Pub Date : 2026-03-01Epub Date: 2026-02-13DOI: 10.1016/j.jvs.2025.12.162
H.J.M. Verhagen, J.A.W. Teijink, A.H. Power, M.M.P.J. Reijnen, L.H. Bouwman, F.E.G. Vermassen, V. Riambau, P. Erhart, S. Ling, P.W.M. Cuypers, I.M. Loftus, ENGAGE Investigators
{"title":"Editor’s Choice – The ENGAGE Registry Ten Year Outcomes with the Endurant Stent Graft System for Endovascular Abdominal Aortic Aneurysm Repair","authors":"H.J.M. Verhagen, J.A.W. Teijink, A.H. Power, M.M.P.J. Reijnen, L.H. Bouwman, F.E.G. Vermassen, V. Riambau, P. Erhart, S. Ling, P.W.M. Cuypers, I.M. Loftus, ENGAGE Investigators","doi":"10.1016/j.jvs.2025.12.162","DOIUrl":"10.1016/j.jvs.2025.12.162","url":null,"abstract":"","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Page 965"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-14DOI: 10.1016/j.jvs.2025.11.011
Natalie V. Hmeluk BS , Martina Jelley MD, MSPH, FACP , Juell Homco PhD, MPH , Wato Nsa MD, PhD , Peter R. Nelson MD, MS, FACS , Julie Miller-Cribbs MSW, PhD , Arad Abadi MD , Kelly Kempe MD, MS, FACS
<div><h3>Background</h3><div>Childhood abuse, neglect, and household dysfunction, collectively known as adverse childhood experiences (ACEs), are strongly associated with the development of severe outcomes from chronic diseases, including ischemic heart attacks and stroke. ACEs also contribute to a higher risk of adult hardships, which increases the risk of health risk behaviors, chronic disease, and social problems. In this study, we describe the period prevalence of ACEs in a patient population with peripheral artery disease (PAD) and explore the relationship between childhood adversity, adult hardships, and PAD severity, such as the need for surgical procedures, among patients with PAD.</div></div><div><h3>Methods</h3><div>In this survey-based, cross-sectional study, individuals with PAD were recruited at an academic outpatient vascular surgery clinic (2022-2025). The survey included five questions about adult hardships—self-reported financial, food, medical, and housing insecurity in the past year—and 10 questions based on the original Centers for Disease Control and Prevention-Kaiser Permanente ACE study. We collected cardiovascular disease-related and amputation surgical procedure data from patient charts. PAD severity was determined by minor (eg, peripheral stent) or major (eg, amputation) surgical procedures and ankle-brachial index and toe-brachial index scores. The Wilcoxon rank-sum test and Fisher exact and χ<sup>2</sup> tests were used to assess differences in ACE or adult hardship scores as either continuous or categorical variables, respectively, in relation to cardiovascular disease-related surgical procedures.</div></div><div><h3>Results</h3><div>A total of 138 participants with PAD were included in the final analysis. Most respondents identified as male (55.8%, n = 77) and White (65.9%, n = 91). For childhood adversity, 37.0% (n = 51) reported experiencing no ACEs, 24.6% (n = 34) reported one ACE, 10.9% (n = 15) reported two ACEs, 10.1% (n = 14) reported three ACEs, and 17.4% (n = 24) reported at least four ACEs. The patient characteristics associated with a high number of ACEs included women, single individuals, Black individuals, and those living in poverty. The median ACE score was significantly higher for those who reported the following adult hardships compared with those who did not: not getting enough to eat (median, 3.0 vs 1.0; <em>P</em> < .001), being behind on bills (median, 2.0 vs 0.0; <em>P</em> < .001), and experiencing disconnected utilities (median, 3.0 vs 1.0; <em>P</em> = .001). No statistically significant association was noted between reporting ACEs and PAD severity or adult hardships and PAD severity.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that a greater number of ACEs may indirectly contribute to an individual's risk for adult hardships in the PAD population, potentially placing these patients at higher risk of poor health outcomes. We did not find evidence to support a significa
童年虐待、忽视和家庭功能障碍,统称为不良童年经历(ace),与慢性疾病(包括缺血性心脏病发作和中风)的严重后果发展密切相关。不良经历还会增加成年后生活困难的风险,从而增加健康风险行为、慢性病和社会问题的风险。在这项研究中,我们描述了在PAD患者群体中ace的时期患病率,并探讨了PAD患者中童年逆境、成年困难和PAD严重程度(如需要手术治疗)之间的关系。方法:在这项基于调查的横断面研究中,在学术门诊血管外科诊所招募了PAD患者(2022-2025)。该调查包括5个关于成年人困难的问题——过去一年里自我报告的财务、食物、医疗和住房不安全状况,以及10个基于CDC-Kaiser Permanente ACE研究的问题。我们从患者图表中收集心血管疾病相关和截肢手术的数据。PAD的严重程度由轻微(如外周支架)或主要(如截肢)外科手术以及踝肱指数(ABI)和脚趾肱指数(TBI)评分来确定。使用Wilcoxon秩和检验和Fisher精确卡方检验分别评估与心血管疾病相关外科手术相关的ACE或成人困难评分作为连续变量或分类变量的差异。结果:共有138名PAD患者被纳入最终分析。大多数被调查者为男性(55.8%,n=77)和白人(65.9%,n=91)。对于童年逆境,37.0% (n=51)报告没有经历过ACE, 24.6% (n=34)报告一次ACE, 10.9% (n=15)报告两次ACE, 10.1% (n=14)报告三次ACE, 17.4% (n=24)报告至少四次ACE。与ace发生率高相关的患者特征包括女性、单身个体、黑人和贫困人群。与那些没有报告以下成年困难的人相比,报告以下成年困难的人的ACE得分中位数显着更高:吃不饱(中位数=3.0 vs. 1.0, p < 0.001),拖欠账单(中位数=2.0 vs. 0.0, p < 0.001),经历中断公用事业(中位数=3.0 vs. 1.0, p = 0.001)。报告ace与PAD严重程度或成人生活困难与PAD严重程度之间没有统计学意义的关联。结论:我们的研究结果表明,在PAD人群中,较高数量的ace可能间接增加了个人成年后的困难风险,可能使这些患者面临更高的不良健康结果风险。我们没有发现证据支持ace和pad严重程度之间的显著关系。其他可改变的危险因素值得持续分析,以改善PAD患者的管理。
{"title":"Adverse childhood experiences, adult hardships, and disease severity in peripheral artery disease","authors":"Natalie V. Hmeluk BS , Martina Jelley MD, MSPH, FACP , Juell Homco PhD, MPH , Wato Nsa MD, PhD , Peter R. Nelson MD, MS, FACS , Julie Miller-Cribbs MSW, PhD , Arad Abadi MD , Kelly Kempe MD, MS, FACS","doi":"10.1016/j.jvs.2025.11.011","DOIUrl":"10.1016/j.jvs.2025.11.011","url":null,"abstract":"<div><h3>Background</h3><div>Childhood abuse, neglect, and household dysfunction, collectively known as adverse childhood experiences (ACEs), are strongly associated with the development of severe outcomes from chronic diseases, including ischemic heart attacks and stroke. ACEs also contribute to a higher risk of adult hardships, which increases the risk of health risk behaviors, chronic disease, and social problems. In this study, we describe the period prevalence of ACEs in a patient population with peripheral artery disease (PAD) and explore the relationship between childhood adversity, adult hardships, and PAD severity, such as the need for surgical procedures, among patients with PAD.</div></div><div><h3>Methods</h3><div>In this survey-based, cross-sectional study, individuals with PAD were recruited at an academic outpatient vascular surgery clinic (2022-2025). The survey included five questions about adult hardships—self-reported financial, food, medical, and housing insecurity in the past year—and 10 questions based on the original Centers for Disease Control and Prevention-Kaiser Permanente ACE study. We collected cardiovascular disease-related and amputation surgical procedure data from patient charts. PAD severity was determined by minor (eg, peripheral stent) or major (eg, amputation) surgical procedures and ankle-brachial index and toe-brachial index scores. The Wilcoxon rank-sum test and Fisher exact and χ<sup>2</sup> tests were used to assess differences in ACE or adult hardship scores as either continuous or categorical variables, respectively, in relation to cardiovascular disease-related surgical procedures.</div></div><div><h3>Results</h3><div>A total of 138 participants with PAD were included in the final analysis. Most respondents identified as male (55.8%, n = 77) and White (65.9%, n = 91). For childhood adversity, 37.0% (n = 51) reported experiencing no ACEs, 24.6% (n = 34) reported one ACE, 10.9% (n = 15) reported two ACEs, 10.1% (n = 14) reported three ACEs, and 17.4% (n = 24) reported at least four ACEs. The patient characteristics associated with a high number of ACEs included women, single individuals, Black individuals, and those living in poverty. The median ACE score was significantly higher for those who reported the following adult hardships compared with those who did not: not getting enough to eat (median, 3.0 vs 1.0; <em>P</em> < .001), being behind on bills (median, 2.0 vs 0.0; <em>P</em> < .001), and experiencing disconnected utilities (median, 3.0 vs 1.0; <em>P</em> = .001). No statistically significant association was noted between reporting ACEs and PAD severity or adult hardships and PAD severity.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that a greater number of ACEs may indirectly contribute to an individual's risk for adult hardships in the PAD population, potentially placing these patients at higher risk of poor health outcomes. We did not find evidence to support a significa","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Pages 848-858.e4"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-07DOI: 10.1016/j.jvs.2025.11.001
Xiaoqi Ye MD, PhD , Yan Li MD, PhD , Siyu Chen MD, PhD , Lihong Chen MD, PhD , Yebei Liang MD, PhD , Feiyan Shi MD , Xingwu Ran MD
Background
Peripheral artery disease (PAD), particularly premature PAD, remains understudied. It is still unclear whether premature PAD exhibits distinct risk profiles and survival outcomes compared with nonpremature PAD. We aimed to compare risk factors and long-term mortality between premature and nonpremature PAD using two large cohorts.
Methods
In this study, we analyzed data from the UK Biobank (N = 348,766) and the U.S. National Health and Nutrition Examination Survey (NHANES; N = 6539). Premature PAD was defined using a sex-specific age cutoff (men <55 years, women <65 years), with sensitivity analyses using a 50-year cutoff. Participants were classified into three groups: no PAD, premature PAD, and nonpremature PAD groups. Multinomial logistic regression assessed associations between risk factors and PAD subtypes. Cox proportional hazards models estimated associations of PAD subtypes with all-cause and cardiovascular mortality risks.
Results
Patients with premature PAD were predominantly female with fewer cardiometabolic comorbidities. Peripheral neuropathy was a strong risk factor specifically for premature PAD (UK Biobank: odds ratio [OR] = 3.96, 95% confidence interval [CI]: 2.73-5.73; NHANES: OR = 2.01, 95% CI: 1.28-3.17), whereas nonpremature PAD showed no significant association (UK Biobank: OR = 1.32, 95% CI: 0.66-2.65; NHANES: OR = 0.87, 95% CI: 0.65-1.16). Over a mean follow-up period of 13.2 (UK Biobank) and 14.9 (NHANES) years, unadjusted analyses showed the highest mortality in nonpremature PAD among the three groups. However, after full adjustment for potential confounders, the patterns of mortality shifted. Premature PAD had a higher all-cause mortality risk (UK Biobank: hazard ratio [HR] = 2.15, 95% CI: 1.93-2.39; NHANES: HR = 2.15, 95% CI: 1.41-3.29) than nonpremature PAD (UK Biobank: HR = 1.91, 95% CI: 1.75-2.09; NHANES: HR = 1.52, 95% CI: 1.28-1.80). Premature PAD also had a higher cardiovascular mortality risk (UK Biobank: HR = 3.10, 95% CI: 2.33-4.13; NHANES: HR = 4.33, 95% CI: 2.47-7.57) vs nonpremature PAD (UK Biobank: HR = 2.26, 95% CI: 1.76-2.88; NHANES: HR = 1.66, 95% CI: 1.34-2.07). This was further confirmed in a direct comparison among patients with PAD, which showed that premature PAD carried a significantly higher risk of cardiovascular mortality than nonpremature PAD.
Conclusions
Premature PAD exhibited distinct risk profiles and had higher adjusted long-term mortality than nonpremature PAD, particularly from cardiovascular causes. Future studies are needed to investigate the mechanisms underlying these differences.
{"title":"Risk profiles and long-term mortality in premature and nonpremature peripheral artery disease from two prospective cohorts","authors":"Xiaoqi Ye MD, PhD , Yan Li MD, PhD , Siyu Chen MD, PhD , Lihong Chen MD, PhD , Yebei Liang MD, PhD , Feiyan Shi MD , Xingwu Ran MD","doi":"10.1016/j.jvs.2025.11.001","DOIUrl":"10.1016/j.jvs.2025.11.001","url":null,"abstract":"<div><h3>Background</h3><div>Peripheral artery disease (PAD), particularly premature PAD, remains understudied. It is still unclear whether premature PAD exhibits distinct risk profiles and survival outcomes compared with nonpremature PAD. We aimed to compare risk factors and long-term mortality between premature and nonpremature PAD using two large cohorts.</div></div><div><h3>Methods</h3><div>In this study, we analyzed data from the UK Biobank (N = 348,766) and the U.S. National Health and Nutrition Examination Survey (NHANES; N = 6539). Premature PAD was defined using a sex-specific age cutoff (men <55 years, women <65 years), with sensitivity analyses using a 50-year cutoff. Participants were classified into three groups: no PAD, premature PAD, and nonpremature PAD groups. Multinomial logistic regression assessed associations between risk factors and PAD subtypes. Cox proportional hazards models estimated associations of PAD subtypes with all-cause and cardiovascular mortality risks.</div></div><div><h3>Results</h3><div>Patients with premature PAD were predominantly female with fewer cardiometabolic comorbidities. Peripheral neuropathy was a strong risk factor specifically for premature PAD (UK Biobank: odds ratio [OR] = 3.96, 95% confidence interval [CI]: 2.73-5.73; NHANES: OR = 2.01, 95% CI: 1.28-3.17), whereas nonpremature PAD showed no significant association (UK Biobank: OR = 1.32, 95% CI: 0.66-2.65; NHANES: OR = 0.87, 95% CI: 0.65-1.16). Over a mean follow-up period of 13.2 (UK Biobank) and 14.9 (NHANES) years, unadjusted analyses showed the highest mortality in nonpremature PAD among the three groups. However, after full adjustment for potential confounders, the patterns of mortality shifted. Premature PAD had a higher all-cause mortality risk (UK Biobank: hazard ratio [HR] = 2.15, 95% CI: 1.93-2.39; NHANES: HR = 2.15, 95% CI: 1.41-3.29) than nonpremature PAD (UK Biobank: HR = 1.91, 95% CI: 1.75-2.09; NHANES: HR = 1.52, 95% CI: 1.28-1.80). Premature PAD also had a higher cardiovascular mortality risk (UK Biobank: HR = 3.10, 95% CI: 2.33-4.13; NHANES: HR = 4.33, 95% CI: 2.47-7.57) vs nonpremature PAD (UK Biobank: HR = 2.26, 95% CI: 1.76-2.88; NHANES: HR = 1.66, 95% CI: 1.34-2.07). This was further confirmed in a direct comparison among patients with PAD, which showed that premature PAD carried a significantly higher risk of cardiovascular mortality than nonpremature PAD.</div></div><div><h3>Conclusions</h3><div>Premature PAD exhibited distinct risk profiles and had higher adjusted long-term mortality than nonpremature PAD, particularly from cardiovascular causes. Future studies are needed to investigate the mechanisms underlying these differences.</div></div>","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Pages 814-825.e10"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-28DOI: 10.1016/j.jvs.2025.11.027
Gianbattista Parlani MD , Giacomo Isernia MD, PhD , Lydia Romano MD , Francesco Pio Del Mastro MD , Piergiorgio Cao MD, FRCS , Massimo Lenti MD, PhD , Gioele Simonte MD, PhD
Objective
The aim of this study was to provide perioperative and mid-term evaluation, safety, and efficacy of CGuard (InspireMD) micromesh self-expanding stent with an embolic protection system during a carotid artery stenting (CAS) procedure.
Methods
All patients who underwent CAS with CGuard stent from January 2016 to June 2024 in a tertiary center were prospectively evaluated. The primary end points were technical success, combined risk of any stroke or death within 30 days (perioperative), and any ipsilateral stroke after the procedure. Secondary end points were stroke, death, transient ischemic attack, myocardial infarction (major adverse event), occurring within 30 days and the rate of stroke, death, and restenosis during the follow-up.
Results
A total of 218 consecutive patients underwent 226 CAS procedures with the CGuard stent during the study period. There were 142 male (63%) and mean age was 74.3 ± 8.0 years. Fifty-nine patients (26%) had a symptomatic stenosis. Technical success was 99.5%, because in 1 patient advancing the CGuard stent in a tight stenosis was impossible despite predilation. The mean procedural time was 33 minutes, the mean fluoroscopic time was 11 minutes, and the mean contrast media used was 41 mL. At 30 day, one patient had a transient ischemic attack (0.5%) and another patient experienced a minor stroke (0.5%). No patient died or developed myocardial infarction. The mean hospitalization duration after the procedure was 1.5 days. The 30-day rate of major adverse event was 0.5%. During a mean follow-up 35 months (range, 1-84 months), one patient had an asymptomatic stent occlusion and two patients experienced restenosis >70% successfully treated with a secondary stenting procedure in one case and stent explantation with Dacron patch closure in the other. The estimate of freedom from restenosis was 99.4% at 1 year, 97.5% at 3 years, and 97.5% at 5 years. Freedom from ipsilateral stroke was estimated 99.6% at 1 year, 98.7% at 3 years, and 98.7% at 5 years. The actuarial survival rate was 97.4% at 1 year, 92.4% at 3 years, and 78.7% at 5 years.
Conclusions
Preliminary data suggest that the CGuard stent with embolic protection system is an effective and safe device for the treatment of carotid artery stenosis with acceptably low perioperative and mid-term neurological event and durable patency rate. Larger, multicenter, randomized studies are advocated to confirm these findings.
目的:本研究的目的是在颈动脉支架置入(CAS)过程中对CGuard (InspireMD, Tel Aviv, Israel)微孔自膨胀支架(EPS)进行围手术期和中期评估、安全性和有效性。方法:2016年1月至2024年6月在三级中心接受颈动脉支架置入(CAS)的所有患者进行前瞻性评估。主要终点为技术成功、30天内卒中或死亡的综合风险(围手术期)以及术后同侧卒中。次要终点为30天内发生的卒中、死亡、短暂性脑缺血发作(TIA)、心肌梗死(主要不良事件或MAE)以及随访期间卒中、死亡和再狭窄的发生率。结果:在研究期间,共有218例连续患者接受了226例使用C Guard支架的CAS手术。男性142例(63%),平均年龄74.3(+ 8)岁。59例(26%)有症状性狭窄。技术上的成功率为99.5%,在一名患者中,尽管预扩张导致狭窄,但仍无法推进C保护支架。平均手术时间33分钟,平均荧光时间11分钟,平均使用造影剂41毫升。30天,1例患者发生短暂性脑缺血发作(0.5%),1例患者发生轻度脑卒中(0.5%)。无患者死亡或发生心肌梗死。术后平均住院时间为1.5天。30天MAE利率为0.5%。在平均随访35个月(1-84个月)期间,1例患者出现无症状支架闭塞,2例患者出现再狭窄,其中1例70%成功地接受了二次支架置入,另1例70%成功地接受了涤纶补片闭合支架置入。估计1年、3年和5年的再狭窄自由度分别为99.4%、97.5%和97.5%。估计1年时同侧卒中自由率为99.6%,3年时为98.7%,5年时为98.7%。精算生存率为1年97,4%,3年92,4%,5年77,7%。结论:初步数据表明,EPS CGuard支架是治疗颈动脉狭窄的有效和安全的装置,可接受的围手术期和中期神经事件低,持久的通畅率。我们提倡进行更大规模的多中心随机研究来证实这些发现。
{"title":"Eight-year single- center experience with double-layer carotid stent","authors":"Gianbattista Parlani MD , Giacomo Isernia MD, PhD , Lydia Romano MD , Francesco Pio Del Mastro MD , Piergiorgio Cao MD, FRCS , Massimo Lenti MD, PhD , Gioele Simonte MD, PhD","doi":"10.1016/j.jvs.2025.11.027","DOIUrl":"10.1016/j.jvs.2025.11.027","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to provide perioperative and mid-term evaluation, safety, and efficacy of CGuard (InspireMD) micromesh self-expanding stent with an embolic protection system during a carotid artery stenting (CAS) procedure.</div></div><div><h3>Methods</h3><div>All patients who underwent CAS with CGuard stent from January 2016 to June 2024 in a tertiary center were prospectively evaluated. The primary end points were technical success, combined risk of any stroke or death within 30 days (perioperative), and any ipsilateral stroke after the procedure. Secondary end points were stroke, death, transient ischemic attack, myocardial infarction (major adverse event), occurring within 30 days and the rate of stroke, death, and restenosis during the follow-up.</div></div><div><h3>Results</h3><div>A total of 218 consecutive patients underwent 226 CAS procedures with the CGuard stent during the study period. There were 142 male (63%) and mean age was 74.3 ± 8.0 years. Fifty-nine patients (26%) had a symptomatic stenosis. Technical success was 99.5%, because in 1 patient advancing the CGuard stent in a tight stenosis was impossible despite predilation. The mean procedural time was 33 minutes, the mean fluoroscopic time was 11 minutes, and the mean contrast media used was 41 mL. At 30 day, one patient had a transient ischemic attack (0.5%) and another patient experienced a minor stroke (0.5%). No patient died or developed myocardial infarction. The mean hospitalization duration after the procedure was 1.5 days. The 30-day rate of major adverse event was 0.5%. During a mean follow-up 35 months (range, 1-84 months), one patient had an asymptomatic stent occlusion and two patients experienced restenosis >70% successfully treated with a secondary stenting procedure in one case and stent explantation with Dacron patch closure in the other. The estimate of freedom from restenosis was 99.4% at 1 year, 97.5% at 3 years, and 97.5% at 5 years. Freedom from ipsilateral stroke was estimated 99.6% at 1 year, 98.7% at 3 years, and 98.7% at 5 years. The actuarial survival rate was 97.4% at 1 year, 92.4% at 3 years, and 78.7% at 5 years.</div></div><div><h3>Conclusions</h3><div>Preliminary data suggest that the CGuard stent with embolic protection system is an effective and safe device for the treatment of carotid artery stenosis with acceptably low perioperative and mid-term neurological event and durable patency rate. Larger, multicenter, randomized studies are advocated to confirm these findings.</div></div>","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Pages 767-774"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thoracoabdominal aortic aneurysms (TAAAs) and juxta/pararenal abdominal aortic aneurysms, reported as complex aortic aneurysms (cAAAs), represent a technical and clinical challenge with endovascular repair embodying a preferred option for high-risk patients. However, in case of nonelective presentation, both technical and clinical management and outcomes remain limited in literature. The aim of this study is to report indications, treatments, and outcomes of nonelective endovascular repair of TAAAs and cAAAs.
Methods
This study is a systematic review and meta-analysis performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) and after PROSPERO registration. Primary end points were the indications, technical success, and procedure-related mortality. Secondary end points were spinal cord ischemia (SCI), grade 3 SCI, dialysis, and respiratory events. Meta-regression was performed for nonintact vs intact aneurysms. Subgroup analysis was performed in studies involving exclusively TAAA repair.
Results
Of 687 articles screened, we selected 18 articles involving 953 patients: TAAAs were 68% (51% Crawford I-III and 49% Crawford IV-V) and cAAAs were 32%. Indications for nonelective treatment were contained of free rupture, symptoms, and large aneurysm diameter. Branched endograft, physician-modified/in situ endograft, parallel graft, and fenestrated endograft were used in 54%, 30%, 14%, and 2%, respectively. Technical success was 94.4%. Overall procedural-related mortality was 16.8% (95% confidence interval: 0.13-0.22; nonintact: 24.5% vs intact: 11.8%; P < .001). Pooled rate for SCI and grade 3 SCI was 12.3% (nonintact: 21.9% vs intact: 8.9%; P = .007) and 5.2% (nonintact: 8.5% vs intact: 2.2%; P = .02), respectively. Pooled rate for permanent dialysis was 3.6% (nonintact: 6.1% vs intact: 1.7%; P = .08) and for respiratory events 14.1% (nonintact: 20.7% vs intact: 9.3%; P = .024). Subgroups analysis for TAAAs reported procedure-related mortality in 18.7% (nonintact: 24.8% vs intact: 12.6%; P = .08); SCI, grade 3 SCI, dialysis, and respiratory events occurred in 16.4% (nonintact: 21.9% vs intact: 9.7%; P = .06), 5.6% (nonintact:8.1% vs intact: 2.8%; P = .08), 5.4% (nonintact: 7.2% vs intact: 2.6%; P = .36), and 18.2% (nonintact: 23.1 vs intact: 10.5%; P = .10), respectively. No statistical differences in metaregression for nonintact vs intact TAAAs.
Conclusions
The indications for nonelective endovascular treatment of TAAA and cAAA are heterogeneous. Technical success is elevated while early mortality and spinal cord injuries were higher for ruptured aneurysm. Interestingly, TAAA outcomes seemed not to be influenced by rupture.
{"title":"Systematic review and meta-analysis on endovascular repair of nonelective thoracoabdominal aortic aneurysms and aneurysms involving visceral arteries","authors":"Paolo Spath MD, PhD, FEBVS , Federica Campana MD , Nikolaos Tsilimparis MD, PhD, FEBVS , Enrico Gallitto MD, PhD, FEBVS , Stefania Caputo MD , Rodolfo Pini MD, PhD, FEBVS , Gianluca Faggioli MD, PhD , Mauro Gargiulo MD, PhD","doi":"10.1016/j.jvs.2025.08.030","DOIUrl":"10.1016/j.jvs.2025.08.030","url":null,"abstract":"<div><h3>Introduction</h3><div>Thoracoabdominal aortic aneurysms (TAAAs) and juxta/pararenal abdominal aortic aneurysms, reported as complex aortic aneurysms (cAAAs), represent a technical and clinical challenge with endovascular repair embodying a preferred option for high-risk patients. However, in case of nonelective presentation, both technical and clinical management and outcomes remain limited in literature. The aim of this study is to report indications, treatments, and outcomes of nonelective endovascular repair of TAAAs and cAAAs.</div></div><div><h3>Methods</h3><div>This study is a systematic review and meta-analysis performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) and after PROSPERO registration. Primary end points were the indications, technical success, and procedure-related mortality. Secondary end points were spinal cord ischemia (SCI), grade 3 SCI, dialysis, and respiratory events. Meta-regression was performed for nonintact vs intact aneurysms. Subgroup analysis was performed in studies involving exclusively TAAA repair.</div></div><div><h3>Results</h3><div>Of 687 articles screened, we selected 18 articles involving 953 patients: TAAAs were 68% (51% Crawford I-III and 49% Crawford IV-V) and cAAAs were 32%. Indications for nonelective treatment were contained of free rupture, symptoms, and large aneurysm diameter. Branched endograft, physician-modified/in situ endograft, parallel graft, and fenestrated endograft were used in 54%, 30%, 14%, and 2%, respectively. Technical success was 94.4%. Overall procedural-related mortality was 16.8% (95% confidence interval: 0.13-0.22; nonintact: 24.5% vs intact: 11.8%; <em>P</em> < .001). Pooled rate for SCI and grade 3 SCI was 12.3% (nonintact: 21.9% vs intact: 8.9%; <em>P</em> = .007) and 5.2% (nonintact: 8.5% vs intact: 2.2%; <em>P</em> = .02), respectively. Pooled rate for permanent dialysis was 3.6% (nonintact: 6.1% vs intact: 1.7%; <em>P</em> = .08) and for respiratory events 14.1% (nonintact: 20.7% vs intact: 9.3%; <em>P</em> = .024). Subgroups analysis for TAAAs reported procedure-related mortality in 18.7% (nonintact: 24.8% vs intact: 12.6%; <em>P</em> = .08); SCI, grade 3 SCI, dialysis, and respiratory events occurred in 16.4% (nonintact: 21.9% vs intact: 9.7%; <em>P</em> = .06), 5.6% (nonintact:8.1% vs intact: 2.8%; <em>P</em> = .08), 5.4% (nonintact: 7.2% vs intact: 2.6%; <em>P</em> = .36), and 18.2% (nonintact: 23.1 vs intact: 10.5%; <em>P</em> = .10), respectively. No statistical differences in metaregression for nonintact vs intact TAAAs.</div></div><div><h3>Conclusions</h3><div>The indications for nonelective endovascular treatment of TAAA and cAAA are heterogeneous. Technical success is elevated while early mortality and spinal cord injuries were higher for ruptured aneurysm. Interestingly, TAAA outcomes seemed not to be influenced by rupture.</div></div>","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Pages 675-687.e3"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Retrograde open mesenteric stenting (ROMS) may provide satisfactory initial results for the treatment of mesenteric ischemia. However, this procedure remains technically demanding and its complications may lead to significantly higher morbidity, mortality, and reinterventions rates in severely ill patients. This study aimed to report stent-related complications and midterm outcomes of ROMS for acute mesenteric ischemia (AMI).
Methods
Clinical data and outcomes of all consecutive patients treated with ROMS for AMI between February 2014 and December 2021 at three university hospitals were reviewed retrospectively. End points included technical success, in-hospital mortality, postoperative complications, stent-related complications, and reinterventions. Three-year overall survival, freedom from reintervention, primary patency, and assisted primary patency rates were analyzed using the Kaplan-Meier time-to-event method.
Results
Sixty-five patients presenting with AMI were included, of which 27 (40.5%) had a history of chronic mesenteric ischemia. All patients presented with mesenteric artery occlusive disease, involving the superior mesenteric artery (in situ thrombosis, n = 46; >70% stenosis, n =19). Overall technical success rate of the ROMS procedure in the cohort was 88%. The overall intestinal resection rate in the cohort was 35.4% (n = 23 patients). In-hospital mortality rate was 31.2%. Stent-related complications at 30 days were reported in 26.3% of patients, including ROMS occlusion (n = 7), residual superior mesenteric artery lesion (dissection/thrombus, n = 4), distal stent kinking (n = 2), and stent migration (n = 2). The mean follow-up duration was 24.9 months. The estimated 3-year overall survival rate for the cohort was 59.7% (95% confidence interval [CI], 46.7%-70.5%). Eight patients required additional stent-related reinterventions during follow-up, giving an estimate of freedom from stent-related reintervention at three years of 68.2% (95% CI, 50%-81%). The estimated three-year primary patency and assisted primary patency rates were 81.3% (95% CI, 65.4%-90.4%) and 87.6% (95% CI, 72.3%-94.7%), respectively.
Conclusions
ROMS provides acceptable technical success rate and midterm outcomes but is associated with high mortality, bowel resection, and specific stent-related complication rates. Such complications, resulting in frequent reinterventions and additional mortality, could be mitigated by implementing specific technical tips.
{"title":"Technical aspects and midterm results of retrograde open mesenteric stenting for acute mesenteric ischemia","authors":"Nathanael Khayat MD , Adriane Mage MD , Iannis Ben Abdallah MD, MhD , Thierry Reix MD, PhD , Yves Castier MD, PhD , Joseph Touma MD, PhD , Arnaud Roussel MD, PhD , Jean Sénémaud MD, PhD","doi":"10.1016/j.jvs.2025.11.012","DOIUrl":"10.1016/j.jvs.2025.11.012","url":null,"abstract":"<div><h3>Background</h3><div>Retrograde open mesenteric stenting (ROMS) may provide satisfactory initial results for the treatment of mesenteric ischemia. However, this procedure remains technically demanding and its complications may lead to significantly higher morbidity, mortality, and reinterventions rates in severely ill patients. This study aimed to report stent-related complications and midterm outcomes of ROMS for acute mesenteric ischemia (AMI).</div></div><div><h3>Methods</h3><div>Clinical data and outcomes of all consecutive patients treated with ROMS for AMI between February 2014 and December 2021 at three university hospitals were reviewed retrospectively. End points included technical success, in-hospital mortality, postoperative complications, stent-related complications, and reinterventions. Three-year overall survival, freedom from reintervention, primary patency, and assisted primary patency rates were analyzed using the Kaplan-Meier time-to-event method.</div></div><div><h3>Results</h3><div>Sixty-five patients presenting with AMI were included, of which 27 (40.5%) had a history of chronic mesenteric ischemia. All patients presented with mesenteric artery occlusive disease, involving the superior mesenteric artery (in situ thrombosis, n = 46; >70% stenosis, n =19). Overall technical success rate of the ROMS procedure in the cohort was 88%. The overall intestinal resection rate in the cohort was 35.4% (n = 23 patients). In-hospital mortality rate was 31.2%. Stent-related complications at 30 days were reported in 26.3% of patients, including ROMS occlusion (n = 7), residual superior mesenteric artery lesion (dissection/thrombus, n = 4), distal stent kinking (n = 2), and stent migration (n = 2). The mean follow-up duration was 24.9 months. The estimated 3-year overall survival rate for the cohort was 59.7% (95% confidence interval [CI], 46.7%-70.5%). Eight patients required additional stent-related reinterventions during follow-up, giving an estimate of freedom from stent-related reintervention at three years of 68.2% (95% CI, 50%-81%). The estimated three-year primary patency and assisted primary patency rates were 81.3% (95% CI, 65.4%-90.4%) and 87.6% (95% CI, 72.3%-94.7%), respectively.</div></div><div><h3>Conclusions</h3><div>ROMS provides acceptable technical success rate and midterm outcomes but is associated with high mortality, bowel resection, and specific stent-related complication rates. Such complications, resulting in frequent reinterventions and additional mortality, could be mitigated by implementing specific technical tips.</div></div>","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Pages 729-737"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-10-30DOI: 10.1016/j.jvs.2025.10.036
Malachi Sheahan MD , Sarah Lauve MD , Amanda Tullos MD , John White MD , Regan Williams MD , Dawn Coleman MD , Claudie M. Sheahan MD
Background
The patterns of pediatric aortic injury have changed and the incidence of penetrating aortic trauma, secondary to ballistic injuries, is increasing. Patterns of treatment have also changed, with fewer open aortic repairs as more endovascular technologies evolve and are able to be applied to the pediatric population.
Methods
This is a review of the current available literature regarding pediatric aortic injury both penetrating and blunt in the abdominal and thoracic aorta.
Results
When comparing thoracic aortic injuries (TAIs) to abdominal aortic injuries (AAIs), TAI is associated with higher mortality rates. Overall, blunt injuries are more common than penetrating injuries, and there are higher mortality rates associated with penetrating mechanisms. Improvements in endovascular repair have facilitated improved outcomes and survival rates for blunt TAIs. Compared with blunt TAIs, blunt AAIs are more rare, and open repair is the mainstay of treatment in symptomatic or life-threatening cases.
Conclusions
Much of the data regarding the management of pediatric aortic injuries comes from limited series and case reports. Future research efforts should aim at tracking these repairs, their outcomes, and technical pitfalls to serve as a foundation for future guidelines.
{"title":"Pediatric aortic trauma: A review of the literature","authors":"Malachi Sheahan MD , Sarah Lauve MD , Amanda Tullos MD , John White MD , Regan Williams MD , Dawn Coleman MD , Claudie M. Sheahan MD","doi":"10.1016/j.jvs.2025.10.036","DOIUrl":"10.1016/j.jvs.2025.10.036","url":null,"abstract":"<div><h3>Background</h3><div>The patterns of pediatric aortic injury have changed and the incidence of penetrating aortic trauma, secondary to ballistic injuries, is increasing. Patterns of treatment have also changed, with fewer open aortic repairs as more endovascular technologies evolve and are able to be applied to the pediatric population.</div></div><div><h3>Methods</h3><div>This is a review of the current available literature regarding pediatric aortic injury both penetrating and blunt in the abdominal and thoracic aorta.</div></div><div><h3>Results</h3><div>When comparing thoracic aortic injuries (TAIs) to abdominal aortic injuries (AAIs), TAI is associated with higher mortality rates. Overall, blunt injuries are more common than penetrating injuries, and there are higher mortality rates associated with penetrating mechanisms. Improvements in endovascular repair have facilitated improved outcomes and survival rates for blunt TAIs. Compared with blunt TAIs, blunt AAIs are more rare, and open repair is the mainstay of treatment in symptomatic or life-threatening cases.</div></div><div><h3>Conclusions</h3><div>Much of the data regarding the management of pediatric aortic injuries comes from limited series and case reports. Future research efforts should aim at tracking these repairs, their outcomes, and technical pitfalls to serve as a foundation for future guidelines.</div></div>","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Pages 914-919"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-13DOI: 10.1016/j.jvs.2025.10.027
Richard J. Powell MD
{"title":"If you're not at the table, you're part of the meal","authors":"Richard J. Powell MD","doi":"10.1016/j.jvs.2025.10.027","DOIUrl":"10.1016/j.jvs.2025.10.027","url":null,"abstract":"","PeriodicalId":17475,"journal":{"name":"Journal of Vascular Surgery","volume":"83 3","pages":"Page 952"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}