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Label-free surface-enhanced Raman scattering (SERS) and machine learning for biological analysis 用于生物分析的无标签表面增强拉曼散射(SERS)和机器学习
Pub Date : 2024-06-06 DOI: 10.1117/12.3013981
Der Vang, Jonathan Pahren, Tom Cambron, Pietro Strobbia
Understanding biological samples is an important part of disease treatment and prevention. Current methods of biological analysis can be time-consuming and costly. Label-free Surface-Enhanced Raman Scattering (SERS) is a useful vibrational technique that incorporates plasmonic metal nanomaterial to amplify Raman signals. This technique requires little sample preparation and provides high informational chemical insights on the target. Herein, we use SERS to test and analyze biological samples of exosomes and bacteria. Each biological sample has similar biomolecular components that are difficult to differentiate or show small differences after interacting with other chemicals. Thus, herein, we show the incorporation of principal component analysis to understand differences and trends in the spectra. These studies highlight the powerful combination of SERS and machine learning for biological analysis.
了解生物样本是疾病治疗和预防的重要组成部分。目前的生物分析方法既耗时又昂贵。无标记表面增强拉曼散射(SERS)是一种有用的振动技术,它结合了等离子体金属纳米材料来放大拉曼信号。这种技术只需很少的样品制备,就能提供关于目标物的高信息化学洞察力。在这里,我们使用 SERS 测试和分析外泌体和细菌的生物样本。每种生物样本都有类似的生物分子成分,与其他化学物质相互作用后难以区分或显示微小差异。因此,我们在本文中展示了主成分分析法,以了解光谱中的差异和趋势。这些研究凸显了 SERS 与机器学习在生物分析中的强大结合。
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引用次数: 0
Countering environmental effects in optical systems using Kapton tape 使用 Kapton 胶带消除光学系统中的环境影响
Pub Date : 2024-06-06 DOI: 10.1117/12.3013786
Joshua B. Bettinger, Steven Vogel, Andrew Dugrenier
Optical systems are frequently used in non-laboratory environments. Extra-orbit launch accelerations, gunfire vibrations, and temperature fluctuations can put dangerous stresses on lenses. In addition to general mechanical ruggedization, Kapton® tape was added to optical surfaces as a go-between for the glass/crystal and the metal structure components. The thought behind this was that using a softer surface interface would act as a sort of cushion for the optics. Kapton® tape has a CTE nearly matching that of Aluminum 6061-T6 and has an effective temperature range of -269°C to 400°C, which makes it an ideal material for use in systems both at or outside of room temperature values. Hand calculations formulated from equations postulated by experts Paul Yoder and R.J. Roark were used in conjunction with Finite Element Analysis via ANSYS. Practical examples used in the field were cited as well.
光学系统经常在非实验室环境中使用。轨道外发射加速度、炮火震动和温度波动都会对透镜造成危险的应力。除了一般的机械加固外,Kapton® 胶带还被添加到光学表面,作为玻璃/晶体和金属结构部件之间的连接物。这样做的考虑是,使用较软的表面界面可以起到缓冲光学元件的作用。Kapton® 胶带的热膨胀系数(CTE)几乎与铝 6061-T6 相同,有效温度范围为 -269°C 至 400°C,是室温或室温以外系统的理想材料。根据专家 Paul Yoder 和 R.J. Roark 提出的方程式进行的手工计算与 ANSYS 有限元分析相结合。同时还引用了现场使用的实际例子。
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引用次数: 0
Risk considerations for the department of defense's fielding of large language models 国防部部署大型语言模型的风险考虑因素
Pub Date : 2024-06-06 DOI: 10.1117/12.3014424
Misty K. Blowers, Santos S. Salinas, Seth A. Bailey
In a 10 August 2023 memo to Senior Department of Defense (DoD) Leaders, the Deputy Secretary of Defense outlined the roles and responsibilities of the DoD's newly established Chief Digital and Artificial Intelligence Officer Generative Artificial Intelligence and Large Language Models Task Force, Task Force Lima. The AI and LLM Task Force is charged with focusing the DoD's exploration and responsible fielding of generative AI and LLM capabilities. While AI and LLM have revolutionized natural language processing in commercial applications, significant concerns must be addressed before the technology is fully deployed within the DoD. This study will explore the current biases in training data, ethical violations, security breaches, potential misuse, and challenges with AI and LLM interpretability. Industry, academic and government partnerships need to ensure a responsible and equitable deployment of LLMs that harnesses the full potential of the capabilities in a manner that is responsible, secure, and well understood by the end user community.
在 2023 年 8 月 10 日致国防部(Department of Defense)高级领导人的备忘录中,国防部副部长概述了国防部新成立的首席数字和人工智能官生成式人工智能和大型语言模型工作组(Task Force Lima)的作用和职责。人工智能和大型语言模型工作组负责集中国防部的力量,探索并负责任地部署生成式人工智能和大型语言模型能力。虽然人工智能和 LLM 在商业应用中为自然语言处理带来了革命性的变化,但在国防部全面部署该技术之前,必须解决一些重大问题。本研究将探讨当前训练数据中的偏差、违反道德的行为、安全漏洞、潜在的滥用以及人工智能和 LLM 可解释性方面的挑战。工业界、学术界和政府需要建立合作伙伴关系,确保负责任地、公平地部署 LLM,以负责任、安全和终端用户充分理解的方式充分发挥 LLM 的潜力。
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引用次数: 0
Inconsistency-based active learning with adaptive pseudo-labeling for fish species identification 基于不一致性的主动学习与自适应伪标记用于鱼类物种识别
Pub Date : 2024-06-06 DOI: 10.1117/12.3013336
M. M. Nabi, Chiranjibi Shah, S. Y. Alaba, Ryan Caillouet, Jack H. Prior, Matthew Campbell, Farron Wallace, John E. Ball, Robert J. Moorhead
The deep neural network has found widespread application in object detection due to its high accuracy. However, its performance typically depends on the availability of a substantial volume of accurately labeled data. Several active learning approaches have been proposed to reduce the labeling dependency based on the confidence of the detector. Nevertheless, these approaches tend to exhibit biases toward high-performing classes, resulting in datasets that do not adequately represent the testing data. In this study, we introduce a comprehensive framework for active learning that considers both the uncertainty and the robustness of the detector, ensuring superior performance across all classes. The robustness-based score for active learning is calculated using the consistency between an image and its augmented version. Additionally, we leverage pseudo-labeling to mitigate potential distribution drift and enhance model performance. To address the challenge of setting the pseudo-labeling threshold, we introduce an adaptive threshold mechanism. This adaptability is crucial, as a fixed threshold can negatively impact performance, particularly for low-performing classes or during the initial stages of training. For our experiment, we employ the Southeast Area Monitoring and Assessment Program Dataset 2021 (SEAMAPD21), comprising 130 fish species classes with 28,328 image samples. The results show that our model outperforms the state-of-the-art method and significantly reduces the annotation cost. Furthermore, we benchmark our model’s performance against a public dataset (PASCAL VOC07), showcasing its effectiveness in comparison to existing methods.
深度神经网络因其高精度而被广泛应用于物体检测。然而,其性能通常取决于是否有大量准确标注的数据。目前已经提出了几种主动学习方法,以减少基于检测器置信度的标记依赖性。然而,这些方法往往会对表现优异的类别产生偏差,导致数据集不能充分代表测试数据。在本研究中,我们引入了一个全面的主动学习框架,该框架同时考虑了检测器的不确定性和鲁棒性,确保在所有类别中都能获得卓越的性能。基于鲁棒性的主动学习得分是通过图像与其增强版本之间的一致性来计算的。此外,我们还利用伪标记来减轻潜在的分布漂移并提高模型性能。为了解决设置伪标记阈值的难题,我们引入了自适应阈值机制。这种适应性至关重要,因为固定的阈值会对性能产生负面影响,尤其是在低性能类或训练的初始阶段。在实验中,我们使用了东南地区监测和评估计划数据集 2021(SEAMAPD21),其中包括 130 个鱼类物种类别和 28328 个图像样本。结果表明,我们的模型优于最先进的方法,并显著降低了标注成本。此外,我们还以一个公共数据集(PASCAL VOC07)为基准测试了我们模型的性能,展示了它与现有方法相比的有效性。
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引用次数: 0
Terahertz sensing through the lens of the Kalman filter: a bibliometric exploration 卡尔曼滤波器透视下的太赫兹传感:文献计量学探索
Pub Date : 2024-06-06 DOI: 10.1117/12.3013848
Khaled Obaideen, Mohammad A. AlShabi, Talal Bonny
The Terahertz (THz) spectrum, situated between microwave and infrared frequencies, is utilized for applications such as imaging and chemical analysis. This project aims to combine THz sensing with the Kalman Filter estimator, a recursive algorithm typically utilized for estimating data with high levels of noise. Upon a thorough effort, we investigate the prospects and challenges in THz sensing using the Kalman filter for assistance. Upon examining this area, we found an increasing pattern in combining THz wavelength technologies that boosts the precision and effectiveness of Kalman Filter applications in THz sensing. The topic being talked about is the significance of this technology in improving the dependability of detecting and measuring data in difficult conditions. Moreover, this document outlines essential advancements and trends in the field of THz sensing, as well as the progress in various disciplines that contribute to the development of THz sensing. This paper presents details about the current planning and disadvantages of utilizing Kalman Filters in THz sensing. It has served as a broad guide for both scientists and professionals, laying the groundwork for future advancements in this field. Incorporating these directivity methods not only enhances detection capabilities but also produces novel contributions to the field of THz sensing that also facilitate knowledge sharing.
太赫兹(THz)频谱介于微波和红外频率之间,可用于成像和化学分析等应用。该项目旨在将太赫兹传感与卡尔曼滤波估计器相结合,卡尔曼滤波估计器是一种递归算法,通常用于估计高噪声数据。经过充分努力,我们研究了使用卡尔曼滤波器辅助太赫兹传感的前景和挑战。在对这一领域进行研究后,我们发现结合太赫兹波长技术的模式越来越多,从而提高了卡尔曼滤波器在太赫兹传感中应用的精度和有效性。本文讨论的主题是这项技术在提高困难条件下检测和测量数据的可靠性方面的重要意义。此外,本文还概述了太赫兹传感领域的重要进展和趋势,以及有助于太赫兹传感发展的各个学科的进展。本文详细介绍了在太赫兹传感中使用卡尔曼滤波器的当前规划和缺点。它为科学家和专业人士提供了广泛的指导,为该领域未来的发展奠定了基础。采用这些方向性方法不仅能提高探测能力,还能为太赫兹传感领域做出新的贡献,促进知识共享。
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引用次数: 0
Enabling space-qualified opto-electronic systems through photonic wirebonding 通过光子线键合实现空间合格光电系统
Pub Date : 2024-06-06 DOI: 10.1117/12.3013559
J. Sherman, Victoria Rosborough, Ruby Gans, Juan Ramirez, D. Kebort, Geoffrey Sitwell, Juergen Musolf, Henry Garrett, Tom Liu, Caleb McEwen, Trevor Cooper, Amin Nehrir, Gordon Morrison, Leif Johansson, M. Mashanovitch
Applications such as LIDAR, ranging/ sensing, and optical communications all require photonic components, such as sources, detectors, and modulators, to be integrated into a single system. For spaceborne applications, SWaP (size, weight and power) is a key consideration: a monolithic indium phosphide (InP) Photonic Integrated Circuit (PIC) can integrate many components onto a chip with a footprint of a few square mm. Photonic Wirebonding (PWB) enables seamless integration of best-in-class optical devices from disparate materials. Connecting and mode-matching different photonic components enables versatility and functionality unachievable by other methods, facilitating co-packaging. PICs and PWBs do not yet have spaceflight heritage: demonstrating increased Technology Readiness Level (TRL) is a key step toward use in orbital and spaceborne missions. Freedom Photonics presents our first hermetic photonic wirebonded PIC package, alongside recent environmental testing results demonstrating that our PIC and PWB technologies are suitable for the harsh conditions of launch and spaceflight: shock, vibration, radiation, and temperature cycling.
激光雷达、测距/传感和光通信等应用都需要将光子元件(如光源、探测器和调制器)集成到单个系统中。对于空间应用而言,SWaP(尺寸、重量和功率)是一个关键的考虑因素:单片磷化铟(InP)光子集成电路(PIC)可将许多元件集成到一个芯片上,占地面积仅为几平方毫米。光子线键合(PWB)可实现不同材料的一流光学器件的无缝集成。将不同的光子元件连接起来并进行模式匹配,可实现其他方法无法实现的多功能性和功能性,从而促进共同封装。PIC 和 PWB 尚不具备航天传统:提高技术就绪水平(TRL)是在轨道和航天任务中使用的关键一步。Freedom Photonics 展示了我们的首款密封式光子线键合 PIC 封装,以及最新的环境测试结果,这些结果表明我们的 PIC 和 PWB 技术适用于发射和太空飞行的苛刻条件:冲击、振动、辐射和温度循环。
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引用次数: 0
Spectral characteristics of generation after next satellite navigational sensors 新一代卫星导航传感器的光谱特性
Pub Date : 2024-06-06 DOI: 10.1117/12.3012179
Jeremy Murray-Krezan, M. Bolden, Erin Griggs
Upcoming space missions are expected to go farther from Earth and be more autonomous and self-sufficient. Most man-made satellites are controlled from Earth-based ground stations that also perform guidance and navigation functions. Onboard star trackers and GPS units are commonplace on satellites and part of the guidance, navigation and control systems, permitting in situ measurement and update to the guidance solution. However, without an extension of the network, GPS units are not expected to operate in deep space, making them suitable for spaceflight in the near-Earth orbits only. Star trackers, which use an optical payload, permit accurate pointing of the satellite via the methods of astrometry, but do not provide a full guidance and navigation solution. In this paper we explore characteristics of a generation-after-next satellite navigational sensor concept where, using optical or infrared spectral measurements in addition to the typical techniques of astrometry for locating stars, onboard autonomous computation of a navigational solution is possible. Spectral measurements allow estimation of stellar velocities, in addition to relative locations. We hypothesize that recent space missions have generated the star catalogs, with both position and velocity measurements, necessary to anchor measurements of the new conceptual sensor.
预计未来的太空任务将离地球更远,并且更加自主和自给自足。大多数人造卫星都是由地球地面站控制的,地面站也执行制导和导航功能。星载跟踪器和全球定位系统是卫星上常见的设备,也是制导、导航和控制系统的一部分,允许对制导方案进行现场测量和更新。但是,如果不扩展网络,GPS 装置预计无法在深空运行,因此只适合近地轨道的航天飞行。使用光学有效载荷的星体跟踪器可以通过天体测量法对卫星进行精确定位,但不能提供完整的制导和导航解决方案。在本文中,我们探讨了下一代卫星导航传感器概念的特点,即除了利用天体测量学的典型技术来确定恒星的位置外,还利用光学或红外光谱测量来实现星载导航解决方案的自主计算。光谱测量除了可以估算相对位置外,还可以估算恒星的速度。我们假设,最近的空间飞行任务已经生成了恒星目录,其中包括位置和速度测量值,这对新概念传感器的测量是必不可少的。
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引用次数: 0
Uncovering deep-rooted cultural differences (UNCOVER) 发现根深蒂固的文化差异(UNCOVER)
Pub Date : 2024-06-06 DOI: 10.1117/12.3012714
Aleksey Panasyuk, Bryan Li, Christopher Callison-Burch
This study delves into the interconnected realms of Debates, Fake News, and Propaganda, with an emphasis on discerning prominent ideological underpinnings distinguishing Russian from English authors. Leveraging the advanced capabilities of Large Language Models (LLMs), particularly GPT-4, we process and analyze a large corpus of over 80,000 Wikipedia articles to unearth significant insights. Despite the inherent linguistic distinctions between Russian and English texts, our research highlights the adeptness of LLMs in bridging these variances. Our approach includes translation, question generation and answering, along with emotional analysis, to probe the gathered information. A ranking metric based on the emotional content is used to assess the impact of our approach. Furthermore, our research identifies important limitations within existing data resources for propaganda identification. To address these challenges and foster future research, we present a curated synthetic dataset designed to encompass a diverse spectrum of topics and achieve balance across various propaganda types.
本研究深入探讨了 "辩论"、"假新闻 "和 "宣传 "这三个相互关联的领域,重点是辨别俄语作者和英语作者的突出意识形态基础。利用大型语言模型(LLM),特别是 GPT-4 的先进功能,我们处理并分析了维基百科上超过 80,000 篇文章的大型语料库,从而发现了重要的见解。尽管俄语和英语文本之间存在固有的语言差异,但我们的研究凸显了 LLM 在弥合这些差异方面的能力。我们的方法包括翻译、问题生成和回答以及情感分析,以探究收集到的信息。我们使用基于情感内容的排名指标来评估我们方法的影响。此外,我们的研究还发现了现有宣传识别数据资源的重要局限性。为了应对这些挑战并促进未来的研究,我们提出了一个经过精心策划的合成数据集,旨在涵盖各种不同的主题,并实现各种宣传类型之间的平衡。
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引用次数: 0
CubeSat reaction wheel attitude control platform 立方体卫星反力轮姿态控制平台
Pub Date : 2024-06-06 DOI: 10.1117/12.3014002
Justin Hartland, Dylan Ballback, Isaac Stitt, Ryan Taylor, Jacob Salazar, Ella Cheatham, Anuhya Suhas, Vishwam Rathod
In traditional classroom settings, spacecraft attitude dynamics and controls are typically presented through 2-D illustrations of complex 3-D dynamics. This often results in students finding it challenging to bridge the gap between theoretical physics and its practical, real-world applications. To address this challenge, our project aims to design, develop, and manufacture CubeSat controls testbeds. These testbeds are equipped with reaction wheels to enable autonomous attitude control system applications. Notably, each testbed will incorporate three distinct reaction wheels, each mounted orthogonally. This arrangement ensures precise attitude control in all three degrees of freedom. The versatility of these CubeSat testbeds allows users to explore and implement a broad range of control systems. These can range from classical PID controllers, state-space control methods, adaptive controllers, sliding mode control, to more advanced techniques like model predictive control, and robust control methods. The platform can serve both as an educational tool for students and a research apparatus for professionals. The ultimate vision for the CubeSat Reaction Wheel Attitude Control Platform is its seamless integration into a dedicated website called Easy Controls. Here, users worldwide can upload their control algorithms. They can then view a live stream of their algorithm being tested and operationalized in real-time on the physical hardware. This platform not only demystifies spacecraft control dynamics for learners but also fosters a global community of innovators collaborating and refining their control algorithms.
在传统的课堂教学中,航天器姿态动力学和控制通常是通过二维图解复杂的三维动力学来展示的。这往往导致学生在理论物理与实际应用之间难以找到平衡点。为了应对这一挑战,我们的项目旨在设计、开发和制造立方体卫星控制试验台。这些试验台配有反作用力轮,可实现自主姿态控制系统应用。值得注意的是,每个试验台都将包含三个不同的反作用力轮,每个反作用力轮都正交安装。这种布置可确保对所有三个自由度进行精确的姿态控制。这些立方体卫星试验台的多功能性使用户能够探索和实施各种控制系统。这些系统包括经典的 PID 控制器、状态空间控制方法、自适应控制器、滑动模式控制,以及模型预测控制和鲁棒控制方法等更先进的技术。该平台既可作为学生的教育工具,也可作为专业人员的研究设备。立方体卫星反力轮姿态控制平台的最终愿景是将其无缝集成到一个名为 "简易控制 "的专用网站上。在这里,全球用户都可以上传他们的控制算法。然后,他们就可以观看他们的算法在物理硬件上进行实时测试和操作的实时流。该平台不仅为学习者揭开了航天器控制动力学的神秘面纱,还促进了全球创新者社区的合作,并完善了他们的控制算法。
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引用次数: 0
Zero trust decision analysis for next generation networks 下一代网络的零信任决策分析
Pub Date : 2024-06-06 DOI: 10.1117/12.3013993
Joseph B. Kroculick
Zero Trust security is being adopted across companies and government organizations to continually verify cybersecurity requirements. This paper investigates architecture development methodologies that can develop a Zero Trust architecture that implements the missions of an enterprise. An enterprise architecture depends on an organization’s strategic priorities and should reflect the organization’s critical decisions. These decisions can be evaluated according to criteria such as interoperability, speed of operations tempo, and cyber-resilience to failures. Zero-Trust architectures must define alternatives tailored to missions. An enterprise architecture can then be developed that describes the context, operations, and resources associated with a strategic implementation decision. A multi-criteria decision-making method such as the Analytic Hierarchy Process can help guide the development and implementation of Zero Trust strategy. Zero Trust criteria are defined according to quality attributes associated with the DoD Reference Architecture Pillars, and security solutions are evaluated against how well they meet these criteria.
各公司和政府组织正在采用零信任安全,以不断验证网络安全要求。本文研究了可开发零信任架构的架构开发方法,以实现企业的使命。企业架构取决于组织的战略重点,并应反映组织的关键决策。这些决策可根据互操作性、运营节奏速度和网络抗故障能力等标准进行评估。零信任架构必须定义适合任务的替代方案。然后可以开发企业架构,描述与战略实施决策相关的背景、操作和资源。多标准决策方法(如层次分析法)有助于指导零信任战略的制定和实施。零信任标准是根据与国防部参考架构支柱相关的质量属性来定义的,并根据安全解决方案满足这些标准的程度对其进行评估。
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引用次数: 0
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Defense + Commercial Sensing
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