Pub Date : 2024-06-11DOI: 10.53342/pharmasci.v9i1.391
G. G. Kusumo, Nia Dwi Wahyuning Arum, Mercyska Suryandari, Andhika Dwi Aristyawan
Rosemary is a grass plant that belongs to the Lamiaceae family of the genus Rosmarinus. In addition to antioxidant activity, rosemary essential oil is also reported to have antifungal and antibacterial, anti-cancer, anti-inflammatory and anti-diabetic activities. This research aimed to determine the antioxidant activity of ethanol 50% extract of rosemary (Rosmarinus officialis L.). rosemary leaves were extracted by maceration extracting method using ethanol 50% with solvent-simplicia ratio 1: 3. Spectrophotometry Visible method with DPPH were selected to test antioxidant activity. Tests were carried out on rosemary extract with concentrations of 10 ppm, 20 ppm, 30 ppm, 40 ppm and 50 ppm with 3 replications. Meanwhile, the DPPH concentration used is 40 ppm. The IC50 of 50%’s ethanolic extract of rosemary leaves value obtained was 35.388 ppm, which shows that the 50% ethanol extract of rosemary leaves has antioxidant activity in the very strong category.
{"title":"Antioxidant Avtivity Test of 50% Ethanol Extract of Rosemary Leaves (Rosmarinus officinalis L.) using DPPH Method","authors":"G. G. Kusumo, Nia Dwi Wahyuning Arum, Mercyska Suryandari, Andhika Dwi Aristyawan","doi":"10.53342/pharmasci.v9i1.391","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.391","url":null,"abstract":"Rosemary is a grass plant that belongs to the Lamiaceae family of the genus Rosmarinus. In addition to antioxidant activity, rosemary essential oil is also reported to have antifungal and antibacterial, anti-cancer, anti-inflammatory and anti-diabetic activities. This research aimed to determine the antioxidant activity of ethanol 50% extract of rosemary (Rosmarinus officialis L.). rosemary leaves were extracted by maceration extracting method using ethanol 50% with solvent-simplicia ratio 1: 3. Spectrophotometry Visible method with DPPH were selected to test antioxidant activity. Tests were carried out on rosemary extract with concentrations of 10 ppm, 20 ppm, 30 ppm, 40 ppm and 50 ppm with 3 replications. Meanwhile, the DPPH concentration used is 40 ppm. The IC50 of 50%’s ethanolic extract of rosemary leaves value obtained was 35.388 ppm, which shows that the 50% ethanol extract of rosemary leaves has antioxidant activity in the very strong category.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141357337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.53342/pharmasci.v9i1.422
Widi Ambar Pratiwi, A. L. Nasyanka
Antibiotics are medications that combat bacterial illnesses. There are several negative health outcomes associated with the current epidemic of antibiotic resistance, including higher rates of illness and death, higher healthcare expenditures, and treatment failures. In 2015, there were an increase of 50 million unnecessary antibiotic prescriptions (Unnescecery prescribing) from 150 million, and this number continues to increase every year. Thus, the number of bacteria that are resistant to antibiotics is increasing. This study aims to determine the extent of public awareness on the utilization of antibiotics in Dusun Blungkan, Sendangrejo village, Lamongan district. The design of this research is descriptive research and data collection using questionnaires with Cronbach's alpha value of 0.83 (>0.60) then the questionnaire is declared reliable that covers 7 domains of knowledge namely understanding antibiotics, antibiotic examples, antibiotics use, dosage, contraindications, side effects, and antibiotic resistance. The results showed that in Dusun Blungkan, Sendangrejo Village, Lamongan District, and Lamongan Province there are 21 (70%) people who are aware of the use of antibiotics. Out of 30 respondents, 21 people (70%) have sufficient knowledge, 7 people (23.3%) have less knowledge, and 2 people (6.7%) have good knowledge. Controlled use of antibiotics can prevent resistance. Therefore, accurate information about the importance of antibiotics and how to use antibiotics properly and correctly is needed, as well as more wisdom in using them to avoid unexpected side effects.
{"title":"Overview of Community Knowledge about The Use of Antibotic in Blungkan Hamlet, Sendangrejo Village, Lamongan Sub-district, Lamongan District","authors":"Widi Ambar Pratiwi, A. L. Nasyanka","doi":"10.53342/pharmasci.v9i1.422","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.422","url":null,"abstract":"Antibiotics are medications that combat bacterial illnesses. There are several negative health outcomes associated with the current epidemic of antibiotic resistance, including higher rates of illness and death, higher healthcare expenditures, and treatment failures. In 2015, there were an increase of 50 million unnecessary antibiotic prescriptions (Unnescecery prescribing) from 150 million, and this number continues to increase every year. Thus, the number of bacteria that are resistant to antibiotics is increasing. This study aims to determine the extent of public awareness on the utilization of antibiotics in Dusun Blungkan, Sendangrejo village, Lamongan district. The design of this research is descriptive research and data collection using questionnaires with Cronbach's alpha value of 0.83 (>0.60) then the questionnaire is declared reliable that covers 7 domains of knowledge namely understanding antibiotics, antibiotic examples, antibiotics use, dosage, contraindications, side effects, and antibiotic resistance. The results showed that in Dusun Blungkan, Sendangrejo Village, Lamongan District, and Lamongan Province there are 21 (70%) people who are aware of the use of antibiotics. Out of 30 respondents, 21 people (70%) have sufficient knowledge, 7 people (23.3%) have less knowledge, and 2 people (6.7%) have good knowledge. Controlled use of antibiotics can prevent resistance. Therefore, accurate information about the importance of antibiotics and how to use antibiotics properly and correctly is needed, as well as more wisdom in using them to avoid unexpected side effects.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-30DOI: 10.53342/pharmasci.v9i1.316
Dyah Ayu Listyaningrum, Intan Kurnia Permatasari
Covid-19 is a highly infectious disease caused by SARS Cov-2. Antibiotics are sometimes given as therapy to patients when there is a secondary bacterial infection. The purpose of this study was to determine the treatment costs associated with using antibiotics Levofloxacin and Cefoperazone Sulbactam for mild to moderate COVID-19 patients at Bhayangkara H.S Samsoeri Mertojoso Hospital in Surabaya. For mild COVID-19 patients who receive levofloxacin antibiotic therapy, the total cost of treatment is IDR. 66,648,632 with a length of stay of 9 days. For patients with moderate degrees of COVID-19, the total cost of treatment is Rp. 81,339,295 with 10 days of hospitalization. For mild COVID-19 patients who receive cefoperazone sulbactam antibiotic therapy, the total cost of treatment is IDR. 81,401,005 with a length of stay of 11 days. For patients with moderate degrees of COVID-19, the total medical costs are Rp. 71,613,107 with 9 days of hospitalization. Based on the evaluation of research results, mild COVID-19 patients can receive levofloxacin antibiotic therapy, while moderate COVID-19 patients can receive cefoperazone sulbactam antibiotic therapy because it is cheaper and results in a shorter length of stay.
{"title":"Study of Levofloxacin and Cefoperazone-Sulbactam Utilization Cost on Patients with Mild and Moderate Corona Virus Disease-2019","authors":"Dyah Ayu Listyaningrum, Intan Kurnia Permatasari","doi":"10.53342/pharmasci.v9i1.316","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.316","url":null,"abstract":"Covid-19 is a highly infectious disease caused by SARS Cov-2. Antibiotics are sometimes given as therapy to patients when there is a secondary bacterial infection. The purpose of this study was to determine the treatment costs associated with using antibiotics Levofloxacin and Cefoperazone Sulbactam for mild to moderate COVID-19 patients at Bhayangkara H.S Samsoeri Mertojoso Hospital in Surabaya. For mild COVID-19 patients who receive levofloxacin antibiotic therapy, the total cost of treatment is IDR. 66,648,632 with a length of stay of 9 days. For patients with moderate degrees of COVID-19, the total cost of treatment is Rp. 81,339,295 with 10 days of hospitalization. For mild COVID-19 patients who receive cefoperazone sulbactam antibiotic therapy, the total cost of treatment is IDR. 81,401,005 with a length of stay of 11 days. For patients with moderate degrees of COVID-19, the total medical costs are Rp. 71,613,107 with 9 days of hospitalization. Based on the evaluation of research results, mild COVID-19 patients can receive levofloxacin antibiotic therapy, while moderate COVID-19 patients can receive cefoperazone sulbactam antibiotic therapy because it is cheaper and results in a shorter length of stay.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"226 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.53342/pharmasci.v9i1.419
Vidya Kartikaningrum
The percentage of household scale drug disposal in Indoseia is quite large. In the general society there is still a disposal of drugs in an inappropriate way. The impact of improper drug disposal can cause environmental damage. Good knowledge of proper disposal of medicines is very important to avoid risks to health and the environment. The purpose of this study was to describe the level of knowledge of the people of Sukowinganun village in Magetan city about the disposal of drugs at home. This research is descriptive analytic cross sectional approach with sampling technique using random sampling. The population of this research in the entire PKK’ mothers, Sukowinangun Village, Magetan City. The data was taken with a validated questionnaire. Questionnaires were distributed to respondents directly. A total of 45 respondents met the inclusion criteria. The results showed that the majority were aged 41-50 years (42.2%), had a college education (60%), and worked as housewives (33.3%). The results of measurements in Sukowinangun Village, Magetan District, Magetan Regency showed that 71% of the community had poor knowledge about drug disposal.
{"title":"Disposal of Drugs in Household Communities in Magetan District","authors":"Vidya Kartikaningrum","doi":"10.53342/pharmasci.v9i1.419","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.419","url":null,"abstract":"The percentage of household scale drug disposal in Indoseia is quite large. In the general society there is still a disposal of drugs in an inappropriate way. The impact of improper drug disposal can cause environmental damage. Good knowledge of proper disposal of medicines is very important to avoid risks to health and the environment. The purpose of this study was to describe the level of knowledge of the people of Sukowinganun village in Magetan city about the disposal of drugs at home. This research is descriptive analytic cross sectional approach with sampling technique using random sampling. The population of this research in the entire PKK’ mothers, Sukowinangun Village, Magetan City. The data was taken with a validated questionnaire. Questionnaires were distributed to respondents directly. A total of 45 respondents met the inclusion criteria. The results showed that the majority were aged 41-50 years (42.2%), had a college education (60%), and worked as housewives (33.3%). The results of measurements in Sukowinangun Village, Magetan District, Magetan Regency showed that 71% of the community had poor knowledge about drug disposal.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"67 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ethnopharmacy is the pharmaceutical science that studies using and treating medicinal plants from certain ethnic groups or ethnic groups. The people of Bollangi Hamlet, Pattallassang District, and Gowa Regency have been using medicinal plants to treat diseases for generations because they have access to treatment, such as the local health center, and the hospital is quite far away. This study aims to determine the types of plants and parts of plants that are used in traditional medicine, how to process them, how to use them, and types of plants that have the potential to be further studied for their bioactivity. This research uses a descriptive research type combining qualitative and quantitative methods. Qualitative research was conducted by way of interviews and experiences of respondents. Based on the research results, it is known that there are 20 types of plants used in traditional medicine. The processing methods are boiling, pounded, and consumed directly. The method of use is by drinking, smearing/pasting, eating/chewing, and plants that have the potential to be further studied for their bioactivity are Guava and Garlic.
{"title":"Ethnopharmaceutical Study of Efficacious Plants As Medicine in Bollangi Hamlet, Pattallassang District, Gowa Regency","authors":"Neneng Wildayanti Putri, Sisilia Teresia Rosmala Dewi, Dwi Rachmawaty","doi":"10.53342/pharmasci.v9i1.392","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.392","url":null,"abstract":"Ethnopharmacy is the pharmaceutical science that studies using and treating medicinal plants from certain ethnic groups or ethnic groups. The people of Bollangi Hamlet, Pattallassang District, and Gowa Regency have been using medicinal plants to treat diseases for generations because they have access to treatment, such as the local health center, and the hospital is quite far away. This study aims to determine the types of plants and parts of plants that are used in traditional medicine, how to process them, how to use them, and types of plants that have the potential to be further studied for their bioactivity. This research uses a descriptive research type combining qualitative and quantitative methods. Qualitative research was conducted by way of interviews and experiences of respondents. Based on the research results, it is known that there are 20 types of plants used in traditional medicine. The processing methods are boiling, pounded, and consumed directly. The method of use is by drinking, smearing/pasting, eating/chewing, and plants that have the potential to be further studied for their bioactivity are Guava and Garlic.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"11 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.53342/pharmasci.v9i1.389
Aulia Dyah Kartika, Lailatus Sa'diyah
Kombucha is a drink made from tea and sugar fermented by SCOBY. One of the ingredients in kombucha that is good for the body is vitamin C. Vitamin C can increase immunity and prevent the body from free radicals. Vitamin C in kombucha is formed through a fermentation process by remodeling glucose. This research aimed to determine the comparison of vitamin C levels in kombucha with 3 and 6 days shelf life. Measurement of vitamin C levels using the UV-Vis spectrophotometry method by measuring absorbance at a maximum wavelength of 248 nm which is then calculated using a linear regression equation and measuring the pH of the preparation. Sampling by pipetting as much as 10 ml kombucha then put into a 100 ml measuring flask and add aquadest up to the mark. The results of the research showed that vitamin C levels in rose kombucha after being stored for 3 days decreased 5.05% and after being stored for 6 days, vitamin C increased by 5.32%. Therefore, the pH of rose flower kombucha also decreased after 7 days of fermentation but stays constant after being stored for 3 and 6 days (pH 4).
昆布茶是一种由茶和糖经 SCOBY 发酵而成的饮料。昆布茶中对人体有益的成分之一是维生素 C。昆布茶中的维生素 C 是通过重塑葡萄糖的发酵过程形成的。这项研究旨在确定保质期为 3 天和 6 天的昆布茶中维生素 C 含量的比较。使用紫外可见分光光度法测量维生素 C 含量，方法是测量最大波长 248 纳米处的吸光度，然后使用线性回归方程进行计算，并测量制剂的 pH 值。用移液管取样，取 10 毫升昆布茶放入 100 毫升的量瓶中，然后加入适量的水。研究结果表明，玫瑰花昆布茶存放 3 天后，维生素 C 含量下降了 5.05%；存放 6 天后，维生素 C 含量增加了 5.32%。因此，玫瑰花昆布茶的 pH 值在发酵 7 天后也有所下降，但在存放 3 天和 6 天后保持不变（pH 值为 4）。
{"title":"Comparison of Vitamin C Levels in Rose Kombucha (Rosa hybrida) during Storage","authors":"Aulia Dyah Kartika, Lailatus Sa'diyah","doi":"10.53342/pharmasci.v9i1.389","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.389","url":null,"abstract":"Kombucha is a drink made from tea and sugar fermented by SCOBY. One of the ingredients in kombucha that is good for the body is vitamin C. Vitamin C can increase immunity and prevent the body from free radicals. Vitamin C in kombucha is formed through a fermentation process by remodeling glucose. This research aimed to determine the comparison of vitamin C levels in kombucha with 3 and 6 days shelf life. Measurement of vitamin C levels using the UV-Vis spectrophotometry method by measuring absorbance at a maximum wavelength of 248 nm which is then calculated using a linear regression equation and measuring the pH of the preparation. Sampling by pipetting as much as 10 ml kombucha then put into a 100 ml measuring flask and add aquadest up to the mark. The results of the research showed that vitamin C levels in rose kombucha after being stored for 3 days decreased 5.05% and after being stored for 6 days, vitamin C increased by 5.32%. Therefore, the pH of rose flower kombucha also decreased after 7 days of fermentation but stays constant after being stored for 3 and 6 days (pH 4).","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"24 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.53342/pharmasci.v9i1.388
Safira Evani, Litalia Early Katreen Juniar, Meyke Herina Syafitri
Red betel (Piper crocatum Ruiz & Pav) and black betel leaves (Piper betle var. nigra) are plant varieties known for their medicinal properties. These plants have various contents including flavonoids, essential oils, tannins and polyphenols. The objective of this research is to ascertain the quantity of phenolic compounds present in ethanol extracts of red and black betel leaves. Determination of the levels of ethanol extracts of red and black betel leaves is done quantitatively by the folin-ciocalteu method. This method relies on the formation of a blue complex compound of of phosphomolybdat-phosphotungstat, generated by the reduction of phenolic compounds in an alkaline environment. The measurement is performed using uv-vis spectrophotometry. Gallic acid, derived from hydroxybenzoic acid and identified as a simple phenolic acid, is employed. This stable and pure polyphenolic compound is commonly found in almost all plants. Drawing conclusions from the study results, it can be affirmed that the average total phenol concentration of red betel was 31.87 GAE per gram extract and the average total phenol concentration of black betel leaves was 39.09 mg GAE per gram extract.
{"title":"Quantification of Total Phenol Concentration in Ethanol Extracts of Red and Black Betel Leaves Using UV-Vis Spectrophotometric","authors":"Safira Evani, Litalia Early Katreen Juniar, Meyke Herina Syafitri","doi":"10.53342/pharmasci.v9i1.388","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.388","url":null,"abstract":"Red betel (Piper crocatum Ruiz & Pav) and black betel leaves (Piper betle var. nigra) are plant varieties known for their medicinal properties. These plants have various contents including flavonoids, essential oils, tannins and polyphenols. The objective of this research is to ascertain the quantity of phenolic compounds present in ethanol extracts of red and black betel leaves. Determination of the levels of ethanol extracts of red and black betel leaves is done quantitatively by the folin-ciocalteu method. This method relies on the formation of a blue complex compound of of phosphomolybdat-phosphotungstat, generated by the reduction of phenolic compounds in an alkaline environment. The measurement is performed using uv-vis spectrophotometry. Gallic acid, derived from hydroxybenzoic acid and identified as a simple phenolic acid, is employed. This stable and pure polyphenolic compound is commonly found in almost all plants. Drawing conclusions from the study results, it can be affirmed that the average total phenol concentration of red betel was 31.87 GAE per gram extract and the average total phenol concentration of black betel leaves was 39.09 mg GAE per gram extract.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.53342/pharmasci.v9i1.412
Farach Khanifah, Evi Puspita Sari, Gerry Nugraha
A Depression is a mental problem that is common in all communities, including teenagers. It is estimated that 10-20% of teenagers in the world experience mental health problems. Turmeric at a dose of 560mg/KgBW was shown to be effective as an antidepressant in Wistar rats (rattus norvegicus). Computers offer in silico test methods as a complement to in vitro and in vivo methods which are commonly used in the process of discovering and developing the biological activity of chemical compounds or natural materials as drug candidates. The research results show that MD simulations on the serotonin transporter complex protein with the ligand Demethoxycurcumin are more stable than curcumin and fluvoxamine. The results of identifying the molecular dynamics determinant of binding with the native ligand are amino acid SER336 and the reference ligand is amino acid SER438.
{"title":"Stability of Serotonin Transporter Essential Amino Acid Complex with Curcumin and Demethoxycurcumin Compounds as Antidepressant Candidates Based on In Silico Test","authors":"Farach Khanifah, Evi Puspita Sari, Gerry Nugraha","doi":"10.53342/pharmasci.v9i1.412","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.412","url":null,"abstract":"A Depression is a mental problem that is common in all communities, including teenagers. It is estimated that 10-20% of teenagers in the world experience mental health problems. Turmeric at a dose of 560mg/KgBW was shown to be effective as an antidepressant in Wistar rats (rattus norvegicus). Computers offer in silico test methods as a complement to in vitro and in vivo methods which are commonly used in the process of discovering and developing the biological activity of chemical compounds or natural materials as drug candidates. The research results show that MD simulations on the serotonin transporter complex protein with the ligand Demethoxycurcumin are more stable than curcumin and fluvoxamine. The results of identifying the molecular dynamics determinant of binding with the native ligand are amino acid SER336 and the reference ligand is amino acid SER438.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"299 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140500929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-22DOI: 10.53342/pharmasci.v9i1.351
Maya Herlinawaty, Ninik Mas Ulfa, Tri Doso Sapto Agus Priyono
Drug interactions are interactions that can occur if the effects of a drug are changed by other drugs, food or drinks. The aim of this research is to determine the potential for interactions between antibiotics and other drugs prescribed to asthma patients. Antibiotics are the drugs most widely used for infections caused by bacteria. Determining the mechanism of potential interactions between antibiotics and other drugs prescribed to asthma patients in this study using the Medscape application. The research results showed that there were 2044 prescriptions for the period Juli - December 2022, which provided the highest potential for drug interactions, namely interactions with pharmacokinetic mechanisms in the metabolic phase with 69 incidents (20.47%). Meanwhile, the highest level of severity was monitoring closely, 291 (86.35%) and those with the potential for serious interactions were 46 incidents (13.65%). In this research, the active role of Pharmacy Technicians and Pharmacists is needed to monitor the use of drugs that have the potential to cause drug interactions with prescribing doctors in the hope that undesirable drug interactions can be avoided.
{"title":"Antibiotic Drug Interaction in Prescribing Asthma Patients in One of the Clinics in the Surabaya Area","authors":"Maya Herlinawaty, Ninik Mas Ulfa, Tri Doso Sapto Agus Priyono","doi":"10.53342/pharmasci.v9i1.351","DOIUrl":"https://doi.org/10.53342/pharmasci.v9i1.351","url":null,"abstract":"Drug interactions are interactions that can occur if the effects of a drug are changed by other drugs, food or drinks. The aim of this research is to determine the potential for interactions between antibiotics and other drugs prescribed to asthma patients. Antibiotics are the drugs most widely used for infections caused by bacteria. Determining the mechanism of potential interactions between antibiotics and other drugs prescribed to asthma patients in this study using the Medscape application. The research results showed that there were 2044 prescriptions for the period Juli - December 2022, which provided the highest potential for drug interactions, namely interactions with pharmacokinetic mechanisms in the metabolic phase with 69 incidents (20.47%). Meanwhile, the highest level of severity was monitoring closely, 291 (86.35%) and those with the potential for serious interactions were 46 incidents (13.65%). In this research, the active role of Pharmacy Technicians and Pharmacists is needed to monitor the use of drugs that have the potential to cause drug interactions with prescribing doctors in the hope that undesirable drug interactions can be avoided.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140500532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.53342/pharmasci.v9i1.350
Femiko Salsabil, Mariawati, Hilya Nur Imtihani
Mangrove Crab (Scylla serrata) is an animal that likes to be consumed but its shell waste is underutilized. The shell contains chitosan which has many benefits, one of which can lower cholesterol levels. The combination of 2 or more excipients is called co-processed excipients which are then continued into tablets by direct compression. The aim of the study was to find out whether chitosan could be formalized into coprocessed tablets (lactose, primogel, and PEG 4000 7.5% & 15%) by direct compression method and the effect of differences in the characteristics of coprocessed and chitosan tablets with a ratio of PEG 4000 7.5% and 15 % as binder. The evaluation results showed that chitosan tablets fulfilled the requirements for the uniformity of weight, hardness, disintegration time (F1) tests, while they did not meet the requirements for the uniformity of tablet size, friability and disintegration times (F2) tests and the results of the coprocessing evaluation met specifications both F1 and F2, namely: particle size distribution, moisture content, flow rate, angle of repose (very good), compressibility index (adequate) and Hausner's ratio (very good). The evaluation results were then processed statistically using the SPSS application using the independent t-test method which showed that there was no significant difference in the effect of PEG 4000 7.5% and 15% as a binder on the characteristics of co-processed and chitosan tablets. Chitosan tablets from mangrove crab shells (Scylla serrata) cannot be formalized by direct compression with co-processing.
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