According to a quite diffuse opinion, also amplified by the media, the serologic test has a limited diagnostic value and is of no use as an indication to the booster dose of a COVID-19 vaccine. In addition, this point of view was strengthened by a hasting criticism, which appeared in television, social networks and newspapers and was based on a personal interpretation of a paper published in NEJM Oct 2021. The current article shows how the NEJM paper asserts just the opposite thesis, supporting the serologic test instead. Details are here provided, especially about the effective antibody/infectivity correlation and the possible threshold value between diseased and healthy people. The conclusion is that the NEJM paper strongly supports the serologic test, while the quick criticism derived from a biased lecture, in search of the confirmation of a preconception.
{"title":"By devaluing the serological test we throw the baby out with the dirty water","authors":"F. Passariello","doi":"10.24019/jtavr.124","DOIUrl":"https://doi.org/10.24019/jtavr.124","url":null,"abstract":"According to a quite diffuse opinion, also amplified by the media, the serologic test has a limited diagnostic value and is of no use as an indication to the booster dose of a COVID-19 vaccine. In addition, this point of view was strengthened by a hasting criticism, which appeared in television, social networks and newspapers and was based on a personal interpretation of a paper published in NEJM Oct 2021. The current article shows how the NEJM paper asserts just the opposite thesis, supporting the serologic test instead. Details are here provided, especially about the effective antibody/infectivity correlation and the possible threshold value between diseased and healthy people. The conclusion is that the NEJM paper strongly supports the serologic test, while the quick criticism derived from a biased lecture, in search of the confirmation of a preconception.","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77540869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In memory of Prof Oldrich Eliska","authors":"A. Macciò","doi":"10.24019/jtavr.122","DOIUrl":"https://doi.org/10.24019/jtavr.122","url":null,"abstract":"","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83650670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Frullini, P. Giannetta, Demetrio Guarnaccia, O. W. Loparco, Edy Pablo Lucca, D. Mancini, Claudio Ravagli, Michele Rendace, Sabino Paradiso, Gianluigi Rosi, P. Pavei, P. Albano, P. Casoni, A. Cavallini, Alfonso Cristiani, Camillo D'Ascanio, M. Forzanini, D. Fruttini, Gaspare Andrea Gerardi
Objective To study the incidence and the possibility of preventing thrombotic complications during major sclerotherapy for venous insufficiency of lower limbs. Methods A total of 2489 sclerotherapy sessions were performed on 2010 patients. 1087 sessions (43.7%) were carried out without heparin prophylaxis while in 1402 sessions (56.3%) a prophylaxis with low molecular weight (LMWH) was used. Thrombotic complications were divided into a) post sclerotherapy transient extension (POSTE) if they consisted of a simple extension of sclerotherapy, and b) deep venous thrombosis (DVT) when the complication occurred in a location separate from that of sclerosis. Results The overall incidence of a thrombotic complication was 0.52%. Out of 2489 sessions, 8 cases of POSTE (0.32%) and 5 thromboses of a gastrocnemius vein (0.2%) were diagnosed The most significant figures were reached in the great saphenous vein (GSV) subgroup, where the incidence of complications was 1.91% without prophylaxis and 0.31% (p = 0.009) with prophylactic heparin. Conclusions In this study prophylaxis with LMWH significantly reduced the incidence of thrombotic complications when sclerotherapy of the great saphenous vein was performed.
{"title":"Heparin prophylaxis in major sclerotherapy (the Prosclep study)","authors":"A. Frullini, P. Giannetta, Demetrio Guarnaccia, O. W. Loparco, Edy Pablo Lucca, D. Mancini, Claudio Ravagli, Michele Rendace, Sabino Paradiso, Gianluigi Rosi, P. Pavei, P. Albano, P. Casoni, A. Cavallini, Alfonso Cristiani, Camillo D'Ascanio, M. Forzanini, D. Fruttini, Gaspare Andrea Gerardi","doi":"10.24019/jtavr.120","DOIUrl":"https://doi.org/10.24019/jtavr.120","url":null,"abstract":"Objective To study the incidence and the possibility of preventing thrombotic complications during major sclerotherapy for venous insufficiency of lower limbs. Methods A total of 2489 sclerotherapy sessions were performed on 2010 patients. 1087 sessions (43.7%) were carried out without heparin prophylaxis while in 1402 sessions (56.3%) a prophylaxis with low molecular weight (LMWH) was used. Thrombotic complications were divided into a) post sclerotherapy transient extension (POSTE) if they consisted of a simple extension of sclerotherapy, and b) deep venous thrombosis (DVT) when the complication occurred in a location separate from that of sclerosis. Results The overall incidence of a thrombotic complication was 0.52%. Out of 2489 sessions, 8 cases of POSTE (0.32%) and 5 thromboses of a gastrocnemius vein (0.2%) were diagnosed The most significant figures were reached in the great saphenous vein (GSV) subgroup, where the incidence of complications was 1.91% without prophylaxis and 0.31% (p = 0.009) with prophylactic heparin. Conclusions In this study prophylaxis with LMWH significantly reduced the incidence of thrombotic complications when sclerotherapy of the great saphenous vein was performed.","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81847250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The paper illustrates a proposal to make green certification protection against the SARS-COV2 virus more efficient and cheaper and make it easier the access to working places. Furthermore, the paper offers critical reflections on the goal of reaching the vaccination level for herd immunity, which is ineffective if the immune status of neighboring countries is not taken into account.
{"title":"Proposal to amend the requirements for green certification","authors":"F. Passariello","doi":"10.24019/jtavr.123","DOIUrl":"https://doi.org/10.24019/jtavr.123","url":null,"abstract":"The paper illustrates a proposal to make green certification protection against the SARS-COV2 virus more efficient and cheaper and make it easier the access to working places. Furthermore, the paper offers critical reflections on the goal of reaching the vaccination level for herd immunity, which is ineffective if the immune status of neighboring countries is not taken into account.","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85120329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"My memory on Professor Krylov","authors":"B. Lee","doi":"10.24019/jtavr.121","DOIUrl":"https://doi.org/10.24019/jtavr.121","url":null,"abstract":"","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74257921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When everything is clear, something new appears: a constant rule in Phlebology","authors":"S. Ricci","doi":"10.24019/jtavr.116","DOIUrl":"https://doi.org/10.24019/jtavr.116","url":null,"abstract":"","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90339459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The author provides a very short history of the learning of medical and surgical knowledge, stressing the importance of studies on man undertaken by the Egyptians, of the Viennese school at the end of the 1800s, and looking at how things are today. The role of anatomical pathology is emphasised along with its importance in the contemporary age thanks to microsurgery, degenerative diseases of the CNS, the Corona Virus pandemic etc. The Project for Body Donation, recently approved by the Italian parliament, is also illustrated.
{"title":"Post mortem body donation and notes on the history of dissection","authors":"Bruno Fedi","doi":"10.24019/jtavr.90","DOIUrl":"https://doi.org/10.24019/jtavr.90","url":null,"abstract":"The author provides a very short history of the learning of medical and surgical knowledge, stressing the importance of studies on man undertaken by the Egyptians, of the Viennese school at the end of the 1800s, and looking at how things are today. The role of anatomical pathology is emphasised along with its importance in the contemporary age thanks to microsurgery, degenerative diseases of the CNS, the Corona Virus pandemic etc. The Project for Body Donation, recently approved by the Italian parliament, is also illustrated.","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73405140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Understanding the nominal venous anatomy and venous hemodynamics is the first and fundamental step in understanding the pathophysiology of venous disorders. Over the last two decades, significant effort has gone into improving the management of chronic venous disorders resulting in substantial improvement in the management of patients affected by venous insufficiency. Given the continuity of the venous system especially pertinent to the relationship between thoracic, abdominal, pelvic, and infrainguinal venous anatomy, combined with the increasing knowledge we gained regarding hemodynamics of the venous system it is imperative that a comprehensive approach to venous disorders is undertaken that evaluates venous system as a continuum rather than an approach that would evaluate only isolated venous territory affected by a specific venous disorder. Understanding of venous anatomy and physiology, as the basic components for venous hemodynamics, is an essential step to gain insights into venous return concepts, initially described by Dr. Guyton. Dr. Guyton's model represents a fundamental and one of the most significant advancements in our understanding of venous return. This manuscript details essential domains of hemodynamics, which can be useful for validation of our current understanding of systemic venous return.
{"title":"Fundamental physiologic concepts of venous hemodynamics and systemic venous return","authors":"J. Markovic","doi":"10.24019/jtavr.117","DOIUrl":"https://doi.org/10.24019/jtavr.117","url":null,"abstract":"Understanding the nominal venous anatomy and venous hemodynamics is the first and fundamental step in understanding the pathophysiology of venous disorders. Over the last two decades, significant effort has gone into improving the management of chronic venous disorders resulting in substantial improvement in the management of patients affected by venous insufficiency. Given the continuity of the venous system especially pertinent to the relationship between thoracic, abdominal, pelvic, and infrainguinal venous anatomy, combined with the increasing knowledge we gained regarding hemodynamics of the venous system it is imperative that a comprehensive approach to venous disorders is undertaken that evaluates venous system as a continuum rather than an approach that would evaluate only isolated venous territory affected by a specific venous disorder. Understanding of venous anatomy and physiology, as the basic components for venous hemodynamics, is an essential step to gain insights into venous return concepts, initially described by Dr. Guyton. Dr. Guyton's model represents a fundamental and one of the most significant advancements in our understanding of venous return. This manuscript details essential domains of hemodynamics, which can be useful for validation of our current understanding of systemic venous return.","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"437 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77511960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Answers to the invited commentaries on 'The hemodynamic impact of the bidirectional flow within calf perforators and conductive veins in varicose vein disease', by C Recek","authors":"C. Recek","doi":"10.24019/jtavr.104","DOIUrl":"https://doi.org/10.24019/jtavr.104","url":null,"abstract":"","PeriodicalId":17406,"journal":{"name":"Journal of Theoretical and Applied Vascular Research","volume":"12 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75530890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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