Pub Date : 2024-08-06DOI: 10.1681/ASN.0000000000000461
Joyce van de Leemput, Zhe Han
{"title":"Drosophila Nephrocyte as a Model for Studying Glomerular Basement Membrane Physiology.","authors":"Joyce van de Leemput, Zhe Han","doi":"10.1681/ASN.0000000000000461","DOIUrl":"10.1681/ASN.0000000000000461","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-05DOI: 10.1681/ASN.0000000000000453
Le-Ting Zhou, Ahmed E Ali, Muthuvel Jayachandran, Zejfa Haskic, Peter C Harris, Andrew D Rule, Kevin Koo, Shannon K McDonnell, Nicholas B Larson, John C Lieske
{"title":"Association between Kidney Stones and CKD: A Bidirectional Mendelian Randomization Study.","authors":"Le-Ting Zhou, Ahmed E Ali, Muthuvel Jayachandran, Zejfa Haskic, Peter C Harris, Andrew D Rule, Kevin Koo, Shannon K McDonnell, Nicholas B Larson, John C Lieske","doi":"10.1681/ASN.0000000000000453","DOIUrl":"10.1681/ASN.0000000000000453","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-05DOI: 10.1681/ASN.0000000000000475
Roslyn B Mannon, Flavio G Vincenti
{"title":"Poised for Innovation: Considerations for End Points for New Drug Development in Kidney Transplantation.","authors":"Roslyn B Mannon, Flavio G Vincenti","doi":"10.1681/ASN.0000000000000475","DOIUrl":"10.1681/ASN.0000000000000475","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-05DOI: 10.1681/ASN.0000000000000473
Richard A Lafayette
{"title":"Stop Sitting on Our RAASes: Get Moving with the Most Effective Care for Our Patients.","authors":"Richard A Lafayette","doi":"10.1681/ASN.0000000000000473","DOIUrl":"10.1681/ASN.0000000000000473","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.1681/ASN.0000000000000445
Cal H Robinson, Nivethika Jeyakumar, Bin Luo, David Askenazi, Akash Deep, Amit X Garg, Stuart Goldstein, Jason H Greenberg, Cherry Mammen, Danielle M Nash, Rulan S Parekh, Samuel A Silver, Lehana Thabane, Ron Wald, Michael Zappitelli, Rahul Chanchlani
Background: Acute kidney injury (AKI) is common in hospitalized children. Pediatric AKI receiving acute kidney replacement therapy (KRT) is associated with long-term chronic kidney disease (CKD), hypertension, and death. We aim to determine the outcomes after AKI in children who did not receive acute KRT, since these remain uncertain.
Methods: Retrospective cohort study of all hospitalized children (0-18 years) surviving AKI without acute KRT between 1996-2020 in Ontario, Canada, identified by validated diagnostic codes in provincial administrative health databases. Children with prior KRT, CKD, or AKI were excluded. Cases were matched with up to four hospitalized comparators without AKI by age, neonatal status, sex, intensive care unit admission, cardiac surgery, malignancy, hypertension, hospitalization era, and a propensity score for AKI. Patients were followed until death, provincial emigration, or censoring in March 2021. The primary outcome was long-term major adverse kidney events (MAKE-LT; a composite of all-cause mortality, long-term KRT, or incident CKD).
Results: We matched 4,173 pediatric AKI survivors with 16,337 hospitalized comparators. Baseline covariates were well-balanced following propensity score matching. During median 9.7-year follow-up, 18% of AKI survivors developed MAKE-LT vs. 5% of hospitalized comparators (hazard ratio [HR] 4.0, 95% confidence interval [CI] 3.6-4.4). AKI survivors had higher rates of long-term KRT (2% vs. <1%; HR 11.7, 95%CI 7.5-18.4), incident CKD (16% vs. 2%; HR 7.9, 95%CI 6.9-9.1), incident hypertension (17% vs. 8%; HR 2.3, 95%CI 2.1-2.6), and AKI during subsequent hospitalization (6% vs. 2%; HR 3.7, 95%CI 3.1-4.5), but no difference in all-cause mortality (3% vs. 3%; HR 0.9, 95%CI 0.7-1.1).
Conclusions: Children surviving AKI without acute KRT were at higher long-term risk of CKD, long-term KRT, hypertension, and subsequent AKI vs. hospitalized comparators.
背景：急性肾损伤（AKI）在住院儿童中很常见。接受急性肾脏替代治疗（KRT）的小儿 AKI 与长期慢性肾脏疾病（CKD）、高血压和死亡有关。我们旨在确定未接受急性肾脏替代治疗的儿童在发生 AKI 后的预后，因为这些预后仍不确定：方法：对加拿大安大略省 1996-2020 年间所有未接受急性 KRT 的 AKI 住院患儿（0-18 岁）进行回顾性队列研究。曾接受过 KRT、CKD 或 AKI 的儿童不包括在内。根据年龄、新生儿状况、性别、入住重症监护室、心脏手术、恶性肿瘤、高血压、住院时间和 AKI 倾向评分，将病例与最多四名无 AKI 的住院对比者进行配对。对患者进行随访，直至死亡、移居他省或 2021 年 3 月剔除。主要结果是长期主要肾脏不良事件（MAKE-LT；全因死亡率、长期KRT或事件性CKD的复合结果）：我们将 4,173 名儿科 AKI 幸存者与 16,337 名住院对比者进行了配对。经过倾向评分匹配后，基线协变量非常均衡。在中位 9.7 年的随访期间，18% 的 AKI 幸存者与 5% 的住院对比者相比，患 MAKE-LT （危险比 [HR] 4.0，95% 置信区间 [CI] 3.6-4.4）。AKI 幸存者接受长期 KRT 的比例更高（2% vs. 5%）：与住院的比较者相比，未进行急性 KRT 的 AKI 幸存儿童患慢性肾脏病、长期 KRT、高血压和继发性 AKI 的长期风险更高。
{"title":"Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury.","authors":"Cal H Robinson, Nivethika Jeyakumar, Bin Luo, David Askenazi, Akash Deep, Amit X Garg, Stuart Goldstein, Jason H Greenberg, Cherry Mammen, Danielle M Nash, Rulan S Parekh, Samuel A Silver, Lehana Thabane, Ron Wald, Michael Zappitelli, Rahul Chanchlani","doi":"10.1681/ASN.0000000000000445","DOIUrl":"10.1681/ASN.0000000000000445","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) is common in hospitalized children. Pediatric AKI receiving acute kidney replacement therapy (KRT) is associated with long-term chronic kidney disease (CKD), hypertension, and death. We aim to determine the outcomes after AKI in children who did not receive acute KRT, since these remain uncertain.</p><p><strong>Methods: </strong>Retrospective cohort study of all hospitalized children (0-18 years) surviving AKI without acute KRT between 1996-2020 in Ontario, Canada, identified by validated diagnostic codes in provincial administrative health databases. Children with prior KRT, CKD, or AKI were excluded. Cases were matched with up to four hospitalized comparators without AKI by age, neonatal status, sex, intensive care unit admission, cardiac surgery, malignancy, hypertension, hospitalization era, and a propensity score for AKI. Patients were followed until death, provincial emigration, or censoring in March 2021. The primary outcome was long-term major adverse kidney events (MAKE-LT; a composite of all-cause mortality, long-term KRT, or incident CKD).</p><p><strong>Results: </strong>We matched 4,173 pediatric AKI survivors with 16,337 hospitalized comparators. Baseline covariates were well-balanced following propensity score matching. During median 9.7-year follow-up, 18% of AKI survivors developed MAKE-LT vs. 5% of hospitalized comparators (hazard ratio [HR] 4.0, 95% confidence interval [CI] 3.6-4.4). AKI survivors had higher rates of long-term KRT (2% vs. <1%; HR 11.7, 95%CI 7.5-18.4), incident CKD (16% vs. 2%; HR 7.9, 95%CI 6.9-9.1), incident hypertension (17% vs. 8%; HR 2.3, 95%CI 2.1-2.6), and AKI during subsequent hospitalization (6% vs. 2%; HR 3.7, 95%CI 3.1-4.5), but no difference in all-cause mortality (3% vs. 3%; HR 0.9, 95%CI 0.7-1.1).</p><p><strong>Conclusions: </strong>Children surviving AKI without acute KRT were at higher long-term risk of CKD, long-term KRT, hypertension, and subsequent AKI vs. hospitalized comparators.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-06DOI: 10.1681/ASN.0000000000000370
Teruhiko Yoshida, Khun Zaw Latt, Briana A Santo, Shashi Shrivastav, Yongmei Zhao, Paride Fenaroli, Joon-Yong Chung, Stephen M Hewitt, Vincent M Tutino, Pinaki Sarder, Avi Z Rosenberg, Cheryl A Winkler, Jeffrey B Kopp
{"title":"Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants.","authors":"Teruhiko Yoshida, Khun Zaw Latt, Briana A Santo, Shashi Shrivastav, Yongmei Zhao, Paride Fenaroli, Joon-Yong Chung, Stephen M Hewitt, Vincent M Tutino, Pinaki Sarder, Avi Z Rosenberg, Cheryl A Winkler, Jeffrey B Kopp","doi":"10.1681/ASN.0000000000000370","DOIUrl":"10.1681/ASN.0000000000000370","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Circulating Proteins and IgA Nephropathy: A Multiancestry Proteome-Wide Mendelian Randomization Study.","authors":"Chen Tang, Pei Chen, Lin-Lin Xu, Ji-Cheng Lv, Su-Fang Shi, Xu-Jie Zhou, Li-Jun Liu, Hong Zhang","doi":"10.1681/ASN.0000000000000379","DOIUrl":"10.1681/ASN.0000000000000379","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-04-26DOI: 10.1681/ASN.0000000000000361
Scott McAlister, Ben Talbot, John Knight, Susan Blair, Forbes McGain, Stephen McDonald, Craig Nelson, Richard Knight, Katherine A Barraclough
{"title":"The Carbon Footprint of Peritoneal Dialysis in Australia.","authors":"Scott McAlister, Ben Talbot, John Knight, Susan Blair, Forbes McGain, Stephen McDonald, Craig Nelson, Richard Knight, Katherine A Barraclough","doi":"10.1681/ASN.0000000000000361","DOIUrl":"10.1681/ASN.0000000000000361","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-04-30DOI: 10.1681/ASN.0000000000000362
Rui Xue, Wai Han Yiu, Kam Wa Chan, Sarah W Y Lok, Yixin Zou, Jingyuan Ma, Hongyu Li, Loretta Y Y Chan, Xiao Ru Huang, Kar Neng Lai, Hui Yao Lan, Sydney C W Tang
{"title":"Long Non-coding RNA NEAT1 , NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury.","authors":"Rui Xue, Wai Han Yiu, Kam Wa Chan, Sarah W Y Lok, Yixin Zou, Jingyuan Ma, Hongyu Li, Loretta Y Y Chan, Xiao Ru Huang, Kar Neng Lai, Hui Yao Lan, Sydney C W Tang","doi":"10.1681/ASN.0000000000000362","DOIUrl":"10.1681/ASN.0000000000000362","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-20DOI: 10.1681/ASN.0000000000000385
Kuo-Chin Hung, Chia-Ter Chao
{"title":"Pharmacokinetic Issue May Influence the Perceived Cardiac Risk Posed by Ondansetron in Patients Undergoing Chronic Hemodialysis.","authors":"Kuo-Chin Hung, Chia-Ter Chao","doi":"10.1681/ASN.0000000000000385","DOIUrl":"10.1681/ASN.0000000000000385","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号