Pub Date : 2021-09-09DOI: 10.22141/2307-1257.6.2.2017.103872
D. Ivanov
Слоган этого номера: «Слушать — не значит слышать. Учимся…»
这个数字的口号是:“倾听不是倾听。学习……”
{"title":"Обращение главного редактора","authors":"D. Ivanov","doi":"10.22141/2307-1257.6.2.2017.103872","DOIUrl":"https://doi.org/10.22141/2307-1257.6.2.2017.103872","url":null,"abstract":"Слоган этого номера: «Слушать — не значит слышать. Учимся…»","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82591473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234328
G. Bonkat, R. Bartoletti, F. Bruyère, T. Cai, S. Geerlings, B. Köves, S. Schubert, F. Wagenlehner
No abstract
没有抽象的
{"title":"Urinary tract infections in adults (selected chapters from Urological Infections 2021)","authors":"G. Bonkat, R. Bartoletti, F. Bruyère, T. Cai, S. Geerlings, B. Köves, S. Schubert, F. Wagenlehner","doi":"10.22141/2307-1257.10.2.2021.234328","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234328","url":null,"abstract":"No abstract","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77395820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234329
J. Floege
No abstract
没有抽象的
{"title":"The revised (KDIGO) Clinical Practice Guideline for Glomerular Diseases (May 13, 2021, based on the ERA-EDTA e-seminars)","authors":"J. Floege","doi":"10.22141/2307-1257.10.2.2021.234329","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234329","url":null,"abstract":"No abstract","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86616107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234324
S. Kushnirenko
Anemia is the most common complication of chronic kidney disease (CKD) associated with reduced quality of life and increased morbidity and mortality. The purpose of this review was to discuss the management of anemia in CKD. The following topics are considered: prevalence of anemia, symptoms, and impact of anemia in CKD, diagnosis, iron replacement therapy, and erythropoiesis-stimulating agents.
{"title":"Management of anemia in chronic kidney disease","authors":"S. Kushnirenko","doi":"10.22141/2307-1257.10.2.2021.234324","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234324","url":null,"abstract":"Anemia is the most common complication of chronic kidney disease (CKD) associated with reduced quality of life and increased morbidity and mortality. The purpose of this review was to discuss the management of anemia in CKD. The following topics are considered: prevalence of anemia, symptoms, and impact of anemia in CKD, diagnosis, iron replacement therapy, and erythropoiesis-stimulating agents.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87335450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234326
C. Radmayr (Chair), G. Bogaert, H. Doğan, J.M. Nijman (Vice-chair), Y. Rawashdeh, M. Sılay, R. Stein, S. Tekgül
No abstract
没有抽象的
{"title":"Urinary tract infections in children (selected chapters from Pediatric urology, EAU, 2021)","authors":"C. Radmayr (Chair), G. Bogaert, H. Doğan, J.M. Nijman (Vice-chair), Y. Rawashdeh, M. Sılay, R. Stein, S. Tekgül","doi":"10.22141/2307-1257.10.2.2021.234326","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234326","url":null,"abstract":"No abstract","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89807667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234323
I. Kuchma
In the review, the author returns to the topic of uremia and uremic toxins, their importance for practitioners in the treatment using renal replacement therapies, gives a modern look at their classification, place during the onset and development of pathological processes in the progression of chronic kidney disease. However, current guidelines and studies for the treatment of chronic kidney disease indicate a lack of attention to the role and importance of uremic toxins in the predialysis stages of uremia treatment, in particular to the possible damaging effects of substances retained in the body with reduced glomerular filtration, directly to the renal function. The tables with the list of uremic toxins according to their classification are presented. References are made to the results of clinical and laboratory studies of uremic toxins, their impact on the general clinical picture of uremia and ways of their influence on the progression of chronic kidney disease and the further progression of the clinical picture of uremia. Attention is drawn to the fact that substances recognized as uremic toxins are present in healthy individuals without manifestations of their negative effects, and therefore the opinion is expressed about the need to study the physiological significance of these solvents under normal glomerular filtration. The question arises about the consideration of the factors of uremic toxins impact as a point of application in terms of the progression of chronic kidney disease and the use of this knowledge in renoprotective therapy in the predialysis stages of chronic kidney disease.
{"title":"Uremic toxins. Back to the future","authors":"I. Kuchma","doi":"10.22141/2307-1257.10.2.2021.234323","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234323","url":null,"abstract":"In the review, the author returns to the topic of uremia and uremic toxins, their importance for practitioners in the treatment using renal replacement therapies, gives a modern look at their classification, place during the onset and development of pathological processes in the progression of chronic kidney disease. However, current guidelines and studies for the treatment of chronic kidney disease indicate a lack of attention to the role and importance of uremic toxins in the predialysis stages of uremia treatment, in particular to the possible damaging effects of substances retained in the body with reduced glomerular filtration, directly to the renal function. The tables with the list of uremic toxins according to their classification are presented. References are made to the results of clinical and laboratory studies of uremic toxins, their impact on the general clinical picture of uremia and ways of their influence on the progression of chronic kidney disease and the further progression of the clinical picture of uremia. Attention is drawn to the fact that substances recognized as uremic toxins are present in healthy individuals without manifestations of their negative effects, and therefore the opinion is expressed about the need to study the physiological significance of these solvents under normal glomerular filtration. The question arises about the consideration of the factors of uremic toxins impact as a point of application in terms of the progression of chronic kidney disease and the use of this knowledge in renoprotective therapy in the predialysis stages of chronic kidney disease.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83452037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234320
A. I. Gorodetska, O. Dyadyk, M. Ivanova
In the era of antiretroviral therapy (ART), the development of chronic kidney disease in HIV-infected patients is a significant complication not directly related to acquired immunodeficiency syndrome (AIDS), the risk of which is increased with co-infection with hepatitis C virus (HCV). The pathogenetic pathways of the development of kidney tissue damage and the formation of a morphological substrate for each of the viruses are different, but the immune-mediated mechanisms are a common link for the development of immune complex diseases. We studied renal necropsy samples in 20 patients with HIV/HCV co-infection who did not receive ART, and the dependence of the identified morphological substrate on the level of CD4+ in the blood, to assess and predict their morphogenesis. We observed predominantly segmental mesangial proliferation with an expansion of the mesangial matrix and glomerular involvement ≥ 50 % in 15 (75 %) cases and glomerular involvement < 50 % in 3 (15 %) cases. Endocapillary proliferation (E), infiltration of glomeruli with monocytes, neutrophil leukocytes, segmental macrophages were found in 2 (10 %) cases with the involvement of ≥ 50 % of glomeruli, which was regarded as an exudative component of the inflammatory response. In all cases, sclerosis of capillary loops was verified, which was mainly accompanied by their collapse, thickening of the capillary walls, namely the basement membranes of capillaries and segmental sclerosis of capillary loops of the glomeruli of varying severity. Initial interstitial stromal fibrosis was found in 5 (25 %) cases, degenerative changes in the convoluted tubules — in 9 (45 %), mainly with the T0–T1 level. Positive expression of IgA, IgM, IgG, and C3 complement fractions in the form of linear and granular deposits along the capillary endothelium was detected with an intensity of “+” to “++”. We compared the verified morphological pattern and the level of CD4+ in the blood and found that patients with deeper immunosuppression show fewer changes, mainly characterized as sclerotic. Moreover, with an increase in the level of CD4+, the morphological substrate is enriched with a proliferative component. Expression of immunoglobulins and components of the complement system in immonohistochemical assay, in particular in areas of sclerotic changes, verifies the presence of prolonged immune complex associated lesions. To determine the detailed morphogenesis, it is advisable to perform a further correlation analysis of the data obtained with the control.
{"title":"Clinical and morphological characteristic of kidney damage in HIV/HCV co-infected patients who did not receive antiretroviral therapy","authors":"A. I. Gorodetska, O. Dyadyk, M. Ivanova","doi":"10.22141/2307-1257.10.2.2021.234320","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234320","url":null,"abstract":"In the era of antiretroviral therapy (ART), the development of chronic kidney disease in HIV-infected patients is a significant complication not directly related to acquired immunodeficiency syndrome (AIDS), the risk of which is increased with co-infection with hepatitis C virus (HCV). The pathogenetic pathways of the development of kidney tissue damage and the formation of a morphological substrate for each of the viruses are different, but the immune-mediated mechanisms are a common link for the development of immune complex diseases. We studied renal necropsy samples in 20 patients with HIV/HCV co-infection who did not receive ART, and the dependence of the identified morphological substrate on the level of CD4+ in the blood, to assess and predict their morphogenesis. We observed predominantly segmental mesangial proliferation with an expansion of the mesangial matrix and glomerular involvement ≥ 50 % in 15 (75 %) cases and glomerular involvement < 50 % in 3 (15 %) cases. Endocapillary proliferation (E), infiltration of glomeruli with monocytes, neutrophil leukocytes, segmental macrophages were found in 2 (10 %) cases with the involvement of ≥ 50 % of glomeruli, which was regarded as an exudative component of the inflammatory response. In all cases, sclerosis of capillary loops was verified, which was mainly accompanied by their collapse, thickening of the capillary walls, namely the basement membranes of capillaries and segmental sclerosis of capillary loops of the glomeruli of varying severity. Initial interstitial stromal fibrosis was found in 5 (25 %) cases, degenerative changes in the convoluted tubules — in 9 (45 %), mainly with the T0–T1 level. Positive expression of IgA, IgM, IgG, and C3 complement fractions in the form of linear and granular deposits along the capillary endothelium was detected with an intensity of “+” to “++”. We compared the verified morphological pattern and the level of CD4+ in the blood and found that patients with deeper immunosuppression show fewer changes, mainly characterized as sclerotic. Moreover, with an increase in the level of CD4+, the morphological substrate is enriched with a proliferative component. Expression of immunoglobulins and components of the complement system in immonohistochemical assay, in particular in areas of sclerotic changes, verifies the presence of prolonged immune complex associated lesions. To determine the detailed morphogenesis, it is advisable to perform a further correlation analysis of the data obtained with the control.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"84 Pt 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82720097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234333
R. Zograbian, V. Zakordonetz, A. Malyk, N.M. Polonchuk
Kidney transplantation is considered the gold standard in the treatment of end-stage renal disease and can be performed if cadaveric or living related donor organ is available. AB0 incompatible kidney transplantation can lead to antibody-mediated rejection. There are a number of methods in the world for the elimination of anti-A/B antibodies to prepare for AB0 incompatible kidney transplantation, each of which has its advantages and disadvantages. Therefore, further researches are needed in this direction to determine the optimal method in each case. Particular attention is paid to modern methods of anti-A/B antibodies elimination, protocols for managing such patients, and their comparison. The possibilities of using these methods in Ukraine are analyzed.
{"title":"Methods of anti-A/B antibodies elimination in preparation for ABО incompatible kidney transplantation","authors":"R. Zograbian, V. Zakordonetz, A. Malyk, N.M. Polonchuk","doi":"10.22141/2307-1257.10.2.2021.234333","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234333","url":null,"abstract":"Kidney transplantation is considered the gold standard in the treatment of end-stage renal disease and can be performed if cadaveric or living related donor organ is available. AB0 incompatible kidney transplantation can lead to antibody-mediated rejection. There are a number of methods in the world for the elimination of anti-A/B antibodies to prepare for AB0 incompatible kidney transplantation, each of which has its advantages and disadvantages. Therefore, further researches are needed in this direction to determine the optimal method in each case. Particular attention is paid to modern methods of anti-A/B antibodies elimination, protocols for managing such patients, and their comparison. The possibilities of using these methods in Ukraine are analyzed.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83565538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.22141/2307-1257.10.2.2021.234330
No Authors
No abstract
没有抽象的
{"title":"World Kidney Day 2021: “Living well with kidney disease”","authors":"No Authors","doi":"10.22141/2307-1257.10.2.2021.234330","DOIUrl":"https://doi.org/10.22141/2307-1257.10.2.2021.234330","url":null,"abstract":"No abstract","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"370 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79824961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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