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Residual calcified material volume of β-tricalcium phosphate with platelet-rich fibrin in unilateral alveolar bone graft. 单侧牙槽骨移植中含有富血小板纤维蛋白的β-磷酸三钙的残余钙化物体积。
IF 2.3 Q1 Medicine Pub Date : 2024-03-01 DOI: 10.1186/s40902-024-00420-1
Chon T Ho Nguyen, Minh H Bui, Phuong H Lam

Background: This study aimed to evaluate the effectiveness of β-tricalcium phosphate (β-TCP) and platelet-rich fibrin (PRF) in unilateral alveolar bone graft, involving the percentage of residual calcified material and the average labiopalatal thickness of the grafts on cone beam computed tomography at 6 months after surgery, comparing two age groups 12 years and under and over 12 years old.

Results: The mean preoperative defect volume was 0.93 ± 0.20 cm3, with no significant difference between the two groups (p = 0.652). In the postoperative period, we did not record any abnormal bleeding and no infection was observed. Six months after surgery, the mean percentage of residual calcified material was 63.53 ± 16.48% with a significantly higher difference in the age group 12 and under (p < 0.001), and the mean average labiopalatal thickness of the grafted bone was 5.72 ± 1.09 mm with a significantly higher difference in the age group 12 and under (p = 0.011).

Conclusion: Using β-TCP and PRF in alveolar bone graft surgery has acceptable effectiveness clinically and on CBCT images, with significantly higher differences of the percentage of residual calcified material and the average labiopalatal thickness of the grafted bone in the group 12 years old and younger than in the older group.

背景:该研究旨在评估β-磷酸三钙(β-TCP)和富血小板纤维蛋白(PRF)在单侧牙槽骨移植中的有效性,涉及术后6个月锥形束计算机断层扫描中残留钙化材料的百分比和移植体的平均唇缘厚度,并对12岁及以下和12岁以上两个年龄组进行了比较:术前平均缺损体积为 0.93 ± 0.20 cm3,两组间无显著差异(p = 0.652)。术后未发现异常出血和感染。术后六个月,残留钙化物的平均百分比为(63.53 ± 16.48)%,12 岁及以下组的差异显著较高(p < 0.001),移植骨的平均唇缘厚度为(5.72 ± 1.09)mm,12 岁及以下组的差异显著较高(p = 0.011):结论:在牙槽骨移植手术中使用β-TCP和PRF在临床上和CBCT图像上都具有可接受的效果,12岁及以下组的残余钙化材料百分比和移植骨平均唇缘厚度的差异明显高于年龄较大组。
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引用次数: 0
Outcomes of treatment with short dental implants compared with standard-length implants: a retrospective clinical study. 短牙种植体与标准长度种植体的治疗效果比较:一项回顾性临床研究。
IF 2.3 Q1 Medicine Pub Date : 2024-02-28 DOI: 10.1186/s40902-024-00419-8
Kinga Bérczy, György Göndöcs, György Komlós, Tatiana Shkolnik, György Szabó, Zsolt Németh

Background: The size of dental implants is a key success factor for appropriate osseointegration. Using shorter implants allows the possibility of avoiding complex surgical procedures and reduces the morbidity of treatment. Shorter implants also enable implant-prosthetic rehabilitation after maxillofacial reconstructions where only limited bone is available. In this study, the success rates of short implants were examined and compared to those of standard-sized implants.

Methods: Patients who received dental implants between 2007 and 2016 at the Department of Oro-Maxillofacial Surgery and Stomatology Semmelweis University were enrolled in the study. Several clinical parameters were recorded and supplemented with radiological examinations. The data were statistically analysed.

Results: Thirty-four patients with a total of 60 implants were included. The average time after prosthetic loading was 39.33 ± 21.96 months in the group with 8-mm implants and 41.6 ± 27.5 months in the group with > 8-mm implants. No significant differences were observed between the two groups in terms of probing depth (short implants, 2.84 ± 0.09 mm; standard implants, 2.91 ± 0.35 mm) or mean marginal bone loss (short implants, 1.2 ± 1.21-mm mesially and 1.36 ± 1.47-mm distally; standard implants: 0.63 ± 0.80-mm mesially and 0.78 ± 0.70-mm distally).

Conclusions: In this study, the success rate of short dental implants was comparable to that of standard-sized implants. Consequently, it can be claimed that the long-term success of short dental implants does not differ significantly from the long-term success of standard implants.

背景:牙科植入物的大小是适当骨结合的关键因素。使用较短的种植体可以避免复杂的外科手术,降低治疗的发病率。较短的种植体还能在骨量有限的颌面部重建后实现种植修复。在这项研究中,我们对短型种植体的成功率进行了研究,并与标准尺寸种植体的成功率进行了比较:研究对象为 2007 年至 2016 年期间在塞梅尔维斯大学颌面外科和口腔医学系接受牙科植入物治疗的患者。研究人员记录了多项临床参数,并辅以放射学检查。对数据进行了统计分析:结果:34名患者共植入了60颗种植体。植入 8 毫米种植体的患者平均修复时间为 39.33 ± 21.96 个月,植入大于 8 毫米种植体的患者平均修复时间为 41.6 ± 27.5 个月。两组在探查深度(短种植体,2.84 ± 0.09 mm;标准种植体,2.91 ± 0.35 mm)或平均边缘骨质流失(短种植体,中线 1.2 ± 1.21 mm,远线 1.36 ± 1.47 mm;标准种植体,0.63 ± 0.80 mm)方面无明显差异:结论:在这项研究中,短牙种植体的成功率与标准尺寸种植体的成功率相当。因此,可以说短牙种植体的长期成功率与标准种植体的长期成功率没有显著差异。
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引用次数: 0
Fibular free flap with proximal perforator skin paddle due to aberrant anatomy - a case report. 腓骨游离皮瓣与近端穿孔器皮瓣因解剖结构异常而导致的畸形--病例报告。
IF 2.3 Q1 Medicine Pub Date : 2024-02-20 DOI: 10.1186/s40902-024-00416-x
Kyu-Bum Kim, Jihye Ryu, Jae-Yeol Lee

Background: The fibular free flap is considered one of the most valuable options for mandible reconstruction. A perforator flap has gained widespread acceptance in oral and maxillofacial reconstruction. Typically, the fibula flap is obtained primarily with the distal perforator due to its reliable blood supply, with less attention given to the proximal perforators during the harvesting process. Normally, the distal perforator of the fibula exhibits stability and shows limited anatomical variations. However, there have been reported cases in which the distal perforator is absent. At times, these vascular abnormalities remain undetectable through Doppler examination or preoperative angiography evaluation. Therefore, this case details the experience of encountering the rare event of vascular abnormality in oral cancer surgery.

Case presentation: This article reports the case of a patient who presented with a congenital absence of the distal perforator in the peroneal artery, attributed to a vascular abnormality. Additionally, we provide a review of the concept of utilizing the proximal perforator as an alternative approach in the flap harvesting process.

Conclusions: While the distal perforator of the peroneal artery is typically utilized for fibula free flap procedures, surgeons must remain cognizant of the potential for its absence due to aberrant anatomy. Recognizing an alternative approach in such cases can be pivotal for precise surgical planning and favorable outcomes in oral and maxillofacial reconstruction.

背景:腓骨游离皮瓣被认为是下颌骨重建最有价值的选择之一。穿孔皮瓣在口腔颌面重建中已被广泛接受。通常情况下,由于腓骨远端穿孔器具有可靠的血液供应,因此主要通过其获取腓骨皮瓣,而在采集过程中较少关注近端穿孔器。通常情况下,腓骨远端穿孔器表现稳定,解剖变化有限。不过,也有报道称腓骨远端穿孔器缺失的病例。有时,通过多普勒检查或术前血管造影评估仍无法发现这些血管异常。因此,本病例详细介绍了在口腔癌手术中遇到血管异常这一罕见情况的经验:本文报告了一例因血管异常导致腓动脉远端穿孔器先天性缺失的患者。此外,我们还回顾了在皮瓣采集过程中利用近端穿孔器作为替代方法的概念:结论:虽然腓动脉远端穿孔器通常用于腓骨游离皮瓣手术,但外科医生必须认识到由于解剖结构异常而导致穿孔器缺失的可能性。在这种情况下,认识到替代方法对于精确的手术规划和口腔颌面重建的良好效果至关重要。
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引用次数: 0
Management of frontal sinus trauma: a retrospective study of surgical interventions and complications. 额窦外伤的处理:手术干预和并发症的回顾性研究。
IF 2.3 Q1 Medicine Pub Date : 2024-01-18 DOI: 10.1186/s40902-024-00414-z
InKyeong Kim, Jeong-Mo Kim, Jiha Kim, Seung Jin Lee, Eui-Cheol Nam

Background: Frontal sinus injuries are relatively rare among facial bone traumas. Without proper treatment, they can lead to fatal intracranial complications, including meningitis or brain abscesses, as well as aesthetic and functional sequelae. The management of frontal sinus injuries remains controversial, with various treatment methods and outcomes being reported. This article describes the clinical characteristics, surgical methods, and outcomes among 17 patients who underwent surgery for frontal sinus injury and related complications.

Case presentation: We retrospectively included 17 patients who underwent surgery for frontal sinus injury and its related complications at the Kangwon National University Hospital between July 2010 and September 2021. Among them, six underwent simple open reduction and fixation of the anterior wall, eight underwent sinus obliteration, and three underwent cranialization. Two patients who underwent sinus obliteration died due to infection-related complications. The patient who underwent cranialization reported experiencing chronic headache and expressed dissatisfaction regarding the esthetic outcomes of the forehead. Except for these three patients, the other patients achieved satisfactory esthetic and functional recovery.

Conclusion: Active surgical management of frontal sinus injuries is often required owing to the various complications caused by these injuries; however, several factors, including the fracture type, clinical presentation, related craniomaxillofacial injury, and medical history, should be considered while formulating the treatment plan. Surgical treatment through the opening of the frontal sinus should be actively considered in patients with severely damaged posterior wall fractures and those at risk of developing infection.

背景:额窦损伤在面部骨骼创伤中较为罕见。如果治疗不当,可导致致命的颅内并发症,包括脑膜炎或脑脓肿,以及美观和功能性后遗症。额窦损伤的治疗仍存在争议,有各种治疗方法和结果的报道。本文描述了 17 例因额窦损伤及相关并发症而接受手术的患者的临床特征、手术方法和结果:我们回顾性地纳入了 2010 年 7 月至 2021 年 9 月期间在江原大学医院接受额窦损伤及其相关并发症手术的 17 例患者。其中,6 名患者接受了简单的前壁切开复位固定术,8 名患者接受了鼻窦闭塞术,3 名患者接受了颅骨切开术。两名接受窦道闭锁术的患者因感染相关并发症死亡。接受开颅手术的患者表示长期头痛,并对前额的美观效果表示不满。除这三位患者外,其他患者的美学和功能恢复均令人满意:然而,在制定治疗方案时应考虑多种因素,包括骨折类型、临床表现、相关的颅颌面损伤和病史。对于后壁骨折严重受损和有感染风险的患者,应积极考虑通过额窦开口进行手术治疗。
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引用次数: 0
The golden ratio-dispelling the myth. 黄金比例--打破神话
IF 2.3 Q1 Medicine Pub Date : 2024-01-17 DOI: 10.1186/s40902-024-00411-2
Farhad B Naini

Background: The purpose of this article is to explore the claims often cited in scientific journals regarding the golden ratio, and its proposed link to beauty and idealized forms in nature, including idealized human proportions.

Main body: Claims made in the nineteenth century through to the modern day in the clinical literature do not appear to be supported by evidence.

Short conclusions: There is no convincing evidence that the golden ratio is linked to idealized human proportions or facial beauty. There is currently no evidence to support the use of the golden ratio in orthognathic or facial aesthetic/reconstructive surgical planning or analysis of results.

背景:本文旨在探讨科学杂志中经常引用的有关黄金比例的说法,以及黄金比例与自然界中的美和理想化形式(包括理想化的人体比例)之间的联系:简短结论:简短结论:没有令人信服的证据表明黄金比例与理想化的人体比例或面部美感有关。目前没有证据支持在正颌或面部美容/整形手术规划或结果分析中使用黄金比例。
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引用次数: 0
One-stage jaw reconstruction and prosthetic rehabilitation with an iliac flap: a case report and literature review. 使用髂骨皮瓣进行单阶段颌骨重建和假体修复:病例报告和文献综述。
IF 2.3 Q1 Medicine Pub Date : 2024-01-17 DOI: 10.1186/s40902-024-00413-0
Yi-Fan Kang, Yan-Jun Ge, Xiao-Ming Lv, Meng-Kun Ding, Xiao-Feng Shan, Zhi-Gang Cai

Background: One-stage jaw reconstruction with fibular flap and prosthetic rehabilitation restores bony and dental continuity simultaneously. It was also called as "jaw-in-a-day (JIAD)" technique. However, bone volume and height of fibular flap may be insufficient for dental implant insertion. The provision of a considerable amount of bone makes an iliac flap the ideal choice in these cases. We present the first case report to document the use of one-stage jaw reconstruction and prosthetic rehabilitation with the iliac flap.

Case presentation: We modified the conventional JIAD workflow to make it suitable for iliac flap. Two cases were presented who both underwent segmental mandibulectomy for ameloblastoma. Virtual surgical planning was performed in all cases. The iliac crest was positioned upward to provide cortical bone for achieving primary stability of dental implants. Similar to the "all-on-4" procedure, the iliac bone was placed 12 to 15 mm below the occlusal plane to create adequate space for the implant-retained prosthesis. Immediate implant-based dental rehabilitation was performed at same stage. The surgery was successful in all cases without any short-term complications. In the first postoperative week, patients were given a liquid diet through a nasal feeding tube. The liquid diet is advised until 1 month after the surgery. Thereafter, a soft diet is recommended. Patients were advised to resume routine mastication and normal diet 3 months after the surgery. Peri-implantitis occurred in one patient, and additional gingival graft was required. Postoperative function and esthetics were satisfactory at the last follow-up visit.

Conclusions: One-stage jaw reconstruction and prosthetic rehabilitation with the iliac flap are safe and useful for restoring postoperative function and esthetics. It should be used in more cases with a longer follow-up in further studies.

背景:使用腓骨瓣和修复体同时重建下颌,可恢复骨骼和牙齿的连续性。这也被称为 "一日下颌(JIAD)"技术。然而,腓骨瓣的骨量和高度可能不足以植入牙种植体。髂骨瓣能提供大量的骨量,是这些病例的理想选择。我们提交了首例使用髂骨瓣进行单阶段颌骨重建和修复的病例报告:我们修改了传统的 JIAD 工作流程,使其适用于髂骨瓣。病例介绍:我们对传统的 JIAD 工作流程进行了修改,使其适用于髂骨瓣。所有病例都进行了虚拟手术规划。髂嵴的位置向上,以提供皮质骨,实现种植牙的主要稳定性。与 "all-on-4 "手术类似,髂骨被放置在咬合平面下方12至15毫米处,以便为种植体固位修复创造足够的空间。在同一阶段立即进行种植牙修复。所有病例的手术都很成功,没有出现任何短期并发症。术后第一周,患者通过鼻饲管进食流质饮食。建议流质饮食一直持续到术后一个月。此后,建议进食软食。建议患者在术后 3 个月恢复日常咀嚼和正常饮食。一名患者发生了种植体周围炎,需要进行额外的牙龈移植。最后一次复诊时,患者的术后功能和美观效果均令人满意:结论:髂骨瓣一期颌骨重建和修复术对恢复术后功能和美观安全有效。在进一步的研究中,应在更多病例中使用这种方法,并进行更长时间的随访。
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引用次数: 0
The presence and distribution of various genes in postnatal CLP-affected palatine tissue. 受CLP影响的出生后腭组织中各种基因的存在和分布。
IF 2.3 Q1 Medicine Pub Date : 2024-01-16 DOI: 10.1186/s40902-024-00412-1
Jana Goida, Mara Pilmane

Background: Worldwide cleft lip with or without a cleft palate (CL/P) is the most common craniofacial birth defect. Apart from changes in facial appearance, additionally affected individuals often suffer from various associated comorbidities requiring complex multidisciplinary treatment with overall high expenses. Understanding the complete pathogenetic mechanisms of CL/P might aid in developing new preventative strategies and therapeutic approaches, help with genetic counselling, and improve quality of life. Many genes have been associated with the development of orofacial clefts; however, the majority require further research. Based on the role of PAX7, PAX9, SHH, SOX3, WNT3A, and WNT9B in orofacial development, the intention was to use chromogenic in situ hybridization to detect the six genes in postnatal CLP-affected palatine tissue and compare their distribution within the tissue samples.

Results: Statistically significant differences in the distribution of PAX7, PAX9, WNT3A, and WNT9B were observed. In total, 19 pairs of moderate to very strong positive correlations were noted.

Conclusions: Changes in the cleft-affected palatine epithelium primarily seem to be associated with the PAX7 gene; however, PAX9, WNT3A, WNT9B, and SOX3 role seems to be more limited. Whilst connective tissue changes seem to depend on PAX7 only, SHH seems to participate individually and indistinctly. Numerous positive correlations reflect the complicating interactions of the pathways and their components in the orofacial cleft morphopathogenesis.

背景:唇裂伴或不伴腭裂(CL/P)是全球最常见的颅面出生缺陷。除了面部外观的改变外,受影响的患者通常还伴有各种相关的并发症,需要进行复杂的多学科治疗,总体费用高昂。了解CL/P的完整致病机制有助于开发新的预防策略和治疗方法,有助于遗传咨询和提高生活质量。许多基因都与口面裂隙的发生有关,但大多数基因还需要进一步研究。基于 PAX7、PAX9、SHH、SOX3、WNT3A 和 WNT9B 在口面发育中的作用,研究人员打算使用色原原位杂交技术检测出生后受 CLP 影响的腭裂组织中的这六种基因,并比较它们在组织样本中的分布情况:结果:观察到 PAX7、PAX9、WNT3A 和 WNT9B 的分布存在统计学意义上的显著差异。共发现 19 对中度到极强的正相关性:结论:受腭裂影响的腭上皮的变化似乎主要与 PAX7 基因有关;但 PAX9、WNT3A、WNT9B 和 SOX3 的作用似乎较为有限。结缔组织的变化似乎只取决于 PAX7,而 SHH 似乎单独参与其中,且作用不明显。大量的正相关性反映了口面裂隙形态发生过程中各种途径及其组成部分之间复杂的相互作用。
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引用次数: 0
Redefining precision and efficiency in orthognathic surgery through virtual surgical planning and 3D printing: a narrative review 通过虚拟手术规划和 3D 打印重新定义正颌外科手术的精度和效率:叙述性综述
IF 2.3 Q1 Medicine Pub Date : 2023-12-18 DOI: 10.1186/s40902-023-00409-2
Yong-Chan Lee, Seong-Gon Kim
Orthognathic surgery, essential for addressing jaw and facial skeletal irregularities, has historically relied on traditional surgical planning (TSP) involving a series of time-consuming steps including two-dimensional radiographs. The advent of virtual surgical planning (VSP) and 3D printing technologies has revolutionized this field, bringing unprecedented precision and customization to surgical processes. VSP facilitates 3D visualization of the surgical site, allowing for real-time adjustments and improving preoperative stress for patients by reducing planning time. 3D printing dovetails with VSP, offering the creation of anatomical models and surgical guides, enhancing the predictability of surgical outcomes despite higher initial setup and material costs. The integration of VSP and 3D printing promises innovative and effective solutions in orthognathic surgery, surpassing the limitations of traditional methods. Patient-reported outcomes show a positive post-surgery impact on the quality of life, underlining the significant role of these technologies in enhancing self-esteem and reducing anxiety. Economic analyses depict a promising long-term fiscal advantage with these modern technologies, notwithstanding the higher initial costs. The review emphasizes the need for large-scale randomized controlled trials to address existing research gaps and calls for a deeper exploration into the long-term impacts and ethical considerations of these technologies. In conclusion, while standing on the cusp of a technological renaissance in orthognathic surgery, it is incumbent upon the medical fraternity to foster a collaborative approach, balancing innovation with scrutiny to enhance patient care. The narrative review encourages the leveraging of VSP and 3D printing technologies for more efficient and patient-centric orthognathic surgery, urging the community to navigate uncharted territories in pursuit of precision and efficiency in the surgical landscape.
正颌外科手术是解决颌骨和面部骨骼不规则问题的关键,历来依赖于传统的手术规划(TSP),包括二维射线照片等一系列耗时的步骤。虚拟手术规划(VSP)和三维打印技术的出现彻底改变了这一领域,为手术过程带来了前所未有的精确性和定制化。VSP 可实现手术部位的三维可视化,允许进行实时调整,并通过减少规划时间来改善患者的术前压力。三维打印与 VSP 相结合,可创建解剖模型和手术指南,尽管初始设置和材料成本较高,但却提高了手术效果的可预测性。VSP 与三维打印技术的结合有望为正颌外科手术提供创新而有效的解决方案,超越传统方法的局限性。患者报告的结果显示,手术后的生活质量受到了积极的影响,凸显了这些技术在增强自尊和减少焦虑方面的重要作用。经济分析表明,这些现代技术尽管初期成本较高,但具有长期的经济优势。综述强调,有必要进行大规模随机对照试验,以弥补现有研究的不足,并呼吁对这些技术的长期影响和伦理因素进行更深入的探讨。总之,正颌外科正处于技术复兴的风口浪尖,医学界有责任促进合作,在创新与审查之间取得平衡,以加强对患者的护理。本综述鼓励利用 VSP 和 3D 打印技术提高正颌外科手术的效率,并以患者为中心,敦促医学界在未知领域中不断探索,追求手术的精确性和效率。
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引用次数: 0
Condylar volume and positional changes following a bilateral sagittal split ramus osteotomy in skeletal class II and III malocclusions. 双侧矢状面劈开支截骨术治疗II型和III型骨错连后髁突体积和位置的变化。
IF 2.3 Q1 Medicine Pub Date : 2023-11-27 DOI: 10.1186/s40902-023-00408-3
Chulyoung Park, Hyejin Kim, Jaeyoung Ryu, Seunggon Jung, Hong-Ju Park, Hee-Kyun Oh, Min-Suk Kook

Background: Mandibular condyle remodeling and displacement are post-orthognathic surgery concerns that can potentially lead to occlusal issues after bilateral sagittal split ramus osteotomy. This retrospective study examined the relationship between condylar volume changes and position alterations after surgery in patients with skeletal class II and III malocclusions using cone-beam CT.

Methods: The study included 16 patients (6 with Class II malocclusion, 10 with Class III malocclusion) who underwent bilateral sagittal split ramus osteotomy at Chonnam National University Hospital. Cone-beam CT data were collected at three specific time points: before surgery, immediately after surgery, and approximately 6 months post-surgery. Mandibular movement was measured using InVivoDental 5.4.6. ITK-SNAP 3.8.0 was used to assessed condylar volume changes post-surgery. Condyle positions were evaluated in four parts with RadiAnt DICOM Viewer 4.6.9. Statistical analyses were performed using the SPSS version 23.

Results: Considering both Class II and III malocclusion, a 2.91% volume reduction was noted immediately and at 6 months after surgery. Both Class II and III cases demonstrated a decrease in superior joint space by -0.59 mm and medial joint space by -1.09 mm. No significant correlation was found between this process and condylar volume change.

Conclusions: The mandibular condyle volume decreased, and superior-medial movement of the condyle was detected in patients with Class II and III malocclusion immediately and at 6 months after surgery with no volume-position correlation.

背景:下颌髁重构和移位是正颌手术后的问题,可能导致双侧矢状分叉支截骨术后的咬合问题。本回顾性研究利用锥束CT检查了II类和III类骨骼错颌患者术后髁突体积变化和位置改变的关系。方法:选取全南大学附属医院行双侧矢状分叉支截骨术的16例患者,其中ⅱ类错合6例,ⅲ类错合10例。锥形束CT数据采集于三个特定时间点:术前、术后即刻和术后约6个月。使用InVivoDental 5.4.6测量下颌运动。采用ITK-SNAP 3.8.0评估术后髁突体积变化。使用RadiAnt DICOM Viewer 4.6.9对髁突位置进行四部分评估。统计学分析采用SPSS version 23进行。结果:考虑到II类和III类错牙合,立即和术后6个月体积减少2.91%。II级和III级病例均显示上关节间隙减少-0.59 mm,内侧关节间隙减少-1.09 mm。该过程与髁突体积变化之间无明显相关性。结论:II类和III类错颌患者即刻及术后6个月均可观察到髁突体积减小,髁突上内侧运动,且无体积-位置相关性。
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引用次数: 0
Effects of rhBMP-2 with various carriers on maxillofacial bone regeneration through computed tomography evaluation. 通过计算机断层扫描评估rhBMP-2与各种载体对颌面骨再生的影响。
IF 2.3 Q1 Medicine Pub Date : 2023-10-27 DOI: 10.1186/s40902-023-00405-6
Ja In Seo, Ji Hye Lim, Woo Min Jo, Jeong Keun Lee, Seung Il Song

Background: rhBMP-2 is regarded as the most potent osteoinductive growth factor, and it has been used in the oral cavity with different carriers. The purpose of this study is to evaluate the bone-regenerative effect of rhBMP-2 delivered with different carrier systems through three-dimensional cone beam computed tomography analysis.

Method: A total of 112 patients underwent oral surgery with rhBMP-2 application (Group 1, n = 53) or without rhBMP-2 application (Group 2, n = 59). Group 1 was divided into 3 groups according to carriers, rhBMP-2 with allograft (Group 1-1, n = 34), rhBMP-2 with xenograft (Group 1-2, n = 5), and rhBMP-2 with absorbable collagen sponge (Group 1-3, n = 14). Cone beam computed tomography scans were taken before surgery (T0) 6 months after surgery (T1). The volume of defects was measured through the three-dimensional image analysis tool.

Results: The average bone regeneration rate of Group 1 was significantly greater than that of Group 2. Within Group 1, the group that used allograft as a carrier (Group 1-1) showed significantly higher bone regeneration rates than the group that used absorbable collagen sponge as a carrier (Group 1-3).

Conclusion: The use of rhBMP-2 after oral surgery results in a superior bone regeneration rate compared to not using rhBMP-2, and its efficacy depends on the carriers it is used with. Allograft affects bone regeneration more than absorbable collagen sponge when it is carried with rhBMP-2. Therefore, the appropriate use of rhBMP-2 with suitable bone grafting materials is useful for promoting postoperative bone regeneration in oral surgery.

背景:rhBMP-2被认为是最有效的骨诱导生长因子,它已被不同载体应用于口腔。本研究的目的是通过三维锥束计算机断层扫描分析,评估不同载体系统递送的rhBMP-2的骨再生效果。方法:共有112例患者接受了应用rhBMP-2的口腔手术(第1组 = 53)或不施用rhBMP-2(组2 = 59)。第1组按载体分为3组,rhBMP-2与同种异体骨移植(1-1组 = 34),rhBMP-2与异种移植物(组1-2,n = 5) ,和rhBMP-2与可吸收胶原海绵(1-3组,n = 14) 。术前(T0)、术后6个月(T1)进行锥束计算机断层扫描。通过三维图像分析工具测量缺陷的体积。结果:第1组的平均骨再生率明显高于第2组。在第1组中,使用同种异体移植物作为载体的组(1-1组)的骨再生率明显高于使用可吸收胶原海绵作为载体的对照组(1-3组)。当与rhBMP-2一起携带时,同种异体移植物比可吸收的胶原海绵更能影响骨再生。因此,在口腔外科手术中,适当使用rhBMP-2和合适的骨移植材料有助于促进术后骨再生。
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Maxillofacial Plastic and Reconstructive Surgery
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