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Systemic hemodynamic atherothrombotic syndrome in the young: An early phenotype of established cardiovascular disease? 年轻人的全身血流动力学动脉粥样硬化综合征:确定的心血管疾病的早期表型?
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-05-01 DOI: 10.4103/jpcs.jpcs_44_21
Andrea Rendón-Ariza, María Urueta-Gaviria, Jhon Contreras-Cabeza, Stephany A Carrera-Patiño, Ivan Lozada-Martínez
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引用次数: 1
Cardiac amyloidosis in India: A clinicopathological study 印度心脏淀粉样变性:临床病理研究
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-05-01 DOI: 10.4103/jpcs.jpcs_35_21
H. Agarwal, T. Ghosh, S. Arava, Ruma Ray, S. Seth
Background: Cardiac amyloidosis (CA) has been rarely reported from India. We aim to describe the experience of diagnosing and treating cardiac amyloid over three decades from a tertiary care center in India. Materials and Methods: Medical records were screened starting from 1987 up to 2019 and patients with histopathological diagnosis of CA were identified. The demographics, clinical presentation, investigations available, prognosis, and outcomes were retrospectively reviewed and analyzed. Results: A total of 40 patients were enrolled, out of which 26 (65%) were males. Median age at presentation was 51 years with a range of 33–65 years. Fatigue, weakness, and shortness of breath were the most common presenting symptoms. Clinical features of systemic amyloidosis including periorbital ecchymosis and macroglossia were present in 7.5% and 10% patients, respectively. Median survival from diagnosis was 2.1 years. Conclusions: Cardiac amyloid is a rarely diagnosed cause of restrictive cardiomyopathy in India and usually fatal. The patients in India are younger than the West. Endomyocardial biopsy is usually required to make a diagnosis of cardiac involvement though magnetic resonance imaging and nuclear imaging may raise a suspicion of cardiac amyloid.
背景:心脏淀粉样变性(CA)在印度很少报道。我们的目的是描述的经验,诊断和治疗心脏淀粉样蛋白超过三十年,从三级保健中心在印度。材料与方法:筛选1987年至2019年的医疗记录,筛选出经组织病理学诊断为CA的患者。回顾性回顾和分析了人口统计学、临床表现、现有调查、预后和结果。结果:共入组40例患者,其中26例(65%)为男性。发病时的中位年龄为51岁,范围为33-65岁。疲劳、虚弱和呼吸短促是最常见的症状。7.5%和10%的患者表现为系统性淀粉样变性,包括眼眶周围瘀斑和大舌肿大。诊断后的中位生存期为2.1年。结论:在印度,心肌淀粉样蛋白是一种罕见的限制性心肌病的病因,通常是致命的。印度的患者比西方年轻。通常需要心肌内膜活检来诊断心脏受累,尽管磁共振成像和核成像可能引起心脏淀粉样蛋白的怀疑。
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引用次数: 3
COVID-19, hypertension, and diabetes – Hunt for the link! COVID-19,高血压和糖尿病-寻找联系!
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-05-01 DOI: 10.4103/JPCS.JPCS_40_20
K. Saha, Shatavisa Mukherjee
The recent pandemic outbreak of coronavirus disease 2019 (COVID-19) has left everyone baffled. The exponential rise in deaths worldwide, with such an extensive rapid spread, has made it a public health emergency. While the scientists at the frontier are untiringly putting their utmost efforts to come up with evidence-based pharmacological interventions, attempts have also been made to demystify the disease link with associated comorbidities and further risk prognostication. The presence of comorbidities has been documented to be associated with increased risk of developing acute respiratory diseases. Older hypertensives have been posed to be at greater risk of being affected, with associated complications and severity in grade. Diabetic and obese individuals have also been shown to be in increased risk of infections and other complications. Cytokine storm, a major complication of this disease, has also led to adverse renal outcomes. The present review aimed to probe the possible link between COVID-19 and various comorbidities.
最近爆发的2019冠状病毒病(COVID-19)大流行让每个人都感到困惑。世界范围内死亡人数的指数增长,以及如此广泛的迅速传播,已使其成为突发公共卫生事件。当前沿的科学家们不知疲倦地尽最大努力提出以证据为基础的药理学干预措施时,人们也试图揭开这种疾病与相关合并症的联系,并进一步预测风险。共病的存在已被证明与发生急性呼吸道疾病的风险增加有关。老年高血压患者受到影响的风险更大,伴有相关并发症和严重程度。糖尿病患者和肥胖者感染和其他并发症的风险也在增加。细胞因子风暴是该疾病的主要并发症,也会导致不良的肾脏结果。本文旨在探讨COVID-19与各种合并症之间的可能联系。
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引用次数: 0
Clinical course and outcomes of heart transplant patients with COVID infection 心脏移植患者感染新冠肺炎的临床过程和结果
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-05-01 DOI: 10.4103/jpcs.jpcs_24_21
M. Sahu, Seshagiribabu Yagani, Prateek Vaswani, P. Sirohiya, S. Singh, M. Hote, S. Seth
Objective: The objective is to assess the clinical course and outcomes of heart transplant (HTx) recipients affected by COVID-19 disease in a tertiary care health care institution. Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a contagious illness with alarming morbidity and mortality. The HTx recipients are chronically immunosuppressed and thus COVID-19 infection in them may result in an unpredictable clinical course. Materials and Methods: HTx recipients in a tertiary care transplant center in North India were retrospectively reviewed from January 2020 to January 2021. Case records of 28 patients of HTx were reviewed, and four (14%) were found to have developed Covid-19 infection. Clinical parameters and outcomes of these four HTx recipients with confirmed SARS-CoV-2 infection are described. Results: Fourteen percent of our HTx patients (4 out of 28 patients under follow-up) developed COVID-19 in the first infection wave. The study population consisted of 3 males and 1 female patient with a median age of 28 years (range 15–39). The most common presenting symptoms were fever (100%), myalgia (100%) and cough (75%). There was no mortality observed in this study. None required intensive care admission or mechanical ventilatory support. Three were managed with hospital admission while one was subjected to home isolation. The mean hospital stay was 13.5 days (12–17 days). Immunosuppressants were modified by reducing tacrolimus and mycophenolate, however, corticosteroids were continued. Conclusion: The dose modification rather than discontinuation of immunomodulatory agents should be established as standard of care for transplant recipients. Steroids may provide added benefit and should be continued. The morbidity and mortality in such cases may be lower than anticipated; however, this needs to be substantiated with larger multicentric studies.
目的:评估三级医疗保健机构中受新冠肺炎疾病影响的心脏移植(HTx)受者的临床过程和结果。背景:严重急性呼吸系统综合征冠状病毒2型是一种传染性疾病,发病率和死亡率惊人。HTx接受者患有慢性免疫抑制,因此他们感染新冠肺炎可能会导致不可预测的临床过程。材料和方法:从2020年1月至2021年1月,对北印度一家三级护理移植中心的HTx接受者进行回顾性审查。审查了28名HTx患者的病例记录,发现4名(14%)患者感染了新冠肺炎。描述了这四名确诊感染严重急性呼吸系统综合征冠状病毒2型的HTx接受者的临床参数和结果。结果:14%的HTx患者(28名随访患者中的4名)在第一波感染中患上了新冠肺炎。研究人群包括3名男性和1名女性患者,中位年龄为28岁(15-39岁)。最常见的症状是发烧(100%)、肌痛(100%)和咳嗽(75%)。本研究中未观察到死亡率。无需重症监护入院或机械通气支持。其中三人入院治疗,一人居家隔离。平均住院时间为13.5天(12-17天)。免疫抑制剂通过减少他克莫司和霉酚酸酯进行修饰,但皮质类固醇仍在继续。结论:应将免疫调节剂的剂量调整而非停用作为移植受者的护理标准。类固醇可能会带来额外的好处,应该继续使用。此类病例的发病率和死亡率可能低于预期;然而,这需要通过更大规模的多中心研究来证实。
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引用次数: 0
Multidetector computed tomographic evaluation of complications following lung transplantation with clinical correlation: A single center experience from India 多探测器计算机断层扫描评价肺移植术后并发症与临床相关性:来自印度的单中心经验
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-05-01 DOI: 10.4103/jpcs.jpcs_17_21
Y. Livingstone, Thirugnanasambandan Sunder, Twinkle Dhanuka, Kapali Sunder, Paul Thangaraj, M. Kuppuswamy
Context: Lung transplantation (LT) is now being performed for end-stage lung and heart-lung disease in a few centers in India. Experience in multidetector computed tomography (MDCT) evaluation of posttransplant complications is currently limited and evolving. Aims: This study analyses the early experience in our center regarding the imaging features of complications following LT with clinical outcome correlation and identify the role of MDCT. Methodology: A retrospective study of patients who underwent LT and had MDCT imaging from January 2017 to March 2019 was performed. There were 22 patients in this period whose clinical course and CT scans were studied. Results: The complications encountered include pleural effusions, atelectasis, bronchostenosis, and reperfusion injury. Rare complications included pulmonary thromboembolism and rejection. The accuracy of computed tomography (CT) imaging in airway evaluation was high but was limited in characterization of consolidation as either infective or noninfective. Conclusions: CT is the noninvasive imaging modality of choice in evaluating chronic rejection, airway complications such as bronchostenosis and pulmonary thromboembolism. Clinical, laboratory, and biopsy correlation are needed to diagnose infection or acute rejection, both of which can present with consolidation. Temporal evaluation of events is critical. Familiarity and awareness by the radiologist are crucial for good clinical outcome.
背景:肺移植(LT)目前正在印度的一些中心进行,用于治疗终末期肺和心肺疾病。目前,多探测器计算机断层扫描(MDCT)评估移植后并发症的经验有限且不断发展。目的:本研究分析了我们中心关于LT后并发症的影像学特征与临床结果相关性的早期经验,并确定了MDCT的作用。方法:对2017年1月至2019年3月接受LT并进行MDCT成像的患者进行回顾性研究。在此期间,共有22名患者进行了临床病程和CT扫描研究。结果:并发症包括胸腔积液、肺不张、支气管狭窄和再灌注损伤。罕见的并发症包括肺血栓栓塞和排斥反应。计算机断层扫描(CT)成像在气道评估中的准确性很高,但在将合并症定性为感染性或非感染性方面受到限制。结论:CT是评估慢性排斥反应、气道并发症(如支气管狭窄和肺血栓栓塞)的无创成像方式。需要临床、实验室和活检的相关性来诊断感染或急性排斥反应,这两者都可能表现为合并。对事件的时间评估至关重要。放射科医生的熟悉程度和意识对良好的临床结果至关重要。
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引用次数: 1
Outcome of pulmonary hypertension in pregnancy in contemporary era: A case-based narrative review 当代妊娠期肺动脉高压的结局:一项基于病例的叙事回顾
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-05-01 DOI: 10.4103/jpcs.jpcs_49_21
M. Mantoo, Nayani Makkar, J. Mahidhar, U. Karuru, Devesh Kumar, S. Seth
A 35-year-old female presented to us with a history of exertional dyspnea from the last 20 years and low oxygen saturation noticed from last 1 month during her COVID-19-related illness. The patient did not seek medical attention over these years as the degree of limitation of physical activity was modest. She had a bad obstetric history: five second trimester pregnancy losses and one early neonatal death. Her symptoms were worse during pregnancy and improved thereafter. Physical examination was notable of cyanosis and features of pulmonary hypertension (PH). Echocardiography was suggestive of double outlet right ventricle, large subaortic ventricular septal defect with bidirectional shunt, and severe PH. This case highlights a variable clinical outcome of Eisenmenger syndrome in pregnancy. We did a literature review for studies reporting the outcomes of PH in pregnancy. The overall mortality rates seem to have declined dramatically from as high as 56% reported in studies in the 1990s to < 5% in more contemporary studies. The common adverse obstetric outcomes include prematurity and growth restriction.
一名35岁女性向我们提出了过去20年的劳累性呼吸困难史,并且在她的covid -19相关疾病期间的最后一个月注意到低氧饱和度。由于身体活动的限制程度不高,患者在这些年中没有寻求医疗照顾。她有不良的产科史:5次妊娠中期流产和1次新生儿早期死亡。她的症状在怀孕期间加重,此后有所改善。体格检查有明显的紫绀和肺动脉高压(PH)特征。超声心动图提示双出口右心室,主动脉下室间隔缺损大,双向分流,严重ph。本病例突出了艾森曼格综合征妊娠期临床结局的变化。我们做了一个文献综述,研究报告妊娠PH的结果。总体死亡率似乎急剧下降,从20世纪90年代研究报告的高达56%降至当代研究报告的< 5%。常见的不良产科结果包括早产和生长受限。
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引用次数: 0
A cardiovascular crossword… 心血管填字游戏…
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-05-01 DOI: 10.4103/jpcs.jpcs_42_21
Armaanjeet Singh, R. Magoon, R. Kashav, Jasvinder K Kohli
{"title":"A cardiovascular crossword…","authors":"Armaanjeet Singh, R. Magoon, R. Kashav, Jasvinder K Kohli","doi":"10.4103/jpcs.jpcs_42_21","DOIUrl":"https://doi.org/10.4103/jpcs.jpcs_42_21","url":null,"abstract":"","PeriodicalId":17503,"journal":{"name":"Journal of the Practice of Cardiovascular Sciences","volume":"7 1","pages":"170 - 171"},"PeriodicalIF":0.1,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49474467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe hypertriglyceridemia with recurrent pancreatitis treated with therapeutic plasma exchange 治疗性血浆置换治疗重症高甘油三酯血症合并复发性胰腺炎
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-01-01 DOI: 10.4103/jpcs.jpcs_99_20
A. Jain, N. Bedi, A. Garg
Severe hypertriglyceridemia (HTG) is associated with an increased risk of cardiovascular disease and acute pancreatitis. We report the case of a 34-year-old female admitted with complaints of recurrent pancreatitis and triglyceride (TG) levels above 995 mg/dl. The patient was started on therapeutic plasma exchange (TPE) to achieve a rapid fall (78%) in serum TG levels. We conclude that TPE is a safe and quick therapeutic treatment modality for patients with HTG-induced recurrent acute pancreatitis who fail to respond to conventional therapy.
严重的高甘油三酯血症(HTG)与心血管疾病和急性胰腺炎的风险增加有关。我们报告了一例34岁女性因复发性胰腺炎和甘油三酯(TG)水平高于995mg/dl而入院的病例。患者开始接受治疗性血浆置换(TPE),以实现血清TG水平的快速下降(78%)。我们的结论是,对于HTG诱导的复发性急性胰腺炎患者,TPE是一种安全快速的治疗方式,这些患者对常规治疗没有反应。
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引用次数: 0
Assessment of thirst intensity and thirst distress and the practices for its management among heart failure patients admitted to the cardiology unit 在心内科住院的心力衰竭患者中,口渴强度和口渴痛苦的评估及其管理实践
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-01-01 DOI: 10.4103/jpcs.jpcs_8_21
Karuna Thapa, Smita Das, Pragya Pathak, S. Singh
Background: Thirst is reported as a troublesome symptom in patients with heart failure (HF), and very few studies have been done to assess thirst in these patients. Therefore, this study aims to assess thirst intensity, thirst distress, and practices of HF patients to manage thirst. Methods: A descriptive, cross-sectional study was conducted on 75 HF patients admitted to the cardiology department. Purposive sampling technique was used for collecting data from July 2019 to November 2019. Visual analog scale (0–100 mm) was used to assess thirst intensity, and 8-item thirst distress scale was used to assess thirst distress. The practices of the participants were assessed using a self-developed questionnaire. Results: The mean age of the participants was 44.83 ± 15.51 years and the majority (72%) was male. The majority of the participants (82.7%) had fluid restriction, and almost 97.3% of all of the participants were receiving diuretics. The median (interquartile range) thirst intensity was 33 (16–50) mm. About 66.7% of the participants had moderate-to-severe thirst distress. Both thirst intensity and thirst distress were associated with fluid restriction, New York Heart Association functional class, and serum urea level. The participants reported that they drink a small amount of water frequently, gargle with water, eat cucumber, drink buttermilk, lemon juice, and coconut water. Very few participants had made changes in their food habits and lifestyle. Conclusion: Two-thirds of the participants had moderate-to-severe thirst distress. Fluid restriction was associated with both thirst intensity and thirst distress. Thus, nurses are responsible to assess thirst among HF patients and help them to manage their thirst effectively.
背景:据报道,口渴是心力衰竭(HF)患者的一个麻烦症状,很少有研究对这些患者的口渴进行评估。因此,本研究旨在评估心衰患者的口渴强度、口渴痛苦和控制口渴的做法。方法:对心内科收治的75例心衰患者进行描述性横断面研究。采用目的抽样方法,于2019年7月至2019年11月收集数据。采用视觉模拟量表(0 ~ 100 mm)评估口渴强度,采用8项口渴痛苦量表评估口渴痛苦。参与者的实践使用自行开发的问卷进行评估。结果:参与者的平均年龄为44.83±15.51岁,男性占72%。大多数参与者(82.7%)有液体限制,几乎97.3%的参与者接受利尿剂。口渴强度的中位数(四分位数范围)为33(16-50)毫米。约66.7%的参与者有中度至重度口渴痛苦。口渴强度和口渴痛苦与液体限制、纽约心脏协会功能分级和血清尿素水平有关。参与者报告说,他们经常喝少量的水,用水漱口,吃黄瓜,喝酪乳,柠檬汁和椰子水。很少有参与者改变了他们的饮食习惯和生活方式。结论:三分之二的参与者有中度到重度的口渴痛苦。饮水限制与口渴强度和口渴痛苦有关。因此,护士有责任评估心衰患者的口渴情况,并帮助他们有效地控制口渴。
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引用次数: 2
25-Year history of heart transplant in India: Lessons learned 印度25年的心脏移植历史:经验教训
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2021-01-01 DOI: 10.4103/jpcs.jpcs_109_20
U. Nagamalesh
{"title":"25-Year history of heart transplant in India: Lessons learned","authors":"U. Nagamalesh","doi":"10.4103/jpcs.jpcs_109_20","DOIUrl":"https://doi.org/10.4103/jpcs.jpcs_109_20","url":null,"abstract":"","PeriodicalId":17503,"journal":{"name":"Journal of the Practice of Cardiovascular Sciences","volume":"7 1","pages":"1 - 2"},"PeriodicalIF":0.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41520791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of the Practice of Cardiovascular Sciences
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