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Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society最新文献

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Piggyback liver transplantation with temporary portocaval shunting. 临时门静脉分流的背驮式肝移植。
T Howard
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引用次数: 0
Split liver/auxiliary liver transplantation for fulminant hepatic failure. 劈裂肝/辅助肝移植治疗暴发性肝衰竭。
P Neuhaus, W O Bechstein
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引用次数: 0
Preservation injury and donor selection: it all starts here. 保存损伤和供体选择:一切都从这里开始。
S M Strasberg
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引用次数: 0
Orthotopic liver transplantation for stage III and stage IV hepatocellular carcinoma. 原位肝移植治疗III期和IV期肝细胞癌。
P A Clavien
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引用次数: 0
Recurrent disease after liver transplantation: implications for the future. 肝移植后复发性疾病:对未来的影响。
W J Wall
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引用次数: 0
Primary transplant treatment of hepatitis B: hepatitis B immunoglobulin (passive immunization). 乙肝的初级移植治疗:乙肝免疫球蛋白(被动免疫)。
T Pruett
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引用次数: 0
Monitoring and handling of reperfusion. 再灌注的监测和处理。
A De Wolf
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引用次数: 0
Transplantation in alcoholics: separating prognosis and responsibility from social biases. 酗酒者移植:从社会偏见中分离预后和责任。
P A Ubel

The general public does not favor transplanting livers into patients with alcoholic cirrhosis. This opinion may reflect a sense that we should not distribute scarce resources to people who are personally responsible for their illness. It may also reflect a sense that alcoholism is socially undesirable, and therefore alcoholics should not receive transplants. This article argues that these positions do not hold up under scrutiny. The only reason to give alcoholic patients lower priority for transplantation is if subgroups of alcoholics can be shown to have unacceptably poor transplant prognoses. However, giving these alcoholics lower priority is justifiable only if it is part of a larger policy that distributes livers on the basis of prognosis. In the meantime, there is no justification for giving lower priority to alcoholics for available livers.

一般公众不赞成对酒精性肝硬化患者进行肝脏移植。这种观点可能反映了一种观念,即我们不应该把稀缺的资源分配给那些对自己的疾病负有个人责任的人。这也可能反映了一种感觉,即酗酒是不受社会欢迎的,因此酗酒者不应该接受移植。本文认为,这些立场经不起推敲。给予酗酒患者较低移植优先级的唯一原因是,如果酗酒亚组可以显示出移植预后不可接受的差。然而,给予这些酗酒者较低的优先级是合理的,只有当它是根据预后分配肝脏的更大政策的一部分。与此同时,没有理由不优先考虑酗酒者的可用肝脏。
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引用次数: 0
Alcoholic liver disease: natural history. 酒精性肝病:自然史。
A M Diehl

Alcohol has been implicated in the genesis of liver disease for centuries. Modern epidemiological data from many societies corroborate the correlation between per capita consumption of alcohol and deaths from cirrhosis. Although significant progress has been made in our understanding of the pathogenesis of alcoholic liver disease, ALD, effective therapies for most individuals with ALD have not been found. High per capita consumption of alcohol, coupled with the dearth of effective treatments and the failure of most affected individuals to abstain from alcohol, explains why ALD is one of the most prevalent forms of disabling, chronic liver disease.

几个世纪以来,酒精一直与肝脏疾病的起源有关。来自许多社会的现代流行病学数据证实了人均酒精消费量与肝硬化死亡之间的相关性。尽管我们对酒精性肝病和ALD的发病机制的了解取得了重大进展,但对大多数ALD患者的有效治疗尚未发现。高人均酒精消费量,加上缺乏有效的治疗方法,以及大多数受影响的人未能戒掉酒精,解释了为什么ALD是最普遍的致残慢性肝病之一。
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引用次数: 0
Survival and quality of life after liver transplantation for acute alcoholic hepatitis. 急性酒精性肝炎肝移植术后的生存和生活质量。
A O Shakil, A Pinna, J Demetris, R G Lee, J J Fung, J Rakela

The applicability of liver transplantation for ALD remains limited because of ethical arguments and also because of the perception of poor outcome after transplantation. Patients with alcoholic cirrhosis are known to do as well as patients with nonalcoholic liver disease after receiving liver allografts; however, the outcome in patients with severe acute alcoholic hepatitis in this setting is unclear. We studied 9 liver transplant recipients in whom severe acute alcoholic hepatitis was retrospectively diagnosed; 8 had underlying cirrhosis, and 1 had advanced fibrosis. All had Maddrey's discriminant function > 32, and most had hepatic encephalopathy and hepatorenal syndrome. History regarding abstinence was unreliable in some patients. Episodes of acute cellular rejection responded quickly to therapy, and despite recidivism in some patients, long-term survival was comparable to that of patients receiving transplants with alcoholic cirrhosis alone and those with a milder degree of alcoholic hepatitis and cirrhosis. This study suggests that severe acute alcoholic hepatitis may not be an appropriate contraindication for liver transplantation.

肝移植治疗ALD的适用性仍然有限,因为伦理上的争论,也因为移植后预后不佳的看法。已知酒精性肝硬化患者在接受同种异体肝脏移植后的表现与非酒精性肝病患者一样好;然而,在这种情况下,严重急性酒精性肝炎患者的预后尚不清楚。我们研究了9例回顾性诊断为严重急性酒精性肝炎的肝移植受者;8人有肝硬化,1人有晚期纤维化。Maddrey’s判别功能> 32,多数有肝性脑病和肝肾综合征。一些患者的禁欲史不可靠。急性细胞排斥反应的发作对治疗反应迅速,尽管在一些患者中再犯,但长期生存率与接受移植的酒精性肝硬化患者和轻度酒精性肝炎和肝硬化患者相当。本研究提示严重急性酒精性肝炎可能不是肝移植的合适禁忌症。
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引用次数: 0
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Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
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