Aim: In this study, it was aimed to investigate the effects of demodicosis on oxidative stress in dogs. Materials and Methods: The material of the study is based on a total of 32 dogs, 21 of which are diagnosed with demodicosis and 11 of which are healthy, with different ages, genders and breeds. Examination for diagnostic evaluation of demodex is performed by examining the samples under the microscope which are taken by trichogram and deep skin scraping methods. In order to evaluate the oxidative stress on dogs with demodicosis at pre and post treatment groups and the control group without demodex diagnosis, the values of SOD (Superoxide dismutase), GPX (Glutation Peroxidase), GSH (Glutation) as antioxidant and MDA (Malondialdehyde) as oxidant are investigated. Results ?: In clinical examinations, manifestations such as alopecia, erythema, generalized pruritus, hyperpigmentation, lichenification, pododermatitis, interdigital pruritus, lymphadenopathy are observed on dogs with demodicosis on pre and post treatment stages. In the analyzes performed in order to evaluate the oxidative stress, MDA 20.30 nmol/ml, GSH 4.9 nmol/ml, GPx 0.42 U/l, SOD 4.1 U/l are measured in dogs with clinical demodicosis. At the post treatment stage, the average values on the same dogs are measured as MDA 6.08 nmol/ml, GSH 8.11 nmol/ml, GPx 0.83 U/l, SOD 6.67 U/l, whilst in the control group they were measured as MDA 4.94 nmol/ml, GSH 9.73 nmol/ml, GPx 0.97 U/l, SOD 7.20 U/l. It is obtained that, GSH, GPx and SOD values in the control and post treatment groups are significantly higher (p˂0.001) and MDA value is lower (p˂0.001) than the clinical demodicosis group. Conslusion: In dogs with clinical demodicosis, compared to control and post-treatment, higher level of MDA which is oxidant and lower level of GSA, GPx and SOD which are antioxidants showed that demodex is caused oxidative stress.
{"title":"Evaluation Of Oxidative Stress On Dogs With Demodicosis","authors":"Gözde Nur Si̇vel, B. Yagci","doi":"10.47748/tjvr.1119988","DOIUrl":"https://doi.org/10.47748/tjvr.1119988","url":null,"abstract":"Aim: In this study, it was aimed to investigate the effects of demodicosis on oxidative stress in dogs. \u0000Materials and Methods: The material of the study is based on a total of 32 dogs, 21 of which are diagnosed with demodicosis and 11 of which are healthy, with different ages, genders and breeds. Examination for diagnostic evaluation of demodex is performed by examining the samples under the microscope which are taken by trichogram and deep skin scraping methods. In order to evaluate the oxidative stress on dogs with demodicosis at pre and post treatment groups and the control group without demodex diagnosis, the values of SOD (Superoxide dismutase), GPX (Glutation Peroxidase), GSH (Glutation) as antioxidant and MDA (Malondialdehyde) as oxidant are investigated. \u0000Results ?: In clinical examinations, manifestations such as alopecia, erythema, generalized pruritus, hyperpigmentation, lichenification, pododermatitis, interdigital pruritus, lymphadenopathy are observed on dogs with demodicosis on pre and post treatment stages. In the analyzes performed in order to evaluate the oxidative stress, MDA 20.30 nmol/ml, GSH 4.9 nmol/ml, GPx 0.42 U/l, SOD 4.1 U/l are measured in dogs with clinical demodicosis. At the post treatment stage, the average values on the same dogs are measured as MDA 6.08 nmol/ml, GSH 8.11 nmol/ml, GPx 0.83 U/l, SOD 6.67 U/l, whilst in the control group they were measured as MDA 4.94 nmol/ml, GSH 9.73 nmol/ml, GPx 0.97 U/l, SOD 7.20 U/l. It is obtained that, GSH, GPx and SOD values in the control and post treatment groups are significantly higher (p˂0.001) and MDA value is lower (p˂0.001) than the clinical demodicosis group. \u0000Conslusion: In dogs with clinical demodicosis, compared to control and post-treatment, higher level of MDA which is oxidant and lower level of GSA, GPx and SOD which are antioxidants showed that demodex is caused oxidative stress.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132123137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Apoptosis is a programmed cell death mechanism, with its presence and absence, directs the progression of most diseases and is targeted in disease treatments. Many factors are influential in the cell's pathway to apoptosis. The defects in these pathways may transform the cell become malignant, and the organism may face a lethal outcome such as cancer. Understanding apoptosis will provide clues in guiding the pathogenesis of diseases. Two main pathway leading to apoptosis, intrinsic and extrinsic, take an active role. Another route is activated by enzymes and enzymes secreted by immune cells such as T and NK. With their initiator and enforcer roles, many caspase molecules are active at critical points in the cell's apoptosis process. In cancer treatments, activation of molecules in these pathways and repair of disrupted pathways are among the target approaches. This review discuss target strategies for inhibiting apoptotic pathways and molecules in cancer cells and the activation of these apoptotic pathways.
{"title":"The Molecular Biology of Apoptosis","authors":"Melisa BEYHAN YILMAZ, D. Muz","doi":"10.47748/tjvr.1121211","DOIUrl":"https://doi.org/10.47748/tjvr.1121211","url":null,"abstract":"Apoptosis is a programmed cell death mechanism, with its presence and absence, directs the progression of most diseases and is targeted in disease treatments. Many factors are influential in the cell's pathway to apoptosis. The defects in these pathways may transform the cell become malignant, and the organism may face a lethal outcome such as cancer. Understanding apoptosis will provide clues in guiding the pathogenesis of diseases. Two main pathway leading to apoptosis, intrinsic and extrinsic, take an active role. Another route is activated by enzymes and enzymes secreted by immune cells such as T and NK. With their initiator and enforcer roles, many caspase molecules are active at critical points in the cell's apoptosis process. In cancer treatments, activation of molecules in these pathways and repair of disrupted pathways are among the target approaches. This review discuss target strategies for inhibiting apoptotic pathways and molecules in cancer cells and the activation of these apoptotic pathways.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125716995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Raw milk is an important source of nutrients. Therefore, today, there is a great demand for raw milk consumption. The positive side of milk consumption on growth and development cannot be ignored, but unfortunately, pathogens in raw milk are always potential public health risks for transmission pathogens. Bacteria such as Enterobacteriaceae in normal flora can cause serious problems due to their extended-spectrum beta-lactamase (ESBL) production. These bacteria and their resistance genes have been reported in raw milk. In this matter, the aim of the study is to determine the status of blaCTX-M-1, blaCTX-M-2, blaTEM, and blaSHV genes responsible for the production of ESBL enzyme in Escherichia coli and Klebsiella spp. strains to identify risk factors in raw milk consumption and to gain an understanding of the epidemiology of these resistant strains. Materials and methods: A total of different 50 raw milk samples were collected and subjected to phenotypic microbiological analysis and Real-time PCR targeting blaCTX-M-1, blaCTX-M-2, blaTEM, and blaSHV genes. In the phenotypic analyses, suspicious isolates were identified by classical microbiological methods and antibiotic resistance profiles were revealed. Results: These results indicated that raw milk is a potential reservoir for ESBL producing E. Coli, Klebsiella spp. strains are obviously significant. And It was determined that CTX-M based ESBL genes are predominant in ESBL production. The present study revealed that raw milk is epidemiologically involved in the transmission of ESBL genes. Raw milk could be distributed to ESBL genes widely with which is consumed in Şanlı Urfa.
{"title":"A Molecular Investigation of Extended Spectrum Beta-Lactamase genes in Escherichia coli and Klebsiella spp. in raw cow Milk","authors":"M. Demirci, A. Yiğin, Serap Kılıç Altun, S. Ekici","doi":"10.47748/tjvr.1092631","DOIUrl":"https://doi.org/10.47748/tjvr.1092631","url":null,"abstract":"Objective: Raw milk is an important source of nutrients. Therefore, today, there is a great demand for raw milk consumption. The positive side of milk consumption on growth and development cannot be ignored, but unfortunately, pathogens in raw milk are always potential public health risks for transmission pathogens. Bacteria such as Enterobacteriaceae in normal flora can cause serious problems due to their extended-spectrum beta-lactamase (ESBL) production. These bacteria and their resistance genes have been reported in raw milk. In this matter, the aim of the study is to determine the status of blaCTX-M-1, blaCTX-M-2, blaTEM, and blaSHV genes responsible for the production of ESBL enzyme in Escherichia coli and Klebsiella spp. strains to identify risk factors in raw milk consumption and to gain an understanding of the epidemiology of these resistant strains. \u0000Materials and methods: A total of different 50 raw milk samples were collected and subjected to phenotypic microbiological analysis and Real-time PCR targeting blaCTX-M-1, blaCTX-M-2, blaTEM, and blaSHV genes. In the phenotypic analyses, suspicious isolates were identified by classical microbiological methods and antibiotic resistance profiles were revealed. \u0000Results: These results indicated that raw milk is a potential reservoir for ESBL producing E. Coli, Klebsiella spp. strains are obviously significant. And It was determined that CTX-M based ESBL genes are predominant in ESBL production. The present study revealed that raw milk is epidemiologically involved in the transmission of ESBL genes. Raw milk could be distributed to ESBL genes widely with which is consumed in Şanlı Urfa.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117100965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In contrary to most domestic livestock species, the common donkey (Equus asinus) is widely known as an animal with a marked seasonality in reproductive activity .The annual cycle of daily photoperiod has been identified as the determining factor in the sexual activity. A synthesis of the particularities of donkey reproduction is important and constitutes a basis of scientific reflection for managing asine livestock farms and to establish a well conservation plan for the different breeds around the world. It is necessary to have a perfect knowledge of the seasonal physiological changes in order to optimize the reproductive characteristics in donkeys.The objective of this paper is to review the current state of knowledge on the reproductionseasonality in common donkey. We start with a remainder of some anatomical of the genital apparatus and sexual behavior aspects. Moreover, the investigations undertaken by many authors reveal the influence of the season on testicular biometry, histology, seminal and hormonal parameters in male donkeys’ populations. In conclusion, despite scientific controversy on reproductive seasonal character in donkeys, it could likely be influenced by several factors mainly the photoperiod.
{"title":"Some reproductive characteristics in common donkey male (Equus asinus)-A mini review","authors":"S. Aissanou, O. Besseboua, A. Ayad","doi":"10.47748/tjvr.1083287","DOIUrl":"https://doi.org/10.47748/tjvr.1083287","url":null,"abstract":"In contrary to most domestic livestock species, the common donkey (Equus asinus) is widely known as an animal with a marked seasonality in reproductive activity .The annual cycle of daily photoperiod has been identified as the determining factor in the sexual activity. A synthesis of the particularities of donkey reproduction is important and constitutes a basis of scientific reflection for managing asine livestock farms and to establish a well conservation plan for the different breeds around the world. It is necessary to have a perfect knowledge of the seasonal physiological changes in order to optimize the reproductive characteristics in donkeys.The objective of this paper is to review the current state of knowledge on the reproductionseasonality in common donkey. We start with a remainder of some anatomical of the genital apparatus and sexual behavior aspects. Moreover, the investigations undertaken by many authors reveal the influence of the season on testicular biometry, histology, seminal and hormonal parameters in male donkeys’ populations. In conclusion, despite scientific controversy on reproductive seasonal character in donkeys, it could likely be influenced by several factors mainly the photoperiod.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133498920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study was to examine the opinions of first year veterinary faculty students about the use of plastinated anatomic prosections in addition to wet cadavers in anatomy practical lessons. Materials and Methods: The students were shown plastinated organs and organs fixed in formaldehyde. Then a questionnaire comprising 7 questions was administered to the 100 student participants. The questionnaire responses were analyzed statistically using SPSS vn. 22.0 Frequencies software. Results: In response to question 1, 58.4% of the students thought that there was no anatomic difference between the plastinated organs and the organs fixed in formaldehyde. In contrast to the strong smell of formaldehyde, 88% of the students stated that the plastinates were odourless. The use of plastinated organs was thought to improve the quality of education by 89.1% of the students, compared to the negative aspects of formaldehyde. It was stated by 84.2% of the students that plastinated organs should be included in anatomy lessons due to the thoughts of the majority of the students that plastinated tissues could make a greater contribution to anatomy lessons. In response to the final question, 92.1% of the students stated that they felt no abhorrence of the plastinated organs. Conclusion: Plastination may be especially useful for educational institutions without access, space, or the financial resources for dissection, and can emphasize unique or pathological samples. The results of this study demonstrated that plastinated samples were perceived as a useful addition to traditional resources in the teaching of anatomy.
{"title":"Perceptions of Students About the Use of Plastination in Anatomy Lessons","authors":"B. Güzel, Saime Betül Baygeldi, E. Özkan","doi":"10.47748/tjvr.1117331","DOIUrl":"https://doi.org/10.47748/tjvr.1117331","url":null,"abstract":"Objective: This study was to examine the opinions of first year veterinary faculty students about the use of plastinated anatomic prosections in addition to wet cadavers in anatomy practical lessons. \u0000Materials and Methods: The students were shown plastinated organs and organs fixed in formaldehyde. Then a questionnaire comprising 7 questions was administered to the 100 student participants. The questionnaire responses were analyzed statistically using SPSS vn. 22.0 Frequencies software. \u0000Results: In response to question 1, 58.4% of the students thought that there was no anatomic difference between the plastinated organs and the organs fixed in formaldehyde. In contrast to the strong smell of formaldehyde, 88% of the students stated that the plastinates were odourless. The use of plastinated organs was thought to improve the quality of education by 89.1% of the students, compared to the negative aspects of formaldehyde. It was stated by 84.2% of the students that plastinated organs should be included in anatomy lessons due to the thoughts of the majority of the students that plastinated tissues could make a greater contribution to anatomy lessons. In response to the final question, 92.1% of the students stated that they felt no abhorrence of the plastinated organs. \u0000Conclusion: Plastination may be especially useful for educational institutions without access, space, or the financial resources for dissection, and can emphasize unique or pathological samples. The results of this study demonstrated that plastinated samples were perceived as a useful addition to traditional resources in the teaching of anatomy.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129552474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to compare the fertility parameters in response to pregnant mare serum gonadotropin (conventional treatment) or gonadotrophin-releasing hormone (alternative treatment) in Romanov sheep subjected to a 7-d short-term protocol out of breeding season. Materials and Methods: Sheep (n=57) received an intravaginal sponge impregnated with 20 mg fluorogestone acetate for 7 days and 125 µg cloprostenol at sponge removal. Sheep were randomly assigned to receive no treatment (CON, n=16), 240 IU pregnant mare serum gonadotropin (PMSG, n=24) at sponge removal or 10 µg busereline acetate (GnRH, n=17) at 30 h after sponge removal. Results: Estrous response and pregnancy rate were 86% and 75.4% in all sheep, respectively. Estrous response was numerically higher about 7% (p>0.05) in treatment groups (PMSG, 87.5%; GnRH, 88.2%) than CON (81.2%). However, pregnancy rate was numerically higher in PMSG (83.3%) than GnRH (70.6%) and CON (68.7%). As in pregnancy rate, lambing rate was approximately 15% numerically greater (p>0.05) in the PMSG (79.1%) than in GnRH (64.7%) and CON (62.5%) groups. Similarly, litter size numerically higher (p>0.05) in PMSG (2.1) than GnRH (1.9) and CON (1.9) groups. Conclusion: The use of GnRH offered similar estrous response compared to PMSG in Romanov sheep synchronized with short-term protocol. However, PMSG had numerically higher pregnancy rate, lambing rate, and litter size than GnRH. Considering the serious ethical concerns and animal welfare for the production of PMSG, it is necessary to use alternatively gonadotropins. Comprehensive studies are needed to compare the fertility parameters between PMSG and GnRH in Romanov sheep.
{"title":"Comparison of fertility parameters in Romanov sheep synchronized with progesterone-based protocol plus PMSG or GnRH","authors":"B. Güner, Ebru Karakaya Bilen","doi":"10.47748/tjvr.1120029","DOIUrl":"https://doi.org/10.47748/tjvr.1120029","url":null,"abstract":"Objective: The aim of this study was to compare the fertility parameters in response to pregnant mare serum gonadotropin (conventional treatment) or gonadotrophin-releasing hormone (alternative treatment) in Romanov sheep subjected to a 7-d short-term protocol out of breeding season. \u0000Materials and Methods: Sheep (n=57) received an intravaginal sponge impregnated with 20 mg fluorogestone acetate for 7 days and 125 µg cloprostenol at sponge removal. Sheep were randomly assigned to receive no treatment (CON, n=16), 240 IU pregnant mare serum gonadotropin (PMSG, n=24) at sponge removal or 10 µg busereline acetate (GnRH, n=17) at 30 h after sponge removal. \u0000Results: Estrous response and pregnancy rate were 86% and 75.4% in all sheep, respectively. Estrous response was numerically higher about 7% (p>0.05) in treatment groups (PMSG, 87.5%; GnRH, 88.2%) than CON (81.2%). However, pregnancy rate was numerically higher in PMSG (83.3%) than GnRH (70.6%) and CON (68.7%). As in pregnancy rate, lambing rate was approximately 15% numerically greater (p>0.05) in the PMSG (79.1%) than in GnRH (64.7%) and CON (62.5%) groups. Similarly, litter size numerically higher (p>0.05) in PMSG (2.1) than GnRH (1.9) and CON (1.9) groups. \u0000Conclusion: The use of GnRH offered similar estrous response compared to PMSG in Romanov sheep synchronized with short-term protocol. However, PMSG had numerically higher pregnancy rate, lambing rate, and litter size than GnRH. Considering the serious ethical concerns and animal welfare for the production of PMSG, it is necessary to use alternatively gonadotropins. Comprehensive studies are needed to compare the fertility parameters between PMSG and GnRH in Romanov sheep.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114026415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bu çalışmada Kocaeli ilinde kliniklere getirilen kedi ve köpeklerde görülen kulak hastalıklarının prevelansının belirlenmesi amaçlandı. Bu amaçla Kocaeli ilinde kliniğe getirilen 112 kedi ve köpeğin genel kulak muayenesi gerçekleştirilmiş ve otoskopla kulak kanalı ve kulak zarı incelenmiştir. Ayrıca radyografik görüntüleme yöntemleri (röntgen), mikrobiyolojik ve histopatolojik muayeneler yapılmıştır. Hastalıklar teşhis edildikten sonra kaydedilmiş ve kulak hastalıkları ile ilgili değerlendirmeler istatistiksel olarak değerlendirilmiştir. Araştırma sonucunda Kocaeli’nde kulak hastalıkları prevelansının (%12,9) olduğu; hayvanların temizlik, beslenme ve barınma koşullarının iyileştirilmesinin bu olguların azalmasında etkili olacağı, periyodik olarak klinik muayenelerinin yapılmasının bu hastalıkların tanısının erken konularak hızlı ve etkili bir tedavi sürecine olanak sağlayacağı belirlenmiştir.
{"title":"The Prevalance of Ear Diseases in Cat and Dogs in Kocaeli Provinces","authors":"I. Canpolat, M. Tanrısever, Selçuk Başer","doi":"10.47748/tjvr.1091743","DOIUrl":"https://doi.org/10.47748/tjvr.1091743","url":null,"abstract":"Bu çalışmada Kocaeli ilinde kliniklere getirilen kedi ve köpeklerde görülen kulak hastalıklarının prevelansının belirlenmesi amaçlandı. Bu amaçla Kocaeli ilinde kliniğe getirilen 112 kedi ve köpeğin genel kulak muayenesi gerçekleştirilmiş ve otoskopla kulak kanalı ve kulak zarı incelenmiştir. Ayrıca radyografik görüntüleme yöntemleri (röntgen), mikrobiyolojik ve histopatolojik muayeneler yapılmıştır. Hastalıklar teşhis edildikten sonra kaydedilmiş ve kulak hastalıkları ile ilgili değerlendirmeler istatistiksel olarak değerlendirilmiştir. Araştırma sonucunda Kocaeli’nde kulak hastalıkları prevelansının (%12,9) olduğu; hayvanların temizlik, beslenme ve barınma koşullarının iyileştirilmesinin bu olguların azalmasında etkili olacağı, periyodik olarak klinik muayenelerinin yapılmasının bu hastalıkların tanısının erken konularak hızlı ve etkili bir tedavi sürecine olanak sağlayacağı belirlenmiştir.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"8 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130357249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ş. Aras, Pinar Aksu Kilicle, S. Eliş Yıldız, Erhan Uluman, B. Bakır, E. Karadağ Sarı, S. Dağ
Objective: This study aimed to investigate the effects of Chia (Salvia hispanica L.) oil and Dandelion (Taraxacum Officinale) extract on Tumor Necrosis Factor-α (TNF-α) and Interleukin 6 (IL-6) release in liver tissue of diabetic rats. Material and Method: Experimental groups were created as control, sham, chia, dandelion, diabetes (DM), diabetes+chia (DC), and diabetes +dandelion (DD). Body weight and blood glucose measurements were taken on the 1st, 3rd, and 17th days of the study and evaluated statistically. A one-way ANOVA test was performed to determine the differences between the groups. The Duncan test was used to compare significant differences between groups. At the end of the study, Masson's trichrome staining and Hematoxylin-Eosin staining were employed for histological examinations of liver tissues, and the distribution of TNF-α and IL-6 was examined by applying the Streptavidin-biotin peroxidase method. Results: It was determined that body weight and blood glucose measurements were significantly decrease for the DC group compared to other groups. Immunoreactivity of TNF-α and IL-6 was found to decrease in DC and DD groups at close to the control levels. Conclusion: Based on our results, it was thought that the use of chia and dandelion in diabetes may contribute to the alleviation of disease-related complications by having a positive effect on proinflammatory cytokine levels.
{"title":"Determination of the effects of Chia (Salvia hispanica L.) oil and Dandelion (Taraxacum Officinale) extract on Tumor Necrosis Factor-α (TNF-α) and Interleukin 6 (IL-6) release in liver tissue of diabetic rats","authors":"Ş. Aras, Pinar Aksu Kilicle, S. Eliş Yıldız, Erhan Uluman, B. Bakır, E. Karadağ Sarı, S. Dağ","doi":"10.47748/tjvr.1062162","DOIUrl":"https://doi.org/10.47748/tjvr.1062162","url":null,"abstract":"Objective: This study aimed to investigate the effects of Chia (Salvia hispanica L.) oil and Dandelion (Taraxacum Officinale) extract on Tumor Necrosis Factor-α (TNF-α) and Interleukin 6 (IL-6) release in liver tissue of diabetic rats. \u0000Material and Method: Experimental groups were created as control, sham, chia, dandelion, diabetes (DM), diabetes+chia (DC), and diabetes +dandelion (DD). Body weight and blood glucose measurements were taken on the 1st, 3rd, and 17th days of the study and evaluated statistically. A one-way ANOVA test was performed to determine the differences between the groups. The Duncan test was used to compare significant differences between groups. At the end of the study, Masson's trichrome staining and Hematoxylin-Eosin staining were employed for histological examinations of liver tissues, and the distribution of TNF-α and IL-6 was examined by applying the Streptavidin-biotin peroxidase method. \u0000Results: It was determined that body weight and blood glucose measurements were significantly decrease for the DC group compared to other groups. Immunoreactivity of TNF-α and IL-6 was found to decrease in DC and DD groups at close to the control levels. \u0000Conclusion: Based on our results, it was thought that the use of chia and dandelion in diabetes may contribute to the alleviation of disease-related complications by having a positive effect on proinflammatory cytokine levels.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134161859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taha Burak Elifoglu, Merve Bi̇şki̇n, H. C. Macun, O. Kul
Squamous cell carcinoma (SCC) is a malignant epithelial tumor of skin. All species of animals are vulnerable to SCC and, sheep are very rarely developing this type of skin carcinoma. The purpose of this report was to describe unusual mammary lobe localization of SCC showing a great resemblance to the mammary tumor according to its gross and clinical examinations. The patient was brought to obstetrics and gynaecology department and, tumoral tissue was totally extirpated with a suspicion of mammary tumor. The diagnosis made as differentiated squamous cell carcinoma originated from the skin surface and invading through the dermis and subcutis but mammary gland parenchyma was remained intact. There are only few reports of SCC cases belonging to the skin of the mammary area in sheep. Therefore, it is thought that this case will make a scientific contribution with its originality and rarity.
{"title":"Unusual localization of squamous cell carcinoma clinically mimicking mammary carcinoma in an Akkaraman sheep","authors":"Taha Burak Elifoglu, Merve Bi̇şki̇n, H. C. Macun, O. Kul","doi":"10.47748/tjvr.1110108","DOIUrl":"https://doi.org/10.47748/tjvr.1110108","url":null,"abstract":"Squamous cell carcinoma (SCC) is a malignant epithelial tumor of skin. All species of animals are vulnerable to SCC and, sheep are very rarely developing this type of skin carcinoma. The purpose of this report was to describe unusual mammary lobe localization of SCC showing a great resemblance to the mammary tumor according to its gross and clinical examinations. The patient was brought to obstetrics and gynaecology department and, tumoral tissue was totally extirpated with a suspicion of mammary tumor. The diagnosis made as differentiated squamous cell carcinoma originated from the skin surface and invading through the dermis and subcutis but mammary gland parenchyma was remained intact. There are only few reports of SCC cases belonging to the skin of the mammary area in sheep. Therefore, it is thought that this case will make a scientific contribution with its originality and rarity.","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126667708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Aydın, A. Yalcın, A. Türk, Orhan Özdi̇ller, A. Yoldaş, H. Keleş, Muhammad Nasir Bhaya
{"title":"Investigation of the Effects of N-Acetylcysteine on Asprosin Hormone Activity and Liver Tissues in Rats with Experimentally-Induced Diabetes","authors":"H. Aydın, A. Yalcın, A. Türk, Orhan Özdi̇ller, A. Yoldaş, H. Keleş, Muhammad Nasir Bhaya","doi":"10.47748/tjvr.1061413","DOIUrl":"https://doi.org/10.47748/tjvr.1061413","url":null,"abstract":"","PeriodicalId":176953,"journal":{"name":"Turkish Journal of Veterinary Research","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131444300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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