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[Ähnliche Wirkung von Lidocain und Kochsalzlösung auf den Zilienschlag von Nasenepithelzellen in vitro].
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-02-21 DOI: 10.1055/a-2544-3857
Sibel Tabea Savas, Stefan A Tschanz, Philipp Latzin, Carmen Casaulta, Loretta Müller
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引用次数: 0
High prevalence of cough and common cold medication intoxications in the Czech paediatric population.
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-02-07 DOI: 10.1055/a-2518-5571
Patrik Konopásek, Kateřina Kotíková, Monika Pecková, Jan David

There has been much debate about the appropriateness of over-the-counter (OTC) cough and common cold medications (CCM). The aim of this nationwide study was to analyse the incidence of CCM intoxications in the Czech paediatric population from 2014 to 2023.We performed a retrospective study on the incidence of CCM intoxications in the Czech paediatric population (ages 0-18 years) from 2014 to 2023.There were 7,056 cases of CCM intoxication in children, of which 6,406 resulted from unintentional intoxication. No lethal doses were reported, but there were 1,769 documented toxic doses. Unintentional CCM intoxications represented 15.60% of all unintentional medication intoxication cases across all ages and medication types. Of the 6,406 unintentional intoxication cases, 5,465 (85.31%) were in children aged 0 to 6 years, including 1,564 (24.41%) in children aged 0 to 2 years. Children aged 0 to 6 years had a significantly higher risk of CCM intoxication compared to those aged 7 to 18 years (RR 9.5, p<0.00001). The annual incidence of unintentional CCM intoxication was 69.26 per 100,000 children aged 0 to 6 years and 7.29 per 100,000 children aged 7 to 18 years.Based on our data, we believe there is low awareness among parents and Czech paediatricians regarding the potential risks of CCM and the lack of proven efficacy of these medications.Our data may contribute to political discussions regarding the general prohibition of CCM use in children younger than six years.

关于非处方药(OTC)止咳药和普通感冒药(CCM)的适当性一直存在很多争议。这项全国性研究旨在分析 2014 年至 2023 年捷克儿科人群中中药中毒的发生率。我们对 2014 年至 2023 年捷克儿科人群(0-18 岁)中中药中毒的发生率进行了回顾性研究。没有致命剂量的报告,但有1769例中毒剂量的记录。在所有年龄段和药物类型的意外中成药中毒病例中,意外中成药中毒占 15.60%。在 6,406 例意外中毒病例中,5,465 例(85.31%)发生在 0-6 岁儿童身上,其中 1,564 例(24.41%)发生在 0-2 岁儿童身上。与 7 至 18 岁的儿童相比,0 至 6 岁的儿童发生中药中毒的风险明显较高(RR 9.5,p
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引用次数: 0
Diagnosis and Management of Giant Ventricular Fibroma in a 14-Month-Old Toddler: Insights from Cardiac MRI.
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-02-07 DOI: 10.1055/a-2523-4533
Hafize Otcu Temur, Özkan Bekler, Can Yilmaz Yozgat, Mehmet Nuri Belge, Yilmaz Yozgat
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引用次数: 0
Successful Treatment of an Adolescent with Severe Amlodipine Poisoning with Charcoal Hemoperfusion.
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-02-07 DOI: 10.1055/a-2501-6082
Türkan Akarsu, Merve Havan, Bayram Bayramov, Tanıl Kendirli
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引用次数: 0
Congenital Lung Malformations: Outcomes after Minimally Invasive and Open Surgery in Infancy.
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-02-07 DOI: 10.1055/a-2518-5261
Benjamin Friedrich Berthold Mayer, Leon Ole Schöneberg, Matthias Christian Schunn, Karl Oliver Kagan, Jürgen Schäfer, Felix Neunhoeffer, Winfried Baden, Frank Fideler, Hans Joachim Kirschner, Justus Lieber, Jörg Fuchs

The management of congenital lung malformations (CLM) remains controversial. The aim of this study was to analyze the timing, approach, and outcomes of surgical treatment in children with CLM.A cohort study was conducted comparing children with CLM who underwent thoracoscopic resection with open resection via thoracotomy. All children were treated according to an institutionalized multidisciplinary coordinated treatment algorithm.Between 2002 and 2019, 68 children with CLM were treated. Thoracoscopic resection of CLM (n=44) resulted in a statistically significant longer operative time (mean 169 vs. 97 minutes, p=0.04) but shorter hospital stay (mean 7.2 vs. 16.7/12 days, p=0.01) compared to thoracotomy (n=15) or after conversion to thoracotomy (n=9). There were no major complications in either group. At a mean follow-up of 32.2 months (range 0.5-163), patients after thoracoscopic resection had statistically significantly fewer rip fusions than patients after open resection (n=0 vs. 2/2, p≤0.004) and less chest wall asymmetry than after conversion (n=0 vs. 2, p=0.004).Thoracotomy proved to be a fast and safe surgical approach in respiratory unstable CLM patients. In respiratory stable CLM patients, thoracoscopic resection was feasible in early infancy with good surgical and musculoskeletal outcomes.Thoracoscopic resection of CLM offers advantages over resection by thoracotomy in terms of surgical recovery and musculoskeletal function. Therefore, it should be offered to respiratory-stable patients in specialized centers.

先天性肺畸形(CLM)的治疗仍存在争议。本研究旨在分析CLM患儿手术治疗的时机、方法和结果。本研究对接受胸腔镜切除术和开胸切除术的CLM患儿进行了队列研究比较。2002年至2019年期间,共有68名CLM患儿接受了治疗。胸腔镜下CLM切除术(44例)与开胸手术(15例)或改用开胸手术(9例)相比,手术时间显著延长(平均169分钟对97分钟,P=0.04),但住院时间更短(平均7.2天对16.7/12天,P=0.01)。两组患者均未出现重大并发症。在平均 32.2 个月(0.5-163 个月)的随访中,胸腔镜切除术后患者的撕裂融合率(n=0 vs. 2/2,p≤0.004)和胸壁不对称率(n=0 vs. 2,p=0.004)均显著低于开胸切除术后患者(n=0 vs. 2/2,p≤0.004)。在呼吸稳定的CLM患者中,胸腔镜切除术在婴儿早期就可行,手术和肌肉骨骼效果良好。胸腔镜切除CLM在手术恢复和肌肉骨骼功能方面比开胸手术更有优势。因此,应在专业中心为呼吸稳定的患者提供胸腔镜切除术。
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引用次数: 0
Is Serum Uric Acid to Creatinine Ratio Associated with Hypertension and Metabolic Syndrome in Children with Obesity?
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-02-04 DOI: 10.1055/a-2510-5233
Emine Gulsah Ozdemir, Ayse Derya Bulus

Childhood obesity is a global health problem with increasing prevalence, leading to long-term cardiovascular complications. Research conducted on adults has established a correlation between serum uric acid to creatinine ratio (SUA/Cr) and metabolic syndrome (MetS) components. The study investigates the relationship between SUA/Cr and hypertension (HT) and MetS components in children with obesity.A total of 103 children with obesity who underwent ambulatory blood pressure measurement (ABPM) were included the study and patients were divided into two groups "HT" (n=60) and "Normal" (n=43). Demographic, anthropometric, and laboratory characteristics were retrospectively analyzed.The study included 103 children (42 female, 61 male) with a mean age of 13.7±2.9 years. HT prevalence was significantly higher in patients with severe obesity and dyslipidemia (p=0.045, p=0.01). Males exhibited significantly higher SUA/Cr than females (p<0.001). However, SUA/Cr showed no significant differences between patients with and without HT, MetS, dyslipidemia, or hyperglycemia (p=0.69, p=0.64, p=0.90, p=0.37). Furthermore, linear regression analysis did not establish a significant effect of SUA/Cr on ABPM parameters (p>0.05).In our cohort, no significant association was found between SUA/Cr and HT, as well as MetS components in children with obesity. These findings highlight the need for further investigation into the complex mechanisms regulating uric acid metabolism, obesity, and cardiovascular risk in children.

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引用次数: 0
Importance of Cerebral-Placental Ratio in the Prenatal Diagnosis, Management, and Postnatal Outcome of a Fetus with Giant Cardiac Rhabdomyoma.
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-01-23 DOI: 10.1055/a-2507-0743
Özkan Bekler, Can Yilmaz Yozgat, Yilmaz Yozgat
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引用次数: 0
Evaluation of the Cow's Milk and Hen's Egg Ladder in Daily Practice: A Parent Perspective. 在日常实践中对牛奶和鸡蛋阶梯的评价:一个家长的视角。
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-01-20 DOI: 10.1055/a-2501-5991
Manuela Bozic, Michèle S Roth, Lina Martin, Andrea Werder, Felicitas Bellutti Enders

Evaluation of the cow's milk (CM) and hen's egg (HE) ladder to improve medical care of children with CM and/or HE allergy. Through an anonymous retrospective online questionnaire, we investigated parent perspectives regarding the therapy option of a CM and HE ladder in children with CM and/or HE allergy. Of the 54 families contacted, 29 took part in the study. 19/29 children had already completed the ladders when the survey took place. 19/29 children showed an allergic reaction during the treatment of whom 17 presented skin rashes. 16/29 parents were anxious to rise to the next step in the protocol. 15/29 had difficulties with the implementation of the therapy due to the child refusing the offered food and organizational issues. Medical support as well as the ladder as a therapy option were scored satisfactory. The participating parents were satisfied with the therapy option and medical care. We identified two main areas for improvement: First, the suggested food for every step should be more diverse, according to the families' culture background and nutritional needs/demands. Second, to reduce anxiety regarding the therapy, parents must be informed that although allergic reactions are common, they remain mild. Furthermore, we will suggest step changes under medical supervision, especially in families with a slow progression of the food ladder. With these improvements, the duration of therapy could be shortened, thus reducing the risk of an allergic reaction, the need for medical care by an allergist and therefore reducing healthcare costs.

牛奶(CM)和鸡蛋(HE)阶梯对改善CM和/或HE过敏儿童医疗护理的评价通过匿名回顾性在线问卷调查,我们调查了父母对CM和/或HE过敏儿童CM和HE阶梯治疗选择的看法。在联系的54个家庭中,有29个参加了这项研究。在进行调查时,有19/29的儿童已经完成了梯子。29例患儿中有19例出现过敏反应,其中17例出现皮疹。16/29家长们急于进入协议的下一步。由于孩子拒绝提供的食物和组织问题,15/29在实施治疗时遇到困难。医疗支持以及作为一种治疗选择的梯子被认为是令人满意的。参与的家长对治疗方案和医疗护理满意。我们确定了两个主要的改进领域:首先,根据家庭的文化背景和营养需求/需求,每一步的建议食物应该更加多样化。其次,为了减少对治疗的焦虑,必须告知家长,虽然过敏反应很常见,但它们仍然是轻微的。此外,我们将建议在医疗监督下逐步改变,特别是在食物阶梯进展缓慢的家庭。有了这些改进,治疗的持续时间可以缩短,从而减少过敏反应的风险,减少过敏专科医生的医疗护理需求,从而降低医疗保健费用。
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引用次数: 0
[Drug-induced liver injury induced by nicotinamide: a case report]. 烟酰胺致药物性肝损伤1例。
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-01-16 DOI: 10.1055/a-2498-9641
Johannes Nadler, Isabel Wettstein, Peter Krieg, Uwe Stedtler, Maren Hermanns-Clausen
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引用次数: 0
Sonographic and Anthropometric Measurements for Body Composition and Their Relationship with Functioning in Adolescent Obesity. 青少年肥胖中身体成分的超声和人体测量及其与功能的关系。
IF 1.2 4区 医学 Q3 PEDIATRICS Pub Date : 2025-01-16 DOI: 10.1055/a-2498-9419
Pinar Ozge Avar-Aydin, Esra Gizem Koyuncu, Duygu Dogan, Nursena Kologlu Ates, Emel Gurel, Nuray Arda, Levent Ozcakar

Obesity is one of the most common chronic diseases seen in children and adolescents. This study aims to examine the impact of obesity on body composition, assessed by sonographic and anthropometric measurements, and health-related quality of life (HRQoL) in adolescents.Anthropometric measurements, sonographic measurements of subcutaneous fat, quadriceps muscle, Achilles tendon thickness, and HRQoL were performed in children between 12-18 years of age. Comparisons between adolescents with obesity and normal body mass index (BMI) were examined.A total of 300 adolescents with similar physical activity levels, 28.7% with obesity, were enrolled. The thickness of mid-forearm/mid-thigh subcutaneous fat tissue and quadriceps muscle was significantly higher in participants with obesity (p≤0.001). Moderate-to-strong correlation with BMI and waist circumference was observed (r>0.40, p<0.01). Participants with longer duration of obesity had thicker quadriceps muscle irrespective of the severity of obesity or presence of metabolic syndrome. Achilles tendon thickness did not differ between the groups. HRQoL was significantly lower in adolescents with obesity and indicated a negative moderate correlation between physical functioning and subcutaneous fat thickness (r<- 0.50, p<0.01).An important relationship between sonographic and anthropometric measurements, and physical functioning was demonstrated in adolescents. Ultrasound seems to have a role in the evaluation of body composition in obesity beyond what is captured by overall BMI. Significantly increased quadriceps muscle thickness in adolescents with obesity, coupled with its relation to the duration of obesity, implies potential temporal association between excess body weight and adaptation of quadriceps muscle.

肥胖是儿童和青少年最常见的慢性疾病之一。本研究旨在通过超声和人体测量来评估肥胖对青少年身体成分和健康相关生活质量(HRQoL)的影响。对12-18岁的儿童进行人体测量、超声测量皮下脂肪、股四头肌、跟腱厚度和HRQoL。比较肥胖青少年和正常体重指数(BMI)。共有300名身体活动水平相似的青少年被纳入研究,其中28.7%为肥胖。肥胖参与者前臂中部/大腿中部皮下脂肪组织和股四头肌的厚度显著高于肥胖参与者(p≤0.001)。BMI和腰围之间存在中强相关性(p < 0.05)
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Klinische Padiatrie
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