Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society最新文献
Pub Date : 2020-01-24DOI: 10.1002/9781119436812.index
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Pub Date : 2020-01-24DOI: 10.1002/9780470747919.CH51
C. Ferrari, M. Mondelli
{"title":"Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis","authors":"C. Ferrari, M. Mondelli","doi":"10.1002/9780470747919.CH51","DOIUrl":"https://doi.org/10.1002/9780470747919.CH51","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73357951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-24DOI: 10.1002/9781119436812.ch52
Y. Rotman, D. Kapuria
{"title":"Non‐alcoholic Fatty Liver Disease","authors":"Y. Rotman, D. Kapuria","doi":"10.1002/9781119436812.ch52","DOIUrl":"https://doi.org/10.1002/9781119436812.ch52","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76552248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-24DOI: 10.1002/9780470747919.CH17
N. Chowdhury, J. Chowdhury
Bilirubin is the end product of degradation of the heme moiety of hemoproteins. Hemoglobin, derived from senescent erythrocytes, is the major source of bilirubin. Significant fractions are also derived from other hemoproteins of liver and other organs. Historically, hyperbilirubinemia has attracted the attention of clinicians as a marker of liver dysfunction. Subsequently, the studies of bilirubin chemistry, synthesis, transport, metabolism, distribution, and excretion have provided important insights into the transport, metabolism, and excretion of biologically important organic anions, particularly those with limited aqueous solubility. Bilirubin is potentially toxic, but is normally rendered harmless by tight binding to albumin, and rapid detoxification and excretion by the liver. Patients with very high levels of unconjugated hyperbilirubinemia are at risk for bilirubin encephalopathy (kernicterus). Kernicterus is found in some cases of severe neonatal jaundice and in inherited disorders associated with severe unconjugated hyperbilirubinemia. This chapter provides a brief review of bilirubin metabolism and its inherited disorders. N. Roy Chowdhury: Department of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461. I. M. Arias: Departments of Physiology and Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111. A. W. Wolkoff: Departments of Medicine and Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461-1602. J. Roy Chowdhury: Department of Medicine and Molecular Genetics, Albert Einstein College of Medicine Liver Center; Department of Medicine, Jack D. Weiler Hospital of Albert Einstein College of Medicine, Bronx, New York 10461. Fate of Bilirubin in the Gastrointestinal Tract 296 Alternative Routes of Bilirubin Elimination 297 Antioxidant Property of Bilirubin 297
胆红素是血红蛋白血红素部分降解的最终产物。来自衰老红细胞的血红蛋白是胆红素的主要来源。重要的部分也来源于肝脏和其他器官的其他血红蛋白。历史上，高胆红素血症作为肝功能障碍的标志引起了临床医生的注意。随后，对胆红素化学、合成、运输、代谢、分布和排泄的研究为了解生物学上重要的有机阴离子的运输、代谢和排泄提供了重要的见解，特别是那些水溶性有限的阴离子。胆红素有潜在毒性，但通常由于与白蛋白紧密结合，并通过肝脏迅速解毒和排泄而无害。非结合性高胆红素血症患者有胆红素脑病(核黄疸)的危险。核黄疸见于一些严重的新生儿黄疸和与严重非共轭高胆红素血症相关的遗传性疾病。本章简要综述了胆红素代谢及其遗传性疾病的研究进展。N. Roy Chowdhury:医学和分子遗传学系，阿尔伯特爱因斯坦医学院，布朗克斯，纽约10461。I. M. Arias:塔夫茨大学医学院生理医学系，马萨诸塞州波士顿02111。A. W. Wolkoff:医学、解剖和结构生物学系，阿尔伯特·爱因斯坦医学院，布朗克斯，纽约10461-1602。J. Roy Chowdhury:阿尔伯特·爱因斯坦医学院肝脏中心医学与分子遗传学系;阿尔伯特·爱因斯坦医学院杰克·维勒医院医学部，布朗克斯，纽约10461。胃肠道中胆红素的命运胆红素消除的替代途径胆红素的抗氧化特性
{"title":"Disorders of Bilirubin Metabolism","authors":"N. Chowdhury, J. Chowdhury","doi":"10.1002/9780470747919.CH17","DOIUrl":"https://doi.org/10.1002/9780470747919.CH17","url":null,"abstract":"Bilirubin is the end product of degradation of the heme moiety of hemoproteins. Hemoglobin, derived from senescent erythrocytes, is the major source of bilirubin. Significant fractions are also derived from other hemoproteins of liver and other organs. Historically, hyperbilirubinemia has attracted the attention of clinicians as a marker of liver dysfunction. Subsequently, the studies of bilirubin chemistry, synthesis, transport, metabolism, distribution, and excretion have provided important insights into the transport, metabolism, and excretion of biologically important organic anions, particularly those with limited aqueous solubility. Bilirubin is potentially toxic, but is normally rendered harmless by tight binding to albumin, and rapid detoxification and excretion by the liver. Patients with very high levels of unconjugated hyperbilirubinemia are at risk for bilirubin encephalopathy (kernicterus). Kernicterus is found in some cases of severe neonatal jaundice and in inherited disorders associated with severe unconjugated hyperbilirubinemia. This chapter provides a brief review of bilirubin metabolism and its inherited disorders. N. Roy Chowdhury: Department of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461. I. M. Arias: Departments of Physiology and Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111. A. W. Wolkoff: Departments of Medicine and Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461-1602. J. Roy Chowdhury: Department of Medicine and Molecular Genetics, Albert Einstein College of Medicine Liver Center; Department of Medicine, Jack D. Weiler Hospital of Albert Einstein College of Medicine, Bronx, New York 10461. Fate of Bilirubin in the Gastrointestinal Tract 296 Alternative Routes of Bilirubin Elimination 297 Antioxidant Property of Bilirubin 297","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80092624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-24DOI: 10.1002/9781119436812.CH9
Michelle A. Veronin, J. Glavy
{"title":"Nuclear Pore Complex","authors":"Michelle A. Veronin, J. Glavy","doi":"10.1002/9781119436812.CH9","DOIUrl":"https://doi.org/10.1002/9781119436812.CH9","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84979380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-24DOI: 10.1002/9780470747919.CH13
P. Kim
{"title":"Peroxisome Assembly, Degradation, and Disease","authors":"P. Kim","doi":"10.1002/9780470747919.CH13","DOIUrl":"https://doi.org/10.1002/9780470747919.CH13","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83752897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-24DOI: 10.1002/9781119436812.ch5
Carolyn M. Ott
{"title":"Primary Cilia","authors":"Carolyn M. Ott","doi":"10.1002/9781119436812.ch5","DOIUrl":"https://doi.org/10.1002/9781119436812.ch5","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86687985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-24DOI: 10.1002/9780470747919.CH52
T. Block, Ju-Tao Guo, W. London
{"title":"Clinical Implications of the Molecular Biology of Hepatitis B Virus","authors":"T. Block, Ju-Tao Guo, W. London","doi":"10.1002/9780470747919.CH52","DOIUrl":"https://doi.org/10.1002/9780470747919.CH52","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75506112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exosomes?","authors":"J. Perkins","doi":"10.24075/brsmu.2019-04","DOIUrl":"https://doi.org/10.24075/brsmu.2019-04","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"1 1","pages":"1466-7"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88706403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.1016/b978-012374410-4.00418-0
X. Meng
{"title":"Hepatitis E Virus","authors":"X. Meng","doi":"10.1016/b978-012374410-4.00418-0","DOIUrl":"https://doi.org/10.1016/b978-012374410-4.00418-0","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82063569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
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