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Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society最新文献

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Protein Maturation and Processing at the Endoplasmic Reticulum 内质网的蛋白质成熟和加工
R. Hegde
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引用次数: 1
Adaptive Regulation of Hepatocyte Transporters in Cholestasis 胆汁淤积症中肝细胞转运体的适应性调节
J. Boyer
{"title":"Adaptive Regulation of Hepatocyte Transporters in Cholestasis","authors":"J. Boyer","doi":"10.1002/9780470747919.CH43","DOIUrl":"https://doi.org/10.1002/9780470747919.CH43","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"722 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86345449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Protein Degradation and the Lysosomal System 蛋白质降解和溶酶体系统
Susmita Kaushik, A. Cuervo
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引用次数: 1
Lipoprotein Metabolism and Cholesterol Balance 脂蛋白代谢和胆固醇平衡
D. Cohen
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引用次数: 7
Is there any benefit to laparoscopic liver resection for hepatocellular carcinoma if a salvage liver transplant is needed later? 如果以后需要补救性肝移植,腹腔镜肝切除术对肝细胞癌有什么好处吗?
J. Perkins
Background/Purpose: In patients with hepatocellular carcinoma (HCC), a previous liver resection (LR) may compromise subsequent liver transplantation (LT) by creating adhesions and increasing surgical difficulty. Initial laparoscopic LR (LLR) may reduce such technical consequences, but its effect on subsequent LT has not been reported. We report the operative results of LT after laparoscopic or open liver resection (OLR). Methods: Twenty-four LT were performed, 12 following prior LLR and 12 following prior OLR. The LT was performed using preservation of the inferior vein cava. Indication for the LT was recurrent HCC in 19 cases (salvage LT), while five patients were listed for LT and underwent resection as a neoadjuvant procedure (bridge resection). Results: In the LLR group, absence of adhesions was associated with straightforward access to the liver in all cases. In the OLR group, 11 patients required long and hemorrhagic dissection. Median durations of the hepatectomy phase and whole LT were 2.5 and 6.2 h, and 4.5 and 8.3 h in the LLR and OLR groups, respectively (P < 0.05). Median blood loss was 1200 ml and 2300 ml in the LLR and OLR groups, respectively (P < 0.05). Median transfusions of hepatectomy phase and whole LT were 0 and 3 U, and 2 and 6 U, respectively (P < 0.05). There were no postoperative deaths. Conclusions: In our study, LLR facilitated the LT procedure as compared with OLR in terms of reduced operative time, blood loss and transfusion requirements. We conclude that LLR should be preferred over OLR when feasible in potential transplant candidates.
背景/目的:在肝细胞癌(HCC)患者中,先前的肝切除术(LR)可能通过产生粘连和增加手术难度而影响随后的肝移植(LT)。最初的腹腔镜下LR (LLR)可以减少这种技术后果,但其对后续LT的影响尚未报道。我们报告腹腔镜或开放肝切除术(OLR)后肝移植的手术结果。方法:24例行肝移植,其中12例为既往轻度肝移植,12例为既往轻度肝移植。肝移植是在保留下腔静脉的情况下进行的。肝移植的适应症为19例复发性HCC(补救性肝移植),而5例患者被列为肝移植并接受了新辅助手术(桥式肝移植)。结果:在LLR组中,所有病例中没有粘连与直接进入肝脏有关。在OLR组中,11例患者需要长时间的出血性剥离。肝切除术和全肝切除术的中位时间分别为2.5和6.2 h, LLR组和OLR组的中位时间分别为4.5和8.3 h (P < 0.05)。LLR组和OLR组的中位失血量分别为1200 ml和2300 ml (P < 0.05)。肝切除期和全肝中位输血量分别为0、3u、2、6u (P < 0.05)。无术后死亡病例。结论:在我们的研究中,与OLR相比,LLR在减少手术时间、出血量和输血需求方面促进了LT手术。我们的结论是,在可行的情况下,在潜在的移植候选人中,LLR应优于OLR。
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引用次数: 1
The evolution of caval implantation in liver transplantation. 肝移植腔静脉植入技术的发展。
J. Perkins
Conventional orthotopic liver transplantation (CON-LT) involves resection of recipient cava, usually with extra-corporeal circulation (veno-venous bypass, VVB), while in the piggyback technique (PC-LT) the cava is preserved. Along with a temporary portacaval shunt (TPCS), better haemodynamic maintenance is purported with PC-LT. A prospective, consecutive series of 384 primary transplants (2000-2003) were analysed, 138 CON-LT (with VVB) and 246 PC-LT (54 without TPCS). Patient/donor characteristics were similar in the two groups. PC-LT required less usage of fresh-frozen plasma and platelets, intensive care stay, number of patients requiring ventilation after day 1 and total days spent on ventilator. The results were not different when comparing, total operating and warm ischaemia time (WIT), red cell usage, requirement for renal support, day 3 serum creatinine and total hospital stay. TPCS had no impact on outcome other than WIT (P = 0.02). Three patients in PC-LT group (three of 246; 1.2%) developed caval outflow obstruction (P = 0.02). There was no difference in short- or long-term graft or patient survival. PC-LT has an advantage over CON-LT using VVB with respect to intraoperative blood product usage, postoperative ventilation requirement and ITU stay. VVB is no longer required and TPCS may be used selectively in adult transplantation. (Transpl Int 2006;19:795-801.)
传统的原位肝移植(CON-LT)包括切除受体腔体,通常伴有体外循环(静脉-静脉旁路,VVB),而背驮式技术(PC-LT)保留腔体。与临时门静脉分流术(TPCS)一起,PC-LT可以更好地维持血流动力学。对2000-2003年384例原发性移植进行前瞻性连续分析,其中138例为CON-LT(合并VVB), 246例为PC-LT(未合并TPCS)。两组患者/供体特征相似。PC-LT需要较少使用新鲜冷冻血浆和血小板、重症监护时间、第1天后需要通气的患者数量和使用呼吸机的总天数。总手术时间和热缺血时间(WIT)、红细胞使用情况、肾支持需求、第3天血清肌酐和总住院时间比较,结果无差异。除WIT外,TPCS对预后无影响(P = 0.02)。PC-LT组3例(246例中3例;1.2%)发生腔静脉流出梗阻(P = 0.02)。短期或长期移植或患者生存无差异。在术中血液制品使用、术后通气要求和ITU停留时间方面,PC-LT优于使用VVB的CON-LT。成人移植不再需要VVB, TPCS可选择性使用。(国际翻译2006;19:795-801。)
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引用次数: 4
Endoscopic retrograde cholangiography in post-orthotopic liver transplant population with Roux-en-Y biliary reconstruction. 内镜逆行胆道造影在原位肝移植术后Roux-en-Y胆道重建中的应用。
P. Chahal, T. Baron, J. Poterucha, C. Rosen
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引用次数: 29
Hepatic tissue engineering for adjunct and temporary liver support: critical technologies. 辅助和临时肝支持的肝组织工程:关键技术。
Christina Chan, F. Berthiaume, Bharath D. Nath, A. Tilles, M. Toner, M. Yarmush
The severe donor liver shortage, high cost, and complexity of orthotopic liver transplantation have prompted the search for alternative treatment strategies for end-stage liver disease, which would require less donor material, be cheaper, and less invasive. Hepatic tissue engineering encompasses several approaches to develop adjunct internal liver support methods, such as hepatocyte transplantation and implantable hepatocyte-based devices, as well as temporary extracorporeal liver support techniques, such as bioartificial liver assist devices. Many tissue engineered liver support systems have passed the "proof of principle" test in preclinical and clinical studies; however, they have not yet been found sufficiently reliably effective for routine clinical use. In this review we describe, from an engineering perspective, the progress and remaining challenges that must be resolved in order to develop the next generation of implantable and extracorporeal devices for adjunct or temporary liver assist.
严重的供肝短缺、高成本和原位肝移植的复杂性促使人们寻找治疗终末期肝病的替代治疗策略,这些策略将需要更少的供体材料、更便宜、更小的侵入性。肝组织工程包括几种开发辅助内部肝支持方法的方法,如肝细胞移植和植入式肝细胞装置,以及临时体外肝支持技术,如生物人工肝辅助装置。许多组织工程肝支持系统已经在临床前和临床研究中通过了“原理证明”测试;然而,他们还没有发现足够可靠有效的常规临床使用。在这篇综述中,我们从工程的角度描述了为了开发下一代用于辅助或临时肝辅助的植入式和体外装置,必须解决的进展和仍然存在的挑战。
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引用次数: 58
Tacrolimus ameliorates cerebral vasodilatation and intracranial hypertension in the rat with portacaval anastomosis and hyperammonemia. 他克莫司改善门静脉吻合伴高氨血症大鼠脑血管舒张和颅内高压。
T. Dethloff, B. Hansen, F. Larsen
{"title":"Tacrolimus ameliorates cerebral vasodilatation and intracranial hypertension in the rat with portacaval anastomosis and hyperammonemia.","authors":"T. Dethloff, B. Hansen, F. Larsen","doi":"10.1016/S0168-8278(04)90142-0","DOIUrl":"https://doi.org/10.1016/S0168-8278(04)90142-0","url":null,"abstract":"","PeriodicalId":18112,"journal":{"name":"Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":"94 1","pages":"922-7"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76323252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Usefulness of albumin scintigraphy in a pediatric liver transplant recipient with gastrointestinal posttransplant lymphoproliferative disorder. 白蛋白显像在小儿肝移植受者并发胃肠道移植后淋巴细胞增生性疾病中的应用价值。
A. Mita, Y. Hashikura, M. Momose, J. Nakayama, E. Sasaki, T. Ikegami, Y. Nakazawa, H. Chisuwa, M. Terada, S. Kawasaki
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引用次数: 1
期刊
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
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