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LUTS: Lower Urinary Tract Symptoms最新文献

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Correction to “Hip dysfunction-related urinary incontinence and total hip arthroplasty with the direct lateral approach” “髋关节功能障碍相关性尿失禁与直接外侧入路全髋关节置换术”的矫正
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-07-19 DOI: 10.1111/luts.12497

Abed MH, Vasaghi-Gharamaleki B, Ghazavi MT, Nikjooy A. Hip dysfunction-related urinary incontinence and total hip arthroplasty with the direct lateral approach. Lower Urinary Tract Symptoms. 2023;15(1):11–15. doi:10.1111/luts.12466

Some of the values in Table 1 were incorrect. Please see revised table below:

We apologize for these errors.

Abed MH, Vasaghi-Gharamaleki B, Ghazavi MT, Nikjooy A.髋关节功能障碍相关性尿失禁与直接外侧入路全髋关节置换术。下尿路症状。2023;15(1):11-15。doi: 10.1111 /附近地区。12466表1中的一些值不正确。请见修改后的下表:我们为这些错误道歉。
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引用次数: 0
Utilization and safety of telemedicine for pediatric lower urinary tract symptoms before and during the COVID-19 pandemic COVID-19大流行之前和期间儿童下尿路症状远程医疗的使用和安全性
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-07-13 DOI: 10.1111/luts.12496
Abby L. Chen, Stav Spinzi, Gunjan Agrawal, Kathleen M. Kan

Objectives

Telemedicine for pediatric lower urinary tract symptoms (pLUTS) is a relatively new mode of delivering bladder health education with scant evidence supporting current practice. We aim to examine the safety of pLUTS-related telemedicine visits surrounding the COVID-19 pandemic.

Methods

We conducted a retrospective cohort study of new pLUTS referral diagnoses to our institution's pediatric urology clinics. Demographics, wait times, and referral diagnoses were captured and compared before and after March 2020 using χ2/Fisher exact tests and t-tests. A retrospective chart review was performed for an initial telemedicine visit followed by an in-person visit to identify missed radiology, lab, or physical exam findings.

Results

Six hundred twelve patients were included from September 2018 to August 2021. Most were 5–10 years old (62.3%), female (56.2%), English speaking (86.5%), White (39.4%), and had private insurance (67.2%). Wait times were shorter for telemedicine versus in-person visits (t190 = −3.56, p < .001). After March 2020, patients with a urinary tract infection (UTI) and females utilized in-person visits more often (p < .001). After chart review (11 patients, mean = 10.4 years), 9 (81.8%) had comorbid conditions and/or family history of lower urinary tract symptoms. None had missed clinical findings that changed management.

Conclusions

pLUTS care can be delivered via telemedicine without a significant change in patient volume and population, though additional investigations will clarify the needs of patients with specific referral diagnoses and comorbid conditions. The in-person exam can be omitted safely with proper clinical history taking, supporting future virtual programs that address delays in care within local communities.

目的儿童下尿路症状远程医疗(pLUTS)是一种相对较新的膀胱健康教育模式,目前缺乏证据支持。我们的目标是在COVID-19大流行期间检查与ppluto相关的远程医疗就诊的安全性。方法我们进行了一个回顾性队列研究新的pLUTS转诊诊断到我们机构的儿科泌尿科诊所。使用χ2/Fisher精确检验和t检验,收集了2020年3月前后的人口统计数据、等待时间和转诊诊断并进行了比较。对首次远程医疗就诊进行回顾性病历回顾,随后进行亲自就诊,以确定遗漏的放射学、实验室或体检结果。结果2018年9月至2021年8月共纳入612例患者。大多数是5-10岁(62.3%),女性(56.2%),说英语(86.5%),白人(39.4%),有私人保险(67.2%)。与面对面就诊相比,远程医疗的等待时间更短(t190 = - 3.56, p < .001)。2020年3月之后,尿路感染(UTI)患者和女性更频繁地进行了亲自就诊(p < .001)。图表回顾(11例患者,平均10.4岁),9例(81.8%)有合并症和/或下尿路症状家族史。没有人错过了改变治疗方法的临床发现。结论:通过远程医疗提供pLUTS治疗不会对患者数量和人群产生显著影响,但进一步的调查将明确具有特定转诊诊断和合并症的患者的需求。通过适当的临床病史记录,可以安全地省略现场检查,支持未来解决当地社区护理延误的虚拟项目。
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引用次数: 0
Incidence and predictors of urinary incontinence rates post-holmium laser enucleation of prostate 钬激光前列腺摘除术后尿失禁发生率及预测因素
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-06-27 DOI: 10.1111/luts.12494
Mohamed Elsaqa, Yu Zhang, Harry Papaconstantinou, Marawan M. El Tayeb

Introduction

One of the main adverse outcomes following Holmium laser enucleation of the prostate (HoLEP) is the development of transient de novo urinary incontinence (UI). We aimed to evaluate the correlation of multiple risk factors to UI rates post-HoLEP.

Methods

A review of prospectively maintained 7 year database for HoLEP patients in a single center was performed. UI data at 6 week, 3 month, and 1 year follow-up intervals were assessed with bivariate and multivariate analysis of multiple potential risk factors.

Results

The study included 666 patients with median (IQR) age of 72 (66–78) years old and median (IQR) preoperative prostate volume of 89 (68–126) gm. UI was seen in 287 (43%), 100 (15%) and 26 (5.8%) at 6 week, 3 month, and 1 year follow up occasions respectively. At 6 weeks follow up, UI type was stress, urge and mixed in 121 (18.16%), 118 (17.72) and 48 (7.21%) patients respectively. Using a multivariate regression analysis, obesity and pre-operative UI were associated with postoperative UI rate at both 6 week (p = .0065, .031) and 3 month (p = .0261, .044) follow up encounters respectively. Also, larger specimen weight was another predictor for 6 week UI (p = .0399) while higher frailty score was a predictor for UI at 3 month occasion (p = .041).

Conclusion

Patients with preoperative UI, obesity, frailty, and large prostate volume are at higher risk of short-term UI post-HoLEP up to 3 months. Patients with one or more of these risk factors should be counseled regarding the higher risk of UI.

钬激光前列腺摘除(HoLEP)后的主要不良后果之一是一过性尿失禁(UI)的发展。我们的目的是评估多种危险因素与holep后UI率的相关性。方法对单中心HoLEP患者7年前瞻性数据库进行回顾性分析。随访6周、3个月和1年的UI数据通过多重潜在危险因素的双因素和多因素分析进行评估。结果666例患者中位(IQR)年龄为72(66 ~ 78)岁,术前前列腺体积中位(IQR)为89 (68 ~ 126)gm。随访6周、3个月和1年分别有287例(43%)、100例(15%)和26例(5.8%)出现尿潴留。随访6周时,尿失联类型分别为应激型、急迫型和混合型121例(18.16%)、118例(17.72)和48例(7.21%)。通过多因素回归分析,肥胖和术前尿失速与术后6周尿失速率相关(p =。0065, 0.031)和3个月(p =。0261, 0.044)分别进行后续接触。此外,较大的标本重量是6周UI的另一个预测因素(p = 0.099),而较高的虚弱评分是3个月UI的预测因素(p = 0.041)。结论术前尿失禁、肥胖、虚弱、前列腺体积大的患者在holep术后3个月内发生短期尿失禁的风险较高。有一种或多种危险因素的患者应被告知患尿失禁的风险较高。
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引用次数: 0
Urinary incontinence in the postpartum 1-year period: Its prevalence and effect on psychosocial status of women 产后1年尿失禁的发生率及其对妇女心理社会状况的影响
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-06-26 DOI: 10.1111/luts.12495
Gulennur Suar, Feride Cevik, Nurgul Simal Yavuz, Nebahat Ozerdogan

Objectives

In this study, it was aimed to determine the prevalence and effect of urinary incontinence in the postpartum 1 year period on psychosocial status of women.

Methods

This study with a cross-sectional and descriptive design was conducted between 01.10.2021 and 01.04.2022. There were 406 women in the postpartum 8 weeks to 1 year period who participated in the study. The data were collected through Identifying Information Form, Edinburgh Postnatal Depression Scale, and Nottingham Health Profile.

Results

In the study, it was determined that 21.9% of the women in the postpartum period experienced urinary incontinence problems, and that the most common type of incontinence experienced was stress incontinence (62.9%). Edinburgh Postnatal Depression Scale mean score of the women who experienced urinary incontinence problems in the postpartum period was found to be significantly higher compared to those who did not experience this problem (P < .05), but no significant difference was found between the rates of those with depression risk according to the cutoff point of the scale (≥13 points). As a result of the regression analysis, it was determined that the increase in depression risk resulted not from urinary incontinence but from age and parity. It was also determined that the mean scores of the women who experienced incontinence problems from the subscales of Nottingham Health profile was significantly high (P < .05).

Conclusions

In conclusion, urinary incontinence in the postpartum period is a prevalent problem affecting approximately one-fifth of women. In addition, this problem negatively affects the psychological and social dimensions of women's health.

目的研究产后1年尿失禁的发生率及对妇女心理社会状况的影响。方法采用横断面和描述性设计,研究时间为2021年10月1日至2022年4月1日。共有406名产后8周至1年的妇女参与了这项研究。数据通过识别信息表、爱丁堡产后抑郁量表和诺丁汉健康概况收集。结果本研究确定21.9%的产后妇女出现尿失禁问题,其中最常见的尿失禁类型为应激性尿失禁(62.9%)。在爱丁堡产后抑郁量表中,出现尿失禁问题的妇女的平均得分明显高于未出现尿失禁问题的妇女(P < 0.05),但根据量表的截止点(≥13分),出现抑郁风险的妇女的发生率无显著差异。回归分析的结果表明,抑郁症风险的增加不是由尿失禁引起的,而是由年龄和胎次引起的。研究还发现,经历过尿失禁问题的女性在诺丁汉健康状况亚量表中的平均得分显著高(P < 0.05)。总之,产后尿失禁是一个普遍的问题,影响了大约五分之一的妇女。此外,这一问题对妇女健康的心理和社会层面产生负面影响。
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引用次数: 1
Memorial address for Emeritus Professor Osamu Yamaguchi—A man of learning 纪念名誉教授山口修——一个有学问的人
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-06-15 DOI: 10.1111/luts.12491
Osamu Nishizawa
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引用次数: 0
Correlation of resistive index of prostatic capsular artery to clinical symptoms in men with chronic prostatitis/chronic pelvic pain syndrome 慢性前列腺炎/慢性盆腔痛综合征男性前列腺包膜动脉阻力指数与临床症状的相关性
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-06-14 DOI: 10.1111/luts.12493
Yasin Yitgin, Ayhan Karakose
To evaluate the relation between resistive index (RI) of prostatic capsular arteries by transrectal Doppler ultrasonography in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and its correlation with lower urinary tract symptoms, erectile dysfunction and premature ejaculation parameters of CP/CPPS.
目的探讨慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)患者前列腺包膜动脉阻力指数(RI)与下尿路症状、勃起功能障碍及早泄参数的关系。方法共纳入68例慢性前列腺炎/慢性盆腔疼痛综合征患者。我们分成两组,第一组35例患者,RI≥0.7;第二组33例患者,RI < 0.7。采用国际前列腺症状评分(IPSS)、国际勃起功能指数(IIEF-5)、早泄诊断工具(PEDT)和美国国立卫生研究院慢性前列腺炎症状指数(CPSI)对所有患者进行评估。此外,所有患者均采用多普勒超声测量前列腺包膜动脉的RI。采用SPSS 18进行统计分析。p值<05被认为是显著的。结果两组患者人口学特征相似。IPSS组1为11.3±6,组2为9.7±5.3。IIEF-5分别为1组18.6±2和2组20.4±2.3。1组PEDT为12.4±5.6,2组为11.2±4。CPSI(总)组1为19.3±12.3,组2为10.6±7.7。两组患者IPSS、IIEF-5、CPSI比较,差异均有统计学意义(p <[j], p <[j], p <001分别)。然而,我们发现两组之间PEDT无显著差异(p = 0.19)。结论CP/CPPS患者的下尿路症状、勃起功能障碍参数与前列腺包膜动脉的RI有显著相关性,RI是评估疾病严重程度的有效、无创方法。
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引用次数: 0
Hygiene management of intermittent self-catheterization using reusable silicone catheters in people with spinal cord lesions: A cross-sectional Internet survey in Japan 脊髓病变患者使用可重复使用的硅胶导管进行间歇性自我导尿的卫生管理:日本的一项横断面互联网调查
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-06-10 DOI: 10.1111/luts.12490
Ryosuke Takahashi, Noritoshi Sekido, Mihoko Matsuoka, Atsushi Sengoku, Masashi Nomi, Fujio Matsuyama, Tatsunori Murata, Takeya Kitta, Takahiko Mitsui

Objectives

To investigate hygiene management and catheter maintenance of reusable silicone catheters for intermittent self-catheterization (ISC) in Japan and examine their relationship with symptomatic urinary tract infection (sUTI).

Methods

We conducted a cross-sectional Internet survey of people performing ISC using reusable silicone catheters owing to spinal cord lesions in Japan. Hygiene management and catheter maintenance of reusable silicone catheters and the incidence and frequency of sUTI were evaluated. We also examined the significant risk factors for sUTI.

Results

Of 136 respondents, 62 (46%), 41 (30%), and 58 (43%) washed hands with water, washed hands with soap, and cleaned or disinfected the urethral meatus every time or most of the time before ISC, respectively. No significant difference was observed in the incidence and frequency of sUTI between respondents who adhered to these procedures and those who did not. There were no significant differences in the incidence and frequency of sUTI in respondents who changed their catheters every month and in those who changed their preservation solution within 2 days compared with those who did not. In multivariate analysis, pain during ISC, inconvenience of indoor mobility, bowel management problems, and participants' feeling of never having received instruction on catheter replacement were significant risk factors for sUTI.

Conclusions

There are individual differences in hygiene management and catheter maintenance of reusable silicone catheters, but the influence of these differences on the incidence and frequency of sUTI is not clear. Pain during ISC, bowel management problems, and inadequate instruction on catheter maintenance procedures are factors associated with sUTI.

目的探讨日本可重复使用的硅导管用于间歇性自导管插入术(ISC)的卫生管理和导管维护,并探讨它们与症状性尿路感染(sUTI)的关系。方法我们对日本因脊髓损伤而使用可重复使用的硅胶导管进行ISC的患者进行了横断面互联网调查。对可重复使用的硅胶导管的卫生管理和导管维护以及sUTI的发生率和频率进行了评估。我们还研究了sUTI的重要危险因素。结果在136名受访者中,分别有62人(46%)、41人(30%)和58人(43%)在ISC前每次或大部分时间用水洗手、用肥皂洗手和清洁或消毒尿道口。在坚持这些手术的受访者和不坚持这些程序的受访者之间,sUTI的发生率和频率没有观察到显著差异。在每月更换导管的受访者和在2个月内更换保存液的受访者中,sUTI的发生率和频率没有显著差异 与那些没有的人相比。在多变量分析中,ISC期间的疼痛、室内活动不便、肠道管理问题以及参与者从未接受过导管更换指导的感觉是sUTI的重要风险因素。结论可重复使用的硅胶导管在卫生管理和导管维护方面存在个体差异,但这些差异对sUTI发生率和频率的影响尚不清楚。ISC期间的疼痛、肠道管理问题和导管维护程序指导不足是导致sUTI的因素。
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引用次数: 0
Predictive factors for the success of trial without catheter for men with urinary retention 男性尿潴留无导尿管试验成功的预测因素
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-06-05 DOI: 10.1111/luts.12492
Masato Takanashi, Hiroki Ito, Takeshi Fukazawa, Hiroki Takizawa, Mari Hioki, Risa Shinoki, Takashi Kawahara, Kazuki Kobayashi

Objective

To investigate the trial of spontaneous urination without catheter (TWOC) outcomes for men with acute urinary retention, determine successful TWOC predictors, and evaluate the impact of add-on medication therapy on TWOC.

Methods

This retrospective study included men with acute urinary retention and post-void residual (PVR) >250 mL who underwent TWOC between July 2009 and July 2019. Patients were divided into a medicated group who received alpha1 blocker on urinary retention diagnosis and a naïve group who did not. The trial was defined as unsuccessful if the PVR was >150 mL or if the patient experienced difficulty emptying their bladder with abdominal discomfort or pain, and a transurethral catheter was reinserted.

Results

Among 576 men with urinary retention, 269 (46.7%) constituted the medicated group and 307 (53.3%) the naïve. The naïve group comprised more elderly patients (P = 0.010) with higher Eastern Cooperative Oncology Group performance status (PS) (P = 0.001) and smaller prostate volume (P = 0.028) than the other. In the medicated group, 153 men received additional oral medication before TWOC to increase the success rate. There were significant age differences (P = 0.041) in the medicated group and significant median PS differences (P = 0.010) in the naïve group between the successful and unsuccessful outcomes of TWOC. The multivariate logistic regression model demonstrated that age <80 years in medicated patients (P = 0.042, odds ratio [OR] 1.701) and PS <2 in naïve patients (P = 0.001, OR 2.710) were significant independent predictors of successful TWOC outcomes.

Conclusions

This is the first study classifying patients with urinary retention according to medication status. Both medicated and naïve groups had different patient backgrounds and TWOC outcome predictors, suggesting a discrepant etiology behind urinary retention. Hence, acute urinary retention management in men should vary based on medication status for male lower urinary tract symptoms when urinary retention is diagnosed.

目的探讨男性急性尿潴留患者无导管自然排尿(TWOC)结局的临床试验,确定成功的TWOC预测因素,并评估附加药物治疗对TWOC的影响。方法回顾性研究2009年7月至2019年7月期间接受TWOC治疗的急性尿潴留和膀胱后残留(PVR) >250 mL的男性患者。患者被分为两组,一组在尿潴留诊断时使用α 1阻滞剂,另一组不使用naïve。如果PVR为150 mL,或者患者因腹部不适或疼痛而排尿困难,则重新插入经尿道导管,则试验被定义为不成功。结果576例尿潴留患者中,给药组269例(46.7%),naïve组307例(53.3%)。naïve组老年患者较多(P = 0.010),东部肿瘤合作组表现状态(PS)较高(P = 0.001),前列腺体积较小(P = 0.028)。在药物组中,153名男性在TWOC前接受了额外的口服药物以提高成功率。治疗组与不治疗组的年龄差异有统计学意义(P = 0.041), naïve组的中位PS差异有统计学意义(P = 0.010)。多因素logistic回归模型显示,用药患者的年龄<80岁(P = 0.042,比值比[OR] 1.701)和naïve患者的年龄<2岁(P = 0.001, OR 2.710)是TWOC成功结局的显著独立预测因子。结论根据用药情况对尿潴留患者进行分类的研究尚属首次。药物组和naïve组都有不同的患者背景和TWOC结果预测因子,提示尿潴留背后的病因不同。因此,男性急性尿潴留的处理应根据诊断出尿潴留时男性下尿路症状的药物状况而有所不同。
{"title":"Predictive factors for the success of trial without catheter for men with urinary retention","authors":"Masato Takanashi,&nbsp;Hiroki Ito,&nbsp;Takeshi Fukazawa,&nbsp;Hiroki Takizawa,&nbsp;Mari Hioki,&nbsp;Risa Shinoki,&nbsp;Takashi Kawahara,&nbsp;Kazuki Kobayashi","doi":"10.1111/luts.12492","DOIUrl":"10.1111/luts.12492","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the trial of spontaneous urination without catheter (TWOC) outcomes for men with acute urinary retention, determine successful TWOC predictors, and evaluate the impact of add-on medication therapy on TWOC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included men with acute urinary retention and post-void residual (PVR) &gt;250 mL who underwent TWOC between July 2009 and July 2019. Patients were divided into a medicated group who received alpha1 blocker on urinary retention diagnosis and a naïve group who did not. The trial was defined as unsuccessful if the PVR was &gt;150 mL or if the patient experienced difficulty emptying their bladder with abdominal discomfort or pain, and a transurethral catheter was reinserted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 576 men with urinary retention, 269 (46.7%) constituted the medicated group and 307 (53.3%) the naïve. The naïve group comprised more elderly patients (<i>P</i> = 0.010) with higher Eastern Cooperative Oncology Group performance status (PS) (<i>P</i> = 0.001) and smaller prostate volume (<i>P</i> = 0.028) than the other. In the medicated group, 153 men received additional oral medication before TWOC to increase the success rate. There were significant age differences (<i>P</i> = 0.041) in the medicated group and significant median PS differences (<i>P</i> = 0.010) in the naïve group between the successful and unsuccessful outcomes of TWOC. The multivariate logistic regression model demonstrated that age &lt;80 years in medicated patients (<i>P</i> = 0.042, odds ratio [OR] 1.701) and PS &lt;2 in naïve patients (<i>P</i> = 0.001, OR 2.710) were significant independent predictors of successful TWOC outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This is the first study classifying patients with urinary retention according to medication status. Both medicated and naïve groups had different patient backgrounds and TWOC outcome predictors, suggesting a discrepant etiology behind urinary retention. Hence, acute urinary retention management in men should vary based on medication status for male lower urinary tract symptoms when urinary retention is diagnosed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for a failed trial without catheter following convective water vapor thermal therapy (CWVTT-Rezum) 对流水蒸气热疗法(CWVTT-Rezum)后无导管试验失败的危险因素
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-05-26 DOI: 10.1111/luts.12483
Michael D. Felice, Kaylin Kim, Sarang Janakiraman, Gaurav Pahouja, William Adams, Erin Fruth, Ahmer Farooq, Kevin T. McVary

Objectives

Convective water vapor thermal therapy (CWVTT-Rezum) is a minimally invasive surgical therapy that is being increasingly utilized for bladder outlet obstruction. Most patients leave the site of care with a Foley catheter in place for a mean reported duration of 3–4 days. A minority of men will fail their trial without catheter (TWOC). We aim to identify the frequency of TWOC failure following CWVTT and its associated risk factors.

Methods

Patients who underwent CWVTT at a single institution from October 2018 to May 2021 were retrospectively identified and pertinent data extracted. The primary endpoint was TWOC failure. Descriptive statistics were performed, and rate of TWOC failure was determined. Potential risk factors for failed TWOC were assessed through univariate and multivariate logistic regression.

Results

A total of 119 patients were analyzed. Seventeen percent (20/119) had a failed TWOC on their first attempt. Of those, 60% (12/20) failed in a delayed fashion. In patients who failed, the median number of total TWOC attempts required for success was two (interquartile range [IQR] = 2–3). All patients eventually had a successful TWOC. The median preoperative postvoid residual for successful and failed TWOC was 56 mL (IQR = 15–125) and 87 mL (IQR = 25–367), respectively. Preoperative elevated postvoid residual (unadjusted odds ratio [OR] 1.02, 95% CI: 1.01–1.04; adjusted OR 1.02, 95% CI: 1.01–1.04) was associated with TWOC failure.

Conclusions

Seventeen percent of patients failed their initial TWOC after CWVTT. Elevated postvoid residual was associated with TWOC failure.

目的:对流水蒸汽热疗法(CWVTT-Rezum)是一种微创手术治疗,越来越多地用于膀胱出口梗阻。大多数患者离开护理地点时,Foley导管放置到位,平均报告持续时间为3-4天。少数男性在没有导管(TWOC)的情况下会失败。我们的目的是确定CWVTT后TWOC失效的频率及其相关的危险因素。方法回顾性分析2018年10月至2021年5月在同一医院接受CWVTT治疗的患者,并提取相关资料。主要终点为TWOC失败。进行描述性统计,并确定TWOC失败率。通过单因素和多因素logistic回归评估TWOC失败的潜在危险因素。结果共分析119例患者。17%(20/119)的人第一次尝试TWOC失败。其中,60%(12/20)以延迟方式失败。在失败的患者中,成功所需的总两次oc尝试的中位数为2次(四分位数间距[IQR] = 2-3)。所有患者最终都成功进行了TWOC。成功和失败的TWOC术前空隙后残留中位数分别为56 mL (IQR = 15-125)和87 mL (IQR = 25-367)。术前空腔后残留升高(未调整优势比[OR] 1.02, 95% CI: 1.01-1.04;调整OR 1.02, 95% CI: 1.01-1.04)与TWOC失败相关。结论:17%的患者在CWVTT后未能完成最初的TWOC。空隙后残留升高与TWOC失败有关。
{"title":"Risk factors for a failed trial without catheter following convective water vapor thermal therapy (CWVTT-Rezum)","authors":"Michael D. Felice,&nbsp;Kaylin Kim,&nbsp;Sarang Janakiraman,&nbsp;Gaurav Pahouja,&nbsp;William Adams,&nbsp;Erin Fruth,&nbsp;Ahmer Farooq,&nbsp;Kevin T. McVary","doi":"10.1111/luts.12483","DOIUrl":"10.1111/luts.12483","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Convective water vapor thermal therapy (CWVTT-Rezum) is a minimally invasive surgical therapy that is being increasingly utilized for bladder outlet obstruction. Most patients leave the site of care with a Foley catheter in place for a mean reported duration of 3–4 days. A minority of men will fail their trial without catheter (TWOC). We aim to identify the frequency of TWOC failure following CWVTT and its associated risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent CWVTT at a single institution from October 2018 to May 2021 were retrospectively identified and pertinent data extracted. The primary endpoint was TWOC failure. Descriptive statistics were performed, and rate of TWOC failure was determined. Potential risk factors for failed TWOC were assessed through univariate and multivariate logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 119 patients were analyzed. Seventeen percent (20/119) had a failed TWOC on their first attempt. Of those, 60% (12/20) failed in a delayed fashion. In patients who failed, the median number of total TWOC attempts required for success was two (interquartile range [IQR] = 2–3). All patients eventually had a successful TWOC. The median preoperative postvoid residual for successful and failed TWOC was 56 mL (IQR = 15–125) and 87 mL (IQR = 25–367), respectively. Preoperative elevated postvoid residual (unadjusted odds ratio [OR] 1.02, 95% CI: 1.01–1.04; adjusted OR 1.02, 95% CI: 1.01–1.04) was associated with TWOC failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Seventeen percent of patients failed their initial TWOC after CWVTT. Elevated postvoid residual was associated with TWOC failure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/luts.12483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10502414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mirabegron is better tolerated than solifenacin in Sjogren's syndrome patients with overactive bladder symptoms—A randomized controlled trial 一项随机对照试验表明,Mirabegron对伴有膀胱过度活动症状的干燥综合征患者的耐受性优于索利那新
IF 1.3 4区 医学 Q2 Medicine Pub Date : 2023-05-16 DOI: 10.1111/luts.12481
Hao Xiang Chen, Shih-Hsin Chang, Der-Yuan Chen, Joung-Liang Lan, Kai-Jieh Yeo, Po-Hao Huang, Chung-Ming Huang, Chi-Ping Huang, Eric Chieh-Lung Chou, Po-Chang Wu

Objectives

This study investigates the efficacy and adverse events of beta-3 agonists and antimuscarinic agents for managing overactive bladder syndrome in Sjogren syndrome.

Methods

Sjogren's syndrome patients with an Overactive Bladder Symptom Score (OABSS) >5 were enrolled and were randomly assigned to mirabegron 50 mg/day or solifenacin 5 mg/day. Patients were evaluated on the recruitment day and reassessed at Week 1, 2, 4, and 12. The study's primary endpoint was to have a significant change in OABSS at Week 12. The secondary endpoint was the adverse event and crossover rate.

Results

A total of 41 patients were included in the final analysis, with 24 in the mirabegron group and 17 in the solifenacin group. The study's primary outcome was a change of the OABSS at Week 12. We found that both mirabegron and solifenacin significantly reduce patients' OABSS after 12 weeks of treatment. The evolution of the OABSS was −3.08 for mirabegron and −3.71 for solifenacin (p = .56). Six out of 17 patients from the solifenacin group crossed over to the mirabegron arm due to severe dry mouth or constipation, while none from the mirabegron arm crossed over to the solifenacin group. Sjogren's syndrome-related pain was also improved in the mirabegron group (4.96–1.67, p = .008) compared to the solifenacin group (4.39–3.4, p = .49).

Conclusions

Our study showed that mirabegron is equally effective as solifenacin in treating Sjogren's syndrome patients with overactive bladder. Mirabegron is superior to solifenacin in terms of treatment-related adverse events.

目的探讨-3受体激动剂和抗毒蕈碱类药物治疗干燥综合征患者膀胱过度活动综合征的疗效和不良反应。方法入选膀胱过度活动症状评分(OABSS) >5分的干燥综合征患者,随机分配米拉米格隆50 mg/d或索利那新5 mg/d。在招募当天对患者进行评估,并在第1、2、4和12周重新评估。该研究的主要终点是在第12周时OABSS发生显著变化。次要终点是不良事件和交叉率。结果共纳入41例患者,其中美瑞比龙组24例,索利那新组17例。该研究的主要结果是第12周时OABSS的变化。我们发现mirabegron和solifenacin治疗12周后显著降低患者OABSS。mirabegron的OABSS演化为- 3.08,solifenacin的OABSS演化为- 3.71 (p = 0.56)。索非那新组的17名患者中有6名由于严重的口干或便秘而转到米拉比格龙组,而米拉比格龙组没有患者转到索非那新组。与索利那新组(4.39-3.4,p = 0.49)相比,mirabegron组干燥综合征相关疼痛(4.96-1.67,p = 0.008)也得到了改善。结论:我们的研究表明,mirabegron与索利那新治疗干燥综合征伴膀胱过度活动的患者同样有效。Mirabegron在治疗相关不良事件方面优于索利那新。
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LUTS: Lower Urinary Tract Symptoms
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