, kitchen and bedroom locations of six homes with low air infiltration rates (i.e., less than 0.25 h-1). The HAC mixed the indoor air efficiently between measurement sites. HAC operation also caused 1.1- to 3.6-fold increases in air infiltration rates, corresponding to absolute increases of 0.02 to 0.1 h-1. In an unoccupied research house, three-fold increases in average air infiltration rate with HAC operation (i.e., from 0.13 to 0.36 h-1) were reduced to two-fold (i.e., from 0.10 to 0.18 h-1) by sealing the external HAC unit and crawlspace ductwork system. This sealing also resulted in a 30 percent reduction in crawlspace-to-indoor transport rates with the HAC turned on. Blower door tests indicated a less than 20 percent reduction in house leakage area.

在对39所居住房屋的示踪气体衰变进行的简短全屋研究中,强制空气加热和空调(HAC)系统导致空气渗透率平均和最大分别增加1.8倍和4.3倍。平均增加0.33 +/- 0.37 h-1的空气入渗速率相当于增加240 m3/h的漏风量(基于近似房屋容积)。更详细的示踪气体衰变研究是在6个低空气渗透率(即小于0.25 h-1)的家庭的地下室、厨房和卧室进行的。HAC有效地混合了各测点之间的室内空气。HAC操作也使空气入渗速率增加1.1 ~ 3.6倍,对应于绝对增加0.02 ~ 0.1 h-1。在一个无人的研究室内,通过密封外部HAC装置和爬行空间管道系统,HAC运行时平均空气入渗率增加了三倍(即从0.13到0.36 h-1),减少到两倍(即从0.10到0.18 h-1)。在开启HAC的情况下,这种密封也使爬行空间到室内的运输速率降低了30%。鼓风机门测试表明,房屋泄漏面积减少了不到20%。
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引用次数: 4
Determination of organic contaminants in residential indoor air using an adsorption-thermal desorption technique. 用吸附-热解吸技术测定住宅室内空气中的有机污染物。
IF 2.7 4区 环境科学与生态学 Pub Date : 1990-01-01 DOI: 10.1080/10473289.1990.10466667
C C Chan, L Vainer, J W Martin, D T Williams
This field study evaluated the ability of a multi-sorbent sampling tube/thermal desorption technique to identify and to provide quantitative data on volatile organic contaminants in indoor air. Air samples, from 12 Canadian homes, were collected on multilayer sorbent cartridges and analyzed using Adsorption/Thermal Desorption coupled with Gas Chromatography/Mass Spectrometry. The study included the identification and quantitation of 23 target compounds. Analysis of sorbent tubes fortified with these target compounds indicated that recoveries were greater than 70 percent and the precision was usually better than 15 percent. These organic compounds were found to be stable on the sorbent tubes for at least seven days. With some exceptions, the target compounds were usually detected at 1 to 10 micrograms/m3 in indoor air samples; other organics identified qualitatively were saturated hydrocarbons, unsaturated hydrocarbons, cyclic hydrocarbons, substituted aromatics, oxygenates, some halogenates and cyclic species such as camphenes/pinenes and carenes.
本实地研究评估了多吸附剂样管/热解吸技术识别和提供室内空气中挥发性有机污染物定量数据的能力。来自12个加拿大家庭的空气样本被收集在多层吸附剂盒上,并使用吸附/热解吸结合气相色谱/质谱分析。该研究包括23个目标化合物的鉴定和定量。对这些目标化合物强化的吸附管的分析表明,回收率大于70%,精密度通常优于15%。这些有机化合物在吸附管上至少能保持7天的稳定。除一些例外情况外,目标化合物通常在室内空气样本中检测到1至10微克/立方米;定性鉴定的其他有机物包括饱和烃、不饱和烃、环烃、取代芳烃、含氧化合物、一些卤化物和环类物质,如莰烯/蒎烯和蒈烯。
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引用次数: 48
A comprehensive survey of graduate education and training in hazardous waste management. 对危险废物管理方面的研究生教育和培训进行全面调查。
IF 2.7 4区 环境科学与生态学 Pub Date : 1990-01-01 DOI: 10.1080/10473289.1990.10466662
R H Kummler, C A Witt, R W Powitz, B Stern

The United States Department of Health and Human Services through Wayne State University (WSU) has completed a study of hazardous waste education and training in the United States. The study documents university course work and degrees as well as non-degree continuing education short courses. Major portions of the study are based on a WSU sponsored survey in which 1469 four-year degree granting institutions were contacted. Of the 732 institutions responding, 113 were identified as offering course work of some kind in hazardous waste. Information on 499 distinct non-degree short courses was also gathered and evaluated. The purpose, methodology and results of the study are summarized in this article.

美国卫生和人类服务部通过韦恩州立大学完成了一项关于美国危险废物教育和培训的研究。该研究记录了大学课程和学位以及非学位继续教育短期课程。这项研究的主要部分是基于华盛顿州立大学赞助的一项调查,该调查联系了1469所四年制学位授予机构。在回应的732所院校中,有113所被确定提供某种形式的危险废物课程。还收集和评价了499种不同的非学位短期课程的资料。本文对研究的目的、方法和结果进行了总结。
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引用次数: 1
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Journal of the Air & Waste Management Association
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