Pub Date : 2021-02-01DOI: 10.23736/s1825-859x.20.00069-9
S. Valverde, R. Valle, F. Gessoni, Letizia Valle, M. Iacoviello, N. Aspromonte, G. Gessoni
{"title":"Heart failure in frail elderly resident in a nurse house: prognostic significance of a multimarker approach","authors":"S. Valverde, R. Valle, F. Gessoni, Letizia Valle, M. Iacoviello, N. Aspromonte, G. Gessoni","doi":"10.23736/s1825-859x.20.00069-9","DOIUrl":"https://doi.org/10.23736/s1825-859x.20.00069-9","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80515988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/s1825-859x.20.00076-6
D. Villalta, P. Martelli, A. Moratto, Valeria Salgarolo, Elita Ligato, R. Giacomello, M. Conte, F. D'Aurizio, M. Fabris, D. Fontana, Rita De Rosa
Background: Recently many serological assays for the detection of antibodies to SARS-COV-2 virus were introduced to the market. The aim of this study was to assess the diagnostic performance of a novel fully automated CLIA assay for combined (anti-IgG and IgM) anti-SARS-CoV-2 antibody detection. Methods: A total of 231 sera, 100 from consecutive patients diagnosed with COVID-19 confirmed by rRT-PCR using nasopharyngeal swabs (54 mild, 32 severe and 14 critical) and 131 controls (50 blood donors, 49 autoimmune diseases, and 32 with other viral diseases) were evaluated for combined (IgG plus IgM) anti-SARS-CoV-2 antibodies with the ADVIA Centaur® COV2T (Siemens Healthineers, Erlangen, Germany) immunoassay. In the same sera anti-SARS-CoV-2 IgM and IgG antibodies were also tested using the MAGLUMI® (SNIBE, Shenzhen, China) immunoassay. Results: Based on the manufacturer's cutoff, sensitivity, specificity, LR+, LR-, PPV and NPV of the ADVIA Centaur COV2T assay were 91% (95% CI: 83.6-95.1), 100% (97.1-100), 121.6, 0.10, 100% and 92.8%, respectively. Sensitivity of the combined antibody assay was slightly higher than that obtained by combining the results of the separate anti-IgM and anti-IgG assays (91% vs. 89% in all patients), especially in mild COVID-19 patients (85.2% vs. 81.5%). A significant difference in antibody levels (ratio) between mild and severe/critical subjects has been shown. Conclusions: The novel ADVIA Centaur COV2T assay for anti-SARS-CoV-2 combined antibody detection showed good diagnostic accuracy and, associated with the elevated automation and throughput of the system, may represent a useful tool for anti-SARS-CoV-2 antibody detection in clinical practice.
{"title":"Diagnostic accuracy of a new fully automated chemiluminescence immunoassay for anti-SARS-CoV-2 combined IgG and IgM antibody detection","authors":"D. Villalta, P. Martelli, A. Moratto, Valeria Salgarolo, Elita Ligato, R. Giacomello, M. Conte, F. D'Aurizio, M. Fabris, D. Fontana, Rita De Rosa","doi":"10.23736/s1825-859x.20.00076-6","DOIUrl":"https://doi.org/10.23736/s1825-859x.20.00076-6","url":null,"abstract":"Background: Recently many serological assays for the detection of antibodies to SARS-COV-2 virus were introduced to the market. The aim of this study was to assess the diagnostic performance of a novel fully automated CLIA assay for combined (anti-IgG and IgM) anti-SARS-CoV-2 antibody detection. Methods: A total of 231 sera, 100 from consecutive patients diagnosed with COVID-19 confirmed by rRT-PCR using nasopharyngeal swabs (54 mild, 32 severe and 14 critical) and 131 controls (50 blood donors, 49 autoimmune diseases, and 32 with other viral diseases) were evaluated for combined (IgG plus IgM) anti-SARS-CoV-2 antibodies with the ADVIA Centaur® COV2T (Siemens Healthineers, Erlangen, Germany) immunoassay. In the same sera anti-SARS-CoV-2 IgM and IgG antibodies were also tested using the MAGLUMI® (SNIBE, Shenzhen, China) immunoassay. Results: Based on the manufacturer's cutoff, sensitivity, specificity, LR+, LR-, PPV and NPV of the ADVIA Centaur COV2T assay were 91% (95% CI: 83.6-95.1), 100% (97.1-100), 121.6, 0.10, 100% and 92.8%, respectively. Sensitivity of the combined antibody assay was slightly higher than that obtained by combining the results of the separate anti-IgM and anti-IgG assays (91% vs. 89% in all patients), especially in mild COVID-19 patients (85.2% vs. 81.5%). A significant difference in antibody levels (ratio) between mild and severe/critical subjects has been shown. Conclusions: The novel ADVIA Centaur COV2T assay for anti-SARS-CoV-2 combined antibody detection showed good diagnostic accuracy and, associated with the elevated automation and throughput of the system, may represent a useful tool for anti-SARS-CoV-2 antibody detection in clinical practice.","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88636738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/s1825-859x.21.00084-0
L. Malloggi, P. Cappelletti, M. Moretti, Francesca Veneziani, Massimiliano Manno, M. A. Burgio, Alessio Gamboni, Matteo Cassin, Elisabetta Stenner, Margherita Morandini, Giulio Marino, Martina Di Pietro, Deborah Mazzei, Jessica Viola, Dina Di Maria, Daniela Rubin, G. Galli
{"title":"Raccomandazioni del GdS MM SIPMeL per l'uso dei biomarcatori cardiaci in NSTEMI. Parte seconda: evidenze nella diagnosi","authors":"L. Malloggi, P. Cappelletti, M. Moretti, Francesca Veneziani, Massimiliano Manno, M. A. Burgio, Alessio Gamboni, Matteo Cassin, Elisabetta Stenner, Margherita Morandini, Giulio Marino, Martina Di Pietro, Deborah Mazzei, Jessica Viola, Dina Di Maria, Daniela Rubin, G. Galli","doi":"10.23736/s1825-859x.21.00084-0","DOIUrl":"https://doi.org/10.23736/s1825-859x.21.00084-0","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74212244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/s1825-859x.21.00085-2
L. Malloggi, P. Cappelletti, M. A. Burgio, Martina Di Pietro, M. Moretti, Francesca Veneziani, Massimiliano Manno, Elisabetta Stenner, Alessio Gamboni, Matteo Cassin, Margherita Morandini, Giulio Marino, Deborah Mazzei, Jessica Viola, Dina Di Maria, Daniela Rubin, G. Galli
{"title":"Raccomandazioni del GdS MM SIPMeL per l'uso dei marcatori miocardiaci nella diagnostica di NSTEMI. Parte terza: prognosi e stratificazione del rischio","authors":"L. Malloggi, P. Cappelletti, M. A. Burgio, Martina Di Pietro, M. Moretti, Francesca Veneziani, Massimiliano Manno, Elisabetta Stenner, Alessio Gamboni, Matteo Cassin, Margherita Morandini, Giulio Marino, Deborah Mazzei, Jessica Viola, Dina Di Maria, Daniela Rubin, G. Galli","doi":"10.23736/s1825-859x.21.00085-2","DOIUrl":"https://doi.org/10.23736/s1825-859x.21.00085-2","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82898732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/s1825-859x.20.00081-x
L. Terzuoli, Marta Panciroli, Emanuela Mobilia, Paola Galluzzi, M. R. Bacarelli, Andrea Guarnieri, Nicola Bizzaro
{"title":"Gli anticorpi anti-rods and rings non sono un marcatore esclusivo di epatite HCV in trattamento con interferone/ribavirina","authors":"L. Terzuoli, Marta Panciroli, Emanuela Mobilia, Paola Galluzzi, M. R. Bacarelli, Andrea Guarnieri, Nicola Bizzaro","doi":"10.23736/s1825-859x.20.00081-x","DOIUrl":"https://doi.org/10.23736/s1825-859x.20.00081-x","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84209568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/s1825-859x.21.00083-9
P. Cappelletti
{"title":"Società scientifiche e COVID-19","authors":"P. Cappelletti","doi":"10.23736/s1825-859x.21.00083-9","DOIUrl":"https://doi.org/10.23736/s1825-859x.21.00083-9","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83857831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/s1825-859x.20.00075-4
T. Carbone, Nicola Bizzaro, M. Infantino, V. Miconi, Renato Tozzoli, A. Antico, Danilo Villalta
{"title":"Indagine nazionale 2019 in Autoimmunologia: stato dell’arte dei Laboratori italiani","authors":"T. Carbone, Nicola Bizzaro, M. Infantino, V. Miconi, Renato Tozzoli, A. Antico, Danilo Villalta","doi":"10.23736/s1825-859x.20.00075-4","DOIUrl":"https://doi.org/10.23736/s1825-859x.20.00075-4","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84811239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/s1825-859x.20.00048-1
P. Cappelletti
{"title":"Indagine nazionale 2019 in Autoimmunologia: stato dell’arte dei Laboratori italiani","authors":"P. Cappelletti","doi":"10.23736/s1825-859x.20.00048-1","DOIUrl":"https://doi.org/10.23736/s1825-859x.20.00048-1","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76577634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.23736/s1825-859x.20.00065-1
M. Brugia, L. Babini, Fabiana Pasquini, Alessandra Calcinari, Marianna Pavani, Vincenzo G. Menditto, Aldo Salvi, M. Moretti
{"title":"Studio della proteina S100B in pazienti con trauma cranico minore in terapia con anticoagulanti orali","authors":"M. Brugia, L. Babini, Fabiana Pasquini, Alessandra Calcinari, Marianna Pavani, Vincenzo G. Menditto, Aldo Salvi, M. Moretti","doi":"10.23736/s1825-859x.20.00065-1","DOIUrl":"https://doi.org/10.23736/s1825-859x.20.00065-1","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79947588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.23736/s1825-859x.19.00034-3
M. Pradella
{"title":"Taratura, armonizzazione e standardizzazione nelle nuove ISO 17511 e ISO 21151","authors":"M. Pradella","doi":"10.23736/s1825-859x.19.00034-3","DOIUrl":"https://doi.org/10.23736/s1825-859x.19.00034-3","url":null,"abstract":"","PeriodicalId":18004,"journal":{"name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79243070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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