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Dirofilarial hemoptytic expectoration in 5 dogs - an uncommon manifestation of canine heartworm disease. 犬心丝虫病少见的一种表现:犬双丝虫性咯血咳痰。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-06-18 DOI: 10.1111/j.1939-1676.2012.00955.x
M Rishniw, A Hess, R Rojas, C Ritchie, A G Laws, T Staudt, D Bowman
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引用次数: 2
Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. Trilostane剂量与体重在治疗犬自然发生的垂体依赖性肾上腺皮质亢进症中的关系。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-06-18 DOI: 10.1111/j.1939-1676.2012.00956.x
E C Feldman, P H Kass

Background: Trilostane is commonly used in the treatment of dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH). Dose recommendations have varied from the manufacturer and the literature.

Hypothesis: As body weight increases, dose/kg or dosage/day of trilostane required to control the clinical signs of PDH decreases.

Animals: 70 dogs with naturally occurring hyperadrenocorticism.

Methods: Retrospective study. Each dog must have been treated for at least 6 months and should have shown a "good response" to trilostane, as determined by owners. Statistical comparisons of dose and dosage were made after the dogs were separated into groups weighing <15 or >15 kg; groups weighing ≤10, 10.1-20, 20.1-30, and ≥30 kg; and then groups based on body surface area versus dose/kg and total amount of trilostane required to control the condition.

Results: There was no significant difference in trilostane dose in mg/kg of body weight or in the total amount of trilostane required daily to control clinical signs, except when the dose for dogs weighing >30 kg was compared with that for the other groups. However, despite lack of statistical significance when comparing groups, there was a significant trend using polynomial regression analysis, suggesting that as body weight increases, the amount of trilostane (mg/kg/dose as well as mg/kg/daily dosage) required to control clinical signs decreases.

Conclusions and clinical importance: Dogs weighing >30 kg, and possibly those weighing >15 kg, might require smaller amounts of trilostane per dose or per day than those weighing less, to control PDH-associated clinical signs.

背景:Trilostane通常用于治疗犬的自然发生的垂体依赖性肾上腺皮质亢进症(PDH)。剂量建议因制造商和文献而异。假设:随着体重的增加,控制PDH临床症状所需的三洛烷剂量/kg或剂量/天减少。动物:70只患有天然肾上腺皮质亢进症的狗。方法:回顾性研究。每只狗必须接受至少6个月的治疗,并且根据主人的判断,对三洛烷应该表现出“良好的反应”。各组体重15 kg后进行剂量和剂量的统计比较;体重≤10 kg、10.1-20 kg、20.1-30 kg、≥30 kg组;然后根据体表面积和剂量/kg以及控制病情所需的三洛烷总量进行分组。结果:除了体重>30 kg的狗与其他组的剂量比较外,三洛烷在体重mg/kg的剂量和控制临床症状所需的每日三洛烷总量方面没有显著差异。虽然组间比较无统计学意义,但多项式回归分析有显著趋势,提示随着体重的增加,控制临床体征所需的三洛烷量(mg/kg/剂量和mg/kg/日剂量)减少。结论和临床意义:体重>30 kg的狗,可能体重>15 kg的狗,每剂量或每天所需的trilostane量可能比体重更轻的狗少,以控制ph相关的临床症状。
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引用次数: 19
Evaluation of arterial blood gases and arterial blood pressures in brachycephalic dogs. 短头犬动脉血气和动脉血压的评价。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-05-11 DOI: 10.1111/j.1939-1676.2012.00941.x
G L Hoareau, G Jourdan, M Mellema, P Verwaerde
BACKGROUNDBrachycephalic dogs (BD) are prone to congenital upper airway obstruction (brachycephalic syndrome, BS). In humans suffering from sleep apnea, upper airway obstruction is known to cause hypertension. There is no information regarding the influence of BS in dogs on cardiorespiratory physiology.HYPOTHESISBD are prone to lower P(a) O(2), higher P(a) CO (2), and hypertension compared with meso- or dolicocephalic dogs (MDD).ANIMALSEleven BD and 11 MDD.METHODSAfter a questionnaire was completed by the owner, a physical examination was performed. Height and thoracic circumferences were measured. Arterial blood gases, electrolyte concentrations, and packed cell volume (PCV) were measured. Systolic (SAP), mean (MAP), and diastolic (DAP) arterial blood pressure recordings were performed.RESULTSA total of 7 French and 4 English bulldogs met the inclusion criteria. The control group consisted in 6 Beagles, 2 mixed breed dogs, 1 Staffordshire Bull Terrier, 1 Parson Russell Terrier, and 1 Australian Cattle Dog. Statistically, BD had lower P(a) O(2), higher P(a) CO2, and higher PCV when compared with controls (86.2 ± 15.9 versus 100.2 ± 12.6 mmHg, P = .017; 36.3 ± 4.6 versus 32.7 ± 2.6 mmHg, P = .019; 48.2 ± 3.5 versus 44.2 ± 5.4%, P = .026, respectively). Also, they had significantly higher SAP (177.6 ± 25.0 versus 153.5 ± 21.7 mmHg, P = .013), MAP (123.3 ± 17.1 versus 108.3 ± 12.2 mmHg, P = .014), and DAP (95.3 ± 19.2 versus 83.0 ± 11.5 mmHg, P = .042). BD with a P(a) CO (2) >35 mmHg were significantly older than those with a P(a) CO (2) ≤35 mmHg (58 ± 16 and 30 ± 11 months, P = .004).CONCLUSIONResults of this study suggest that some BD are prone to lower P(a) O(2), higher P(a) CO (2), and hypertension when compared with MDD. Age may be a contributing factor.
背景:短头犬(BD)容易出现先天性上气道阻塞(短头综合征,BS)。患有睡眠呼吸暂停的人,已知上呼吸道阻塞可引起高血压。目前还没有关于犬类BS对心肺生理影响的资料。假设:与中脑或多头犬(MDD)相比,BD更易出现较低的P(a) O(2)、较高的P(a) CO(2)和高血压。动物:11例BD和11例MDD。方法:业主填写问卷后,进行体格检查。测量身高和胸围。测量动脉血气、电解质浓度和堆积细胞体积(PCV)。记录收缩压(SAP)、平均血压(MAP)和舒张压(DAP)。结果:共有7只法国斗牛犬和4只英国斗牛犬符合纳入标准。对照组为6只比格犬、2只杂交犬、1只斯塔福德郡牛头梗、1只帕森罗素梗和1只澳大利亚牛犬。统计上,与对照组相比,BD患者P(a) O(2)较低,P(a) CO2较高,PCV较高(86.2±15.9 vs 100.2±12.6 mmHg, P = 0.017;36.3±4.6 vs 32.7±2.6 mmHg, P = 0.019;48.2±3.5 vs . 44.2±5.4%,P = 0.026)。此外,他们的SAP(177.6±25.0比153.5±21.7 mmHg, P = 0.013)、MAP(123.3±17.1比108.3±12.2 mmHg, P = 0.014)和DAP(95.3±19.2比83.0±11.5 mmHg, P = 0.042)均显著升高。P(a) CO (2) >35 mmHg的患者比P(a) CO(2)≤35 mmHg的患者(58±16和30±11个月,P = 0.004)明显衰老。结论:本研究结果提示,与MDD相比,部分BD患者更易发生低P(a) O(2)、高P(a) CO(2)及高血压。年龄可能是一个影响因素。
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引用次数: 68
Pathophysiology of acute pancreatitis: potential application from experimental models and human medicine to dogs. 急性胰腺炎的病理生理学:从实验模型和人类医学到狗的潜在应用。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-06-07 DOI: 10.1111/j.1939-1676.2012.00949.x
Caroline Mansfield

The cellular events leading to pancreatitis have been studied extensively in experimental models. Understanding the cellular events and inciting causes of the multisystem inflammatory cascades that are activated with this disease is of vital importance to advance diagnosis and treatment of this condition. Unfortunately, the pathophysiology of pancreatitis in dogs is not well understood, and extrapolation from experimental and human medicine is necessary. The interplay of the inflammatory cascades (kinin, complement, cytokine) is extremely complex in both initiating leukocyte migration and perpetuating disease. Recently, nitric oxide (NO) and altered microcirculation of the pancreas have been proposed as major initiators of inflammation. In addition, the role of the gut is becoming increasingly explored as a cause of oxidative stress and potentiation of systemic inflammation in pancreatitis.

在实验模型中对导致胰腺炎的细胞事件进行了广泛的研究。了解这种疾病激活的多系统炎症级联反应的细胞事件和刺激原因对于提前诊断和治疗这种疾病至关重要。不幸的是,狗胰腺炎的病理生理学还没有很好地理解,从实验和人类医学推断是必要的。炎症级联反应(激肽、补体、细胞因子)的相互作用在启动白细胞迁移和使疾病永久化方面都是极其复杂的。最近,一氧化氮(NO)和胰腺微循环的改变被认为是炎症的主要发起者。此外,肠道在胰腺炎中作为氧化应激和全身性炎症增强的原因的作用正在被越来越多地探索。
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引用次数: 68
Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and secondary hemochromatosis in dogs. 红细胞丙酮酸激酶突变导致犬溶血性贫血、骨硬化症和继发性血色沉着病。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 DOI: 10.1111/j.1939-1676.2012.00958.x
G Inal Gultekin, K Raj, P Foureman, S Lehman, K Manhart, O Abdulmalik, U Giger

Background: Erythrocytic pyruvate kinase (PK) deficiency, first documented in Basenjis, is the most common inherited erythroenzymopathy in dogs.

Objectives: To report 3 new breed-specific PK-LR gene mutations and a retrospective survey of PK mutations in as mall and selected group of Beagles and West Highland White Terriers (WHWT).

Animals: Labrador Retrievers (2 siblings, 5 unrelated), Pugs (2 siblings, 1 unrelated), Beagles (39 anemic, 29 other),WHWTs (22 anemic, 226 nonanemic), Cairn Terrier (n = 1).

Methods: Exons of the PK-LR gene were sequenced from genomic DNA of young dogs (<2 years) with persistent highly regenerative hemolytic anemia.

Results: A nonsense mutation (c.799C>T) resulting in a premature stop codon was identified in anemic Labrador Retriever siblings that had osteosclerosis, high serum ferritin concentrations, and severe hepatic secondary hemochromatosis. Anemic Pug and Beagle revealed 2 different missense mutations (c.848T>C, c.994G>A, respectively) resulting in intolerable amino acid changes to protein structure and enzyme function. Breed-specific mutation tests were developed. Among the biased group of 248 WHWTs, 9% and 35% were homozygous (affected) and heterozygous, respectively, for the previously described mutation (mutant allele frequency 0.26). A PK-deficient Cairn Terrier had the same insertion mutation as the affected WHWTs. Of the selected group of 68 Beagles, 35% were PK-deficient and 3% were carriers (0.37).

Conclusions and clinical importance: Erythrocytic PK deficiency is caused by different mutations in different dog breeds and causes chronic severe hemolytic anemia, hemosiderosis, and secondary hemochromatosis because of chronic hemolysis and, an as yet unexplained osteosclerosis. The newly developed breed-specific mutation assays simplify the diagnosis of PK deficiency.

背景:红细胞丙酮酸激酶(PK)缺乏症是狗中最常见的遗传性红细胞酶病:报告 3 种新的犬种特异性 PK-LR 基因突变,并对比格犬和西高地白梗犬(WHWT)的 PK 基因突变进行回顾性调查:动物:拉布拉多寻回犬(2 只同胞,5 只无亲属关系)、巴哥犬(2 只同胞,1 只无亲属关系)、比格犬(39 只贫血,29 只其他)、西高地白梗犬(22 只贫血,226 只非贫血)、凯恩梗(n = 1):方法:从幼犬的基因组 DNA 中对 PK-LR 基因的外显子进行测序(结果:一个无义突变(c.7.0)被测出:结果:在贫血的拉布拉多猎犬兄弟姐妹中发现了一个导致过早终止密码子的无义突变(c.799C>T),这些兄弟姐妹患有骨硬化症、高血清铁蛋白浓度和严重的肝继发性血色病。贫血的八哥犬和比格犬发现了两种不同的错义突变(分别为 c.848T>C、c.994G>A),导致蛋白质结构和酶功能发生难以容忍的氨基酸变化。开发了针对特定犬种的突变测试。在有偏差的 248 只 WHWT 中,9% 和 35% 分别是之前描述的突变的同卵(受影响)和杂合子(突变等位基因频率为 0.26)。一只PK缺陷凯恩梗与受影响的WHWT犬具有相同的插入突变。在选定的68只比格犬中,35%为PK缺乏症,3%为携带者(0.37):红细胞PK缺乏症是由不同犬种的不同突变引起的,会导致慢性重度溶血性贫血、血色素沉着症和继发性血色素沉着症,原因是慢性溶血和尚未解释的骨硬化。新开发的犬种特异性突变测定简化了 PK 缺乏症的诊断。
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引用次数: 0
Sensitivity and specificity of a blood and urine galactomannan antigen assay for diagnosis of systemic aspergillosis in dogs. 血液和尿液半乳甘露聚糖抗原检测诊断犬系统性曲霉病的敏感性和特异性。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-04-21 DOI: 10.1111/j.1939-1676.2012.00935.x
R S Garcia, L J Wheat, A K Cook, E J Kirsch, J E Sykes

Background: Diagnosis of canine systemic aspergillosis requires fungal culture from a sterile site, or confirmatory histopathology from a nonsterile site. Invasive specimen collection techniques may be necessary.

Objective: To evaluate the sensitivity and specificity of a serum and urine Aspergillus galactomannan antigen (GMA) ELISA assay for diagnosis of systemic aspergillosis in dogs.

Design: Multicenter study.

Animals: Thirteen dogs with systemic aspergillosis and 89 dogs with other diseases. Thirty-seven of the 89 dogs had signs that resembled those of systemic aspergillosis and 52 dogs were not suspected to have aspergillosis.

Procedure: The GMA ELISA was performed on serum specimens from all dogs and urine specimens from 67 dogs. Galactomannan indices (GMI) ≥ 0.5 were considered positive. Results for dogs in each group were compared.

Results and conclusions: The sensitivity and specificity of the assay for serum were 92 and 86%, respectively, and for urine were 88 and 92%, respectively. False negatives were seen only in dogs with localized pulmonary aspergillosis. Use of a cutoff GMI of 1.5 increased specificity to 93% for both serum and urine without loss of sensitivity for diagnosis of disseminated infection. High-level false positives (> 1.5) occurred in dogs with other systemic mycoses and those treated with Plasmalyte.

Clinical relevance: Serum and urine Aspergillus GMA ELISA is a noninvasive, sensitive, and specific test for the diagnosis of disseminated aspergillosis in dogs when a cutoff GMI of ≥ 1.5 is used.

背景:犬全身性曲霉病的诊断需要无菌部位的真菌培养,或非无菌部位的组织病理学证实。侵入性标本采集技术可能是必要的。目的:评价血清和尿液半乳甘露聚糖曲霉抗原(GMA) ELISA法诊断犬全体性曲霉病的敏感性和特异性。设计:多中心研究。动物:13只狗患有全身性曲霉病,89只狗患有其他疾病。89只狗中有37只有类似系统性曲霉病的症状,52只没有怀疑患有曲霉病。操作步骤:对所有犬的血清标本和67只犬的尿液标本进行GMA ELISA检测。半乳甘露聚糖指数(GMI)≥0.5为阳性。比较各组狗的结果。结果与结论:该方法对血清的敏感性和特异性分别为92%和86%,对尿液的敏感性和特异性分别为88%和92%。假阴性仅见于局限性肺曲霉病的犬。使用1.5的GMI临界值可将血清和尿液的特异性提高到93%,而不会丧失诊断播散性感染的敏感性。高假阳性(> 1.5)发生在患有其他全身性真菌病的狗和接受Plasmalyte治疗的狗中。临床相关性:血清和尿液曲霉GMA ELISA是一种无创、敏感和特异性的检测方法,当临界值GMI≥1.5时,可用于诊断犬播散性曲霉病。
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引用次数: 42
A multi-institutional study evaluating the diagnostic utility of the spec cPL™ and SNAP® cPL™ in clinical acute pancreatitis in 84 dogs. 一项多机构研究评估了spec cPL™和SNAP®cPL™在84只狗的临床急性胰腺炎中的诊断效用。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-06-07 DOI: 10.1111/j.1939-1676.2012.00951.x
K McCord, P S Morley, J Armstrong, K Simpson, M Rishniw, M A Forman, D Biller, N Parnell, K Arnell, S Hill, S Avgeris, H Gittelman, M Moore, M Hitt, G Oswald, S Marks, D Burney, D Twedt

Background: Pancreas-specific lipase is reported to aid in diagnosing acute pancreatitis (AP) in dogs but has not been rigorously evaluated clinically.

Hypothesis/objectives: To describe variability of disease in dogs with suspected clinical AP, and to evaluate accuracy of 2 pancreatic-specific lipase immunoassays, Spec cPL (SPEC) and SNAP cPL (SNAP), in diagnosing clinical AP. We hypothesized that SPEC and SNAP provide better diagnostic accuracy than serum amylase or total lipase.

Animals: A total of 84 dogs; 27 without AP and 57 with clinical signs associated with AP.

Methods: Multicenter study. Dogs were prospectively enrolled based upon initial history and physical examination, then retrospectively classified into groups according to the likelihood of having clinical AP by a consensus of experts blinded to SPEC and SNAP results. Bayesian latent class analyses were used to estimate the diagnostic accuracy of SPEC and SNAP.

Results: The estimates for test sensitivities and specificities, respectively, ranged between 91.5-94.1% and 71.1-77.5% for SNAP, 86.5-93.6% and 66.3-77.0% for SPEC (cutoff value of 200 μg/L), 71.7-77.8% and 80.5-88.0% for SPEC (cutoff value of 400 μg/L), and were 52.4-56.0% and 76.7-80.6% for amylase, and 43.4-53.6% and 89.3-92.5% for lipase.

Conclusions and clinical importance: SNAP and SPEC have higher sensitivity for diagnosing clinical AP than does measurement of serum amylase or lipase activity. A positive SPEC or SNAP has a good positive predictive value (PPV) in populations likely to have AP and a good negative predictive value (NPV) when there is low prevalence of disease.

背景:据报道,胰腺特异性脂肪酶有助于犬的急性胰腺炎(AP)的诊断,但尚未得到严格的临床评估。假设/目的:描述疑似临床AP犬的疾病变异性,并评估两种胰腺特异性脂肪酶免疫测定,Spec cPL (Spec)和SNAP cPL (SNAP)诊断临床AP的准确性。我们假设Spec和SNAP比血清淀粉酶或总脂肪酶提供更好的诊断准确性。动物:共84只狗;27例无AP, 57例有AP相关临床症状。方法:多中心研究。根据狗的初始病史和体格检查前瞻性地入组,然后根据专家对SPEC和SNAP结果不知情的共识,根据临床AP的可能性进行回顾性分类。采用贝叶斯潜类分析估计SPEC和SNAP的诊断准确性。结果:SNAP的敏感性和特异性分别为91.5 ~ 94.1%和71.1 ~ 77.5%,SPEC的敏感性和特异性分别为86.5 ~ 93.6%和66.3 ~ 77.0%(临界值为200 μg/L), SPEC的敏感性和特异性分别为71.7 ~ 77.8%和80.5 ~ 88.0%(临界值为400 μg/L),淀粉酶的敏感性和特异性分别为52.4 ~ 56.0%和76.7 ~ 80.6%,脂肪酶的敏感性和特异性分别为43.4 ~ 53.6%和89.3 ~ 92.5%。结论及临床意义:SNAP和SPEC对临床AP的诊断敏感性高于血清淀粉酶和脂肪酶活性测定。SPEC或SNAP阳性在AP易发人群中具有良好的阳性预测值(PPV),在低患病率人群中具有良好的阴性预测值(NPV)。
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引用次数: 107
Intravenous hypertonic saline solution (7.5%) and oral electrolytes to treat of calves with noninfectious diarrhea and metabolic acidosis. 静脉注射高渗生理盐水(7.5%)和口服电解质治疗犊牛非感染性腹泻和代谢性酸中毒。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-06-18 DOI: 10.1111/j.1939-1676.2012.00960.x
M L R Leal, S S Fialho, F C Cyrillo, H G Bertagnon, E L Ortolani, F J Benesi

Objective: The aim of this study was to compare the efficacy of treating osmotic diarrhea and dehydration in calves with hypertonic saline solution (HSS) IV, isotonic electrolyte solution (IES) PO, and a combination of these 2 solutions (HSS + IES).

Experimental design: Eighteen male calves 8-30 days of age were used to evaluate the efficacy of 3 methods of fluid therapy after induction of osmotic diarrhea and dehydration. The diarrhea and dehydration were induced by administration of saccharose, spironolactone, and hydrochlorothiazide for 48 hours. The animals were randomly divided into 3 experimental groups: Group 1: 7.2% hypertonic saline solution-HSS (5 mL/kg IV); Group 2: oral isotonic electrolyte solution IES (60 mL/kg PO); or Group 3: HSS+IES. Clinical signs and laboratory finding observed 48 hours post-induction (Time 0) included diarrhea, dehydration, lethargy, and metabolic acidosis.

Results: Calves treated with HSS + IES experienced decreases in hematocrit, total protein concentration, albumin concentration, urea nitrogen concentration, and plasma volume as well as increases in blood pH, blood bicarbonate concentration, and central venous pressure between 1 and 3 hours post-treatment. These findings also were observed in animals treated with IES, however, at a slower rate than in the HSS + IES-treated animals. Animals treated with HSS continued to display signs of dehydration, lethargy, and metabolic acidosis 24 hours post-treatment.

Conclusion: Treatment with a combination of HSS and IES produced rapid and sustainable correction of hypovolemia and metabolic acidosis in calves with noninfections diarrhea and dehydration.

目的:比较高渗生理盐水(HSS) IV、等渗电解质溶液(IES) PO以及两者联合(HSS + IES)治疗犊牛渗透性腹泻和脱水的疗效。试验设计:选用18头8 ~ 30日龄的公犊牛,对诱导渗透性腹泻和脱水后3种液体疗法的效果进行评价。给予糖、螺内酯和氢氯噻嗪48小时,引起腹泻和脱水。实验动物随机分为3个实验组:第1组:7.2%高渗生理盐水- hss (5 mL/kg IV);第二组:口服等渗电解质溶液IES (60 mL/kg PO);第3组:HSS+IES。诱导后48小时(时间0)观察到的临床体征和实验室结果包括腹泻、脱水、嗜睡和代谢性酸中毒。结果:经HSS + IES治疗的犊牛在治疗后1 ~ 3小时内,红细胞压比、总蛋白浓度、白蛋白浓度、尿素氮浓度和血浆体积下降,血pH值、血碳酸氢盐浓度和中心静脉压升高。然而,在接受IES治疗的动物中也观察到这些发现,其速度比HSS + IES治疗的动物慢。用HSS治疗的动物在治疗24小时后继续表现出脱水、嗜睡和代谢性酸中毒的迹象。结论:HSS和IES联合治疗可以快速持续地纠正犊牛低血容量和代谢性酸中毒,并伴有非感染性腹泻和脱水。
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引用次数: 20
Recombinant human thyrotropin in veterinary medicine: current use and future perspectives. 重组人促甲状腺素在兽药中的应用现状及展望。
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-06-07 DOI: 10.1111/j.1939-1676.2012.00950.x
M Campos, I van Hoek, K Peremans, S Daminet

Recombinant human thyrotropin (rhTSH) was developed after bovine thyrotropin (bTSH) was no longer commercially available. It was approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) as an aid to diagnostic follow-up of differentiated thyroid carcinoma in humans and for thyroid remnant ablation with radioiodine. In addition, rhTSH is used in human medicine to evaluate thyroid reserve capacity and to enhance radioiodine uptake in patients with metastatic thyroid cancer and multinodular goiter. Likewise, rhTSH has been used in veterinary medicine over the last decade. The most important veterinary use of rhTSH is thyroidal functional reserve testing for the diagnosis of canine hypothyroidism. Recent pilot studies performed at Ghent University in Belgium have investigated the use of rhTSH to optimize radioiodine treatment of canine thyroid carcinoma and feline hyperthyroidism. Radioiodine treatment optimization may allow a decreased therapeutic dosage of radioiodine and thus may improve radioprotection. This review outlines the current uses of rhTSH in human and veterinary medicine, emphasizing research performed in dogs and cats, as well as potential future applications.

重组人促甲状腺素(rhTSH)是在牛促甲状腺素(bTSH)不再市售后开发的。它已被美国食品和药物管理局(FDA)和欧洲药品管理局(EMEA)批准用于人类分化性甲状腺癌的诊断随访和放射性碘残留甲状腺消融。此外,rhTSH在人类医学中用于评估甲状腺储备能力,并增强转移性甲状腺癌和多结节性甲状腺肿患者的放射性碘摄取。同样,rhTSH在过去十年中也被用于兽药。rhTSH最重要的兽医应用是甲状腺功能储备测试诊断犬甲状腺功能减退症。最近在比利时根特大学进行的试点研究调查了使用rhTSH优化犬甲状腺癌和猫甲状腺功能亢进的放射性碘治疗。放射性碘治疗的优化可以降低放射性碘的治疗剂量,从而可以改善放射性防护。本文概述了rhTSH目前在人类和兽药中的应用,强调了在狗和猫身上进行的研究,以及潜在的未来应用。
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引用次数: 5
Association of asinine herpesvirus-5 with pyogranulomatous pneumonia in a mare. 驴疱疹病毒-5与母马脓肉芽肿性肺炎的关系
IF 2.6 2区 农林科学 Pub Date : 2012-07-01 Epub Date: 2012-05-18 DOI: 10.1111/j.1939-1676.2012.00943.x
F Gomez De Witte, N Frank, R P Wilkes, J M Novak
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引用次数: 11
期刊
Journal of Veterinary Internal Medicine
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