Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa3596
S. Auteri, C. Garbarino, M. G. Blanco, M. L. Alberti, F. Paulin, M. Fernández, G. Carballo, M. Rayá, G. Guman, F. Caro
{"title":"Minor salivary gland biopsy and dry ocular tests to detect occult Sjögren Syndrome in patients with interstitial pneumonia with autoimmune features","authors":"S. Auteri, C. Garbarino, M. G. Blanco, M. L. Alberti, F. Paulin, M. Fernández, G. Carballo, M. Rayá, G. Guman, F. Caro","doi":"10.1183/13993003.congress-2019.oa3596","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa3596","url":null,"abstract":"","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128248681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa1610
E. Doran, Darren Ruane, Alexander R. Abbas, D. DePianto, P. Caplazi, C. Emson, J. Arron
{"title":"Identification of an IL-6-dependent macrophage population required for driving fibrotic disease","authors":"E. Doran, Darren Ruane, Alexander R. Abbas, D. DePianto, P. Caplazi, C. Emson, J. Arron","doi":"10.1183/13993003.congress-2019.oa1610","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa1610","url":null,"abstract":"","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133190445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa1357
Leiqian Xu, Jie Cao
{"title":"Follistatin-like 1 promotes intermittent hypoxia-induced lung fibroblast activation in vitro and in vivo","authors":"Leiqian Xu, Jie Cao","doi":"10.1183/13993003.congress-2019.pa1357","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1357","url":null,"abstract":"","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125680505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa1372
Karina Smidt Simon, C. Melo-Silva, P. Veloso, L. Coelho, J. P. Longo, L. Vianna, V. Amado, A. Bocca
{"title":"Peptide ToAP3 from T. obscurus interferes with idiopathic pulmonary fibrosis progression in murine model","authors":"Karina Smidt Simon, C. Melo-Silva, P. Veloso, L. Coelho, J. P. Longo, L. Vianna, V. Amado, A. Bocca","doi":"10.1183/13993003.congress-2019.pa1372","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1372","url":null,"abstract":"","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115304393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa5199
Auriléia Aparecida De Brito Léia, K. Herculano, T. G. Santos, N. C. Rigonato-Oliveira, Cintia Estefano Alves, R. Palma, Cristiano Rodrigo Alvarenga-Nascimento, A. P. Ligeiro-Oliveira
Pulmonary fibrosis is one of the most common interstitial diseases, which causes a great impact on the health of the affected population, has environmental and genetic risk factors, a poor prognosis and no effective treatment available. It is a normal consequence of tissue injury and chronic inflammation, characterized by accumulation and activation of excessive numbers of fibroblasts, deposition of extracellular matrix proteins (ECM), such as collagen, and distortion of normal tissue architecture. Photobiomodulation - PBM is a relatively new and effective therapy, low cost, with no side effects and possible use in the treatment of lung diseases. In this sense, the objective was to evaluate the inflammation and the level of TGF-b in the lung after PBM in an experimental model of fibrosis. We studied some parameters in C57BL/6 with fibrosis submitted to diode laser therapy (808nm, 30mW, 180s) for 15 days. The protocol used for the induction of fibrosis consisted of the application of bleomycin sulphate (1.5U/kg - orotracheal - 1x/day 0). Bronchoalveolar lavage (BAL) and lungs were collected for analysis. Data were submitted to the one-way ANOVA test followed by the Newman-Keuls test. Significance levels adjusted to 5% (p
{"title":"Effect of photobiomodulation on inflammation and production of TGF-ß in experimental model of pulmonary fibrosis","authors":"Auriléia Aparecida De Brito Léia, K. Herculano, T. G. Santos, N. C. Rigonato-Oliveira, Cintia Estefano Alves, R. Palma, Cristiano Rodrigo Alvarenga-Nascimento, A. P. Ligeiro-Oliveira","doi":"10.1183/13993003.congress-2019.pa5199","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa5199","url":null,"abstract":"Pulmonary fibrosis is one of the most common interstitial diseases, which causes a great impact on the health of the affected population, has environmental and genetic risk factors, a poor prognosis and no effective treatment available. It is a normal consequence of tissue injury and chronic inflammation, characterized by accumulation and activation of excessive numbers of fibroblasts, deposition of extracellular matrix proteins (ECM), such as collagen, and distortion of normal tissue architecture. Photobiomodulation - PBM is a relatively new and effective therapy, low cost, with no side effects and possible use in the treatment of lung diseases. In this sense, the objective was to evaluate the inflammation and the level of TGF-b in the lung after PBM in an experimental model of fibrosis. We studied some parameters in C57BL/6 with fibrosis submitted to diode laser therapy (808nm, 30mW, 180s) for 15 days. The protocol used for the induction of fibrosis consisted of the application of bleomycin sulphate (1.5U/kg - orotracheal - 1x/day 0). Bronchoalveolar lavage (BAL) and lungs were collected for analysis. Data were submitted to the one-way ANOVA test followed by the Newman-Keuls test. Significance levels adjusted to 5% (p","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122375143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa1609
C. Hesse, S. Wollin, Sebastian Konzok, M. Niehof, D. Leeming, S. Rønnow, J. Sand, P. Braubach, D. Jonigk, M. Kühnel, G. Warnecke, H. Fieguth, O. Pfennig, K. Sewald, A. Braun
{"title":"Nintedanib mediates effective modulation of relevant pro-fibrotic biomarkers ex vivo","authors":"C. Hesse, S. Wollin, Sebastian Konzok, M. Niehof, D. Leeming, S. Rønnow, J. Sand, P. Braubach, D. Jonigk, M. Kühnel, G. Warnecke, H. Fieguth, O. Pfennig, K. Sewald, A. Braun","doi":"10.1183/13993003.congress-2019.oa1609","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa1609","url":null,"abstract":"","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126631337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa1363
T. Ho, C. Scallan, N. Hambly, G. Cox, M. Kolb, Parameswaran Nair
{"title":"The prevalence of bronchitis and associations with spirometry in patients with interstitial lungdisease in a Canadian tertiary care centre","authors":"T. Ho, C. Scallan, N. Hambly, G. Cox, M. Kolb, Parameswaran Nair","doi":"10.1183/13993003.congress-2019.pa1363","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1363","url":null,"abstract":"","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124132480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa1375
E. Mancuzo, Deborah Strela, Luiz Fernando Ferreira Pereira, R. A. Corrêa
Background: Familial pulmonary fibrosis (FPF) is defined as an idiopathic diffuse parenchymal lung disease affecting two or more members of the same primary biological family. Aim: to evaluete if the pattern of fibrosis on HRCT has a significant impact on disease progression or mortality in patients with FPF. Methods: Baseline clinical, functional and radiological data of a FPF population were retrospectively collected and analysed according to the 2018 IPF guidelines High Resolution Computerized Tomography (HRCT) classification. There was considered disease progress, decline in CVF more then 10% in a year. Results: 49 patients were included, 29 male and 20 female patients (age at diagnosis 53 ± 8.5 years-old), with a predominance of former smokers (51%), belonging to 31 families. Radiological analysis demonstrated the presence of a “UIP“ pattern at HRCT was 15 (29 %) of patients, “Probable-UIP” in 10 (19.5 %), “Indeterminate-UIP” in 7(13,5%) and “CT features most consistent with non-IPF diagnosis” in 17 (33%) . The main diagnostic was idiopathic pulmonary fibrosis (IPF), 21(41%). Initial forced vital capacity (FVC) was 75,07 ± 17,01 % of predicted and Rest SpO2 was 92 ± 5.8%. After analysis, the survival time 28.3 ± 17 months. No difference was observed in the survival or progression of the disease when we compared the “UIP“ pattern and “Probable-UIP” with “Indeterminate-UIP” and “CT features most consistent with non-IPF diagnosis”(p = 0,81) Reference: 1-Bennett D et al. Respiratory Medicine. 2017: 126: 75-83.
{"title":"Tomographic pattern and disease progress or mortality in familial pulmonary fibrosis","authors":"E. Mancuzo, Deborah Strela, Luiz Fernando Ferreira Pereira, R. A. Corrêa","doi":"10.1183/13993003.congress-2019.pa1375","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1375","url":null,"abstract":"Background: Familial pulmonary fibrosis (FPF) is defined as an idiopathic diffuse parenchymal lung disease affecting two or more members of the same primary biological family. Aim: to evaluete if the pattern of fibrosis on HRCT has a significant impact on disease progression or mortality in patients with FPF. Methods: Baseline clinical, functional and radiological data of a FPF population were retrospectively collected and analysed according to the 2018 IPF guidelines High Resolution Computerized Tomography (HRCT) classification. There was considered disease progress, decline in CVF more then 10% in a year. Results: 49 patients were included, 29 male and 20 female patients (age at diagnosis 53 ± 8.5 years-old), with a predominance of former smokers (51%), belonging to 31 families. Radiological analysis demonstrated the presence of a “UIP“ pattern at HRCT was 15 (29 %) of patients, “Probable-UIP” in 10 (19.5 %), “Indeterminate-UIP” in 7(13,5%) and “CT features most consistent with non-IPF diagnosis” in 17 (33%) . The main diagnostic was idiopathic pulmonary fibrosis (IPF), 21(41%). Initial forced vital capacity (FVC) was 75,07 ± 17,01 % of predicted and Rest SpO2 was 92 ± 5.8%. After analysis, the survival time 28.3 ± 17 months. No difference was observed in the survival or progression of the disease when we compared the “UIP“ pattern and “Probable-UIP” with “Indeterminate-UIP” and “CT features most consistent with non-IPF diagnosis”(p = 0,81) Reference: 1-Bennett D et al. Respiratory Medicine. 2017: 126: 75-83.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131096578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa5192
A. Jiménez, Gema Jiménez Gómez, A. H. Molina, Antonio Córdoba Doña, Antonio Campos Caro
Background: Silicosis produced by Artificial Quartz Agglomerates (AQA) evolves more aggressively than the classical form in miners. This entity is emerging worldwide and a significant group of cases has been detected in the province of Cadiz (Spain) in recent years. Biomarkers in the blood of silicotic patients are needed as tools for diagnosis, prognosis of the disease and response to treatment. Objective: To evaluate the plasma levels of some biomarkers (MP-1, MMP-2, MMP-7, MMP-9 and MMP-10, TGFβ, IL-1β, TNFα, IL-18 and MIP-1α), in healthy subjects compared with patients with simple (SS) or complicated (CS) silicosis, in order to use them as biomarkers of the disease. Methods: Fifty-seven patients diagnosed with silicosis by AQA and 18 healthy controls were studied. The blood biomarkers were quantified by single or multiplex ELISA. Results: MMP-2 and MMP-7 were increased in patients with silicosis compared to healthy volunteers, but only MMP-7 (not MMP-2) was found significantly augmented when silicotic patients were split in SS and CS according to the ILO classification. No differences were found for MMP-1, MMP-9, MMP-10, IL-18 and TGFβ. However, IL-1β and TNFα were significantly increased in CS group compared to healthy patients, but not compared to SS group. MIP-1α, showed an increasing gradient when healthy, SS and CS groups were compared. Conclusions: Combining the results of some of the biomarkers studied may be useful in the diagnosis of silicosis. Moreover, several biomarkers, such as MIP-1α, should be helpful to improve predictions of the evolution of the disease
{"title":"Biomarkers in peripheral blood from patients with chronic silicosis caused by artificial quartz agglomerates","authors":"A. Jiménez, Gema Jiménez Gómez, A. H. Molina, Antonio Córdoba Doña, Antonio Campos Caro","doi":"10.1183/13993003.congress-2019.pa5192","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa5192","url":null,"abstract":"Background: Silicosis produced by Artificial Quartz Agglomerates (AQA) evolves more aggressively than the classical form in miners. This entity is emerging worldwide and a significant group of cases has been detected in the province of Cadiz (Spain) in recent years. Biomarkers in the blood of silicotic patients are needed as tools for diagnosis, prognosis of the disease and response to treatment. Objective: To evaluate the plasma levels of some biomarkers (MP-1, MMP-2, MMP-7, MMP-9 and MMP-10, TGFβ, IL-1β, TNFα, IL-18 and MIP-1α), in healthy subjects compared with patients with simple (SS) or complicated (CS) silicosis, in order to use them as biomarkers of the disease. Methods: Fifty-seven patients diagnosed with silicosis by AQA and 18 healthy controls were studied. The blood biomarkers were quantified by single or multiplex ELISA. Results: MMP-2 and MMP-7 were increased in patients with silicosis compared to healthy volunteers, but only MMP-7 (not MMP-2) was found significantly augmented when silicotic patients were split in SS and CS according to the ILO classification. No differences were found for MMP-1, MMP-9, MMP-10, IL-18 and TGFβ. However, IL-1β and TNFα were significantly increased in CS group compared to healthy patients, but not compared to SS group. MIP-1α, showed an increasing gradient when healthy, SS and CS groups were compared. Conclusions: Combining the results of some of the biomarkers studied may be useful in the diagnosis of silicosis. Moreover, several biomarkers, such as MIP-1α, should be helpful to improve predictions of the evolution of the disease","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133382360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa4730
E. A. Vallejos, F. Felder, S. Leiva, J. Enghelmayer, R. Gomez, P. Rossi, Federico Zenón, G. Legarreta, S. Acuña, Mariano M Volpacchio
{"title":"Predictors of pulmonary-functional decline in systemic sclerosis: A university hospital experience","authors":"E. A. Vallejos, F. Felder, S. Leiva, J. Enghelmayer, R. Gomez, P. Rossi, Federico Zenón, G. Legarreta, S. Acuña, Mariano M Volpacchio","doi":"10.1183/13993003.congress-2019.pa4730","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4730","url":null,"abstract":"","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125285161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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