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[Molecular diagnosis of HIV-1 infection: potential roles and applications]. [HIV-1感染的分子诊断:潜在作用和应用]。
L'union medicale du Canada
Pub Date : 1994-06-01
F Coutlée

Diagnostic tests for HIV-1 infection have allowed to reduce the transmission of this virus by blood transfusions. They have also allowed to offer prophylactic as well as therapeutic measures early in the infection. The laboratory diagnosis of HIV-1 infection relies mainly on serological testings. Seroconversion can be detected earlier than previous assays with the use of purified HIV antigens such as peptides or recombinant proteins. The low sensitivity level of p24 antigen detection can be improved by acid dissociation of immune complexes in serum samples. A promising method, the polymerase chain reaction (PCR) will facilitate the diagnosis of HIV infection for newborns from seropositive mothers. During PCR, a segment of the genome of HIV is amplified a million-fold and products of amplification are detected by specific probes. The status of individuals with indeterminate serology results could be clarified with PCR. It could also potentially allow the prospective follow-up of patients under therapy to detect viral resistance. The usefulness of this powerful technology in clinical medicine still needs to be determined for HIV-1 diagnosis.

艾滋病毒-1感染的诊断测试可以减少这种病毒通过输血的传播。它们还允许在感染早期提供预防和治疗措施。HIV-1感染的实验室诊断主要依靠血清学检测。使用纯化的HIV抗原(如多肽或重组蛋白)可以比以前的检测更早地检测血清转化。血清样品中免疫复合物的酸解离可改善p24抗原检测的低灵敏度水平。聚合酶链反应(PCR)是一种很有前途的方法，它将有助于诊断血清阳性母亲所生的新生儿是否感染艾滋病毒。在PCR过程中，HIV基因组的一个片段被扩增一百万倍，扩增产物被特定的探针检测到。血清学结果不确定的个体的状态可以用PCR来澄清。它还可能允许对正在接受治疗的患者进行前瞻性随访，以检测病毒耐药性。这种强大的技术在临床医学中的有用性仍然需要确定HIV-1诊断。
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引用次数: 0
[Acute sarcoidosis]. (急性结节病)。
L'union medicale du Canada
Pub Date : 1994-06-01
C Bourque, A Lussier
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引用次数: 0
[Baudelaire: a genius born of malediction]. 波德莱尔:天生诅咒的天才。
L'union medicale du Canada
Pub Date : 1994-06-01
R Henry
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引用次数: 0
[Antihypertensive and anti-inflammatory, non-steroidal drugs: significant interactions?]. [降压和抗炎，非甾体药物:显著相互作用?]。
L'union medicale du Canada
Pub Date : 1994-06-01
M M Perreault
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引用次数: 0
[Update on seasonal rhinitis]. [季节性鼻炎最新消息]。
L'union medicale du Canada
Pub Date : 1994-05-01
A Caron, G Darval, C Langlois, B Laramée, F Léger
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引用次数: 0
[Chopin: a genius who lent himself but who never gave himself up]. 肖邦:一个把自己借给别人但从不放弃自己的天才。
L'union medicale du Canada
Pub Date : 1994-05-01
R Henry
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引用次数: 0
[Etymologic roots of medicine]. [medicine的词源]。
L'union medicale du Canada
Pub Date : 1994-05-01
R Henry
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引用次数: 0
[Profile of microbiological analyses needed for hospitalized clients at the Maisonneuve-Rosemont hospital]. [Maisonneuve-Rosemont医院住院病人所需的微生物分析概况]。
L'union medicale du Canada
Pub Date : 1994-05-01
M Laverdière, J Delorme, L Desrosiers, S Racine, P Boyle

During five consecutive administrative periods, a computer data bank was set up from informations written on laboratory forms requesting tests in microbiology. A total of 13,260 forms were received and 11,591 were included in our study. 7,010 tests (60%) were requested from medical specialties; 40% of these tests were from patients admitted on hematology and on pediatrics wards. Of the 4,581 remaining tests, 36% were ordered for patients admitted on general surgery and on ophthalmology wards. Medical patients had three times as much blood cultures requested than surgical patients. The numbers of urine cultures done for medical and surgical patients were however similar (1,832 and 1,699 respectively). The average cost for microbiology cultures was twice as much in medical than in surgical patients. Such analysis of prescribing profile for laboratory tests provides useful information for the diagnosis related groups (DRG) system and can allow for a more efficient distribution of hospital resources.

在连续五个行政期间，根据要求进行微生物试验的实验室表格上的资料建立了一个计算机数据库。我们共收到13260份表格，其中11591份被纳入我们的研究。医疗专业要求进行7 010次检测(60%);其中40%的检测来自血液科和儿科病房的住院患者。在剩余的4,581项测试中，36%是为普通外科和眼科病房住院的患者订购的。内科病人的血培养量是外科病人的三倍。然而，内科病人和外科病人的尿液培养次数相似(分别为1832次和1699次)。内科病人微生物培养的平均费用是外科病人的两倍。这种对实验室检测处方概况的分析为诊断相关组(DRG)系统提供了有用的信息，并可以允许更有效地分配医院资源。
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引用次数: 0
[Principles of care of various arterial diseases. Part 2: acute arterial ischemia]. 各种动脉疾病的护理原则。第2部分:急性动脉缺血]。
L'union medicale du Canada
Pub Date : 1994-05-01
J V Patenaude, P Couture, S Desmarais, R Lecours, M Lussier, D Q Nguyen, R Parent, P D'Amico
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引用次数: 0
[Antiviral agents: their proper use in immunodeficient patients]. 抗病毒药物:免疫缺陷患者的正确使用。
L'union medicale du Canada
Pub Date : 1994-05-01
M C Pineau
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引用次数: 0
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