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Endovascular Aneurysm Sealing (EVAS) in Combination with the Chimney Technique for the Treatment of Aortic Allograft Rupture 血管内动脉瘤封闭联合烟囱技术治疗同种异体主动脉瓣破裂
Pub Date : 2017-08-29 DOI: 10.4172/2329-6925.1000334
S. Rustum, B. Meyer, J. Hinrichs, T. Aper, A. Haverich, M. Wilhelmi
We report on a 62-year old male patient with complicated surgical history and actual covered ruptures of an aortic allograft. Considering the hostile abdomen we decided for an interventional/endovascular treatment. We implanted an aortic-(EVAS; Nellix®) as well as two renal stentgrafts in „chimney “technique. Following an uneventful perioperative course the patient was discharged on 14th postoperative day. This unusual case demonstrates that endovascular aneurysm sealing especially in combination with the chimney technique may be a feasible and reasonable alternative approach for the urgent/emergent treatment of aortic (prosthesis) associated complications where traditional surgical approaches are not applicable.
我们报告一个62岁男性患者复杂的手术史和实际覆盖的主动脉移植破裂。考虑到敌对腹部,我们决定进行介入/血管内治疗。我们植入了主动脉(EVAS);Nellix®)以及两个采用“烟囱”技术的肾支架移植。术后14天,患者顺利出院。这个不寻常的病例表明,在传统手术方法不适用的主动脉(假体)相关并发症的紧急治疗中,血管内动脉瘤密封特别是与烟囱技术的结合可能是一种可行和合理的替代方法。
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引用次数: 0
Successful Treatment of LVAD Patient with Infection-Induced Pseudoaneurysm using Endovascular Stent Graft 血管内支架成功治疗LVAD感染性假性动脉瘤
Pub Date : 2017-08-29 DOI: 10.4172/2329-6925.1000333
Rustum S, Schmitto J, Dogan G, Umminger J, Haverich A, Wilhelmi M
Peudoaneurysms are rare complications related to left ventricular assist device (LVAD) implantation and mostly occur at the left ventricular apex, as well as the anastomosis of the outflow graft to the ascending aorta. Beside anastomosis related complications and an erosion of the graft with a sternal wire they can occur due to an infection. Nevertheless pseudoaneurysms represent a major complication potentially leading to significant morbidity and mortality and in most cases necessitating open-surgical management. Here we report on a case of an infectioninduced pseudoaneurysm in close proximity to the LAVD’s outflow cannula which was treated successfully with an endovascular stentgraft.
假动脉瘤是与左心室辅助装置(left ventricular assist device, LVAD)植入相关的罕见并发症,多发生在左心室尖部及流出部移植物与升主动脉吻合处。除了吻合相关的并发症和胸骨丝对移植物的侵蚀外,它们还可能由于感染而发生。然而假性动脉瘤是一种主要的并发症,可能导致严重的发病率和死亡率,在大多数情况下需要开放手术治疗。在这里,我们报告一例感染引起的假性动脉瘤靠近LAVD的流出管,并成功地治疗血管内支架移植。
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引用次数: 0
Thrombectomy and Lung Resection for Massive Left Pulmonary Embolism in a 30 Years Old Man in Yaounde, Cameroon 喀麦隆雅温得一名30岁男子大面积左肺栓塞的血栓切除术和肺切除术
Pub Date : 2017-08-24 DOI: 10.4172/2329-6925.1000329
Ngo Nonga Bernadette, Ze Jj, D. Messomo, Handy De, A. Pondy, Mballa Jc
Pulmonary embolism is a well-recognized clinical entity with significant morbidity and mortality. It is called massive when it extends over more than half of the vascular bed. In the past, surgical treatment was the last therapeutic option but more and more surgical treatments are performed in several centers with few side effects and a lower mortality rate. Pulmonary embolectomy has never been attempted in Cameroon. We are reporting herein the first case of massive pulmonary embolism in a 30 years old man complicated by lung gangrene treated by thrombectomy and lung resection.
肺栓塞是一种公认的临床疾病,具有很高的发病率和死亡率。当它延伸到一半以上的维管床时被称为块状。在过去,手术治疗是最后的治疗选择,但越来越多的手术治疗是在几个中心进行的,副作用少,死亡率低。在喀麦隆从未尝试过肺栓塞切除术。我们在此报告第一例大面积肺栓塞,在一个30岁的男性合并肺坏疽治疗血栓切除术和肺切除术。
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引用次数: 1
Successful Management of Refractory Prosthetic Vessel Infection, Prosthetic Valve Endocarditis and Mediastinitis: Report of a Case-Late Timing Caused Repeated Surgery 难治性假体血管感染、假体瓣膜心内膜炎和纵隔炎的成功治疗:延迟手术导致重复手术1例报告
Pub Date : 2017-08-24 DOI: 10.4172/2329-6925.1000328
T. Ando, Daichi Akiyama, H. Okada, M. Takeda
The patient was diagnosed with anuloaortic ectasia with localized dissection in the right Valsalva sinus. He underwent aortic root replacement with mechanical valve. But, he was re-admitted for mediastinitis. Although his serum (CRP) level was normalized for one month, his body temperature suddenly rose to 40°C. An emergency operation was performed including re-sternotomy, drainage, and irrigation. However, a proximal anastomotic site ruptured and he went into shock. Following cardiopulmonary bypass, we performed a second aortic root replacement. Therefore, the patient was operated for sternum debridement and to wrap the prosthetic vessel into an omental pedicle. Nine days after the last intervention, bleeding from the chest wound suddenly appeared and he went into shock. He was transported to the operating room to initiate cardiopulmonary bypass. During circulatory arrest, laceration was detected at the same annular position. Deep into the left ventricle, we made interrupted sutures in the left cardiac muscle. Next, we implanted a Freestyle aortic root bioprosthesis using the full root technique. After removing all former implants, another prosthetic vessel was anastomosed between the Freestyle conduit and the distal aorta, and wrapped with omental pedicle. After three weeks, his serum CRP level was normal. He remained free of infection for at least three years.
患者被诊断为右主动脉瓣窦局部夹层的环形主动脉扩张。他接受了机械主动脉瓣置换术。但是,他因纵隔炎再次入院。虽然他的血清(CRP)水平正常一个月,但他的体温突然上升到40°C。紧急手术包括胸腔切开、引流和冲洗。然而,近端吻合口破裂,他休克了。体外循环后,我们进行了第二次主动脉根部置换术。因此,患者接受胸骨清创手术,并将假血管包入大网膜蒂。在最后一次干预后的第9天,胸部伤口突然出血,他休克了。他被送到手术室进行体外循环。在循环停止时,在同一环形位置发现撕裂伤。深入左心室,我们在左心肌上做了间断缝合。接下来,我们使用全根技术植入自由式主动脉根部生物假体。移除所有前植入物后,在自由式导管和远端主动脉之间吻合另一根假血管,并用大网膜蒂包裹。三周后,他的血清CRP水平正常。他至少有三年没有受到感染。
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引用次数: 1
The Effect of Continuous Positive Airway Pressure (CPAP) in Treatment of Patients with Refractory High Blood Pressure Associated with Severe Obstructive Sleep Apnea (OSA) 持续气道正压通气(CPAP)治疗难治性高血压合并严重阻塞性睡眠呼吸暂停(OSA)的疗效观察
Pub Date : 2017-08-16 DOI: 10.4172/2329-6925.1000327
Anh Vo-Thi-Kim, Bai Nguyen-Xuan, D. Dao-Van, S. Duong-Quy
Introduction: Obstructive sleep apnea is very common in patients with high blood pressure (HBP), especially in whom with refractory HBP (R-HBP). It has been suggested treatment with continuous positive airway pressure (CPAP) might ameliorate the blood pressure in these patients. This study was planned to evaluate the effect of CPAP for treatment of R-HBP patients with severe OSA. Methods: It was a cross-sectional and descriptive study. All patients with R-HBP associated with clinical symptoms of OSA were included in this study. They underwent polysomnography (PSG) for diagnosis severe OSA. The patients with severe OSA (apnea-hypopnea index (AHI) >30/hour) were treated with CPAP. They had been followed-up during 3 months. Result: There was 48 patients with R-HBP and symptoms of OSA had PSG. Thirty-nine patients had severe OSA (81.2%) and 32/39 (82.1%) accepted to treat with CPAP. The mean age was 54 ± 8 years (45-64 years) with male-female ratio was 1.6; mean BMI was 27.5 ± 4.6 kg/m2 (23.2-32.5 kg/m2); mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 160 ± 15 mmHg and 105 ± 10 mmHg, respectively. Epworth score was 16 ± 4 with AHI was 37 ± 5/hour. There were a significant reduction of SBP and DBP before and after 3 months treated with CPAP (P<0.01 and P<0.01; respectively). Epworth score was significant lower after 3 months with CPAP than at inclusion (P<0.01). Fasting glucose and total and LDL cholesterol were significantly reduced after treatment with CPAP (P<0.05 and P<0.05). Conclusion: The prevalence of severe OSA is high in patients with R-HBP having clinical symptoms of OSA. This high prevalence is usually associated with overweight, a high risk factor for R-HBP and OSA. The treatment with CPAP might help to control of blood pressure in patients with R-HBP associated with severe OSA.
梗阻性睡眠呼吸暂停在高血压(HBP)患者中非常常见,尤其是难治性HBP (R-HBP)患者。持续气道正压通气(CPAP)治疗可能会改善这些患者的血压。本研究旨在评估CPAP治疗R-HBP合并重度OSA患者的效果。方法:采用横断面描述性研究。所有与OSA临床症状相关的R-HBP患者均纳入本研究。他们接受了多导睡眠图(PSG)诊断严重的OSA。重度OSA患者(呼吸暂停低通气指数(AHI) bbb30 /h)采用CPAP治疗。随访3个月。结果:48例有OSA症状的R-HBP患者有PSG。重度OSA 39例(81.2%),接受CPAP治疗的32/39例(82.1%)。平均年龄54±8岁(45 ~ 64岁),男女比1.6;平均BMI为27.5±4.6 kg/m2 (23.2 ~ 32.5 kg/m2);平均收缩压(SBP)和舒张压(DBP)分别为160±15 mmHg和105±10 mmHg。Epworth评分为16±4,AHI为37±5/h。CPAP治疗3个月前后收缩压和舒张压均显著降低(P<0.01和P<0.01);分别)。CPAP治疗3个月后Epworth评分显著低于对照组(P<0.01)。CPAP治疗后空腹血糖、总胆固醇和低密度脂蛋白胆固醇均显著降低(P<0.05和P<0.05)。结论:在有OSA临床症状的R-HBP患者中,重度OSA的患病率较高。这种高患病率通常与超重有关,超重是R-HBP和OSA的高风险因素。CPAP治疗可能有助于控制伴有严重OSA的R-HBP患者的血压。
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引用次数: 1
Symptoms Improvement after Uterine Artery Embolization for Myomas Management 子宫动脉栓塞治疗肌瘤后症状改善
Pub Date : 2017-08-10 DOI: 10.4172/2329-6925.1000326
S. Belczak, D. Szejnfeld, Nathalia Almeida Cardoso da Silva, R. Klajner, L. Ogawa, Marcos Vinícius Maia da Mata
Background: Management of uterine myomas aims at improving symptoms that can be a problem and interfere in the patient’s quality of life. Less invasive approaches, such as uterine artery embolization (UAE), for selected patients is supposed to be a safer choice. Methods: Thirty-one women (mean age 38.5 ± 5.9) with symptomatic uterine myomas underwent UAE. All them scored 0 (mildest) to 10 (worst) for discomforting symptoms (abdominal pain (cramping) during and out of menstrual periods; bleeding during and out of menstrual periods; discomforting abdominal swelling; pain during sexual intercourse; general discomfort in diary activities and in social activities) before and 90 days after UAE. Results: Mean scores before and 90 days after UAE were significantly different for all symptoms, except for pain in sexual intercourse. Scores for bleeding out of menstrual periods increased after UAE, and decreased for all the other symptoms. Total scores before management (43.8 ± 25.4) decreased significantly (p<0.001) three months after UAE (16.1 ± 22.6). Conclusion: Clinical outcomes from UAE were very positive for this group of women, especially those presenting higher mean scores for abdominal pain and bleeding during menstrual periods.
背景:子宫肌瘤的治疗旨在改善可能成为问题并影响患者生活质量的症状。侵入性较小的方法,如子宫动脉栓塞(UAE),被认为是一个更安全的选择。方法:31例有症状的子宫肌瘤患者(平均年龄38.5±5.9岁)行子宫内膜切除术。他们在月经期间和月经后的不适症状(腹痛(痉挛))都得到了0(最轻微)到10(最严重)的评分;经期出血:经期中和经期外出血;令人不适的腹部肿胀;性交时的疼痛;一般不适的日记活动和社交活动),在阿联酋之前和之后90天。结果:除性交疼痛外,UAE前和术后90天所有症状的平均评分均有显著差异。经期出血的评分在UAE后增加,而其他所有症状的评分则下降。治疗前总分(43.8±25.4)显著低于治疗前总分(16.1±22.6)(p<0.001)。结论:UAE的临床结果对这组妇女非常积极,特别是那些在月经期间腹痛和出血的平均得分较高的妇女。
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引用次数: 2
Comparison of Long Term Oxygen-Therapy (LTOT) and LTOT Combined with Sildenafil and Simvastatin in the Treatment of Severe Chronic Obstructive Pulmonary (COPD) with Hypoxia at Rest and Severe Pulmonary Arterial Hypertension 长期氧疗(LTOT)与LTOT联合西地那非、辛伐他汀治疗重度慢性阻塞性肺(COPD)静息缺氧及重度肺动脉高压的疗效比较
Pub Date : 2017-07-20 DOI: 10.4172/2329-6925.1000324
H. Tran-Van, Anh Vo-Thi-Kim, T. Tran-Ngoc, S. Duong-Quy
Background: Pulmonary arterial hypertension is frequent in patients with severe chronic obstructive pulmonary disease (COPD). It increases the morbidity and mortality of patients with advanced stage of COPD. The use of long-term oxygen therapy (LTOT) and some other vasodilators seems necessary to prevent pulmonary arterial hypertension (PAH) and right heart failure in these patients. Objective: This study was planned to compare the effect of LTOT alone and LTOT combined with sildenafil (PDE-5 inhibitor) and simvastatin (HMG CoA reductase inhibitor) on pulmonary arterial pressure of patients with severe COPD having hypoxia at rest. Methods: It was a cross-sectional and comparative study. All patients with severe COPD having hypoxia at rest (SpO2<88%) had been classified in three groups: Group 1 (treated with LTOT), Group 2 (treated with LTOT+sildenafil), and Group 3 (treated with LTOT+sildenafil+simvastatin). All study patients had been treated with conventional therapy (long-acting beta2-agonists+inhaled corticosteroids+long-acting muscarinic antagonists) and followed up during 6 months with one visit every three months. The mean systolic pulmonary arterial pressures (PAP) had been measured by transthoracic echocardiography (TTE). Results: Ninety-eight patients with severe COPD and hypoxia at rest were included in this study (Group 1:32 patients, Group 2:35 patients, and Group 3:31 patients). The systolic PAPs and diffusing capacity of the lungs for carbon monoxide (DLCO) were significantly ameliorated after 3 to 6 months. The mean systolic PAP in patients from Group 2 and Group 3 were significantly lower than that in Group 1 at 3 months (41 ± 9 mmHg and 39 ± 7 mmHg vs. 46 ± 10 mmHg; P<0.05 and P<0.05; respectively). After 6 months, oxygen consumption (VO2 max) and 6 minutes walking distances were significantly increased in patients from Group 2 and Group 3 (P<0.05 and P<0.05; respectively). Conclusion: LTOT is an efficacy treatment for severe COPD patients with hypoxia at rest and PAH. Sildenafil and simvastatin have some additional effect on the reduction of PAP and physical exercise capacity.
背景:肺动脉高压常见于重度慢性阻塞性肺疾病(COPD)患者。它增加了晚期COPD患者的发病率和死亡率。使用长期氧疗(LTOT)和一些其他血管扩张剂似乎是必要的,以防止肺动脉高压(PAH)和右心衰在这些患者。目的:本研究拟比较LTOT单用与LTOT联合西地那非(PDE-5抑制剂)、辛伐他汀(HMG CoA还原酶抑制剂)对重度COPD静息缺氧患者肺动脉压的影响。方法:采用横断面对比研究。将所有静息缺氧(SpO2<88%)的重度COPD患者分为三组:1组(LTOT治疗)、2组(LTOT+西地那非治疗)、3组(LTOT+西地那非+辛伐他汀治疗)。所有患者均接受常规治疗(长效β -受体激动剂+吸入皮质类固醇+长效毒蕈碱拮抗剂),随访6个月,每3个月随访一次。经胸超声心动图(TTE)测量平均收缩期肺动脉压(PAP)。结果:本研究共纳入98例重度COPD伴静息缺氧患者(1:32组、2:35组、3:31组)。3 ~ 6个月后,收缩期pap和肺一氧化碳弥散能力(DLCO)明显改善。3个月时,组2和组3患者的平均收缩期PAP显著低于组1(41±9 mmHg和39±7 mmHg vs. 46±10 mmHg);P<0.05, P<0.05;分别)。6个月后,2组和3组患者的耗氧量(VO2 max)和6分钟步行距离均显著增加(P<0.05和P<0.05;分别)。结论:LTOT治疗重度COPD静息缺氧合并肺动脉高压疗效确切。西地那非和辛伐他汀对降低PAP和身体运动能力有一些额外的作用。
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引用次数: 1
Duplex Guided Foam Sclerotherapy Versus Surgery in Management of Primary Varicose Veins 双重引导泡沫硬化疗法与手术治疗原发性静脉曲张
Pub Date : 2017-07-20 DOI: 10.4172/2329-6925.1000325
W. M. Gamal, Elammary Mk, A. Mohamed
Background: Varicose veins is a major problem among adult population. It has a major effect on life quality as well as healthcare system resources, we aim in this study to compare ultrasound guided foam sclerotherapy (UGFS) with surgery in management of primary varicose veins patients and to measure patients’ satisfaction with either modalities. Methods: 100 lower limbs of 100 patients with great saphenous vein (GSV) incompetence were prospectively randomized to undergo either surgical treatment or foam sclerotherapy. Clinical, etiological, anatomical and pathophysiological (CEAP) Classification and the Venous Clinical Severity Score (VCSS) were completed and investigated with a follow-up period of 1 year. Results: Total occlusion of great saphenous vein (GSV) was 88% in foam group as well as in the surgery group, recurrence rate in the foam group was 6% as well as in surgery group. Patient satisfaction at 1 year was 94% in foam group while in surgery group it was 90%. There were no statistical significant differences in follow up regarding VCSS, recurrence, patient satisfaction between both groups at 1 month, 6 months and 1 year (p value>0.001). Conclusion: Surgical treatment and UGFS achieved elevated rates of total occlusion of GSV incompetence with no significant difference. Both treatments led to significant improvements in VCSS, demonstrating improvements in clinical outcomes. UGFS is a valid noninvasive modality in management of great saphenous vein incompetence and is comparable to surgery.
背景:静脉曲张是成年人的主要疾病。超声引导泡沫硬化疗法(UGFS)与外科手术治疗原发性静脉曲张患者的效果比较,并衡量患者对两种治疗方式的满意度。方法:对100例大隐静脉(GSV)功能不全患者的100例下肢进行前瞻性随机分组,分别进行手术治疗和泡沫硬化治疗。随访1年,完成临床、病因、解剖和病理生理(CEAP)分型和静脉临床严重程度评分(VCSS)。结果:泡沫组和手术组大隐静脉完全闭塞率分别为88%和6%,泡沫组和手术组的复发率分别为6%和6%。泡沫组患者1年满意度为94%,手术组患者1年满意度为90%。两组患者随访1个月、6个月、1年VCSS、复发率、患者满意度差异均无统计学意义(p值>0.001)。结论:手术治疗和UGFS均能提高GSV功能不全的全闭塞率,差异无统计学意义。两种治疗方法均能显著改善VCSS,表明临床结果有所改善。UGFS是一种有效的无创治疗大隐静脉功能不全的方法,可与手术相媲美。
{"title":"Duplex Guided Foam Sclerotherapy Versus Surgery in Management of Primary Varicose Veins","authors":"W. M. Gamal, Elammary Mk, A. Mohamed","doi":"10.4172/2329-6925.1000325","DOIUrl":"https://doi.org/10.4172/2329-6925.1000325","url":null,"abstract":"Background: Varicose veins is a major problem among adult population. It has a major effect on life quality as well as healthcare system resources, we aim in this study to compare ultrasound guided foam sclerotherapy (UGFS) with surgery in management of primary varicose veins patients and to measure patients’ satisfaction with either modalities. \u0000Methods: 100 lower limbs of 100 patients with great saphenous vein (GSV) incompetence were prospectively randomized to undergo either surgical treatment or foam sclerotherapy. Clinical, etiological, anatomical and pathophysiological (CEAP) Classification and the Venous Clinical Severity Score (VCSS) were completed and investigated with a follow-up period of 1 year. \u0000Results: Total occlusion of great saphenous vein (GSV) was 88% in foam group as well as in the surgery group, recurrence rate in the foam group was 6% as well as in surgery group. Patient satisfaction at 1 year was 94% in foam group while in surgery group it was 90%. There were no statistical significant differences in follow up regarding VCSS, recurrence, patient satisfaction between both groups at 1 month, 6 months and 1 year (p value>0.001). \u0000Conclusion: Surgical treatment and UGFS achieved elevated rates of total occlusion of GSV incompetence with no significant difference. Both treatments led to significant improvements in VCSS, demonstrating improvements in clinical outcomes. UGFS is a valid noninvasive modality in management of great saphenous vein incompetence and is comparable to surgery.","PeriodicalId":17397,"journal":{"name":"Journal of Vascular Medicine & Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83124438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Multicenter Evaluation of Chronic Ulcer Recurrence with the Use of Varying Mechanical Wound Healing Modalities 不同机械伤口愈合方式对慢性溃疡复发的多中心评价
Pub Date : 2017-06-29 DOI: 10.4172/2329-6925.1000323
J. Rosenblum, Gazes Mi, S. Rosenblum, A. Karpf, N. Greenberg
Chronic wound care is a growing medical problem, reaching epidemic proportions worldwide. Even after the wound has healed, wound recurrence remains a significant issue, with rates approximating 40% in 6 months after healing. The authors evaluate a retrospective analysis of their wound care clinics healing and recurrence rates. The authors evaluate the efficacy of varying physical modalities on preventing recurrence of wounds after their healing. The authors take their evaluation out to one year.
慢性伤口护理是一个日益严重的医疗问题,在世界范围内达到流行病的程度。即使在伤口愈合后,伤口复发率仍然是一个重要问题,在愈合后6个月内复发率约为40%。作者评估了他们的伤口护理诊所愈合和复发率的回顾性分析。作者评估了不同的物理方式对预防伤口愈合后复发的功效。作者将他们的评估延长到一年。
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引用次数: 2
Effectiveness of Remote Ischaemic Conditioning in Critical Ischemia of the Digitals of Upper and Lower Limbs 远端缺血调理治疗下肢和上肢严重缺血的疗效
Pub Date : 2017-06-29 DOI: 10.4172/2329-6925.1000321
N. Schahab, A. Aksoy, Schamim Schahab, M. Steinmetz, Christian Berg, C. Schaefer, G. Nickenig, V. Tiyerili
`Aim: The aim of our study was to determine the effectiveness and safety of remote ischaemic conditioning (RIC) in combination with i.v. prostavasin as a method of treatment for patients with peripheral acral vasculopathy, presenting as critical ischemia of the digitals of upper and lower limbs at the time of presentation with either surgical nor interventional treatment option Method: 33 patients were included in this non-randomized, prospective pilot-study with compassionate use. Primary endpoints were healing of ulcerations and amputation free time, secondary endpoint was safety of RIC. For the RIC, a blood flow reduction in the extremities was held in 2 cycles for over 5 minutes (20 mmHg over the systolic blood pressure) with 5 minutes reperfusion. During this time the medical agents were infused through a superficial vein into index extremity transvenously. The medication included: 2500 i.e., Heparin bolus, 5 μg PGE-1 in a 50 mL syringe with an isotonic solution. In cases where a vascular occlusion was seen in angiography additionally to PGE-1, 20 mg rt-PA was infused. Results: In 33 cases, transcutaneous oxygen partial pressure (TcPO2) levels increased significantly from 33 ± 16 mmHg to 48 ± 13 mmHg (p=0.0005) after the therapy compared to baseline. In 33 cases there was an improvement from 55 ± 27 mmHg to 73 ± 27 mmHg (p ≤ 0.004) in the acral arterial pressure measurement. 31 patients showed significantly better perfusion and vascularisation of the ischemic extremity after the therapy demonstrated in acral oscillography (31/94%) and angiography (6/18%). In 16 cases ulcerations (n=20) healed after 15 sessions of RIC. There was no need of any major or minor amputation in all patients. Conclusion: The presented RIC therapy proved to be an effective and safe treatment in addition to best medical treatment for patients with acute acral vascular disorder, especially in acute digital ischaemia, without a surgical or an interventional option.
目的:我们研究的目的是确定远程缺血调节(RIC)联合前列他伐辛静脉注射作为一种治疗外周肢端血管病变患者的有效性和安全性,这些患者在手术或介入治疗时表现为上肢和下肢手指严重缺血。方法:33名患者被纳入这项非随机的前瞻性试点研究。主要终点是溃疡愈合和截肢空闲时间,次要终点是RIC的安全性。对于RIC,在2个周期内保持四肢血流减少超过5分钟(比收缩压高20 mmHg),再灌注5分钟。在此期间,药物通过浅表静脉经静脉注入食指。药物包括:2500即肝素丸,5 μg PGE-1, 50ml注射器加等渗溶液。在血管造影中除PGE-1外还发现血管闭塞的病例中,输注20 mg rt-PA。结果:33例患者治疗后经皮氧分压(TcPO2)水平从33±16 mmHg显著升高至48±13 mmHg (p=0.0005)。33例患者的肢端动脉压由55±27 mmHg改善至73±27 mmHg (p≤0.004)。经肢端示波(31/94%)和血管造影(6/18%)检查,31例患者缺血肢体灌注和血管化明显改善。16例溃疡(n=20)在15次RIC治疗后愈合。所有患者均无需进行或大或小的截肢。结论:对于急性肢端血管紊乱患者,特别是急性指端缺血患者,在没有手术或介入选择的情况下,RIC治疗被证明是一种有效和安全的治疗方法,也是最佳的药物治疗方法。
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引用次数: 0
期刊
Journal of Vascular Medicine & Surgery
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