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Neighborhood Socioeconomic Status and Cardiovascular Events in Adults With CKD: The CRIC Study 社区社会经济状况与慢性肾脏病成人心血管事件:CRIC 研究
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-12 DOI: 10.1016/j.xkme.2024.100901
Avi G. Aronov , Milda R. Saunders , Jesse Y. Hsu , Daohang Sha , Martha Daviglus , Michael J. Fischer , Lawrence J. Appel , James Sondheimer , Jiang He , Hernan Rincon-Choles , Edward J. Horwitz , Tanika N. Kelly , Ana C. Ricardo , James P. Lash
<div><h3>Rationale & Objective</h3><div>In the general population, neighborhood socioeconomic status (SES) has been found to be associated with cardiovascular risk, but this relationship has not been well studied among patients with chronic kidney disease (CKD). This study seeked to evaluate the association between neighborhood SES and cardiovascular outcomes in a CKD cohort.</div></div><div><h3>Study Design</h3><div>Multicenter prospective cohort.</div></div><div><h3>Setting & Participants</h3><div>In total, 3,197 participants in the Chronic Renal Insufficiency Cohort Study without cardiovascular disease at baseline.</div></div><div><h3>Exposure</h3><div>Neighborhood SES quartiles using a validated neighborhood-level SES summary measure for 6 census-derived variables.</div></div><div><h3>Outcome</h3><div>Incident heart failure, myocardial infarction, and all-cause death.</div></div><div><h3>Analytical Approach</h3><div>Cox proportional hazards.</div></div><div><h3>Results</h3><div>During median follow-up of 8.8 years, there were 465 incident heart failure events, 297 myocardial infarctions, and 891 deaths. In a fully adjusted model, among individuals with estimated glomerular filtration rate<!--> <!-->≥45<!--> <!-->mL/min/1.73<!--> <!-->m<sup>2</sup>, lowest neighborhood SES quartile was associated with higher risk of heart failure (HR, 1.96 [95% CI, 1.04-3.67]) compared with the highest quartile. This association was not significant among those with estimated glomerular filtration rate<!--> <!--><45<!--> <!-->mL/min/1.73<!--> <!-->m<sup>2</sup> (<em>P</em> for interaction<!--> <!--><<!--> <!-->0.1). There was no association between neighborhood SES and myocardial infarction; however, in the same multivariable-adjusted model, less than high school education was associated with higher risk of myocardial infarction (HR, 1.52 [95% CI, 1.06-2.17]). Among those aged greater than 60 years, there was a significant association between the lowest neighborhood SES quartile and death (HR, 1.72 [95% CI, 1.06-2.78]), but this association was not significant among those aged 60 years and younger (<em>P</em> for interaction<!--> <!--><<!--> <!-->0.05).</div></div><div><h3>Limitations</h3><div>Findings are subject to residual confounding and bias.</div></div><div><h3>Conclusions</h3><div>In a CKD cohort, neighborhood-level SES was associated with incident heart failure among individuals with more preserved kidney function and death in those younger than 60 years. Policies and public health and health system interventions are needed to address individual- and neighborhood-level SES factors to improve outcomes for patients with CKD residing in disadvantaged communities.</div></div><div><h3>Plain-Language Summary</h3><div>Because patients with chronic kidney disease (CKD) experience high rates of cardiovascular complications, we evaluated the relationship between neighborhood-level socioeconomic status (SES) and cardiovascular outcomes using data
理论依据& 目标在普通人群中,邻里社会经济地位(SES)被发现与心血管风险有关,但在慢性肾脏病(CKD)患者中,这种关系还没有得到很好的研究。本研究旨在评估 CKD 队列中邻里社会经济地位与心血管预后之间的关系。研究设计多中心前瞻性队列。结果在中位随访 8.8 年期间,共发生 465 例心衰、297 例心肌梗死和 891 例死亡。在完全调整模型中,在估计肾小球滤过率≥45 mL/min/1.73 m2的个体中,与最高四分位数相比,邻近地区社会经济地位最低的四分位数与较高的心衰风险相关(HR,1.96 [95% CI,1.04-3.67])。在估计肾小球滤过率为 45 mL/min/1.73 m2 的人群中,这种关联并不显著(交互作用 P 为 0.1)。邻里社会经济地位与心肌梗死之间没有关联;但是,在同一多变量调整模型中,高中以下教育程度与心肌梗死风险较高有关(HR,1.52 [95% CI,1.06-2.17])。结论在一个慢性肾脏病队列中,邻里水平的社会经济状况与肾功能较好的人发生心力衰竭以及60岁以下人群的死亡有关。由于慢性肾脏病(CKD)患者的心血管并发症发生率较高,我们利用慢性肾功能不全队列研究的数据评估了邻里社会经济地位(SES)与心血管预后之间的关系。我们发现,居住在条件较差的社区与轻度慢性肾脏病患者发生心力衰竭的风险较高以及年龄小于 60 岁的患者死亡风险较高有关。这些发现突出表明,需要采取公共卫生和卫生系统干预措施来解决这些差异。
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引用次数: 0
Chronic Kidney Disease-Associated Pruritus Burden: A Patient Survey Study 与慢性肾脏病相关的瘙痒负担:患者调查研究
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-12 DOI: 10.1016/j.xkme.2024.100900
Jeffrey Thompson , Jennifer Kammerer , Tasha Boshears , Juliana Oliveira , Kirsten L. Johansen , Anna Kovar , Lulu Lee , Gil Yosipovitch
<div><h3>Rationale & Objective</h3><div>Chronic kidney disease-associated pruritus (CKD-aP) is a common, underrecognized condition in patients with chronic kidney disease (CKD), especially those receiving hemodialysis (HD). The present study analyzed the clinical treatment journey and overall burden of pruritus among patients with CKD-aP.</div></div><div><h3>Study Design</h3><div>Cross-sectional, patient-reported online survey.</div></div><div><h3>Setting & Participants</h3><div>Data from adult patients undergoing HD (December 2021–May 2022) in the United States.</div></div><div><h3>Exposure</h3><div>Patients participated in an online survey and responded to questions on validated patient-reported outcome instruments related to CKD-aP.</div></div><div><h3>Outcomes</h3><div>Self-reported measures analyzed at the end of this survey include itch characteristics; symptom management; health care provider (HCP) engagement; and effect on HD, quality of life (QoL), sleep, and work productivity.</div></div><div><h3>Analytical Approach</h3><div>Bivariate analysis assessed the association of itch severity with CKD-specific QoL.</div></div><div><h3>Results</h3><div>Overall, 354 patients with CKD-aP were included in analyses, of which 49% and 30% had moderate and severe itch, respectively (22% were mild). Around 68% reported symptoms to HCPs, most commonly a nephrologist or primary care provider, and 55% received a treatment recommendation. The most common treatments were topical lotions/moisturizers (75%) and corticosteroids (48%); use of oral prescriptions was low (20%), with limited satisfaction with treatments. Overall, 23% of patients reported shortening and 17% reported missing HD sessions because of itch. In bivariate analysis, patients with more severe CKD-aP reported significantly worse disease and function scores (kidney disease score, cognitive function, quality of social interaction, sleep [all, <em>P</em> <!--><<!--> <!-->0.001], and sexual function [<em>P</em> <!--><<!--> <!-->0.05]), suggesting a direct effect of CKD-aP on QoL.</div></div><div><h3>Limitations</h3><div>Possible recall bias, especially for questions with longer recall periods.</div></div><div><h3>Conclusions</h3><div>CKD-aP is often inadequately treated and disruptive of dialysis treatment, even among patients who report itch to HCPs. Worse itch severity is associated with poorer QoL, sleep quality, and functional/work impairment.</div></div><div><h3>Plain-Language Summary</h3><div>Chronic kidney disease-associated pruritus (CKD-aP) is a common problem in patients with kidney disease, especially in those who are receiving dialysis. There are few approved treatment options for CKD-aP. Understanding how CKD-related itch affects patients may help identify ways to improve CKD-aP symptoms/signs. This patient-reported survey assessed itch characteristics, symptom management attempts and effectiveness, and burdens caused by itch in patients with CKD-aP. Although<!--> <!-->
依据& 目的慢性肾脏病相关性瘙痒症(CKD-aP)是慢性肾脏病(CKD)患者,尤其是接受血液透析(HD)患者中一种常见的、未得到充分认识的疾病。本研究分析了CKD-aP患者的临床治疗历程和瘙痒症的总体负担。研究设计横断面、患者报告的在线调查。设置& 参与者数据来自美国接受血液透析(HD)的成年患者(2021年12月至2022年5月)。暴露患者参与在线调查,并回答与CKD-aP相关的经过验证的患者报告结果工具的问题。分析方法二元分析评估了瘙痒严重程度与 CKD 特异性 QoL 的相关性。结果总计有 354 名 CKD-aP 患者参与了分析,其中 49% 和 30% 分别患有中度和重度瘙痒(22% 为轻度)。约 68% 的患者向保健医生(最常见的是肾科医生或初级保健医生)报告了症状,55% 的患者得到了治疗建议。最常见的治疗方法是外用洗剂/保湿剂(75%)和皮质类固醇(48%);口服处方的使用率较低(20%),且对治疗的满意度有限。总体而言,23% 的患者称因瘙痒而缩短了治疗时间,17% 的患者称因瘙痒而错过了血液透析疗程。在双变量分析中,CKD-aP 更严重的患者报告的疾病和功能评分(肾病评分、认知功能、社会交往质量、睡眠 [全部,P < 0.001] 和性功能 [P < 0.局限性可能存在回忆偏差,尤其是回忆期较长的问题。结论即使是向医护人员报告瘙痒的患者,CKD-aP 通常也未得到充分治疗,并且会影响透析治疗。白话摘要慢性肾病相关性瘙痒症(CKD-aP)是肾病患者,尤其是接受透析治疗的患者的常见问题。目前已批准的治疗慢性肾脏病相关性瘙痒症的方法很少。了解与 CKD 相关的瘙痒对患者的影响有助于找出改善 CKD-aP 症状/体征的方法。这项由患者报告的调查评估了 CKD-aP 患者的瘙痒特征、症状处理尝试和效果,以及瘙痒造成的负担。尽管60%的血液透析患者报告有痒相关症状,但CKD-aP可能诊断不足。大多数患者表示,他们没有获得治疗方案和/或对目前的治疗不满意。研究还显示,瘙痒强度会影响患者全面参与规定的透析疗程、生活质量、睡眠质量和工作效率。
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引用次数: 0
Preliminary Outcomes of NephSIM Nephrons: A Virtual Mentorship Program to Foster Interest in Nephrology NephSIM Nephrons 的初步成果:培养肾脏病学兴趣的虚拟导师计划
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.xkme.2024.100899
Samira S. Farouk , Matthew A. Sparks , Jessica Joseph
<div><h3>Background</h3><div>Despite concerted efforts by the nephrology community to increase the quality of nephrology education via a plethora of free open access medical education tools and efforts by national nephrology societies, interest in nephrology has mostly remained stagnant.</div></div><div><h3>Methods</h3><div>A 6-month virtual learning and mentoring program (NephSIM Nephrons) was launched in January 2021 to increase interest in nephrology careers among medical students and residents. Trainees were assigned one faculty mentor and a small group with faculty and other trainees. Learning opportunities consisted of both live and virtual sessions and an asynchronous curriculum. Feedback was collected from trainees at the end of the program each year through an online, anonymous survey. For trainees in the 2021 and 2022 cohort, residency/fellowship status for the July 2024-2025 academic year was assessed by survey.</div></div><div><h3>Results</h3><div>Of 319 and 315 eligible applications received for the 2021 and 2022 programs, 111 and 108 trainees were accepted, respectively; 31 participants in the 2023 cohort completed the exit survey (response rate: 31/84, 37%) and rated the mean overall NephSIM Nephrons experience as 4.7 of 5. All respondents were very likely or somewhat likely to recommend the experience to other trainees. In the 2021 and 2022 cohorts, 37 of 49 (77%) and 29 of 38 (76%) trainees, respectively, who were eligible to match into adult or pediatric nephrology fellowships by July 2024 successfully matched. Similarly, among the 2021 and 2022 cohorts, 11 of 19 (58%) and 21 of 23 (91%), respectively, who could be internal medicine or pediatrics residents in July 2024 successfully matched.</div></div><div><h3>Limitations</h3><div>Low survey response rate.</div></div><div><h3>Conclusions</h3><div>Early outcome analysis of the NephSIM Nephrons program shows promising results, and individuals who participated had high rates of enrollment in nephrology pipeline residencies and nephrology fellowships. More work is needed to first continue rigorous follow-up of program participants, obtain qualitative program feedback, and improve participant and mentor engagement.</div></div><div><h3>Plain-Language Summary</h3><div>Despite concerted efforts by the nephrology community to increase the quality of nephrology education via a plethora of free, open access medical education tools and efforts by national nephrology societies, interest in nephrology has mostly remained stagnant. A 6-month virtual learning and mentoring program (NephSIM Nephrons) was launched in January 2021 to increase interest in nephrology careers among medical students and residents. Early outcome analysis of the NephSIM Nephrons program shows promising results, and individuals who participated had high rates of enrollment in nephrology pipeline residencies and nephrology fellowships. More work is needed to continue rigorous follow-up of program participants, obtain qual
背景尽管肾脏病学界通过大量免费开放的医学教育工具和各国肾脏病学会的努力提高了肾脏病学教育的质量,但人们对肾脏病学的兴趣大多仍然停滞不前。方法2021年1月启动了一项为期6个月的虚拟学习和指导计划(NephSIM Nephrons),以提高医学生和住院医师对肾脏病学职业的兴趣。受训人员被指派一名教师导师,并与教师和其他受训人员组成一个小组。学习机会包括现场和虚拟课程以及异步课程。每年项目结束时,都会通过在线匿名调查收集学员的反馈意见。结果 2021 年和 2022 年项目分别收到 319 份和 315 份符合条件的申请,其中分别有 111 名和 108 名学员被录取;2023 年学员中有 31 人完成了结业调查(回复率:31/84,37%),他们对 NephSIM 尼普龙项目总体体验的平均评分为 4.7 分(满分为 5 分)。所有受访者都表示很有可能或有点可能向其他学员推荐这次经历。在 2021 年和 2022 年两批学员中,有资格在 2024 年 7 月之前匹配到成人或儿科肾脏病研究员职位的学员分别为 49 人中的 37 人(77%)和 38 人中的 29 人(76%)。同样,在 2021 年和 2022 年的学员中,分别有 19 人中的 11 人(58%)和 23 人中的 21 人(91%)能在 2024 年 7 月成功匹配为内科或儿科住院医师。尽管肾脏病学界通过大量免费、开放的医学教育工具和各国肾脏病学协会的努力来提高肾脏病学教育的质量,但人们对肾脏病学的兴趣却始终停滞不前。2021 年 1 月,一项为期 6 个月的虚拟学习和指导计划(NephSIM Nephrons)启动,旨在提高医学生和住院医师对肾脏病学职业的兴趣。对 NephSIM Nephrons 计划的早期成果分析表明,该计划取得了可喜的成果,参与该计划的个人在肾脏病学专业住院医师和肾脏病学研究员中的入学率很高。我们还需要做更多的工作,继续对项目参与者进行严格的跟踪,获得项目的定性反馈,并提高参与者和导师的参与度。
{"title":"Preliminary Outcomes of NephSIM Nephrons: A Virtual Mentorship Program to Foster Interest in Nephrology","authors":"Samira S. Farouk ,&nbsp;Matthew A. Sparks ,&nbsp;Jessica Joseph","doi":"10.1016/j.xkme.2024.100899","DOIUrl":"10.1016/j.xkme.2024.100899","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Despite concerted efforts by the nephrology community to increase the quality of nephrology education via a plethora of free open access medical education tools and efforts by national nephrology societies, interest in nephrology has mostly remained stagnant.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A 6-month virtual learning and mentoring program (NephSIM Nephrons) was launched in January 2021 to increase interest in nephrology careers among medical students and residents. Trainees were assigned one faculty mentor and a small group with faculty and other trainees. Learning opportunities consisted of both live and virtual sessions and an asynchronous curriculum. Feedback was collected from trainees at the end of the program each year through an online, anonymous survey. For trainees in the 2021 and 2022 cohort, residency/fellowship status for the July 2024-2025 academic year was assessed by survey.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Of 319 and 315 eligible applications received for the 2021 and 2022 programs, 111 and 108 trainees were accepted, respectively; 31 participants in the 2023 cohort completed the exit survey (response rate: 31/84, 37%) and rated the mean overall NephSIM Nephrons experience as 4.7 of 5. All respondents were very likely or somewhat likely to recommend the experience to other trainees. In the 2021 and 2022 cohorts, 37 of 49 (77%) and 29 of 38 (76%) trainees, respectively, who were eligible to match into adult or pediatric nephrology fellowships by July 2024 successfully matched. Similarly, among the 2021 and 2022 cohorts, 11 of 19 (58%) and 21 of 23 (91%), respectively, who could be internal medicine or pediatrics residents in July 2024 successfully matched.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Limitations&lt;/h3&gt;&lt;div&gt;Low survey response rate.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Early outcome analysis of the NephSIM Nephrons program shows promising results, and individuals who participated had high rates of enrollment in nephrology pipeline residencies and nephrology fellowships. More work is needed to first continue rigorous follow-up of program participants, obtain qualitative program feedback, and improve participant and mentor engagement.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Plain-Language Summary&lt;/h3&gt;&lt;div&gt;Despite concerted efforts by the nephrology community to increase the quality of nephrology education via a plethora of free, open access medical education tools and efforts by national nephrology societies, interest in nephrology has mostly remained stagnant. A 6-month virtual learning and mentoring program (NephSIM Nephrons) was launched in January 2021 to increase interest in nephrology careers among medical students and residents. Early outcome analysis of the NephSIM Nephrons program shows promising results, and individuals who participated had high rates of enrollment in nephrology pipeline residencies and nephrology fellowships. More work is needed to continue rigorous follow-up of program participants, obtain qual","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"6 11","pages":"Article 100899"},"PeriodicalIF":3.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dialysis Modality Education Timing and Home Dialysis Uptake: A Quality Improvement Study 透析方式教育时机与家庭透析使用率:质量改进研究
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-05 DOI: 10.1016/j.xkme.2024.100898
Declan (Shiyu) Lu , Mishal Akhtar , Lisa Dubrofsky , Bourne L. Auguste
<div><h3>Rationale & Objective</h3><div>Investigating the effect of a quality improvement intervention aimed at enhancing the choice of home dialysis among patients through improved educational sessions on dialysis modalities.</div></div><div><h3>Study Design</h3><div>A new referral protocol initiated on September 15, 2022, sought to direct patients with advanced kidney disease to modality education sessions. This protocol involved an updated referral form and process, requiring nephrologists to refer patients with an estimated glomerular filtration rate below 15<!--> <!-->mL/min/1.73<!--> <!-->m<sup>2</sup> or specified Kidney Failure Risk Equation scores to modality educators for education. The impact was measured by the uptake of the education and the choice of home dialysis by patients.</div></div><div><h3>Setting & Participants</h3><div>The study took place at Sunnybrook Health Sciences Centre in Toronto, Canada, involving 532 patients across 1,723 clinical encounters from October 2019 to June 2023.</div></div><div><h3>Predictor</h3><div>The intervention was predicted to lead to an increase in both the number of patients receiving modality education and those choosing home dialysis.</div></div><div><h3>Outcomes</h3><div>The primary outcome measured was the selection of home dialysis following modality education, with a secondary focus on the proportion of patients educated post intervention.</div></div><div><h3>Analytical Approach</h3><div>Statistical process charts were used for monitoring changes in education uptake and home dialysis selection rates following the intervention.</div></div><div><h3>Results</h3><div>After implementing the standardized referral system, the proportion of patients receiving modality education increased from 27.1%-56.7%. However, the rate of selecting home dialysis remained constant at 50.9%. Overall home dialysis prevalence at our center averaged 19.6%, remaining lower than the provincial average of 24.4% by the end of the study period.</div></div><div><h3>Limitations</h3><div>The study was limited to 1 center, without evaluating patient satisfaction or dissecting the complexity of educational content and delivery.</div></div><div><h3>Conclusions</h3><div>We succeeded in boosting education rates but failed to achieve higher home dialysis choice rates, possibly owing to the complexity involved in modality choices. We plan to further investigate the factors influencing patient choices during modality education to better promote home dialysis selection.</div></div><div><h3>Plain-Language Summary</h3><div>The study focused on whether teaching patients more about their dialysis options would encourage them to choose home dialysis. A new system was introduced at an academic hospital in Toronto, requiring doctors to refer patients with advanced kidney disease to educational sessions. The aim was to see if patients who learned more about dialysis would be more likely to manage their treatment at home. The result
研究设计2022年9月15日启动的新转诊协议旨在引导晚期肾病患者参加透析方式教育课程。该方案包括更新转诊表格和流程,要求肾科医生将估计肾小球滤过率低于 15 mL/min/1.73 m2 或特定肾衰竭风险方程评分的患者转诊至透析方式教育者接受教育。该研究在加拿大多伦多桑尼布鲁克健康科学中心进行,从2019年10月至2023年6月,共涉及1723例临床就诊的532名患者。预测该干预措施将导致接受方式教育和选择家庭透析的患者人数增加。结果测量的主要结果是接受方式教育后选择家庭透析的患者人数,其次是干预后接受教育的患者比例。分析方法使用统计过程图监测干预后教育接受率和家庭透析选择率的变化。但是,选择家庭透析的比例仍保持在 50.9%。结论我们成功地提高了教育率,但未能实现更高的家庭透析选择率,这可能是由于透析方式选择的复杂性。我们计划进一步研究影响患者在透析方式教育过程中做出选择的因素,以更好地促进患者选择家庭透析。多伦多一家学术医院引入了一个新系统,要求医生推荐晚期肾病患者参加教育课程。这样做的目的是为了了解患者在了解了更多透析知识后,是否更愿意在家接受治疗。结果是更多的病人接受了这些教育课程,但这并没有导致更多的病人选择在家透析。未来的研究必须调查还有哪些因素会影响患者考虑在家透析治疗的决定。
{"title":"Dialysis Modality Education Timing and Home Dialysis Uptake: A Quality Improvement Study","authors":"Declan (Shiyu) Lu ,&nbsp;Mishal Akhtar ,&nbsp;Lisa Dubrofsky ,&nbsp;Bourne L. Auguste","doi":"10.1016/j.xkme.2024.100898","DOIUrl":"10.1016/j.xkme.2024.100898","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Rationale &amp; Objective&lt;/h3&gt;&lt;div&gt;Investigating the effect of a quality improvement intervention aimed at enhancing the choice of home dialysis among patients through improved educational sessions on dialysis modalities.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study Design&lt;/h3&gt;&lt;div&gt;A new referral protocol initiated on September 15, 2022, sought to direct patients with advanced kidney disease to modality education sessions. This protocol involved an updated referral form and process, requiring nephrologists to refer patients with an estimated glomerular filtration rate below 15&lt;!--&gt; &lt;!--&gt;mL/min/1.73&lt;!--&gt; &lt;!--&gt;m&lt;sup&gt;2&lt;/sup&gt; or specified Kidney Failure Risk Equation scores to modality educators for education. The impact was measured by the uptake of the education and the choice of home dialysis by patients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting &amp; Participants&lt;/h3&gt;&lt;div&gt;The study took place at Sunnybrook Health Sciences Centre in Toronto, Canada, involving 532 patients across 1,723 clinical encounters from October 2019 to June 2023.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Predictor&lt;/h3&gt;&lt;div&gt;The intervention was predicted to lead to an increase in both the number of patients receiving modality education and those choosing home dialysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Outcomes&lt;/h3&gt;&lt;div&gt;The primary outcome measured was the selection of home dialysis following modality education, with a secondary focus on the proportion of patients educated post intervention.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Analytical Approach&lt;/h3&gt;&lt;div&gt;Statistical process charts were used for monitoring changes in education uptake and home dialysis selection rates following the intervention.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;After implementing the standardized referral system, the proportion of patients receiving modality education increased from 27.1%-56.7%. However, the rate of selecting home dialysis remained constant at 50.9%. Overall home dialysis prevalence at our center averaged 19.6%, remaining lower than the provincial average of 24.4% by the end of the study period.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Limitations&lt;/h3&gt;&lt;div&gt;The study was limited to 1 center, without evaluating patient satisfaction or dissecting the complexity of educational content and delivery.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;We succeeded in boosting education rates but failed to achieve higher home dialysis choice rates, possibly owing to the complexity involved in modality choices. We plan to further investigate the factors influencing patient choices during modality education to better promote home dialysis selection.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Plain-Language Summary&lt;/h3&gt;&lt;div&gt;The study focused on whether teaching patients more about their dialysis options would encourage them to choose home dialysis. A new system was introduced at an academic hospital in Toronto, requiring doctors to refer patients with advanced kidney disease to educational sessions. The aim was to see if patients who learned more about dialysis would be more likely to manage their treatment at home. The result","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"6 11","pages":"Article 100898"},"PeriodicalIF":3.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alzheimer Disease–Related Biomarkers in Patients on Maintenance Hemodialysis 维持性血液透析患者的阿尔茨海默病相关生物标志物
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-28 DOI: 10.1016/j.xkme.2024.100897
Arjun V. Masurkar MD, PhD , Nisha Bansal MD , David K. Prince PhD , Wolfgang C. Winkelmayer MD, MPH, ScD , Daniela F. Ortiz MPH , Gianna Ramos MD , Qandeel Soomro MD , Alok Vedvyas MS , Ricardo S. Osorio MD , Mark A. Bernard PhD , Ludovic Debure BS , Wajiha Ahmed MD , Allal Boutajangout PhD , Thomas Wisniewski MD , David M. Charytan MD, MSc
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引用次数: 0
Allopurinol, Febuxostat, and Nonuse of Xanthine Oxidoreductase Inhibitor Treatment in Patients Receiving Hemodialysis: A Longitudinal Analysis 血液透析患者的别嘌醇、非布索坦和不使用黄嘌呤氧化还原酶抑制剂治疗:纵向分析
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-28 DOI: 10.1016/j.xkme.2024.100896
Takeo Ishii , Nodoka Seya , Masataka Taguri , Hiromichi Wakui , Ashio Yoshimura , Kouichi Tamura
<div><h3>Rationale & Objective</h3><div>Allopurinol and febuxostat, which are xanthine oxidoreductase inhibitors, have been widely used as uric acid-lowering medications. However, evidence regarding their cardiovascular effects in hemodialysis is insufficient. This study compared the effects of allopurinol and febuxostat on mortality and cardiovascular outcomes in patients receiving hemodialysis.</div></div><div><h3>Study Design</h3><div>A retrospective observational cohort study.</div></div><div><h3>Setting & Participants</h3><div>Data of 6,791 patients who had no history of topiroxostat usage and underwent maintenance hemodialysis between March 2016 and March 2019 at Yokohama Daiichi Hospital, Zenjinkai, and its affiliated dialysis clinics in Japan’s Kanagawa and Tokyo metropolitan areas were collected.</div></div><div><h3>Exposure</h3><div>Allopurinol, febuxostat, and nontreatment.</div></div><div><h3>Outcomes</h3><div>All-cause mortality, cardiovascular disease (CVD) events, heart failure (HF), acute myocardial infarction (AMI), and stroke.</div></div><div><h3>Analytical Approach</h3><div>For the main analyses, marginal structural Cox proportional hazards models were used to estimate HRs adjusted for time-varying confounding and selection bias because of censoring.</div></div><div><h3>Results</h3><div>Allopurinol and febuxostat showed significantly better survival than nontreatment for all-cause mortality (HR, 0.40; 95% CI, 0.30-0.54 and HR, 0.49; 95% CI, 0.38-0.63, respectively), without significant difference between allopurinol and febuxostat. Allopurinol showed significantly better survival than nontreatment, whereas febuxostat did not for CVD events (HR, 0.89; 95% CI, 0.84-0.95 and HR, 1.01; 95% CI, 0.96-1.07, respectively), HF (HR, 0.71; 95% CI, 0.56-0.90 and HR, 1.03; 95% CI, 0.87-1.21, respectively), and AMI (HR, 0.48; 95% CI, 0.25-0.91 and HR, 0.76; 95% CI, 0.49-1.19, respectively). No comparisons showed significant results for stroke.</div></div><div><h3>Limitations</h3><div>The ratio of renal or intestinal excretion of uric acid and uremic toxins could not be elucidated, and we could not investigate gene polymorphism because of the large number of cases.</div></div><div><h3>Conclusions</h3><div>Allopurinol and febuxostat improved survival for all-cause mortality. Allopurinol and not febuxostat reduced the risk of CVD events, HF, and AMI.</div></div><div><h3>Plain Language Summary</h3><div>Uric acid-lowering therapy has been used to prevent gout attacks and protect organs by reducing inflammation by lowering uric acid levels. However, uric acid-lowering medications have recently been found to have a side effect of inhibiting a channel responsible for excreting toxins, such as adenosine triphosphate-binding cassette transporter G2; the effects of medications with a strong inhibitory effect, such as febuxostat, are currently under investigation. Patients with kidney failure or dialysis excrete toxins through feces from their i
理由与amp; 目的别嘌醇和非布索坦是黄嘌呤氧化还原酶抑制剂,已被广泛用作降尿酸药物。然而,有关它们对血液透析患者心血管影响的证据尚不充分。本研究比较了别嘌醇和非布索坦对血液透析患者死亡率和心血管预后的影响。设置&amp; 参与者收集了2016年3月至2019年3月期间在日本神奈川和东京都的横滨第一医院、善进会及其附属透析诊所接受维持性血液透析的6791名无托吡索坦使用史的患者的数据。结果全因死亡率、心血管疾病(CVD)事件、心力衰竭(HF)、急性心肌梗死(AMI)和中风。分析方法在主要分析中,使用边际结构Cox比例危险模型估算HRs,并对时变混杂因素和由于人口普查造成的选择偏差进行调整。结果 在全因死亡率方面,别嘌醇和非布索坦的生存率明显优于未接受治疗者(HR,分别为0.40;95% CI,0.30-0.54和HR,0.49;95% CI,0.38-0.63),别嘌醇和非布索坦之间无明显差异。在心血管疾病事件(HR,0.89;95% CI,0.84-0.95 和 HR,1.01;95% CI,0.96-1.07)、HF(HR,0.49;95% CI,0.38-0.63)和HR(HR,0.49;95% CI,0.38-0.63)方面,别嘌醇的生存率明显优于未治疗者,而非布司他则不然。07)、HF(分别为HR,0.71;95% CI,0.56-0.90和HR,1.03;95% CI,0.87-1.21)和AMI(分别为HR,0.48;95% CI,0.25-0.91和HR,0.76;95% CI,0.49-1.19)。局限性无法阐明尿酸和尿毒症毒素的肾脏或肠道排泄比例,而且由于病例较多,我们无法研究基因多态性。别嘌醇而非布索坦可降低心血管疾病事件、高血压和急性心肌梗死的风险。白话摘要降尿酸疗法已被用于预防痛风发作,并通过降低尿酸水平减少炎症来保护器官。然而,最近发现降尿酸药物具有抑制负责排泄毒素的通道(如三磷酸腺苷结合盒转运体 G2)的副作用;目前正在研究具有强烈抑制作用的药物(如非布索坦)的效果。肾衰竭或透析患者除了通过透析清除毒素外,还会通过粪便从肠道排出毒素。如果降尿酸药物抑制了负责肠道毒素排泄的通道,是否会导致心力衰竭或中风的发生?本研究对这一问题进行了调查。
{"title":"Allopurinol, Febuxostat, and Nonuse of Xanthine Oxidoreductase Inhibitor Treatment in Patients Receiving Hemodialysis: A Longitudinal Analysis","authors":"Takeo Ishii ,&nbsp;Nodoka Seya ,&nbsp;Masataka Taguri ,&nbsp;Hiromichi Wakui ,&nbsp;Ashio Yoshimura ,&nbsp;Kouichi Tamura","doi":"10.1016/j.xkme.2024.100896","DOIUrl":"10.1016/j.xkme.2024.100896","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Rationale &amp; Objective&lt;/h3&gt;&lt;div&gt;Allopurinol and febuxostat, which are xanthine oxidoreductase inhibitors, have been widely used as uric acid-lowering medications. However, evidence regarding their cardiovascular effects in hemodialysis is insufficient. This study compared the effects of allopurinol and febuxostat on mortality and cardiovascular outcomes in patients receiving hemodialysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study Design&lt;/h3&gt;&lt;div&gt;A retrospective observational cohort study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting &amp; Participants&lt;/h3&gt;&lt;div&gt;Data of 6,791 patients who had no history of topiroxostat usage and underwent maintenance hemodialysis between March 2016 and March 2019 at Yokohama Daiichi Hospital, Zenjinkai, and its affiliated dialysis clinics in Japan’s Kanagawa and Tokyo metropolitan areas were collected.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Exposure&lt;/h3&gt;&lt;div&gt;Allopurinol, febuxostat, and nontreatment.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Outcomes&lt;/h3&gt;&lt;div&gt;All-cause mortality, cardiovascular disease (CVD) events, heart failure (HF), acute myocardial infarction (AMI), and stroke.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Analytical Approach&lt;/h3&gt;&lt;div&gt;For the main analyses, marginal structural Cox proportional hazards models were used to estimate HRs adjusted for time-varying confounding and selection bias because of censoring.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Allopurinol and febuxostat showed significantly better survival than nontreatment for all-cause mortality (HR, 0.40; 95% CI, 0.30-0.54 and HR, 0.49; 95% CI, 0.38-0.63, respectively), without significant difference between allopurinol and febuxostat. Allopurinol showed significantly better survival than nontreatment, whereas febuxostat did not for CVD events (HR, 0.89; 95% CI, 0.84-0.95 and HR, 1.01; 95% CI, 0.96-1.07, respectively), HF (HR, 0.71; 95% CI, 0.56-0.90 and HR, 1.03; 95% CI, 0.87-1.21, respectively), and AMI (HR, 0.48; 95% CI, 0.25-0.91 and HR, 0.76; 95% CI, 0.49-1.19, respectively). No comparisons showed significant results for stroke.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Limitations&lt;/h3&gt;&lt;div&gt;The ratio of renal or intestinal excretion of uric acid and uremic toxins could not be elucidated, and we could not investigate gene polymorphism because of the large number of cases.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Allopurinol and febuxostat improved survival for all-cause mortality. Allopurinol and not febuxostat reduced the risk of CVD events, HF, and AMI.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Plain Language Summary&lt;/h3&gt;&lt;div&gt;Uric acid-lowering therapy has been used to prevent gout attacks and protect organs by reducing inflammation by lowering uric acid levels. However, uric acid-lowering medications have recently been found to have a side effect of inhibiting a channel responsible for excreting toxins, such as adenosine triphosphate-binding cassette transporter G2; the effects of medications with a strong inhibitory effect, such as febuxostat, are currently under investigation. Patients with kidney failure or dialysis excrete toxins through feces from their i","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"6 11","pages":"Article 100896"},"PeriodicalIF":3.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590059524001079/pdfft?md5=0825111d5fdbb51834c89ad06c223f76&pid=1-s2.0-S2590059524001079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabis-Containing Cream for CKD-Associated Pruritus: A Double-Blind, Placebo Controlled Trial 治疗慢性肾脏病相关性瘙痒的含大麻药膏:双盲安慰剂对照试验
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-21 DOI: 10.1016/j.xkme.2024.100894
Suthiya Anumas , Pranporn Kuropakornpong , Panlop Chakkavittumrong , Adis Tasanarong , Pattharawin Pattharanitima
<div><h3>Rationale & Objective</h3><p>This study aims to compare the efficacy of a cannabis cream and a placebo in the treatment of chronic kidney disease (CKD)-associated pruritus.</p></div><div><h3>Study Design</h3><p>A double-blind randomized controlled study.</p></div><div><h3>Setting & Participants</h3><p>Sixty hemodialysis patients with the worst itching intensity numerical rating scale (WI-NRS) ≥3.</p></div><div><h3>Exposure</h3><p>Patients received cannabis cream or placebo.</p></div><div><h3>Outcomes</h3><p>The primary endpoint was the WI-NRS score at week 4. The secondary endpoints included the WI-NRS at week 2, the Skindex-10 score at weeks 2 and 4, and the mean difference score between baseline and week 4 for the WI-NRS and the Skindex-10 score.</p></div><div><h3>Analytical Approach</h3><p>We used unpaired t tests or Mann Whitney U tests, along with χ<sup>2</sup> or Fisher exact tests as appropriate. The adjusted mean differences were determined using ANCOVA, adjusting for baseline scores.</p></div><div><h3>Results</h3><p>Among 60 participants, the mean age was 61.6<!--> <!-->±<!--> <!-->14.4 years and the mean baseline WI-NRS was 6.7<!--> <!-->±<!--> <!-->1.7. The placebo and cannabis cream groups were similar at baseline, although more individuals in the placebo group had diabetes. At 4 weeks, the WI-NRS dropped to 2.6 in the cannabis group and 3.6 in the placebo group (the mean difference after adjustment for baseline scores:−1.1, 95% CI, −2.1 to<!--> <!-->−0.2; <em>P</em> <!-->=<!--> <!-->0.02). Skindex-10 scores at week 4 were also lower in the cannabis group, but after adjustment for baseline scores, statistical significance was not maintained. No side effects were observed in either group.</p></div><div><h3>Limitations</h3><p>A single study with a small sample size restricts its generalizability. Variances in participants’ diabetes statuses might have affected the itch outcomes. The absence of cannabinoid level assessment in blood prevents conclusive determination of the potential systemic impacts. A 4-week follow-up period inadequately captures long-term effect.</p></div><div><h3>Conclusions</h3><p>In CKD-associated pruritus, the topical cream containing cannabis significantly reduced the severity of itching symptoms compared to the placebo.</p></div><div><h3>Trial Registration</h3><p><span><span>clinicaltrials.gov</span><svg><path></path></svg></span> Identifier: <span><span>NCT06159686</span><svg><path></path></svg></span></p></div><div><h3>Plain Language Summary</h3><p>Chronic kidney disease (CKD)-associated pruritus presents a significant burden to hemodialysis patients, with current medications often falling short in alleviating symptoms. Cannabinoids, with their anti-inflammatory, antioxidative, and peripheral nerve activation reduction properties, hold promise in treating CKD-associated pruritus. Especially when applied topically, cannabinoids could provide moisturized skin along with their other effects. We ana
本研究旨在比较大麻膏和安慰剂在治疗慢性肾病 (CKD) 相关瘙痒症方面的疗效。研究设计双盲随机对照研究。次要终点包括第 2 周的 WI-NRS、第 2 周和第 4 周的 Skindex-10 评分,以及 WI-NRS 和 Skindex-10 评分在基线和第 4 周之间的平均差异。结果在 60 名参与者中,平均年龄为 61.6 ± 14.4 岁,平均基线 WI-NRS 为 6.7 ± 1.7。安慰剂组和大麻膏组的基线相似,但安慰剂组中有更多人患有糖尿病。4 周后,大麻组的 WI-NRS 降至 2.6,安慰剂组降至 3.6(调整基线分数后的平均差异:-1.1,95% CI,-2.1 至 -0.2;P = 0.02)。大麻组在第 4 周的 Skindex-10 评分也较低,但在对基线评分进行调整后,统计学意义并未保持。两组均未观察到副作用。参与者糖尿病状况的差异可能会影响瘙痒的结果。由于没有对血液中的大麻素水平进行评估,因此无法对潜在的系统性影响做出定论。结论与安慰剂相比,在慢性肾功能衰竭相关性瘙痒症中,含有大麻成分的外用药膏能显著减轻瘙痒症状的严重程度:NCT06159686白皮书摘要慢性肾脏病(CKD)相关瘙痒症给血液透析患者带来了沉重的负担,目前的药物往往无法缓解症状。大麻素具有抗炎、抗氧化和减少外周神经激活的特性,有望治疗慢性肾病相关性瘙痒症。尤其是在局部使用时,大麻素在发挥其他功效的同时还能滋润皮肤。我们分析了大麻膏与安慰剂相比的疗效,结果表明大麻膏可以改善瘙痒的严重程度,正如治疗第四周结束时的 WI-NRS 评分所报告的那样。这种创新的治疗方法有望为有效治疗慢性肾功能衰竭相关瘙痒症的新药铺平道路,最终减轻症状的严重程度,并有可能提高患者的生活质量。
{"title":"Cannabis-Containing Cream for CKD-Associated Pruritus: A Double-Blind, Placebo Controlled Trial","authors":"Suthiya Anumas ,&nbsp;Pranporn Kuropakornpong ,&nbsp;Panlop Chakkavittumrong ,&nbsp;Adis Tasanarong ,&nbsp;Pattharawin Pattharanitima","doi":"10.1016/j.xkme.2024.100894","DOIUrl":"10.1016/j.xkme.2024.100894","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Rationale &amp; Objective&lt;/h3&gt;&lt;p&gt;This study aims to compare the efficacy of a cannabis cream and a placebo in the treatment of chronic kidney disease (CKD)-associated pruritus.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study Design&lt;/h3&gt;&lt;p&gt;A double-blind randomized controlled study.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting &amp; Participants&lt;/h3&gt;&lt;p&gt;Sixty hemodialysis patients with the worst itching intensity numerical rating scale (WI-NRS) ≥3.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Exposure&lt;/h3&gt;&lt;p&gt;Patients received cannabis cream or placebo.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Outcomes&lt;/h3&gt;&lt;p&gt;The primary endpoint was the WI-NRS score at week 4. The secondary endpoints included the WI-NRS at week 2, the Skindex-10 score at weeks 2 and 4, and the mean difference score between baseline and week 4 for the WI-NRS and the Skindex-10 score.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Analytical Approach&lt;/h3&gt;&lt;p&gt;We used unpaired t tests or Mann Whitney U tests, along with χ&lt;sup&gt;2&lt;/sup&gt; or Fisher exact tests as appropriate. The adjusted mean differences were determined using ANCOVA, adjusting for baseline scores.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Among 60 participants, the mean age was 61.6&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;14.4 years and the mean baseline WI-NRS was 6.7&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;1.7. The placebo and cannabis cream groups were similar at baseline, although more individuals in the placebo group had diabetes. At 4 weeks, the WI-NRS dropped to 2.6 in the cannabis group and 3.6 in the placebo group (the mean difference after adjustment for baseline scores:−1.1, 95% CI, −2.1 to&lt;!--&gt; &lt;!--&gt;−0.2; &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.02). Skindex-10 scores at week 4 were also lower in the cannabis group, but after adjustment for baseline scores, statistical significance was not maintained. No side effects were observed in either group.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Limitations&lt;/h3&gt;&lt;p&gt;A single study with a small sample size restricts its generalizability. Variances in participants’ diabetes statuses might have affected the itch outcomes. The absence of cannabinoid level assessment in blood prevents conclusive determination of the potential systemic impacts. A 4-week follow-up period inadequately captures long-term effect.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;In CKD-associated pruritus, the topical cream containing cannabis significantly reduced the severity of itching symptoms compared to the placebo.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Trial Registration&lt;/h3&gt;&lt;p&gt;&lt;span&gt;&lt;span&gt;clinicaltrials.gov&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt; Identifier: &lt;span&gt;&lt;span&gt;NCT06159686&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Plain Language Summary&lt;/h3&gt;&lt;p&gt;Chronic kidney disease (CKD)-associated pruritus presents a significant burden to hemodialysis patients, with current medications often falling short in alleviating symptoms. Cannabinoids, with their anti-inflammatory, antioxidative, and peripheral nerve activation reduction properties, hold promise in treating CKD-associated pruritus. Especially when applied topically, cannabinoids could provide moisturized skin along with their other effects. We ana","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"6 10","pages":"Article 100894"},"PeriodicalIF":3.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590059524001055/pdfft?md5=9ebd8c183076a7f011c19ee48f1febdc&pid=1-s2.0-S2590059524001055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postpartum Renal Cortical Necrosis: A Case Series 产后肾皮质坏死:一个病例系列
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-14 DOI: 10.1016/j.xkme.2024.100892
Lei Jiang , Suxia Wang , Ying Tan , Tao Su
<div><h3>Rationale & Objective</h3><p>Postpartum renal cortical necrosis (postpartum RCN) is a severe form of obstetric acute kidney injury. This study aimed to identify clinicopathologic features in Chinese postpartum RCN cases to determine how pathologic findings may contribute to the treatment and prognosis.</p></div><div><h3>Study Design</h3><p>Single-center, case series.</p></div><div><h3>Setting & Participants</h3><p>Twelve patients with postpartum RCN had kidney biopsies at Peking University First Hospital between 2014 and 2021. The diagnosis of postpartum RCN was made according to typical magnetic resonance imaging or pathologic features. Clinical, laboratory, and pathologic data were compared between patients with estimated glomerular filtration rate<!--> <!--><30 (poor outcome) and<!--> <!-->≥30<!--> <!-->mL/min/1.73<!--> <!-->m<sup>2</sup> after 6 months.</p></div><div><h3>Observations</h3><p>All patients with postpartum RCN presented with stage 3 acute kidney injury attributed to a probable atypical hemolytic uremic syndrome. Pregnancy terminations occurred at a median gestational age of 35.5 weeks. Kidney biopsy was performed from 18 days to 4 months from delivery. On biopsy, hemoglobin, platelet count, and lactate dehydrogenase levels had been restored to 137<!--> <!-->g/L, 214 ×<!--> <!-->10<sup>9</sup>/L, and 231.50<!--> <!-->±<!--> <!-->65.01<!--> <!-->U/L, respectively. Four patients exhibited poor outcome, demonstrating higher schistocyte count, serum creatinine, and mean arterial pressure at onset. Pathologically, glomerular segmental sclerosis was prevalent. The “not otherwise specified” variant was the most common type, followed by collapsing variant, cellular variant, and tip variant. Patients with poor kidney outcome had more glomerular coagulative necrosis, capillary thrombosis, extensive cortical coagulative necrosis, and pronounced arteriole/artery lesions including increased interlobular arteriole intimal edema and fibrin thrombosis, but a lower occurrence of segmental sclerosis.</p></div><div><h3>Limitations</h3><p>Limited sample size and retrospective design.</p></div><div><h3>Conclusions</h3><p>We identified key pathologic features in patients with postpartum RCN and atypical hemolytic uremic syndrome, highlighting the necessity for more effective therapeutic options. There is a clear demand for noninvasive biomarkers that can accurately track disease progression and inform treatment duration for long-term outcomes improvement.</p></div><div><h3>Plain-Language Summary</h3><p>Our study investigated postpartum renal cortical necrosis (RCN) in 12 Chinese women, a severe form of kidney injury that occurs after childbirth, often linked to atypical hemolytic uremic syndrome (aHUS). We aimed to identify clinical and pathologic features to improve treatment and predict patient outcomes. The women experienced stage 3 acute kidney injury, with kidney biopsies revealing various degrees of glomerular and vascular dam
依据& 目的产后肾皮质坏死(postpartum renal cortical necrosis,postpartum RCN)是一种严重的产科急性肾损伤。本研究旨在确定中国产后RCN病例的临床病理特征,以确定病理结果如何有助于治疗和预后。研究设计单中心、病例系列。根据典型的磁共振成像或病理学特征诊断为产后 RCN。对6个月后估计肾小球滤过率<30(预后差)和≥30 mL/min/1.73 m2的患者的临床、实验室和病理数据进行比较。观察结果所有产后RCN患者均出现急性肾损伤3期,可能是非典型性溶血性尿毒综合征。终止妊娠的中位胎龄为 35.5 周。在分娩后 18 天至 4 个月期间进行了肾活检。活检时,血红蛋白、血小板计数和乳酸脱氢酶水平分别恢复到 137 g/L、214 × 109/L 和 231.50 ± 65.01 U/L。四名患者的预后较差,发病时血吸虫计数、血清肌酐和平均动脉压较高。病理上,肾小球节段性硬化很普遍。未另作说明 "的变异型是最常见的类型,其次是塌陷变异型、细胞变异型和尖端变异型。肾功能不佳的患者有更多的肾小球凝固性坏死、毛细血管血栓形成、广泛的皮质凝固性坏死以及明显的动脉/动脉病变,包括小叶间动脉内膜水肿和纤维蛋白血栓形成,但节段硬化的发生率较低。结论我们发现了产后 RCN 和非典型溶血性尿毒症综合征患者的主要病理特征,强调了更有效治疗方案的必要性。我们的研究调查了 12 名中国妇女的产后肾皮质坏死(RCN),这是一种发生在产后的严重肾损伤,通常与非典型性溶血性尿毒症综合征(aHUS)有关。我们旨在确定临床和病理特征,以改善治疗并预测患者的预后。这些妇女经历了急性肾损伤三期,肾活检发现了不同程度的肾小球和血管损伤。主要发现包括节段性肾小球硬化和动脉病变,这些病变在预后较差的患者中更为明显。这项研究虽然因规模小和回顾性设计而受到限制,但它强调了在产后 RCN 中识别 aHUS 以改善管理的重要性,并突出了对无创生物标志物的迫切需要,以监测疾病进展和改善长期预后。
{"title":"Postpartum Renal Cortical Necrosis: A Case Series","authors":"Lei Jiang ,&nbsp;Suxia Wang ,&nbsp;Ying Tan ,&nbsp;Tao Su","doi":"10.1016/j.xkme.2024.100892","DOIUrl":"10.1016/j.xkme.2024.100892","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Rationale &amp; Objective&lt;/h3&gt;&lt;p&gt;Postpartum renal cortical necrosis (postpartum RCN) is a severe form of obstetric acute kidney injury. This study aimed to identify clinicopathologic features in Chinese postpartum RCN cases to determine how pathologic findings may contribute to the treatment and prognosis.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study Design&lt;/h3&gt;&lt;p&gt;Single-center, case series.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting &amp; Participants&lt;/h3&gt;&lt;p&gt;Twelve patients with postpartum RCN had kidney biopsies at Peking University First Hospital between 2014 and 2021. The diagnosis of postpartum RCN was made according to typical magnetic resonance imaging or pathologic features. Clinical, laboratory, and pathologic data were compared between patients with estimated glomerular filtration rate&lt;!--&gt; &lt;!--&gt;&lt;30 (poor outcome) and&lt;!--&gt; &lt;!--&gt;≥30&lt;!--&gt; &lt;!--&gt;mL/min/1.73&lt;!--&gt; &lt;!--&gt;m&lt;sup&gt;2&lt;/sup&gt; after 6 months.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Observations&lt;/h3&gt;&lt;p&gt;All patients with postpartum RCN presented with stage 3 acute kidney injury attributed to a probable atypical hemolytic uremic syndrome. Pregnancy terminations occurred at a median gestational age of 35.5 weeks. Kidney biopsy was performed from 18 days to 4 months from delivery. On biopsy, hemoglobin, platelet count, and lactate dehydrogenase levels had been restored to 137&lt;!--&gt; &lt;!--&gt;g/L, 214 ×&lt;!--&gt; &lt;!--&gt;10&lt;sup&gt;9&lt;/sup&gt;/L, and 231.50&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;65.01&lt;!--&gt; &lt;!--&gt;U/L, respectively. Four patients exhibited poor outcome, demonstrating higher schistocyte count, serum creatinine, and mean arterial pressure at onset. Pathologically, glomerular segmental sclerosis was prevalent. The “not otherwise specified” variant was the most common type, followed by collapsing variant, cellular variant, and tip variant. Patients with poor kidney outcome had more glomerular coagulative necrosis, capillary thrombosis, extensive cortical coagulative necrosis, and pronounced arteriole/artery lesions including increased interlobular arteriole intimal edema and fibrin thrombosis, but a lower occurrence of segmental sclerosis.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Limitations&lt;/h3&gt;&lt;p&gt;Limited sample size and retrospective design.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;We identified key pathologic features in patients with postpartum RCN and atypical hemolytic uremic syndrome, highlighting the necessity for more effective therapeutic options. There is a clear demand for noninvasive biomarkers that can accurately track disease progression and inform treatment duration for long-term outcomes improvement.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Plain-Language Summary&lt;/h3&gt;&lt;p&gt;Our study investigated postpartum renal cortical necrosis (RCN) in 12 Chinese women, a severe form of kidney injury that occurs after childbirth, often linked to atypical hemolytic uremic syndrome (aHUS). We aimed to identify clinical and pathologic features to improve treatment and predict patient outcomes. The women experienced stage 3 acute kidney injury, with kidney biopsies revealing various degrees of glomerular and vascular dam","PeriodicalId":17885,"journal":{"name":"Kidney Medicine","volume":"6 10","pages":"Article 100892"},"PeriodicalIF":3.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590059524001031/pdfft?md5=384ac10f418f779e7eb6cf2cc390cb8e&pid=1-s2.0-S2590059524001031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimated GFR in the Korean and US Asian Populations Using the 2021 Creatinine-Based GFR Estimating Equation Without Race 使用基于肌酸酐的 2021 年无种族 GFR 估算公式估算韩国和美国亚裔人口的 GFR
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-14 DOI: 10.1016/j.xkme.2024.100890
Jimin Hwang , Kwanghyun Kim , Josef Coresh , Lesley A. Inker , Morgan E. Grams , Jung-Im Shin
<div><h3>Rationale & Objective</h3><p>In 2021, the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) updated the creatinine-based estimated glomerular filtration rate (eGFR) equation and removed the coefficient for race. The development and validation of this equation involved binarizing race into African American and non-African American, involving few Asian participants. This study aimed to examine the difference between the 2021 equation and the previous 2009 equation on CKD prevalence estimates in 2 Asian populations.</p></div><div><h3>Study Design</h3><p>Observational study using 2 national surveys.</p></div><div><h3>Setting & Participants</h3><p>Participants from the 2019 Korea National Health and Nutrition Survey and participants self-reported as Asian from the 2011-2020 US National Health and Nutrition Survey.</p></div><div><h3>Exposure</h3><p>eGFR using 2009 and 2021 CKD-EPI creatinine equation.</p></div><div><h3>Outcomes</h3><p>Prevalence of CKD (eGFR<!--> <!--><60<!--> <!-->mL/min/1.73<!--> <!-->m<sup>2</sup> or urine albumin-creatinine ratio<!--> <!-->≥30<!--> <!-->mg/g).</p></div><div><h3>Analytical Approach</h3><p>Sampling-weighted prevalence estimated using the 2009 and 2021 equations as well as the percentage of individuals with CKD G3+<!--> <!-->using the 2009 equation being reclassified as not having CKD G3+<!--> <!-->using the 2021 equation.</p></div><div><h3>Results</h3><p>The prevalence of CKD estimated using the 2021 equation was 9.75% (95% confidence intervals [CI], 8.80-10.80%) in Koreans and 11.60% (95% CI, 10.23-13.13%) in US Asians. The prevalence of CKD estimated using the 2021 equation was slightly lower than that using the 2009 equation in both Korean and US Asian populations by 0.63% (95% CI, 0.44-0.90%) and 0.84% (95% CI, 0.52-1.34%), respectively. Furthermore, 32.8% and 30.2% of Koreans and US Asians with CKD G3-5, respectively, estimated using the 2009 equation were reclassified as not having CKD G3-5 when the eGFR was calculated using the 2021 equation.</p></div><div><h3>Limitations</h3><p>Measured GFR was not available.</p></div><div><h3>Conclusions</h3><p>Use of the 2021 CKD-EPI creatinine equation leads to a small decrease in CKD prevalence in both Korean and US Asian populations, and of similar magnitude, resulting in significant reclassification among those originally classified as having CKD G3+.</p></div><div><h3>Plain-Language Summary</h3><p>The 2009 serum creatinine-based kidney function estimating equation used demographic information including race. Because race is a social construct, race was eliminated in the new equation developed in 2021. As race was categorized into African American and non-African American during its development, this study examined the impact of the 2021 equation in 2 distinct Asian populations (Koreans and US Asians) using 2 national datasets. We found that the prevalence of chronic kidney disease (CKD) estimated using the 2021 equation was slightly lo
理由与amp; 目标2021年,新的慢性肾脏病流行病学合作组织(CKD-EPI)更新了基于肌酐的估计肾小球滤过率(eGFR)方程,并取消了种族系数。该方程的开发和验证涉及将种族分为非洲裔美国人和非非洲裔美国人,很少有亚裔参与者参与。本研究旨在检验 2021 年方程与之前的 2009 年方程在 2 个亚洲人群中的 CKD 患病率估计值之间的差异。研究设计使用 2 项全国性调查进行观察性研究。结果CKD患病率(eGFR <60毫升/分钟/1.73平方米或尿白蛋白-肌酐比值≥30毫克/克).分析方法使用2009年和2021年方程估算的抽样加权患病率,以及使用2009年方程估算的CKD G3+患者中使用2021年方程重新分类为非CKD G3+患者的百分比。结果使用 2021 年方程估计的韩国人 CKD 患病率为 9.75%(95% 置信区间 [CI],8.80-10.80%),美国亚裔为 11.60%(95% 置信区间 [CI],10.23-13.13%)。在韩国和美国的亚裔人群中,使用 2021 年方程估计的 CKD 患病率比使用 2009 年方程估计的患病率略低,分别为 0.63% (95% CI, 0.44-0.90%) 和 0.84% (95% CI, 0.52-1.34%)。此外,在使用 2009 年方程估计的 CKD G3-5 韩国人和美国亚洲人中,分别有 32.8% 和 30.2% 的人在使用 2021 年方程计算 eGFR 时被重新归类为未患 CKD G3-5。结论使用 2021 年 CKD-EPI 肌酐方程会导致韩国和美国亚裔人群的 CKD 患病率略有下降,且下降幅度相似,从而导致原本被归类为 CKD G3+ 的人群被重新显著分类。由于种族是一种社会建构,因此在 2021 年开发的新方程中取消了种族。由于在开发过程中将种族分为非洲裔美国人和非非洲裔美国人,本研究利用两个国家的数据集研究了 2021 年方程对两个不同亚洲人群(韩国人和美国亚洲人)的影响。我们发现,在韩国人和美国亚洲人中,使用 2021 年方程估算的慢性肾病 (CKD) 患病率略低于使用 2009 年方程估算的患病率。在使用 2009 年方程估计的慢性肾脏病患者中,约有三分之一的人被重新归类为使用 2021 年方程估计的非慢性肾脏病患者。
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引用次数: 0
Dipstick Leukocyturia as a Kidney Damage Biomarker in Rural Uganda and Kenya 乌干达和肯尼亚农村地区作为肾脏损伤生物标志物的浸量白细胞尿
IF 3.2 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-14 DOI: 10.1016/j.xkme.2024.100895
Sahra Mohamed BA, MS , Chi-Yuan Hsu MD, MS , Edwin D. Charlebois MPH, PhD , Jane Kabami BNS, MPH , Mucunguzi Atukunda MBChB, MPH , James Ayieko MBChB, PhD , Gordon Orori BSc , Matthew D. Hickey MD , Maya Petersen M.D, PhD , Moses R. Kamya MBChB, MMed, MPH, PhD , Diane Havlir MD , Michelle M. Estrella MD, MHS , Anthony N. Muiru MD, MPH
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引用次数: 0
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Kidney Medicine
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