Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.06.009
Daan P.C. van Doorn , Pieter van Paassen , Sjoerd A.M.E.G. Timmermans , Limburg Renal Registry
{"title":"Kidney-limited TMA is common in patients with complement dysregulation","authors":"Daan P.C. van Doorn , Pieter van Paassen , Sjoerd A.M.E.G. Timmermans , Limburg Renal Registry","doi":"10.1016/j.kint.2024.06.009","DOIUrl":"10.1016/j.kint.2024.06.009","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Pages 536-537"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.04.012
Tajamul H. Mir , Bushra Jabeen
{"title":"Unfair enough: the cosmetic-TIM-kidney syndromes","authors":"Tajamul H. Mir , Bushra Jabeen","doi":"10.1016/j.kint.2024.04.012","DOIUrl":"10.1016/j.kint.2024.04.012","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Page 536"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.06.008
Kah Cheong Tong , Khui Wei Wee
{"title":"Cardiovascular disease as a risk factor for frailty in dialysis patients","authors":"Kah Cheong Tong , Khui Wei Wee","doi":"10.1016/j.kint.2024.06.008","DOIUrl":"10.1016/j.kint.2024.06.008","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Pages 537-538"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.06.014
Priti Meena , Vivekanand Jha
{"title":"The unfairness of fairness creams: unveiling the toxic impact on kidneys of mercury in beauty products","authors":"Priti Meena , Vivekanand Jha","doi":"10.1016/j.kint.2024.06.014","DOIUrl":"10.1016/j.kint.2024.06.014","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Pages 337-340"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.06.020
Ubong S. Ekperikpe , Ilse S. Daehn
Jiang et al. show that zinc finger FYVE-type containing 21, a Rab5 effector in glomerular endothelial cells is involved in the maintenance of glomerular filtration barrier homeostasis through the stabilization of activated endothelial nitric oxide synthase on subcellular vesicles. The study demonstrates that zinc finger FYVE-type containing 21 could modulate the levels of caveolin-1 in glomerular endothelial cells using vesicle-based trafficking, thereby supporting endothelial nitric oxide synthase activity. The authors provide evidence that decreased zinc finger FYVE-type containing 21 expression in glomerular endothelial cells could play a role in aging-related glomerular filtration barrier dysfunction.
{"title":"Aging kidneys reveal underlying mechanisms of endothelial dysfunction","authors":"Ubong S. Ekperikpe , Ilse S. Daehn","doi":"10.1016/j.kint.2024.06.020","DOIUrl":"10.1016/j.kint.2024.06.020","url":null,"abstract":"<div><p>Jiang <em>et al.</em> show that zinc finger FYVE-type containing 21, a Rab5 effector in glomerular endothelial cells is involved in the maintenance of glomerular filtration barrier homeostasis through the stabilization of activated endothelial nitric oxide synthase on subcellular vesicles. The study demonstrates that zinc finger FYVE-type containing 21 could modulate the levels of caveolin-1 in glomerular endothelial cells using vesicle-based trafficking, thereby supporting endothelial nitric oxide synthase activity. The authors provide evidence that decreased zinc finger FYVE-type containing 21 expression in glomerular endothelial cells could play a role in aging-related glomerular filtration barrier dysfunction.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Pages 356-358"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.06.016
Zhenjie Chen , Xuewang Li , Chao Li , Jianfang Cai , Hang Li
{"title":"The significance of subclassifying focal segmental glomerulosclerosis lesions (S1) in IgA nephropathy","authors":"Zhenjie Chen , Xuewang Li , Chao Li , Jianfang Cai , Hang Li","doi":"10.1016/j.kint.2024.06.016","DOIUrl":"10.1016/j.kint.2024.06.016","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Page 540"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.05.021
Carla M. Nester , David L. Feldman , Richard Burwick , Spero Cataland , Shruti Chaturvedi , H. Terence Cook , Adam Cuker , Bradley P. Dixon , Fadi Fakhouri , Sangeeta R. Hingorani , Anuja Java , Nicole C.A.J. van de Kar , David Kavanagh , Nelson Leung , Christoph Licht , Marina Noris , Michelle M. O’Shaughnessy , Samir V. Parikh , Flora Peyandi , Giuseppe Remuzzi , Marina Vivarelli
The term atypical hemolytic uremic syndrome has been in use since the mid-1970s. It was initially used to describe the familial or sporadic form of hemolytic uremic syndrome as opposed to the epidemic, typical form of the disease. Over time, the atypical hemolytic uremic syndrome term has evolved into being used to refer to anything that is not Shiga toxin–associated hemolytic uremic syndrome. The term describes a heterogeneous group of diseases of disparate causes, a circumstance that makes defining disease-specific natural history and/or targeted treatment approaches challenging. A working group of specialty-specific experts in the thrombotic microangiopathies was convened to review the validity of this broad term in an era of swiftly advancing science and targeted therapeutics. A Delphi approach was used to define and interrogate some of the key issues related to the atypical hemolytic uremic syndrome nomenclature.
{"title":"An expert discussion on the atypical hemolytic uremic syndrome nomenclature—identifying a road map to precision: a report of a National Kidney Foundation Working Group","authors":"Carla M. Nester , David L. Feldman , Richard Burwick , Spero Cataland , Shruti Chaturvedi , H. Terence Cook , Adam Cuker , Bradley P. Dixon , Fadi Fakhouri , Sangeeta R. Hingorani , Anuja Java , Nicole C.A.J. van de Kar , David Kavanagh , Nelson Leung , Christoph Licht , Marina Noris , Michelle M. O’Shaughnessy , Samir V. Parikh , Flora Peyandi , Giuseppe Remuzzi , Marina Vivarelli","doi":"10.1016/j.kint.2024.05.021","DOIUrl":"10.1016/j.kint.2024.05.021","url":null,"abstract":"<div><p>The term <em>atypical hemolytic uremic syndrome</em> has been in use since the mid-1970s. It was initially used to describe the familial or sporadic form of hemolytic uremic syndrome as opposed to the epidemic, <em>typical</em> form of the disease. Over time, the atypical hemolytic uremic syndrome term has evolved into being used to refer to anything that is <em>not</em> Shiga toxin–associated hemolytic uremic syndrome. The term describes a heterogeneous group of diseases of disparate causes, a circumstance that makes defining disease-specific natural history and/or targeted treatment approaches challenging. A working group of specialty-specific experts in the thrombotic microangiopathies was convened to review the validity of this broad term in an era of swiftly advancing science and targeted therapeutics. A Delphi approach was used to define and interrogate some of the key issues related to the atypical hemolytic uremic syndrome nomenclature.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Pages 326-336"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0085253824004022/pdfft?md5=2b97809560922b12e6443760e75e23a2&pid=1-s2.0-S0085253824004022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.06.018
Phoom Narongkiatikhun , Petter Bjornstad
The attenuation of glomerular hyperfiltration is posited to be a principal mechanism underlying the kidney protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors in diabetic kidney disease. Notably, the impact of SGLT2 inhibitors on kidney hemodynamic function has been posited to vary between type 1 and type 2 diabetes. The study by Wada et al. documents that in an animal model of type 2 diabetes, SGLT2 inhibitors mitigate glomerular hyperfiltration predominantly through afferent arteriolar constriction, a process mediated by the adenosine/A1 receptor pathway. This observation is consistent with mechanisms identified in type 1 diabetes, arguing for similar methods in type 1 and 2 diabetes.
{"title":"Deciphering the kidney hemodynamic effects of SGLT2 inhibition: translating insights from rats to humans in type 2 diabetes","authors":"Phoom Narongkiatikhun , Petter Bjornstad","doi":"10.1016/j.kint.2024.06.018","DOIUrl":"10.1016/j.kint.2024.06.018","url":null,"abstract":"<div><p>The attenuation of glomerular hyperfiltration is posited to be a principal mechanism underlying the kidney protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors in diabetic kidney disease. Notably, the impact of SGLT2 inhibitors on kidney hemodynamic function has been posited to vary between type 1 and type 2 diabetes. The study by Wada <em>et al.</em> documents that in an animal model of type 2 diabetes, SGLT2 inhibitors mitigate glomerular hyperfiltration predominantly through afferent arteriolar constriction, a process mediated by the adenosine/A1 receptor pathway. This observation is consistent with mechanisms identified in type 1 diabetes, arguing for similar methods in type 1 and 2 diabetes.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Pages 354-356"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.kint.2024.03.024
Samih H. Nasr , Samar M. Said , Allen Flickinger
{"title":"Nitrofurantoin-associated crystalline and granulomatous interstitial nephritis","authors":"Samih H. Nasr , Samar M. Said , Allen Flickinger","doi":"10.1016/j.kint.2024.03.024","DOIUrl":"10.1016/j.kint.2024.03.024","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 3","pages":"Page 542"},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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