J. Hunter Collins, Shannon M Lenz, Nashone A. Ray, R. Lahiri, L. Adams
{"title":"Assessment of esxA, hsp18, and 16S transcript expression as a measure of Mycobacterium leprae viability: A comparison with the mouse footpad assay","authors":"J. Hunter Collins, Shannon M Lenz, Nashone A. Ray, R. Lahiri, L. Adams","doi":"10.47276/lr.94.1.7","DOIUrl":"https://doi.org/10.47276/lr.94.1.7","url":null,"abstract":"","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46047829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health workers’ perceptions of leprosy and factors influencing their perceptions in endemic countries: A systematic literature review","authors":"E. Haverkort, A. T. van 't Noordende","doi":"10.47276/lr.93.4.332","DOIUrl":"https://doi.org/10.47276/lr.93.4.332","url":null,"abstract":"","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48935931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rising percentage of new female leprosy cases since 2004","authors":"Emily E V Quilter, D. Lockwood, C. Ruth Butlin","doi":"10.47276/lr.93.4.364","DOIUrl":"https://doi.org/10.47276/lr.93.4.364","url":null,"abstract":"","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47217069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. F. dos Santos, Victor Herlys Gomes Braga, Thales Junqueira Oliveira, Isabella Sabião Borges, I. Goulart
{"title":"Guillain-Barré syndrome following a Type 2 leprosy reaction: A case report","authors":"D. F. dos Santos, Victor Herlys Gomes Braga, Thales Junqueira Oliveira, Isabella Sabião Borges, I. Goulart","doi":"10.47276/lr.93.4.420","DOIUrl":"https://doi.org/10.47276/lr.93.4.420","url":null,"abstract":"","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42728308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SummaryIntroduction Leprosy is an infection caused by Mycobacterium leprae . Despite curative treatment being available, leprosy is still prevalent worldwide, with little change in annual cases observed in the past decade. The WHO South East Asia region is the worst affected, accounting for over 70% of new cases. One reason leprosy transmission still occurs is non-adherence to multi-drug therapy. This project aims to determine the factors that influence adherence. Methods A systematic review was performed using 6 databases. This returned 402 unique results. Screening of the title and abstract resulted in 362 of these being excluded. From the remaining 40, full-text analysis identified 17 studies that met the inclusion criteria and formed the review. Both qualitative and quantitative methods of collecting and analyzing data were used to form a non-quantitative synthesis of the findings. Results Four factors influenced adherence: medication-related, healthcare-related, patient-related and society-related. From these, lack of knowledge about leprosy and multi-drug therapy was a predominant barrier to adherence, which related to all of these factors. Stigma and being female were also seen as important barriers to adherence - these manifested in numerous ways. Conclusion The review identified diverse barriers to adherence to MDT and no simple intervention will overcome these. Rather, wider issues such as continuous access to healthcare (particularly for women), stigma reduction and patient education need to be addressed. Improving these will increase patient confidence in, and access to, MDT, which will ultimately result in improved adherence to therapy.
{"title":"What factors influence adherence and non-adherence to multi-drug therapy for the treatment of leprosy within the World Health Organisation South East Asia region? A systematic review","authors":"T. Meadows, G. Davey","doi":"10.47276/lr.93.4.311","DOIUrl":"https://doi.org/10.47276/lr.93.4.311","url":null,"abstract":"SummaryIntroduction Leprosy is an infection caused by Mycobacterium leprae . Despite curative treatment being available, leprosy is still prevalent worldwide, with little change in annual cases observed in the past decade. The WHO South East Asia region is the worst affected, accounting for over 70% of new cases. One reason leprosy transmission still occurs is non-adherence to multi-drug therapy. This project aims to determine the factors that influence adherence. Methods A systematic review was performed using 6 databases. This returned 402 unique results. Screening of the title and abstract resulted in 362 of these being excluded. From the remaining 40, full-text analysis identified 17 studies that met the inclusion criteria and formed the review. Both qualitative and quantitative methods of collecting and analyzing data were used to form a non-quantitative synthesis of the findings. Results Four factors influenced adherence: medication-related, healthcare-related, patient-related and society-related. From these, lack of knowledge about leprosy and multi-drug therapy was a predominant barrier to adherence, which related to all of these factors. Stigma and being female were also seen as important barriers to adherence - these manifested in numerous ways. Conclusion The review identified diverse barriers to adherence to MDT and no simple intervention will overcome these. Rather, wider issues such as continuous access to healthcare (particularly for women), stigma reduction and patient education need to be addressed. Improving these will increase patient confidence in, and access to, MDT, which will ultimately result in improved adherence to therapy.","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46005447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving early case detection in leprosy: Reports from recent workshops","authors":"P. Saunderson","doi":"10.47276/lr.93.4.292","DOIUrl":"https://doi.org/10.47276/lr.93.4.292","url":null,"abstract":"","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44646078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Taal, Avilash Chakrawarti, N. Banstola, Anil Kumar, Bikash Man Singh, R. Baskota, W. V. van Brakel, J. Richardus, D. Blok
{"title":"Trends and geographical variation in leprosy case detection and disability in Nepal, 2010–2021","authors":"A. Taal, Avilash Chakrawarti, N. Banstola, Anil Kumar, Bikash Man Singh, R. Baskota, W. V. van Brakel, J. Richardus, D. Blok","doi":"10.47276/lr.93.4.348","DOIUrl":"https://doi.org/10.47276/lr.93.4.348","url":null,"abstract":"","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47520489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leprosy in Europe – towards zero leprosy","authors":"P. Saunderson, Anil Fastenau","doi":"10.47276/lr.93.4.298","DOIUrl":"https://doi.org/10.47276/lr.93.4.298","url":null,"abstract":"","PeriodicalId":18196,"journal":{"name":"Leprosy review","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42917110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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