Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.2023.02.004
Dai Linfeng, Zhuang Yan, Lü Hai, Chen Mingqi, Wang Xing
Objective: To evaluate the efficacy and safety of Suhuang Zhike capsule in the adjuvant treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods: The database including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Chinese Biomedical Literature Database and Wanfang Data was searched. The retrieval time was from database establishment to May 2021. Randomized controlled trial (RCT) of Suhuang zhike capsule adjuvant treatment for AECOPD was included. The quality of the studies was independently evaluated and cross-checked by two reviewers, and Meta-analysis was performed by using RevMan5.3 software.
Results: Thirteen RCT results were included with a total sample number of 1195 cases, including 597 in the experimental group and 598 in the control group. The results showed that Suhuang zhike capsule adjuvant treatment of AECOPD could improve the total clinical effect rate compared with conventional treatment. Suhuang zhike capsule adjuvant treatment could improve forced vital capacity (FVC), forced expiratory volume in one second (FEV), FEV/FVC, peak expiratory flow (PEF) and other pulmonary function indexes; decrease C-reactive protein (CRP), white blood cells, neutrophils and other infectious indicators; besides, the 1-year recurrence rate of the disease was decreased (all 0.05).
Conclusions: Suhuang Zhike capsule can improve the lung function and clinical efficacy of AECOPD, thus increasing the exercise endurance, and reducing the infection and recurrence rate in AECOPD patients.
{"title":"Effectiveness and safety of Suhuang Zhike capsule as adjuvant treatment for acute exacerbation of chronic obstructive pulmonary disease: a systematic review and Meta-analysis.","authors":"Dai Linfeng, Zhuang Yan, Lü Hai, Chen Mingqi, Wang Xing","doi":"10.19852/j.cnki.jtcm.2023.02.004","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2023.02.004","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of Suhuang Zhike capsule in the adjuvant treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).</p><p><strong>Methods: </strong>The database including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Chinese Biomedical Literature Database and Wanfang Data was searched. The retrieval time was from database establishment to May 2021. Randomized controlled trial (RCT) of Suhuang zhike capsule adjuvant treatment for AECOPD was included. The quality of the studies was independently evaluated and cross-checked by two reviewers, and Meta-analysis was performed by using RevMan5.3 software.</p><p><strong>Results: </strong>Thirteen RCT results were included with a total sample number of 1195 cases, including 597 in the experimental group and 598 in the control group. The results showed that Suhuang zhike capsule adjuvant treatment of AECOPD could improve the total clinical effect rate compared with conventional treatment. Suhuang zhike capsule adjuvant treatment could improve forced vital capacity (FVC), forced expiratory volume in one second (FEV), FEV/FVC, peak expiratory flow (PEF) and other pulmonary function indexes; decrease C-reactive protein (CRP), white blood cells, neutrophils and other infectious indicators; besides, the 1-year recurrence rate of the disease was decreased (all 0.05).</p><p><strong>Conclusions: </strong>Suhuang Zhike capsule can improve the lung function and clinical efficacy of AECOPD, thus increasing the exercise endurance, and reducing the infection and recurrence rate in AECOPD patients.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012210/pdf/JTCM-43-2-231.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.2023.02.005
Yang Cunqing, Lian Fengmei, Yang Guiping, Huang Yufeng, Zhang Shuangbin, Wang Jianghua, Zhou Jing, Guo Dongqing, Shen Chuanyun, Y E Tiansong, F U Aojie, L I Xiaoli, Chen Le, Zhang Huifeng, T U Qiyin, Wang Ying, Yang Wenzhe, Tong Xiaolin, B A Yuanming
Objective: To study the efficacy of Xiaoyao capsule in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019 (COVID-19).
Methods: The study cohort comprised 200 patients with sleep and mood disorders during recovery from COVID-19. Patients were randomized into the control group and the experimental group in a 1:1 ratio by blocked randomization. The patients received either Xiaoyao capsule (experimental group) or a placebo Xiaoyao capsule (control group) for 2 weeks. The improvements in the Traditional Chinese Medicine (TCM) syndrome scales, total effective rates, and disappearance rates of irritability, anxiety, and poor sleep were compared between the two groups.
Results: The TCM syndrome pattern scales, total effective rates, and disappearance rates of irritability, anxiety, and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment ( > 0.05).
Conclusions: Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19.
{"title":"Effectiveness of Xiaoyao capsule on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019: a randomized controlled trial.","authors":"Yang Cunqing, Lian Fengmei, Yang Guiping, Huang Yufeng, Zhang Shuangbin, Wang Jianghua, Zhou Jing, Guo Dongqing, Shen Chuanyun, Y E Tiansong, F U Aojie, L I Xiaoli, Chen Le, Zhang Huifeng, T U Qiyin, Wang Ying, Yang Wenzhe, Tong Xiaolin, B A Yuanming","doi":"10.19852/j.cnki.jtcm.2023.02.005","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2023.02.005","url":null,"abstract":"<p><strong>Objective: </strong>To study the efficacy of Xiaoyao capsule in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>The study cohort comprised 200 patients with sleep and mood disorders during recovery from COVID-19. Patients were randomized into the control group and the experimental group in a 1:1 ratio by blocked randomization. The patients received either Xiaoyao capsule (experimental group) or a placebo Xiaoyao capsule (control group) for 2 weeks. The improvements in the Traditional Chinese Medicine (TCM) syndrome scales, total effective rates, and disappearance rates of irritability, anxiety, and poor sleep were compared between the two groups.</p><p><strong>Results: </strong>The TCM syndrome pattern scales, total effective rates, and disappearance rates of irritability, anxiety, and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment ( > 0.05).</p><p><strong>Conclusions: </strong>Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012199/pdf/JTCM-43-2-343.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.20221108.002
Xie Le, Mao Guo, Xie Yao, Cao Sijia, Zhou Shen, Jiang Junlin, Yao Ting, Fan Jianhu, Liu Dong, Kang Fuliang, W U Dahua, G E Jinwen
Objective: To evaluate the efficacy of Baishao Luoshi decoction (, BD) on synaptic plasticity in rats with post stroke spasticity (PSS), and to study the mechanism behind the action.
Methods: The PSS model of rat was established by middle cerebral artery occlusion (MCAO). The neurological deficit symptoms were evaluated by modified neurological deficit score (mNSS). Muscle tension were evaluated by Modified Ashworth score (MAS). Transmission electron microscopy (TEM) was used to observe the synaptic ultrastructure. The expression of synaptic plasticity-related protein brain derived neurotrophic factor (BDNF), growth associated protein-43 (GAP43), synaptophysin (p38) and microtubule-associated protein 2 (MAP2) in the brain tissue around the infarct were detected by Western blotting.
Results: We found that mNSS were significantly improved and limb spasticity was ameliorated treated by BD. The thickness of postsynaptic density and the synaptic curvature increased significantly. The expression of synaptic plasticity-related protein BDNF, GAP43, p38, MAP2 in the brain tissue around the infarct were raised remarkably after treated by BD.
Conclusions: Alleviating PSS by BD may be related to rescuing the synaptic plasticity, which provides a probable new therapeutic method for PSS.
{"title":"Efficacy of Baishao Luoshi decoction on synaptic plasticity in rats with post stroke spasticity.","authors":"Xie Le, Mao Guo, Xie Yao, Cao Sijia, Zhou Shen, Jiang Junlin, Yao Ting, Fan Jianhu, Liu Dong, Kang Fuliang, W U Dahua, G E Jinwen","doi":"10.19852/j.cnki.jtcm.20221108.002","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.20221108.002","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of Baishao Luoshi decoction (, BD) on synaptic plasticity in rats with post stroke spasticity (PSS), and to study the mechanism behind the action.</p><p><strong>Methods: </strong>The PSS model of rat was established by middle cerebral artery occlusion (MCAO). The neurological deficit symptoms were evaluated by modified neurological deficit score (mNSS). Muscle tension were evaluated by Modified Ashworth score (MAS). Transmission electron microscopy (TEM) was used to observe the synaptic ultrastructure. The expression of synaptic plasticity-related protein brain derived neurotrophic factor (BDNF), growth associated protein-43 (GAP43), synaptophysin (p38) and microtubule-associated protein 2 (MAP2) in the brain tissue around the infarct were detected by Western blotting.</p><p><strong>Results: </strong>We found that mNSS were significantly improved and limb spasticity was ameliorated treated by BD. The thickness of postsynaptic density and the synaptic curvature increased significantly. The expression of synaptic plasticity-related protein BDNF, GAP43, p38, MAP2 in the brain tissue around the infarct were raised remarkably after treated by BD.</p><p><strong>Conclusions: </strong>Alleviating PSS by BD may be related to rescuing the synaptic plasticity, which provides a probable new therapeutic method for PSS.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012212/pdf/JTCM-43-2-295.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.20220617.005
Wang Yide, Gao Zhen
Objective: To integrate Meta-analysis and bioinformatics strategies in the preliminary exploration of the potential mechanism of Yinyanghuo () and its extract in treating chronic obstructive pulmonary disease (COPD).
Methods: First, Meta-analysis was carried out. The Chinese and English literature of Yinyanghuo () in treating COPD was searched using the systematic strategy of combining subject words with free words. The included studies were evaluated by the SYRCLE risk bias assessment tool, after which the review manager software was used to combine the effect quantities for statistical analysis. Then, based on bioinformatics technology, the active ingredients and their targets of Yinyanghuo () were screened, and the intersection genes were obtained by mapping and comparing with the targets of COPD. The "medicinal materials-compounds-targets model" was constructed, and the key pathways were annotated. Finally, the core target was docked with important compounds.
Results: A total of 8 studies were included in the Meta-analysis. The results showed that the Yinyanghuo (Herba Epimedii Brevicornus) group could significantly down-regulate pro-inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-8 and increase the expression of anti-inflammatory factors and antioxidant factors such as IL-10 and phospho-protein kinase B (p-AKT) in the COPD model (all P < 0.05). A total of 23 active components and 102 corresponding target genes of Yinyanghuo (Herba Epimedii Brevicornus) were obtained by bioinformatics technology, among which 17 compounds and 63 targets were closely related to COPD. The results of enrichment analysis mainly included TNF signaling pathway, phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, cancer signaling pathway, and other inflammatory reactions, oxidative stress, and tumor-related pathways. The molecular docking results showed that the binding energy fractions of the top five components of 24-epicampesterol with 10 core targets such as IL-6 were all less than ﹣5.0 kcal/mol, suggesting good binding ability.
Conclusions: Meta-analysis and bioinformatics results indicated that the therapeutic effect of Yinyanghuo () and its components on COPD might be related to antagonizing inflammation and oxidative stress. The above findings provide a preliminary basis for the development of Yinyanghuo () as a natural drug for preventing and treating COPD.
{"title":"Yinyanghuo () and its components for chronic obstructive pulmonary disease: preclinical evidence and possible mechanisms.","authors":"Wang Yide, Gao Zhen","doi":"10.19852/j.cnki.jtcm.20220617.005","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.20220617.005","url":null,"abstract":"<p><strong>Objective: </strong>To integrate Meta-analysis and bioinformatics strategies in the preliminary exploration of the potential mechanism of Yinyanghuo () and its extract in treating chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>First, Meta-analysis was carried out. The Chinese and English literature of Yinyanghuo () in treating COPD was searched using the systematic strategy of combining subject words with free words. The included studies were evaluated by the SYRCLE risk bias assessment tool, after which the review manager software was used to combine the effect quantities for statistical analysis. Then, based on bioinformatics technology, the active ingredients and their targets of Yinyanghuo () were screened, and the intersection genes were obtained by mapping and comparing with the targets of COPD. The \"medicinal materials-compounds-targets model\" was constructed, and the key pathways were annotated. Finally, the core target was docked with important compounds.</p><p><strong>Results: </strong>A total of 8 studies were included in the Meta-analysis. The results showed that the Yinyanghuo (Herba Epimedii Brevicornus) group could significantly down-regulate pro-inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-8 and increase the expression of anti-inflammatory factors and antioxidant factors such as IL-10 and phospho-protein kinase B (p-AKT) in the COPD model (all P < 0.05). A total of 23 active components and 102 corresponding target genes of Yinyanghuo (Herba Epimedii Brevicornus) were obtained by bioinformatics technology, among which 17 compounds and 63 targets were closely related to COPD. The results of enrichment analysis mainly included TNF signaling pathway, phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, cancer signaling pathway, and other inflammatory reactions, oxidative stress, and tumor-related pathways. The molecular docking results showed that the binding energy fractions of the top five components of 24-epicampesterol with 10 core targets such as IL-6 were all less than ﹣5.0 kcal/mol, suggesting good binding ability.</p><p><strong>Conclusions: </strong>Meta-analysis and bioinformatics results indicated that the therapeutic effect of Yinyanghuo () and its components on COPD might be related to antagonizing inflammation and oxidative stress. The above findings provide a preliminary basis for the development of Yinyanghuo () as a natural drug for preventing and treating COPD.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012194/pdf/JTCM-43-2-386.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.20221206.002
Xue Jianyi, X U Jinyan, Huang Mao, Y U Wentao, Yan Yihui, Yan Yuanjie, Yin Zhenjin, L U Qian, Peng Wanying, Yan Siyang
Objective: To investigate the efficacy of scalp acupuncture Yikang therapy on Baihui (GV20), Sishencong (EX-HN1), Zhisanzhen, Niesanzhen, on neurobehavior in young rats with cerebral palsy based on Notch signaling pathway.
Methods: Thirty 7-day-old rats were randomly divided into sham, model and acupuncture, 10 rats in each group. The cerebral palsy model was established by the accepted modeling method, the acupuncture group selected "Baihui (GV20)", "Sishencong (EX-HN1)", "Zhisanzhen" and "Niesanzhen" for intervention 24 h after the model was made. The body masses were recorded before and after the treatment, respectively. After the intervention, the rats were subjected to suspension experiment, slope experiment, tactile stimulation experiment and Morris water maze experiment. After the end of the experiment, the morphological changes of hippocampal histology were observed by hematoxylin-eosin (HE) staining under light microscope, and the expression of Notch1, Notch3 and Hes5 were detected by Western blot and quantitative real-time polymerase chain reaction (PCR).
Results: The changes in body mass of the rats in each group were different; in behavioral experiments, compared with the sham, the suspension time of the model was shortened, the slope experiment, tactile stimulation experiment, and escape latency time were prolonged, and the number of platform crossing was reduced in the model, compared with the model, the suspension time of the acupuncture was prolonged, the slope experiment, tactile stimulation experiment, and escape latency time were shortened, and the number of platform crossing times was increased; HE staining showed severe hippocampal damage in the model and reduced hippocampal damage in the acupuncture. Western Blot and real-time fluorescence quantitative PCR showed that the expression of Notch1, Notch3 and Hes5 were increased in the model and the expression of Notch1, Notch3, Hes5 in acupuncture were decreased.
Conclusions: Scalp acupuncture Yikang therapy may improve neurobehavior and reduce brain injury in rats with cerebral palsy by downregulating the expression of Notch1, Notch3, and Hes5.
{"title":"Scalp acupuncture Yikang therapy on Baihui (GV20), Sishencong (EX-HN1), Zhisanzhen, Niesanzhen improves neurobehavior in young rats with cerebral palsy through Notch signaling pathway.","authors":"Xue Jianyi, X U Jinyan, Huang Mao, Y U Wentao, Yan Yihui, Yan Yuanjie, Yin Zhenjin, L U Qian, Peng Wanying, Yan Siyang","doi":"10.19852/j.cnki.jtcm.20221206.002","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.20221206.002","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy of scalp acupuncture Yikang therapy on Baihui (GV20), Sishencong (EX-HN1), Zhisanzhen, Niesanzhen, on neurobehavior in young rats with cerebral palsy based on Notch signaling pathway.</p><p><strong>Methods: </strong>Thirty 7-day-old rats were randomly divided into sham, model and acupuncture, 10 rats in each group. The cerebral palsy model was established by the accepted modeling method, the acupuncture group selected \"Baihui (GV20)\", \"Sishencong (EX-HN1)\", \"Zhisanzhen\" and \"Niesanzhen\" for intervention 24 h after the model was made. The body masses were recorded before and after the treatment, respectively. After the intervention, the rats were subjected to suspension experiment, slope experiment, tactile stimulation experiment and Morris water maze experiment. After the end of the experiment, the morphological changes of hippocampal histology were observed by hematoxylin-eosin (HE) staining under light microscope, and the expression of Notch1, Notch3 and Hes5 were detected by Western blot and quantitative real-time polymerase chain reaction (PCR).</p><p><strong>Results: </strong>The changes in body mass of the rats in each group were different; in behavioral experiments, compared with the sham, the suspension time of the model was shortened, the slope experiment, tactile stimulation experiment, and escape latency time were prolonged, and the number of platform crossing was reduced in the model, compared with the model, the suspension time of the acupuncture was prolonged, the slope experiment, tactile stimulation experiment, and escape latency time were shortened, and the number of platform crossing times was increased; HE staining showed severe hippocampal damage in the model and reduced hippocampal damage in the acupuncture. Western Blot and real-time fluorescence quantitative PCR showed that the expression of Notch1, Notch3 and Hes5 were increased in the model and the expression of Notch1, Notch3, Hes5 in acupuncture were decreased.</p><p><strong>Conclusions: </strong>Scalp acupuncture Yikang therapy may improve neurobehavior and reduce brain injury in rats with cerebral palsy by downregulating the expression of Notch1, Notch3, and Hes5.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012189/pdf/JTCM-43-2-337.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.2023.02.006
Minh Duc Nguyen, Thanh Van Tran, Quoc Vinh Nguyen, Ninh Khac Nguyen, Son Truong Vu, Luu Trong Nguyen, Linh Vu Phuong Dang
Objective: To evaluate the effectiveness of cycling in combination with electroacupuncture in treatment of post-stroke hemiplegia patients at National Hospital of Acupuncture, Vietnam.
Methods: The study was designed as a single-centre, outcome-assessor-blinded parallel randomised controlled trial with 120 post-stroke hemiplegia patients randomly assigned into two groups: electroacupuncture plus cycling (CT group) and electroacupuncture (AT group). Patients were assessed before and after the treatment (using muscle grading, modified Rankin, Barthel, Orgorozo scores and electromyography). Statistical Man-Whitney U test, and Fisher's exact tests were used to compare between CT and AT groups.
Results: The results reported statistically significant improvement in motor function in patients suffering from hemiplegia following ischemic stroke in both CT and AT groups. Patients in CT group experienced a greater improvement compared to those in AT group including better muscle contraction (increased frequency and amplitude of electromyography and increased muscle grading scale); increased recovery (Orgogozo scale), increased independency (Barthel scale) and decreased disability (Modified Rankin scale) (< 0.01).
Conclusions: Combination with cycling training significantly improves the recovery of post-stroke patients treated with electroacupuncture.
{"title":"Effectiveness on post-stroke hemiplegia in patients: electroacupuncture plus cycling electroacupuncture alone.","authors":"Minh Duc Nguyen, Thanh Van Tran, Quoc Vinh Nguyen, Ninh Khac Nguyen, Son Truong Vu, Luu Trong Nguyen, Linh Vu Phuong Dang","doi":"10.19852/j.cnki.jtcm.2023.02.006","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2023.02.006","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of cycling in combination with electroacupuncture in treatment of post-stroke hemiplegia patients at National Hospital of Acupuncture, Vietnam.</p><p><strong>Methods: </strong>The study was designed as a single-centre, outcome-assessor-blinded parallel randomised controlled trial with 120 post-stroke hemiplegia patients randomly assigned into two groups: electroacupuncture plus cycling (CT group) and electroacupuncture (AT group). Patients were assessed before and after the treatment (using muscle grading, modified Rankin, Barthel, Orgorozo scores and electromyography). Statistical Man-Whitney U test, and Fisher's exact tests were used to compare between CT and AT groups.</p><p><strong>Results: </strong>The results reported statistically significant improvement in motor function in patients suffering from hemiplegia following ischemic stroke in both CT and AT groups. Patients in CT group experienced a greater improvement compared to those in AT group including better muscle contraction (increased frequency and amplitude of electromyography and increased muscle grading scale); increased recovery (Orgogozo scale), increased independency (Barthel scale) and decreased disability (Modified Rankin scale) (< 0.01).</p><p><strong>Conclusions: </strong>Combination with cycling training significantly improves the recovery of post-stroke patients treated with electroacupuncture.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012188/pdf/JTCM-43-2-352.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.2023.02.002
Wang Yumeng, Shou Xintian, Li Dong
{"title":"A commentary on \"Acupoint application therapies for essential hypertension: a systematic review and Meta-analysis\".","authors":"Wang Yumeng, Shou Xintian, Li Dong","doi":"10.19852/j.cnki.jtcm.2023.02.002","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2023.02.002","url":null,"abstract":"","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012183/pdf/JTCM-43-2-211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.2023.02.001
Liu Hengrui
{"title":"An example of toxic medicine used in Traditional Chinese Medicine for cancer treatment.","authors":"Liu Hengrui","doi":"10.19852/j.cnki.jtcm.2023.02.001","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2023.02.001","url":null,"abstract":"","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012187/pdf/JTCM-43-2-209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.20230201.001
H U Xingyao, Liu Hongning, Yan Xiaojun, Chen Zhong, F U Liu, Liu Ge, Chen Xuan, Shang Guangbin
Objective: To investigate the mechanism of deficiency syndrome (YDS) by analyzing the liver metabolomic characteristics of three different deficiency rat models METHODS: Following the TCM etiology, for clinical features and pathological manifestations of modern medicine, three kinds of animal models of deficiency were induced and replicated. Totally 48 Sprague-Dawley (SD) male rats were randomly divided into blank group, irritation induced model group, Fuzi-Ganjiang induced model group, and thyroxine-reserpine induced model group. After successful development of model, the ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was carried out to detect metabolites in each group. The metabolites of rat liver were analyzed for the characteristics of their biomarkers. The pathway enrichment analysis and metabolic network construction were performed through various online databases including Metabolite Biology Role, Human Metabolome Database, MetaboAnalyst, and Kyoto Encyclopedia of Genes and Genomes.
Results: The SD rats in the experimental group showed symptoms like less weight gain, reduced diet and water intake, high body temperature, increased liver and kidney indexes, and abnormal liver and kidney tissue morphology. Moreover, the rats showed high increased levels of serum cyclic adenosine monophosphate, estradiol, alanine transaminase, and aspartate aminotransferase and decreased levels of cyclic guanosinc monophosphate and testosterone. We found four key interrelated metabolic pathways in the liver tissue metabolomics, including the biosynthesis of pantothenic acid and coenzyme A, and metabolism of alpha-linolenic acid metabolism, glycerophospholipid metabolism, and sphingolipid.
Conclusion: The liver and kidney YDS is closely related to the biosynthesis of pantothenic acid and CoA and abnormal metabolism of α-linolenic acid, glycerophospholipid, and sphingolipid in SD rats.
目的:通过分析3种不同虚证模型大鼠肝脏代谢组学特征,探讨虚证(YDS)形成的机制。方法:根据中医病因学,结合现代医学的临床特点和病理表现,建立3种虚证动物模型并进行复制。将48只SD雄性大鼠随机分为空白组、刺激模型组、扶子甘姜模型组和甲状腺素利血平模型组。模型建立成功后,采用超高效液相色谱-四极杆飞行时间质谱联用技术检测各组代谢产物。分析了大鼠肝脏代谢产物的生物标志物特征。通过Metabolite Biology Role、Human Metabolome Database、MetaboAnalyst和Kyoto Encyclopedia of Genes and Genomes等在线数据库进行通路富集分析和代谢网络构建。结果:实验组SD大鼠出现增重减少、饮食饮水减少、体温升高、肝肾指标升高、肝肾组织形态异常等症状。此外,大鼠血清环磷酸腺苷、雌二醇、丙氨酸转氨酶和天冬氨酸转氨酶水平升高,环磷酸鸟苷和睾酮水平降低。我们在肝组织代谢组学中发现了四个关键的相互关联的代谢途径,包括泛酸和辅酶A的生物合成,α -亚麻酸代谢,甘油磷脂代谢和鞘脂代谢。结论:SD大鼠肝肾YDS与泛酸、辅酶a的生物合成及α-亚麻酸、甘油磷脂、鞘脂代谢异常密切相关。
{"title":"Liver metabolomic characteristics in three different rat models of deficiency based on ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.","authors":"H U Xingyao, Liu Hongning, Yan Xiaojun, Chen Zhong, F U Liu, Liu Ge, Chen Xuan, Shang Guangbin","doi":"10.19852/j.cnki.jtcm.20230201.001","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.20230201.001","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the mechanism of deficiency syndrome (YDS) by analyzing the liver metabolomic characteristics of three different deficiency rat models METHODS: Following the TCM etiology, for clinical features and pathological manifestations of modern medicine, three kinds of animal models of deficiency were induced and replicated. Totally 48 Sprague-Dawley (SD) male rats were randomly divided into blank group, irritation induced model group, Fuzi-Ganjiang induced model group, and thyroxine-reserpine induced model group. After successful development of model, the ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was carried out to detect metabolites in each group. The metabolites of rat liver were analyzed for the characteristics of their biomarkers. The pathway enrichment analysis and metabolic network construction were performed through various online databases including Metabolite Biology Role, Human Metabolome Database, MetaboAnalyst, and Kyoto Encyclopedia of Genes and Genomes.</p><p><strong>Results: </strong>The SD rats in the experimental group showed symptoms like less weight gain, reduced diet and water intake, high body temperature, increased liver and kidney indexes, and abnormal liver and kidney tissue morphology. Moreover, the rats showed high increased levels of serum cyclic adenosine monophosphate, estradiol, alanine transaminase, and aspartate aminotransferase and decreased levels of cyclic guanosinc monophosphate and testosterone. We found four key interrelated metabolic pathways in the liver tissue metabolomics, including the biosynthesis of pantothenic acid and coenzyme A, and metabolism of alpha-linolenic acid metabolism, glycerophospholipid metabolism, and sphingolipid.</p><p><strong>Conclusion: </strong>The liver and kidney YDS is closely related to the biosynthesis of pantothenic acid and CoA and abnormal metabolism of α-linolenic acid, glycerophospholipid, and sphingolipid in SD rats.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012192/pdf/JTCM-43-2-274.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.19852/j.cnki.jtcm.20230124.001
Xie Jing, B I Zheng, Wang Sihai, Shen Guoming, Fang Zhaohui
Objective: To investigate the effect and mechanisms of Danzhi Jiangtang capsule (, DJC) on renal injury in streptozotocin (STZ)-induced diabetes of rats.
Methods: Sprague-Dawley rats were fed with high fat diet for 6 weeks followed by streptozotocin (STZ, 35 mg/kg) injection. These rats were then treated with DJC (270, 540 and 1080 mg/kg) daily for 8 weeks.
Results: A combination of high fat diet and STZ significantly increased blood glucose creatinine, urea nitrogen, and urine albumin in rats. Meanwhile, the glomerular and tubular lesions were observed in rats fed with high fat diet and injected with STZ. These biochemical and pathological changes were significantly attenuated by DJC treatments in a dose-dependent manner. Mechanistically, DJC treatments significantly decreased toll-like receptor 4 (TLR4), mitogen-activated protein kinase (MAPK), and nuclear factor-κB (NF-κB) signals in the kidney of rats fed with high fat diet and injected with STZ. Terminal deoxynucleotidyl transferase dUTP nick end labeling staining and caspase-8 levels showed that renal apoptosis was increased in rats fed with high fat diet and injected with STZ, and this was attenuated by DJC treatments.
Conclusions: DJC treatments protect against diabetic kidney disease, and the mechanism may be closely related to downregulation of TLR4/MAPK/NF-κB pathways and apoptosis. This study provides further evidence of using DJC as a potential therapeutic option for diabetic kidney disease.
{"title":"Danzhi Jiangtang capsule reduces renal injury in rats with diabetes induced by high fat diet and streptozotocin downregulating toll-like receptor 4-nuclear factor-κB pathway and apoptosis.","authors":"Xie Jing, B I Zheng, Wang Sihai, Shen Guoming, Fang Zhaohui","doi":"10.19852/j.cnki.jtcm.20230124.001","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.20230124.001","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect and mechanisms of Danzhi Jiangtang capsule (, DJC) on renal injury in streptozotocin (STZ)-induced diabetes of rats.</p><p><strong>Methods: </strong>Sprague-Dawley rats were fed with high fat diet for 6 weeks followed by streptozotocin (STZ, 35 mg/kg) injection. These rats were then treated with DJC (270, 540 and 1080 mg/kg) daily for 8 weeks.</p><p><strong>Results: </strong>A combination of high fat diet and STZ significantly increased blood glucose creatinine, urea nitrogen, and urine albumin in rats. Meanwhile, the glomerular and tubular lesions were observed in rats fed with high fat diet and injected with STZ. These biochemical and pathological changes were significantly attenuated by DJC treatments in a dose-dependent manner. Mechanistically, DJC treatments significantly decreased toll-like receptor 4 (TLR4), mitogen-activated protein kinase (MAPK), and nuclear factor-κB (NF-κB) signals in the kidney of rats fed with high fat diet and injected with STZ. Terminal deoxynucleotidyl transferase dUTP nick end labeling staining and caspase-8 levels showed that renal apoptosis was increased in rats fed with high fat diet and injected with STZ, and this was attenuated by DJC treatments.</p><p><strong>Conclusions: </strong>DJC treatments protect against diabetic kidney disease, and the mechanism may be closely related to downregulation of TLR4/MAPK/NF-κB pathways and apoptosis. This study provides further evidence of using DJC as a potential therapeutic option for diabetic kidney disease.</p>","PeriodicalId":17450,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012198/pdf/JTCM-43-2-312.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}