Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2025.11.008
Jaleh Zand PhD , Milovan Suvakov PhD , Shauna M. Overgaard PhD , Chester G. Kozikowski MEd , Ryan C. Jimison MEd , Kristina B. Nelson MS , Carmen J. Silvano , Laura M. Meiners MBA , Jungwei W. Fan PhD , Kate E. Schultz PhD , Rickey E. Carter PhD , Mark L. Wieland MD, MPH , Christi A. Patten PhD , Sagar B. Dugani MD, PhD, MPH , Jenny A. Weis MAN , John D. Poe MBA , David R. Holmes III PhD , Leigh G. Griffiths MRCVS, PhD , Heidi L. Dieter MBA , Young J. Juhn MD, MPH , Vesna D. Garovic MD, PhD
{"title":"Building Artificial Intelligence and Data Literacy Across the Health Care Research Workforce in the Mayo Clinic Center for Clinical and Translational Science: Why It Matters and What We Are Doing About It","authors":"Jaleh Zand PhD , Milovan Suvakov PhD , Shauna M. Overgaard PhD , Chester G. Kozikowski MEd , Ryan C. Jimison MEd , Kristina B. Nelson MS , Carmen J. Silvano , Laura M. Meiners MBA , Jungwei W. Fan PhD , Kate E. Schultz PhD , Rickey E. Carter PhD , Mark L. Wieland MD, MPH , Christi A. Patten PhD , Sagar B. Dugani MD, PhD, MPH , Jenny A. Weis MAN , John D. Poe MBA , David R. Holmes III PhD , Leigh G. Griffiths MRCVS, PhD , Heidi L. Dieter MBA , Young J. Juhn MD, MPH , Vesna D. Garovic MD, PhD","doi":"10.1016/j.mayocp.2025.11.008","DOIUrl":"10.1016/j.mayocp.2025.11.008","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 17-25"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2025.11.007
Vinaya Simha MD
{"title":"Mayo Clinic Proceedings and Evolution of Diabetes Management: A Century of Companionship","authors":"Vinaya Simha MD","doi":"10.1016/j.mayocp.2025.11.007","DOIUrl":"10.1016/j.mayocp.2025.11.007","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 4-6"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2025.11.010
Karl A. Nath MBChB (Editor-in-Chief)
{"title":"Educating Health Care Professionals About Artificial Intelligence","authors":"Karl A. Nath MBChB (Editor-in-Chief)","doi":"10.1016/j.mayocp.2025.11.010","DOIUrl":"10.1016/j.mayocp.2025.11.010","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 7-11"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2025.05.027
Kirk J. Brower MD , Iris F. Litt MD , Tait D. Shanafelt MD
This manuscript is the last chapter in a series of 5 articles considering physician well-being during the course of a career. It focuses on the retirement stage, which follows planning for retirement and deciding when and how to retire. We view retirement as a process, characterized by recalibrating professional and personal activities while maintaining a sense of purpose and meaning in life. Some retirees may continue to work in medicine by seeing patients part-time or mentoring medical students, residents, and junior colleagues. Others may leave their lifelong work and seek joy and meaning in travel, spending time with family and friends, volunteering, and developing their personal interests and activities. Ideally, well-being in retirement includes having sufficient energy for activities and relationships that are meaningful, provide purpose, and are enjoyable. Stress during retirement usually shifts from occupational concerns to personal challenges with professional identity, caring for family and friends, maintaining one’s health, and relationship losses. Programs that specifically support retired physicians exist at some large health systems and select academic centers, which can complement resources provided by general medical associations and specialty societies. These can serve as models for other medical centers and a foundation for extending and expanding support to retired physicians.
{"title":"Retirement: Fostering Physician Well-being Over the Career Life Cycle","authors":"Kirk J. Brower MD , Iris F. Litt MD , Tait D. Shanafelt MD","doi":"10.1016/j.mayocp.2025.05.027","DOIUrl":"10.1016/j.mayocp.2025.05.027","url":null,"abstract":"<div><div>This manuscript is the last chapter in a series of 5 articles considering physician well-being during the course of a career. It focuses on the retirement stage, which follows planning for retirement and deciding when and how to retire. We view retirement as a process, characterized by recalibrating professional and personal activities while maintaining a sense of purpose and meaning in life. Some retirees may continue to work in medicine by seeing patients part-time or mentoring medical students, residents, and junior colleagues. Others may leave their lifelong work and seek joy and meaning in travel, spending time with family and friends, volunteering, and developing their personal interests and activities. Ideally, well-being in retirement includes having sufficient energy for activities and relationships that are meaningful, provide purpose, and are enjoyable. Stress during retirement usually shifts from occupational concerns to personal challenges with professional identity, caring for family and friends, maintaining one’s health, and relationship losses. Programs that specifically support retired physicians exist at some large health systems and select academic centers, which can complement resources provided by general medical associations and specialty societies. These can serve as models for other medical centers and a foundation for extending and expanding support to retired physicians.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 179-186"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2025.05.031
Hyo Jeong Kim MD , Hee Byung Koh MD , Chan-Young Jung MD, PhD , Hyung Woo Kim MD , Jung Tak Park MD, PhD , Tae Ik Chang MD, PhD , Tae-Hyun Yoo MD, PhD , Shin-Wook Kang MD, PhD , Seung Hyeok Han MD, PhD
Objective
To investigate the association between the Mediterranean lifestyle and incident chronic kidney disease (CKD).
Patients and Methods
This population-based, prospective, observational study used data from the UK Biobank cohort, collected from March 13, 2006, through July 31, 2010, and included 158,080 participants without CKD who completed a dietary assessment. The main predictor was the Mediterranean Lifestyle (MEDLIFE) index, comprising 3 blocks: (1) Mediterranean food consumption, (2) Mediterranean dietary habits, and (3) physical activity, rest, social habits, and conviviality. A Cox proportional hazards model was used to investigate the association between the MEDLIFE index and incident CKD. Further analysis was conducted to examine the associations between the individual blocks and items of the MEDLIFE index and the incidence of CKD.
Results
At baseline, individuals with a higher MEDLIFE index score had lower blood pressure and body mass index and were less likely to have diabetes, hypertension, or cardiovascular disease. During median follow-up of 11.2 years, CKD occurred in 4354 participants (2.75%). The adjusted hazard ratio per 1-point increase in the MEDLIFE index for incident CKD was 0.94 (95% CI, 0.93 to 0.96). Compared with quartile 1 of the MEDLIFE index, the adjusted hazard ratios (95% CIs) for quartiles 2 to 4 were 0.80 (0.74 to 0.87), 0.76 (0.70 to 0.82), and 0.65 (0.59 to 0.72), respectively. This favorable association was consistently observed for all 3 blocks of the MEDLIFE index.
Conclusion
These results suggest that a higher MEDLIFE index is associated with a lower risk of incident CKD.
{"title":"Association Between Mediterranean Lifestyle and Lower Risk of Chronic Kidney Disease: A Population-Based Prospective Study","authors":"Hyo Jeong Kim MD , Hee Byung Koh MD , Chan-Young Jung MD, PhD , Hyung Woo Kim MD , Jung Tak Park MD, PhD , Tae Ik Chang MD, PhD , Tae-Hyun Yoo MD, PhD , Shin-Wook Kang MD, PhD , Seung Hyeok Han MD, PhD","doi":"10.1016/j.mayocp.2025.05.031","DOIUrl":"10.1016/j.mayocp.2025.05.031","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between the Mediterranean lifestyle and incident chronic kidney disease (CKD).</div></div><div><h3>Patients and Methods</h3><div>This population-based, prospective, observational study used data from the UK Biobank cohort, collected from March 13, 2006, through July 31, 2010, and included 158,080 participants without CKD who completed a dietary assessment. The main predictor was the Mediterranean Lifestyle (MEDLIFE) index, comprising 3 blocks: (1) Mediterranean food consumption, (2) Mediterranean dietary habits, and (3) physical activity, rest, social habits, and conviviality. A Cox proportional hazards model was used to investigate the association between the MEDLIFE index and incident CKD. Further analysis was conducted to examine the associations between the individual blocks and items of the MEDLIFE index and the incidence of CKD.</div></div><div><h3>Results</h3><div>At baseline, individuals with a higher MEDLIFE index score had lower blood pressure and body mass index and were less likely to have diabetes, hypertension, or cardiovascular disease. During median follow-up of 11.2 years, CKD occurred in 4354 participants (2.75%). The adjusted hazard ratio per 1-point increase in the MEDLIFE index for incident CKD was 0.94 (95% CI, 0.93 to 0.96). Compared with quartile 1 of the MEDLIFE index, the adjusted hazard ratios (95% CIs) for quartiles 2 to 4 were 0.80 (0.74 to 0.87), 0.76 (0.70 to 0.82), and 0.65 (0.59 to 0.72), respectively. This favorable association was consistently observed for all 3 blocks of the MEDLIFE index.</div></div><div><h3>Conclusion</h3><div>These results suggest that a higher MEDLIFE index is associated with a lower risk of incident CKD.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 49-62"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2024.11.038
Trenton R. Madison MD , Carlie A. Aurubin MD, PhD , Dacre R.T. Knight MD
{"title":"65-Year-Old Man With Oral Ulcers","authors":"Trenton R. Madison MD , Carlie A. Aurubin MD, PhD , Dacre R.T. Knight MD","doi":"10.1016/j.mayocp.2024.11.038","DOIUrl":"10.1016/j.mayocp.2024.11.038","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 173-178"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2025.11.006
Enrique R. Soriano MD, MSC
{"title":"Control of Metabolic Factors in the Psoriasis–Psoriatic Arthritis Transition","authors":"Enrique R. Soriano MD, MSC","doi":"10.1016/j.mayocp.2025.11.006","DOIUrl":"10.1016/j.mayocp.2025.11.006","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 12-14"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2024.12.018
Nirav Patel MD, MSPH , Mokshad Gaonkar MS , Akhil Pampana MS , Jasninder S. Dhaliwal MD , Nehal Vekariya MS , Naman S. Shetty MD , Peng Li PhD , Rajat Kalra MBChB, MS , Garima Arora MD , Pankaj Arora MD
Objective
To elucidate the interplay between genetic predisposition and cardiovascular health (CVH) factors in individuals with pathogenic or likely pathogenic variants in hypertrophic cardiomyopathy sarcomere-encoding genes (SARC-HCM-P/LP).
Methods
This retrospective cohort study used data from the UK Biobank, including 159,375 participants aged 40 to 69 years with whole exome sequencing data and no baseline cardiovascular disease. Participants were stratified into 2 groups based on the presence of SARC-HCM-P/LP variants (SARC-HCM-P/LP vs SARC-NEG). Cardiovascular health was assessed by the Life’s Essential 8 score, categorizing participants into favorable, intermediate, and unfavorable CVH profiles. The primary outcome was a composite of heart failure, arrhythmias, and cardiovascular mortality. Adjusted Cox models examined the association between genetic variant status, CVH, and risk of adverse cardiovascular outcomes.
Results
Of 159,375 participants, 446 were SARC-HCM-P/LP carriers (median age, 56 years; 47.3% male). The median Life’s Essential 8 score was similar between SARC-HCM-P/LP and SARC-NEG groups (68.1 vs 66.9; P=.36). Compared with SARC-NEG carriers with favorable CVH, the risk of the primary outcome was higher in SARC-NEG carriers with intermediate (adjusted hazard ratio [HRadj), 1.14; 95% CI, 1.10 to 1.18) and unfavorable (HRadj, 1.52; 95% CI, 1.47 to 1.58) CVH profiles. Importantly, SARC-HCM-P/LP carriers, regardless of CVH profile, had a significantly higher risk of the primary outcome with favorable (HRadj, 2.12; 95% CI, 1.45 to 3.09), intermediate (HRadj, 2.19; 95% CI, 1.51 to 3.18), and unfavorable (HRadj, 2.30; 95% CI, 1.65 to 3.19) profiles.
Conclusion
SARC-HCM-P/LP carriers remain at elevated cardiovascular risk despite favorable CVH, highlighting the significant role of genetics in this population.
{"title":"Cardiovascular Health and Outcomes in Carriers With Genetic Variants of Hypertrophic Cardiomyopathy","authors":"Nirav Patel MD, MSPH , Mokshad Gaonkar MS , Akhil Pampana MS , Jasninder S. Dhaliwal MD , Nehal Vekariya MS , Naman S. Shetty MD , Peng Li PhD , Rajat Kalra MBChB, MS , Garima Arora MD , Pankaj Arora MD","doi":"10.1016/j.mayocp.2024.12.018","DOIUrl":"10.1016/j.mayocp.2024.12.018","url":null,"abstract":"<div><h3>Objective</h3><div>To elucidate the interplay between genetic predisposition and cardiovascular health (CVH) factors in individuals with pathogenic or likely pathogenic variants in hypertrophic cardiomyopathy sarcomere-encoding genes (SARC-HCM-P/LP).</div></div><div><h3>Methods</h3><div>This retrospective cohort study used data from the UK Biobank, including 159,375 participants aged 40 to 69 years with whole exome sequencing data and no baseline cardiovascular disease. Participants were stratified into 2 groups based on the presence of SARC-HCM-P/LP variants (SARC-HCM-P/LP vs SARC-NEG). Cardiovascular health was assessed by the Life’s Essential 8 score, categorizing participants into favorable, intermediate, and unfavorable CVH profiles. The primary outcome was a composite of heart failure, arrhythmias, and cardiovascular mortality. Adjusted Cox models examined the association between genetic variant status, CVH, and risk of adverse cardiovascular outcomes.</div></div><div><h3>Results</h3><div>Of 159,375 participants, 446 were SARC-HCM-P/LP carriers (median age, 56 years; 47.3% male). The median Life’s Essential 8 score was similar between SARC-HCM-P/LP and SARC-NEG groups (68.1 vs 66.9; <em>P</em>=.36). Compared with SARC-NEG carriers with favorable CVH, the risk of the primary outcome was higher in SARC-NEG carriers with intermediate (adjusted hazard ratio [HR<sub>adj</sub>), 1.14; 95% CI, 1.10 to 1.18) and unfavorable (HR<sub>adj</sub>, 1.52; 95% CI, 1.47 to 1.58) CVH profiles. Importantly, SARC-HCM-P/LP carriers, regardless of CVH profile, had a significantly higher risk of the primary outcome with favorable (HR<sub>adj</sub>, 2.12; 95% CI, 1.45 to 3.09), intermediate (HR<sub>adj</sub>, 2.19; 95% CI, 1.51 to 3.18), and unfavorable (HR<sub>adj</sub>, 2.30; 95% CI, 1.65 to 3.19) profiles.</div></div><div><h3>Conclusion</h3><div>SARC-HCM-P/LP carriers remain at elevated cardiovascular risk despite favorable CVH, highlighting the significant role of genetics in this population.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 73-84"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mayocp.2025.09.007
Fadi B. Yahya MD, MHA, Amy L. Van Abel PharmD, RPh, BCPS
{"title":"In Reply: Comments on “Maternal Sepsis: Review and Update”","authors":"Fadi B. Yahya MD, MHA, Amy L. Van Abel PharmD, RPh, BCPS","doi":"10.1016/j.mayocp.2025.09.007","DOIUrl":"10.1016/j.mayocp.2025.09.007","url":null,"abstract":"","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 1","pages":"Pages 196-199"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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