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[Hypertrophic cardiomyopathy]. (肥厚性心肌病)。
Pub Date : 2020-12-20 DOI: 10.1201/9780429330346
N. Maki, Tomoaki Shimizu, Chie Nishiyama, A. Murata, T. Kita
A 68-year-old woman with severe cardiac dysfunction due to dilated phase of hypertrophic cardiomyopathy was diagnosed with sigmoid cancer and scheduled for high anterior resection. Preoperative left ventricular ejection fraction (EF) was 16% by transthoracic echocardiography. After placement of an epidural catheter at the T12-L1 interspace, and artery catheters in the left radial artery for invasive blood pressure monitoring and in the right femoral artery for stand-by IABE general anesthesia was induced by midazolam, fentanyl and sevoflurane, and maintained with sevoflurane. Analgesia was obtained by epidural administration of 1% lidocaine and 0.2% ropivacaine. A central venous catheter was placed in the right internal jugular vein through which dobutamine was infused throughout the operation. Cardiac function monitored by transesophageal echocardiography showed EF of 9% just after insertion. After arbitrary administration of phenylephrine and landiolol, the operation and anesthesia were completed without serious problems. However, congestive heart failure worsened on postoperative day 2, and was improved by increasing dobutamine and by administration of milrinone.
一位68岁的女性,由于肥厚性心肌病扩张期导致严重的心功能障碍,被诊断为乙状结肠癌,并计划高位前切除术。术前经胸超声心动图显示左室射血分数(EF)为16%。在T12-L1间隙置入硬膜外导管,左桡动脉置入有创血压监测动脉导管,右股动脉置入静置IABE动脉导管后,咪达唑仑、芬太尼、七氟醚诱导全身麻醉,七氟醚维持麻醉。硬膜外给予1%利多卡因和0.2%罗哌卡因镇痛。在右颈内静脉内放置中心静脉导管,在整个手术过程中注入多巴酚丁胺。经食管超声心动图监测心功能显示插入后EF为9%。在任意给药苯肾上腺素和兰地洛尔后,手术和麻醉均顺利完成,无严重问题。然而,充血性心力衰竭在术后第2天加重,并通过增加多巴酚丁胺和给予米力酮得到改善。
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引用次数: 0
Intraoperative Aortic Dissection during Lung Transplantation in a Patient with Alpha-1 Antitrypsin Deficiency. α -1抗胰蛋白酶缺乏症患者肺移植术中主动脉夹层1例。
Kenichiro Tatsumi, Yusuke Hamai, Toshiyuki Mizota, Kazuhiko Fukuda

Alpha-1 antitrypsin deficiency (AATD) is an inherited disorder affecting the lung, liver, and rarely skin. The most frequent features of AATD consist of chronic lung disorders related to protease-antiprotease imbalance in the respiratory system, to which lung transplantation is frequently indicated. We describe a case of aortic dissection in a 55-year-old male who underwent left single lung transplantation for respiratory failure due to AATD-related emphysema. Extracorporeal membrane oxygenation (ECMO) was indicated during the procedure, and an arterial cannula was placed into the descending aorta and a venous cannula was placed into the right femoral vein. Bronchial and vascular anastomoses were finished without any problems and ECMO was weaned off However, transesophageal echocardiography carried out at the end of the operation showed a dissected descending aorta. Alpha-1 antitrypsin (AAT) is the major serum inhibitor of seine proteinases, which enzymatically destroys collagen and elastin. Degeneration of connective tissues, in particular elastic tissues, is established in AATD, and decreased stiffness of the aorta due to degradation of elastic fibers has also been reported in AATD. In this patient, reduced AAT activity might have boosted the enzymatic destruction of his arterial walls, leading to enhanced vulnerability to aortic dissections.

α -1抗胰蛋白酶缺乏症(AATD)是一种遗传性疾病,影响肺、肝,很少影响皮肤。AATD最常见的特征是与呼吸系统蛋白酶-抗蛋白酶失衡相关的慢性肺部疾病,肺移植常用于此。我们描述了一个55岁男性因aatd相关肺气肿导致呼吸衰竭而接受左单肺移植的主动脉夹层病例。术中行体外膜氧合(ECMO),降主动脉置入动脉插管,右股静脉置入静脉插管。支气管和血管吻合术顺利完成,停用ECMO。然而,手术结束时经食管超声心动图显示降主动脉剥离。α -1抗胰蛋白酶(AAT)是血清中主要的丝氨酸蛋白酶抑制剂,它通过酶破坏胶原蛋白和弹性蛋白。结缔组织变性,特别是弹性组织变性,在AATD中是建立的,并且在AATD中也报道了由于弹性纤维降解而导致的主动脉刚度降低。在该患者中,AAT活性降低可能促进了酶对动脉壁的破坏,导致主动脉夹层的易感性增加。
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引用次数: 0
Use of Sugammadex in a Patient with Myotonic Dystrophy Undergoing Laparoscopic Cholecystectomy. Sugammadex在强直性肌营养不良患者行腹腔镜胆囊切除术中的应用。
Rieko Uno, Shoko Matsuda, Kohei Murao, Kumiko Nakamura, Michiyo Shirakawa, Koh Shingu

A 37-year-old female patient with myotonic dystrophy was scheduled for laparoscopic cholecystectomy for gall stone under general anesthesia with continuous propofol infusion. Rocuronium was administered with careful monitoring using TOF- Watch®, measuring train-of-four count (Tc), TOF ratio (Tr), and posttetanic count The total amount of rocuronium was 70 mg ; 0.6 mg .kg⁻1 for anesthetic induction and 0.3 mg .kg⁻1 when Tc exceeded 1. When the operation was completed, Tc was 4, Tr was uncountable and she showed reaction to calling her name. Then sugammadex 2 mg .kg⁻1, rapidly antagonized the neuromuscular block, such that the Tr recovered to 100% but tidal volume was 250 ml in 3 minutes. Additional dorsage of sugammadex, 2 mg .kg⁻1, was required for tidal volume to recover to 530 ml. After 20 minutes of first administration of sugammadex, we extubated the tracheal tube without respiratory depression. To avoid respiratory depression, we did not use postoperative opioids. Intraoperative transversus abdominis plane block and postoperative thoracic epidural block with ropivacaine were successful for postoperative pain relief.

一例37岁女性强直性肌营养不良患者,在全身麻醉下持续输注异丙酚,行胆囊切除术治疗胆囊结石。给予罗库溴铵时,使用TOF- Watch®仔细监测,测量四列细胞计数(Tc)、TOF比值(Tr)和破伤风后计数,罗库溴铵总剂量为70 mg;麻醉诱导0.6 mg .kg毒血症,Tc超过1时0.3 mg .kg毒血症。当手术完成时,Tc是4,Tr是不可数的,她对叫她的名字有反应。2 mg .kg - 1迅速拮抗神经肌肉阻滞,使Tr恢复到100%,但潮气量在3分钟内为250 ml。再注射2 mg .kg - 1,潮气量才恢复到530 ml。第一次给药20分钟后,我们拔管,没有呼吸抑制。为避免呼吸抑制,我们术后未使用阿片类药物。术中经腹平面阻滞和术后胸腔硬膜外阻滞罗哌卡因均能成功缓解术后疼痛。
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引用次数: 0
Unexpected Systolic Anterior Motion of the Mitral Valve Diagnosed by Transthoracic Echocardiography after the Induction of General Anesthesia. 全麻诱导后经胸超声心动图诊断二尖瓣意外收缩前运动。
Toshiyuki Nakanishi, Manabu Yoshimura, Seishi Sakamoto, Takashi Toriumi

We report an 87-year-old woman who presented with unexpected systolic anterior motion (SAM) of the mitral valve after the induction of general anesthesia. She was receiving medication for hypertension and cerebral infarction. There were no abnormal findings on her preoperative transthoracic echocardiography (TTE) examination. After the induction of general anesthesia, she presented with refractory hypotension. We performed TTE and diagnosed SAM of the mitral valve. Her hemodynamic state was improved by fluid infusion and administering intravenous phenylephrine. After the surgery, we performed a morphologic assessment of the patient's heart using TTE. We found a thick basal interventricular septum and a small distance from the mitral coaptation point. to the septum. This case shows that SAM of the mitral valve can occur in a patient without preoperative cardiac abnormalities. SAM of the mitral valve should be considered in the differential diagnosis of refractory hypotension, particularly in elderly patients. Perioperative TTE is a useful tool for the rapid diagnosis and treatment of hemodynamic instability.

我们报告了一位87岁的女性,她在全身麻醉诱导后出现了意想不到的二尖瓣收缩前运动(SAM)。她当时正在接受治疗高血压和脑梗塞的药物治疗。术前经胸超声心动图检查未见异常。全麻诱导后出现难治性低血压。我们进行了TTE检查并诊断为二尖瓣SAM。她的血流动力学状态通过输液和静脉注射苯肾上腺素得到改善。手术后,我们使用TTE对患者的心脏进行了形态学评估。我们发现一个厚的基底室间隔和距离二尖瓣接合点很短的距离。到鼻中隔。本病例显示二尖瓣SAM可发生在术前无心脏异常的患者。在难治性低血压的鉴别诊断中应考虑二尖瓣SAM,特别是在老年患者中。围手术期TTE是快速诊断和治疗血流动力学不稳定的有效工具。
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引用次数: 0
Point-of-care Lung Ultrasound. 即时肺部超声检查。
Makoto Sera

The evaluation of the lung has usually been considered off-limits for ultrasound, because ultrasound energy is rapidly dissipated by air. Lung ultrasound is not useful for the evaluation of the pulmonary parenchyma and the pleural line. However ultrasound machines have become more portable, with decreased start-up time, while simultaneously providing improved image quality and ease of image acquisition. Additionally, lung ultrasound is highly accurate for the diagnosis of pneumothorax, hemothorax. pleural effusions, pulmonary edema (cardiogenic or noncardiogenic), interstitial syndrome, and pneumonia. These factors make lung ultrasound suitable for operating rooms, intensive care units, and emergency departments. Adequate interpretation of lung ultrasonographic findings, including artifacts, requires some training and experience. Since lung ultrasound abnormalities, however, are well defined and easy to recognize, learn and reproduce, operator dependence is minimal. So let's try lung ultrasound! In this article, the author will discuss the examination method for adequate lung ultrasonographic images, lung ultrasonographic findings and signs, leading to the diagnosis.

肺的评估通常被认为是禁止超声,因为超声能量被空气迅速消散。肺超声对肺实质和胸膜线的评价是无用的。然而,超声仪器变得更加便携,减少了启动时间,同时提供了改进的图像质量和易于图像采集。此外,肺超声对气胸、血胸的诊断准确率很高。胸腔积液,肺水肿(心源性或非心源性),间质综合征和肺炎。这些因素使得肺部超声适合于手术室、重症监护病房和急诊科。充分解释肺部超声检查结果,包括假影,需要一些培训和经验。然而,由于肺部超声异常定义明确,易于识别、学习和重现,因此对操作人员的依赖性最小。那我们试试肺超声吧!在本文中,笔者将讨论检查方法,充分的肺部超声图像,肺部超声表现和体征,导致诊断。
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引用次数: 0
Anesthetic Management of Caesarean Section in a Patient with Verapamil Sensitive Ventricular Tachycardia after Catheter Ablation. 维拉帕米敏感性室性心动过速导管消融后剖宫产术的麻醉处理。
Minori Morita

A 32-year-old pregnant woman with verapamil sensitive ventricular tachycardia underwent elective caesarean section. She received catheter ablation for frequent tachycardia, but ventricular tachycardia appeared. In the operating room, a defibrillator pad was placed on her chest for external defibrillation, with A-line in a left radial artery. General anesthesia was started with rapid sequence induction. The anesthetic course was uneventful, and the infant showed no complication during the perioperative period. General anesthesia can be considered as safe anesthetic management for caesarean section in a patient with verapamil sensitive ventricular tachycardia.

一32岁孕妇维拉帕米敏感性室性心动过速行择期剖宫产术。她因频繁心动过速接受导管消融,但出现室性心动过速。在手术室,除颤器垫被放置在她的胸部进行体外除颤,在左桡动脉上有a线。全麻开始于快速序列诱导。麻醉过程顺利,患儿围手术期无并发症发生。对于维拉帕米敏感性室性心动过速剖宫产患者,全麻可视为安全的麻醉管理。
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引用次数: 0
Cardiac Point-of-care Using Ultrasound. 心脏护理点使用超声。
Mitsuharu Kodaka

Patients with cardiac disease have high mortality rates, mainly owing to shock. Therefore, evaluation of cardiac function is one of the most challenging issues in the intensive and critical care unit. Cardiac point-of-care tests using ultrasound, such as focus assessed transthoracic echo (FATE) and rapid ultrasound in shock (RUSH). are useful for diagnosis and initial care of such patients. The author will introduce first a basic FATE protocol of how to scan from position 1-4, including subcostal 4-chamber, apical 4-chamber, parasternal long and short axis, and pleural scanning. A simple measurement method is described to evaluate the left and right ventricular function using mitral annular plane systolic excursion (MAPSE), mitral septal separation (MSS), and tricuspid annular plane systolic excursion (TAPSE). Next the RUSH protocol is discussed, which is useful for evaluation and care of patients with hypovolemic, cardiogenic, obstructive, or distributive shock. RUSH involves evaluation of the three main components : the pump (cardiac function, volume, pericardial function), the trunk (inferior vena cava, pleural fluid, lining), and the pipes (abdominal aneurysm, aortic dissection, deep vein thrombosis).

心脏病患者的死亡率很高,主要是由于休克。因此,心功能的评估是重症监护病房最具挑战性的问题之一。心脏护理点超声检查,如焦点评估经胸回声(FATE)和休克快速超声(RUSH)。对这类病人的诊断和初步护理是有用的。作者将首先介绍如何从1-4位扫描的基本FATE方案,包括肋下4室,根尖4室,胸骨旁长、短轴和胸膜扫描。本文描述了一种评估左右心室功能的简单测量方法:二尖瓣环平面收缩偏移(MAPSE)、二尖瓣间隔分离(MSS)和三尖瓣环平面收缩偏移(TAPSE)。接下来讨论了RUSH方案,它对低血容量性、心源性、梗阻性或分布性休克患者的评估和护理是有用的。RUSH包括对三个主要组成部分的评估:泵(心功能、容积、心包功能)、主干(下腔静脉、胸膜液、衬里)和管道(腹动脉瘤、主动脉夹层、深静脉血栓形成)。
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引用次数: 0
History of Tracheal Intubation :5. Use for Resuscitation in Neonates. 5.气管插管史。用于新生儿复苏。
Takashi Asai

In the 18th century, tracheal intubation was introduced to clinical practice, mainly in patients with airway obstruction in children due to diphtheria, and in patients who were apparently dead. In this article, I describe the fourth reason for tracheal intubation :a newborn with apnea. Until the mid-18th century, delivery was performed only by midwives, and mouth-to-mouth resuscitation was "secretly" performed by them (midwives' secret). In the mid-18th century, obstetricians started to be involved in the delivery, and in 1750's, Benjamin Pugh (1715-1798) and William Smellie (1697-1763) might have intubated the tracheas of neonates with apnea Since 1790's, Paul Scheel (1773-1811), Frangois Chaussier (1746-1828), James Blundell (1791-1878). Jean Anne Henri Depaul (1811-1883), Heinrich Alexander Pagenstecher (1825-1889), and Alban Alphonse Ambroise Ribemont-Dessaignes (1847-1940) intubated the trachea. Tracheal intubation might have been widely performed by midwives, because Chaussier had educated them at his school.

在18世纪,气管插管被引入临床实践,主要用于因白喉导致气道阻塞的儿童患者,以及明显死亡的患者。在这篇文章中,我描述了气管插管的第四个原因:新生儿呼吸暂停。直到18世纪中期,分娩都是由助产士来完成的,而且人工呼吸是由助产士“秘密”进行的(助产士的秘密)。在18世纪中期,产科医生开始参与分娩,在18世纪50年代,本杰明·皮尤(1715-1798)和威廉·斯梅利(1697-1763)可能为患有呼吸暂停的新生儿插管。自18世纪90年代以来,保罗·舍尔(1773-1811),弗朗索瓦·肖西尔(1746-1828),詹姆斯·布伦德尔(1791-1878)。Jean Anne Henri Depaul (1811-1883), Heinrich Alexander Pagenstecher(1825-1889)和Alban Alphonse Ambroise Ribemont-Dessaignes(1847-1940)插管气管。由于乔西尔在他的学校里对助产士进行了教育,所以气管插管可能已经广泛地由助产士进行。
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引用次数: 0
Pre-anesthetic Whole Body Point-of-care Ultrasonography. 麻醉前全身即时超声检查。
Takeshi Nomura, Itaru Watanabe

Point-of-care ultrasonography has become widely used in diagnosis and managements of patients. In the field of anesthesiology, ultrasound guided nerve blocks and central venous catheterization (CVC), and transesophageal echocardiography (TEE) have become popular. Now, ultrasound devices are familiar to anesthesiologists. In pre-anesthetic patient risk evaluation, the sonographic results of transthoracic echocardiography (TTE) or the examination of deep venous thrombus are often helpful for anesthesia planning. Both examinations usually have been performed by sonographer. However, the ultrasonographic assessment of neck vessels, lung condition with diaphragm function are still less familiar among anesthesiologists. Here, we have introduced a series of pre-anesthetic whole body ultrasound evaluation of the patients. Because of less invasive technique, whole body ultrasound evaluation is suitable to use when anesthesiologists may have questions whether the patient's condition is good or not. No doubt that point-of-care ultrasonography by anesthesiologists themselves in pre-anesthesia. clinic can be the useful decision making tool of anesthesia plan. To be tomorrow's anesthesiologists, please start point-of-care pre-anesthetic ultrasonographic assessment.

即时超声检查已广泛应用于患者的诊断和治疗。在麻醉学领域,超声引导神经阻滞和中心静脉插管(CVC)以及经食管超声心动图(TEE)已成为流行。现在,麻醉师对超声设备很熟悉。在麻醉前患者风险评估中,经胸超声心动图(TTE)或深静脉血栓检查的超声结果往往有助于麻醉计划。这两种检查通常都由超声医师进行。然而,麻醉医师对颈部血管、肺状况及膈肌功能的超声评估仍不甚了解。在此,我们介绍了一系列麻醉前全身超声对患者的评估。由于微创技术,全身超声评估适用于麻醉医师对患者病情是否良好存有疑问的情况。毫无疑问,现场超声检查是由麻醉医师自己在麻醉前进行的。临床可作为麻醉方案的有效决策工具。要成为明天的麻醉师,请开始在护理点进行麻醉前超声检查。
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引用次数: 0
The PEAS Protocol, an Airway Ultrasound Technique. 豌豆协议,气道超声技术。
Akihiro Suzuki

In the past ultrasound identification of the airway structure was rather difficult However, recent advancement of the high frequency linear type transducer allows us to visualize airway structure easily. Accordingly, now we have difficult airway society guideline 2015. resuscitation guideline 2015, and Australia and New Zealand Intensive Care Society guidelines for percutaneous dilatational tracheostomy which recommend use of ultrasound in airway management Airway ultrasound is an emerging technique for all physicians, and the author introduces perioperative evaluation of the airway via sonography, the PEAS protocol.

过去超声对气道结构的识别是相当困难的,而近年来高频线性型换能器的发展使我们能够轻松地看到气道结构。因此,现在我们有困难气道社会指南2015。2015年复苏指南,以及澳大利亚和新西兰重症监护学会经皮气管扩张造口术指南,建议在气道管理中使用超声。气道超声对所有医生来说都是一项新兴技术,作者介绍了通过超声对气道进行围手术期评估的pea协议。
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引用次数: 0
期刊
Masui. The Japanese journal of anesthesiology
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