Medicinski arhiv最新文献_第6页

Intravitreal Sustained-release Dexamethasone Implant in Treatment for Chronic Macular Edema in Syphilis Infection: a Case Report 玻璃体内地塞米松缓释植入治疗梅毒感染慢性黄斑水肿1例

Q2 Medicine

Medicinski arhiv

Pub Date : 2023-01-01 DOI: 10.5455/medarh.2023.77.405-408

Azra Mehmedovic, Vernesa Drino, Alma Biscevic, Melisa Pjano

Background: Macular edema results from many conditions, such as diabetic retinopathy, macular degeneration, inflammatory diseases, cataract operation, trauma, and tumors. Specifically, the capillary filtration rate should equal the speed of fluid removal from extracellular retinal tissue, such as the glial and retinal pigment epithelium cells layer (RPE). Once these forces are imbalanced, fluid accumulates in cystoid spaces within the inner layers of the retina. Objective: The main purpose of this case report is to show that macular edema caused by any inflammation, either bacteria, virus, or autoimmune origin, can be treated successfully, even if it is chronic. Case report: A 31-year-old man has been reported to our clinic with symptoms of blurry vision in the left eye, which occurred during the last year. Essential examinations included CDVA, IOP measurement, slit-lamp examination, indirect ophthalmoscopy, and OCT scan that showed significant macular edema (central foveal thickness of 353 microns). We initiated laboratory searches, such as blood, serology, and immunology testing for the next three months after his first visit, together with prescribed topical and periocular corticosteroid therapy. The test to VDRL (venereal disease research laboratory) for Syphilis and Toxocariasis came positive. We took the best decision and recommended further treatment with the intravitreal application of Dexamethasone Implant 0.7mg. One week after the intravitreal application of corticosteroids on the control exam, there were normal findings on the posterior segment with no macular edema (central foveal thickness of 269 microns). Conclusion: It is unexclusive that infection by Treponema pallidum (TP) causes isolated macular edema without any other symptoms on the anterior segment of the eye. It has indirect action on the macula, not just causing papilledema, retinal vasculitis, retinochoroiditis, and inflammatory disc edema, as expected. TP or the bacteria transmembrane protein (treponemal ligands) directly acting on vascular endothelial cells of the RPE cells, will be the key to the most certain mechanism of this condition. It is related to the possibility of the secretion of cytokines and the interactions between immune cells indirectly.

背景:黄斑水肿是由多种情况引起的，如糖尿病视网膜病变、黄斑变性、炎症性疾病、白内障手术、创伤和肿瘤。具体来说，毛细血管滤过率应等于细胞外视网膜组织(如胶质和视网膜色素上皮细胞层(RPE))中液体清除的速度。一旦这些力量不平衡，液体就会积聚在视网膜内层的囊状空间中。目的:本病例报告的主要目的是表明由任何炎症引起的黄斑水肿，无论是细菌、病毒还是自身免疫性，都可以成功治疗，即使是慢性的。病例报告:一名31岁男子因左眼视力模糊，于去年就诊。基本检查包括CDVA, IOP测量，裂隙灯检查，间接检眼镜，OCT扫描显示明显黄斑水肿(中央中央凹厚度353微米)。在他第一次就诊后的三个月内，我们开始了实验室检查，如血液、血清学和免疫学检查，并给予处方局部和眼周皮质类固醇治疗。性病研究实验室梅毒和弓形虫病检测呈阳性。我们做出了最好的决定，建议进一步治疗，玻璃体内应用地塞米松植入体0.7mg。在玻璃体内应用皮质类固醇一周后的对照检查中，后节检查结果正常，无黄斑水肿(中央中央凹厚度269微米)。结论:梅毒螺旋体(Treponema pallidum, TP)感染引起孤立性黄斑水肿，在眼前段无其他症状，并不是唯一的。它对黄斑有间接作用，不像预期的那样只引起乳头水肿、视网膜血管炎、视网膜脉络膜炎和炎性椎间盘水肿。TP或细菌跨膜蛋白(密螺旋体配体)直接作用于RPE细胞的血管内皮细胞，将是该疾病最确定机制的关键。它与细胞因子分泌的可能性及免疫细胞间的相互作用间接相关。

{"title":"Intravitreal Sustained-release Dexamethasone Implant in Treatment for Chronic Macular Edema in Syphilis Infection: a Case Report","authors":"Azra Mehmedovic, Vernesa Drino, Alma Biscevic, Melisa Pjano","doi":"10.5455/medarh.2023.77.405-408","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.405-408","url":null,"abstract":"Background: Macular edema results from many conditions, such as diabetic retinopathy, macular degeneration, inflammatory diseases, cataract operation, trauma, and tumors. Specifically, the capillary filtration rate should equal the speed of fluid removal from extracellular retinal tissue, such as the glial and retinal pigment epithelium cells layer (RPE). Once these forces are imbalanced, fluid accumulates in cystoid spaces within the inner layers of the retina. Objective: The main purpose of this case report is to show that macular edema caused by any inflammation, either bacteria, virus, or autoimmune origin, can be treated successfully, even if it is chronic. Case report: A 31-year-old man has been reported to our clinic with symptoms of blurry vision in the left eye, which occurred during the last year. Essential examinations included CDVA, IOP measurement, slit-lamp examination, indirect ophthalmoscopy, and OCT scan that showed significant macular edema (central foveal thickness of 353 microns). We initiated laboratory searches, such as blood, serology, and immunology testing for the next three months after his first visit, together with prescribed topical and periocular corticosteroid therapy. The test to VDRL (venereal disease research laboratory) for Syphilis and Toxocariasis came positive. We took the best decision and recommended further treatment with the intravitreal application of Dexamethasone Implant 0.7mg. One week after the intravitreal application of corticosteroids on the control exam, there were normal findings on the posterior segment with no macular edema (central foveal thickness of 269 microns). Conclusion: It is unexclusive that infection by Treponema pallidum (TP) causes isolated macular edema without any other symptoms on the anterior segment of the eye. It has indirect action on the macula, not just causing papilledema, retinal vasculitis, retinochoroiditis, and inflammatory disc edema, as expected. TP or the bacteria transmembrane protein (treponemal ligands) directly acting on vascular endothelial cells of the RPE cells, will be the key to the most certain mechanism of this condition. It is related to the possibility of the secretion of cytokines and the interactions between immune cells indirectly.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134979772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology, Etiology, Timing and Severity of Open Fracture - a Five Years Review From a Tertiary Trauma Center, Eastern Province, Saudi Arabia 开放性骨折的流行病学，病因学，时间和严重程度-来自沙特阿拉伯东部省三级创伤中心的五年回顾

Q2 Medicine

Medicinski arhiv

Pub Date : 2023-01-01 DOI: 10.5455/medarh.2023.77.391-395

Abdulaziz Alhavas, Mohannad Alghamdi

Background: Open fractures are severe injuries resulting from the bone breaking through the skin, and they have a negative impact on patients' physical, mental, and financial well-being as well as that of the healthcare system. The incidence of open fractures varies globally. These injuries can lead to prolonged disability, increased healthcare costs, and psychological distress. The Gustilo-Anderson classification system is used to classify open fractures into three categories which surgeons use as an index for the severity of an injury and as a prognostic tool. Management involves a multidisciplinary approach, focusing on preventing infection, promoting wound healing, and restoring function. Objective: The objective of this study is to provide statistics on the epidemiology of open fractures presented to the emergency department to be used later to create management protocols. Methods: This 5-year retrospective observational analysis of open fracture patients at King Fahad Hospital, a tertiary trauma care institute in Alkhobar from 2018-2023, aimed to understand socio-demographics, injury mechanisms, fracture patterns, and timing. Data were collected electronically, and found 373 cases which were reviewed, and only 138 open fractures fit our inclusion and exclusion criteria and were added to the study. Results: The study analyzed 138 openly fractured bones in 132 patients aged 2 to 68. Most bones affected were in the lower extremities, the most common being the forefoot bones. The most common mode of injury was a motorbike, followed by MVA. The most common Gustilo type was type 2, with no significant correlation between gender and severity. Musculoskeletal system injury was the highest associated system. Furthermore, we observe a slight increase in cases in Winter/Fall weather seasons. Conclusion: Total amount of 84.8% of patients with open fractures are men, compared to 15.2% of women. The average age of patients is 25.6 ± 15.6 years. Motorbike accidents, then MVA, are the two leading causes of open fractures. Weather seasons, especially in fall and winter, may also contribute to an increase in open fractures. We found that type 2 is the most common Gustilo type among the injured bones (59.1%).

背景:开放性骨折是由骨头穿过皮肤而导致的严重损伤，对患者的身体、精神、经济健康以及医疗保健系统都有负面影响。开放性骨折的发生率在全球范围内各不相同。这些伤害可能导致长期残疾、医疗费用增加和心理困扰。Gustilo-Anderson分类系统用于将开放性骨折分为三类，外科医生将其作为损伤严重程度的指标和预后工具。治疗涉及多学科方法，重点是预防感染，促进伤口愈合和恢复功能。目的:本研究的目的是为急诊部门提供开放性骨折的流行病学统计数据，以便日后制定治疗方案。方法:对2018-2023年在阿尔霍巴尔市三级创伤护理机构法赫德国王医院就诊的开放性骨折患者进行为期5年的回顾性观察分析，旨在了解社会人口统计学、损伤机制、骨折模式和时间。通过电子方式收集数据，我们回顾了373例病例，其中只有138例开放性骨折符合我们的纳入和排除标准，并被添加到研究中。结果:本研究分析了132例2 ~ 68岁患者的138例开放性骨折。大多数受影响的骨骼位于下肢，最常见的是前足骨。最常见的伤害方式是摩托车，其次是MVA。最常见的Gustilo型为2型，性别与严重程度无显著相关性。肌肉骨骼系统损伤是最高的相关系统。此外，我们观察到冬季/秋季天气季节的病例略有增加。结论:开放性骨折患者中男性占84.8%，女性占15.2%。患者平均年龄25.6±15.6岁。摩托车事故，然后是MVA，是开放性骨折的两个主要原因。天气季节，特别是秋季和冬季，也可能导致开放性骨折的增加。我们发现2型是损伤骨中最常见的Gustilo型(59.1%)。

{"title":"Epidemiology, Etiology, Timing and Severity of Open Fracture - a Five Years Review From a Tertiary Trauma Center, Eastern Province, Saudi Arabia","authors":"Abdulaziz Alhavas, Mohannad Alghamdi","doi":"10.5455/medarh.2023.77.391-395","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.391-395","url":null,"abstract":"Background: Open fractures are severe injuries resulting from the bone breaking through the skin, and they have a negative impact on patients' physical, mental, and financial well-being as well as that of the healthcare system. The incidence of open fractures varies globally. These injuries can lead to prolonged disability, increased healthcare costs, and psychological distress. The Gustilo-Anderson classification system is used to classify open fractures into three categories which surgeons use as an index for the severity of an injury and as a prognostic tool. Management involves a multidisciplinary approach, focusing on preventing infection, promoting wound healing, and restoring function. Objective: The objective of this study is to provide statistics on the epidemiology of open fractures presented to the emergency department to be used later to create management protocols. Methods: This 5-year retrospective observational analysis of open fracture patients at King Fahad Hospital, a tertiary trauma care institute in Alkhobar from 2018-2023, aimed to understand socio-demographics, injury mechanisms, fracture patterns, and timing. Data were collected electronically, and found 373 cases which were reviewed, and only 138 open fractures fit our inclusion and exclusion criteria and were added to the study. Results: The study analyzed 138 openly fractured bones in 132 patients aged 2 to 68. Most bones affected were in the lower extremities, the most common being the forefoot bones. The most common mode of injury was a motorbike, followed by MVA. The most common Gustilo type was type 2, with no significant correlation between gender and severity. Musculoskeletal system injury was the highest associated system. Furthermore, we observe a slight increase in cases in Winter/Fall weather seasons. Conclusion: Total amount of 84.8% of patients with open fractures are men, compared to 15.2% of women. The average age of patients is 25.6 ± 15.6 years. Motorbike accidents, then MVA, are the two leading causes of open fractures. Weather seasons, especially in fall and winter, may also contribute to an increase in open fractures. We found that type 2 is the most common Gustilo type among the injured bones (59.1%).","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134979961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy 术前低白蛋白血症作为Whipple胰十二指肠切除术患者严重术后并发症的预测因子

Q2 Medicine

Medicinski arhiv

Pub Date : 2023-01-01 DOI: 10.5455/medarh.2023.77.350-353

Emir Ahmetasevic, Sefik Hasukic, Mirha Agic, Selmira Brkic

Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, delayed gastric empting. Severe postoperative complications (SPC) can be reason for reoperation and reason of bad outcome of treatment and life treathening condition. Objective: To investigate predicitive value of preoperative hypoalbuminemia for severe postoperative complications (SPC) in patients who have undergone Whipple pancreaticoduodenetomy (PD). However, no similiar study has been ever reported from our country until now. Methods: In this retrospective-prospective study, 100 patients who have had Whipple pancreaticoduodenectomy for malignant periampullary tumors at the Department for Surgery of University Clinic Center Tuzla, Bosnia and Herzegovina were enrolled, from january of 2009 to decembre of 2021. All patients were preoperatively analysed according to serum albumine levels and presensce of hypolabuminemia (serum albumine levels <32g/l). Serum albumine biochemical test were done 1-2 days preoperatively. Clavien Dindo classification was used for determination patients with SPC. Patients who did not have SPC belonged to (I-II) Clavien Dindo group of patients while those who had SPC belonged to( III-V) Clavien Dindo group of patients. Results: Out of 100 patients who have undergone pancreaticoduodenetomy, in 55 (55%) patients postoperative complications were noticed. Mortality rate was 18 (18%) and reoperation has been done in 20 cases (20%). SPC were noticed in 19 patients and most often were: delayed gastric emptying (20%), pancreatic fistula (13%) and intraabdominal collections (9%). Hypoalbuminemic patients had a significantly higher rate of severe postoperative complications ( p<0.05). Using hypoalbuminemia-SPC correlation analaysis, there is confirmed statistically significant correlation between hypoalbuminemia and SPC (ρ= 0.236; p<0.05). Conclusion: Preoperative hypoalbuminemia can be used as predictor and prognostic factor for severe postoperative complications after Whipple pancreaticoduodenectomy. Identification and optimization of serum albumin level prior to Whipple pancreatoduodenectomy may improve surgical outcomes.

背景:胰十二指肠切除术(PD)被称为Whipple手术，仍然是治疗壶腹周围肿瘤最复杂的腹部手术之一。PD通常伴有术后并发症(胰腺、胆道或肠瘘、出血、腹内脓肿、胃排空延迟)。严重的术后并发症(SPC)可成为再次手术的原因，也可成为治疗效果和生存状况不佳的原因。目的:探讨术前低白蛋白血症对惠普尔胰十二指肠切除术(PD)患者严重术后并发症(SPC)的预测价值。但目前国内尚无类似的研究报道。方法:本回顾性前瞻性研究纳入2009年1月至2021年12月在波斯尼亚和黑塞哥维那图兹拉大学临床中心外科行惠普尔胰十二指肠切除术治疗壶腹周围恶性肿瘤的100例患者。所有患者术前均根据血清白蛋白水平和低尿血症(血清白蛋白水平≤32g/l)进行分析。术前1 ~ 2天进行血清白蛋白生化试验。采用Clavien Dindo分级法测定SPC患者。未发生SPC的患者属于(I-II) Clavien Dindo组，发生SPC的患者属于(III-V) Clavien Dindo组。结果:100例胰十二指肠切除术患者中有55例(55%)出现术后并发症。死亡18例(18%)，再手术20例(20%)。19例患者发现SPC，最常见的是:胃排空延迟(20%)，胰瘘(13%)和腹腔内收集(9%)。低白蛋白血症患者术后严重并发症发生率显著高于对照组(p < 0.05)。通过低白蛋白血症与SPC相关分析，证实了低白蛋白血症与SPC之间有统计学意义的相关性(ρ= 0.236;术中,0.05)。结论:术前低白蛋白血症可作为Whipple胰十二指肠切除术后严重并发症的预测和预后因素。惠普尔胰十二指肠切除术前血清白蛋白水平的鉴定和优化可改善手术效果。

{"title":"Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy","authors":"Emir Ahmetasevic, Sefik Hasukic, Mirha Agic, Selmira Brkic","doi":"10.5455/medarh.2023.77.350-353","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.350-353","url":null,"abstract":"Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, delayed gastric empting. Severe postoperative complications (SPC) can be reason for reoperation and reason of bad outcome of treatment and life treathening condition. Objective: To investigate predicitive value of preoperative hypoalbuminemia for severe postoperative complications (SPC) in patients who have undergone Whipple pancreaticoduodenetomy (PD). However, no similiar study has been ever reported from our country until now. Methods: In this retrospective-prospective study, 100 patients who have had Whipple pancreaticoduodenectomy for malignant periampullary tumors at the Department for Surgery of University Clinic Center Tuzla, Bosnia and Herzegovina were enrolled, from january of 2009 to decembre of 2021. All patients were preoperatively analysed according to serum albumine levels and presensce of hypolabuminemia (serum albumine levels <32g/l). Serum albumine biochemical test were done 1-2 days preoperatively. Clavien Dindo classification was used for determination patients with SPC. Patients who did not have SPC belonged to (I-II) Clavien Dindo group of patients while those who had SPC belonged to( III-V) Clavien Dindo group of patients. Results: Out of 100 patients who have undergone pancreaticoduodenetomy, in 55 (55%) patients postoperative complications were noticed. Mortality rate was 18 (18%) and reoperation has been done in 20 cases (20%). SPC were noticed in 19 patients and most often were: delayed gastric emptying (20%), pancreatic fistula (13%) and intraabdominal collections (9%). Hypoalbuminemic patients had a significantly higher rate of severe postoperative complications ( p<0.05). Using hypoalbuminemia-SPC correlation analaysis, there is confirmed statistically significant correlation between hypoalbuminemia and SPC (ρ= 0.236; p<0.05). Conclusion: Preoperative hypoalbuminemia can be used as predictor and prognostic factor for severe postoperative complications after Whipple pancreaticoduodenectomy. Identification and optimization of serum albumin level prior to Whipple pancreatoduodenectomy may improve surgical outcomes.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135159754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indoor Aeroallergen Sensitization and Associated Factors in Hospitalized Children with Asthma Exacerbations 住院儿童哮喘加重的室内空气过敏原致敏及相关因素

Q2 Medicine

Medicinski arhiv

Pub Date : 2023-01-01 DOI: 10.5455/medarh.2023.77.338-344

Nguyen Thao, To Kien, Tran Tuan, Nguyen Duc, Phan Hoang, Le Vu

Background: Allergic asthma represents the most popular phenotype of childhood asthma and is characterized by eosinophilic airway inflammation associated with specific immunoglobulin E (IgE) antibodies sensitization to various allergens, as evidenced by serology or skin prick test.2 Sensitization to indoor aeroallergens is associated with severe asthma and severe asthma exacerbations. Objective: This study aimed to identify the prevalence of aeroallergen sensitization and its associated factors in children with an asthma exacerbation in Vietnam. Methods: A cross-sectional study was conducted at Children’s Hospital 1, Ho Chi Minh City (HCMC). Children who were aged 3 to 15 and admitted to the hospital with moderate or severe asthma exacerbation were recruited to the study. Data was collected from interviews and medical records. SPT was used to identify aeroallergen sensitization. The association between school-age, living area, and passive smoking with the odds of aeroallergen sensitization was assessed using a multivariable logistic regression. Results: The prevalence of aeroallergen sensitization was 82.6% and this figure in school-age children was higher than that in preschool-age ones (93.8% vs 72.1%, p=0.001). School-age, living in HCMC, and passive smoking significantly increased the odds of aeroallergen sensitization in asthmatic children with adjusted OR [95%CI] as 6.9 [2.1-23.3], 4.1 [1.5-11.5], and 2.9 [1.0-8.4], respectively. Asthmatic children with aeroallergen sensitization required more hours to resolve an asthma exacerbation than those without (22.4 vs 15.2, p=0.006). Conclusion: Aeroallergen sensitization was common in hospitalized children with moderate or severe asthma exacerbation. It is necessary to establish environmental policy and screening practices of aeroallergen sensitization to improve the quality of asthma management for Vietnamese children.

背景:过敏性哮喘是儿童哮喘最常见的表型，其特征是嗜酸性气道炎症与特异性免疫球蛋白E (IgE)抗体对各种过敏原致敏相关，血清学或皮肤点刺试验证实了这一点对室内空气过敏原的致敏与严重哮喘和严重哮喘加重有关。目的:本研究旨在确定越南哮喘加重儿童中空气过敏原致敏的患病率及其相关因素。方法:在胡志明市第一儿童医院(HCMC)进行横断面研究。研究招募了年龄在3至15岁之间，因中度或重度哮喘加重而入院的儿童。数据收集自访谈和医疗记录。SPT用于鉴别空气过敏原致敏性。使用多变量logistic回归评估学龄、居住面积和被动吸烟与空气过敏原致敏几率之间的关系。结果:空气过敏原致敏率为82.6%，学龄儿童高于学龄前儿童(93.8% vs 72.1%， p=0.001)。学龄、居住在HCMC和被动吸烟显著增加哮喘儿童气致过敏原致敏的几率，调整后的OR [95%CI]分别为6.9[2.1-23.3]、4.1[1.5-11.5]和2.9[1.0-8.4]。空气过敏原致敏的哮喘儿童比没有致敏的哮喘儿童需要更多的时间来缓解哮喘加重(22.4 vs 15.2, p=0.006)。结论:空气变应原致敏在住院的中重度哮喘患儿中较为常见。有必要制定环境政策和空气过敏原致敏的筛查措施，以提高越南儿童哮喘管理的质量。

{"title":"Indoor Aeroallergen Sensitization and Associated Factors in Hospitalized Children with Asthma Exacerbations","authors":"Nguyen Thao, To Kien, Tran Tuan, Nguyen Duc, Phan Hoang, Le Vu","doi":"10.5455/medarh.2023.77.338-344","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.338-344","url":null,"abstract":"Background: Allergic asthma represents the most popular phenotype of childhood asthma and is characterized by eosinophilic airway inflammation associated with specific immunoglobulin E (IgE) antibodies sensitization to various allergens, as evidenced by serology or skin prick test.2 Sensitization to indoor aeroallergens is associated with severe asthma and severe asthma exacerbations. Objective: This study aimed to identify the prevalence of aeroallergen sensitization and its associated factors in children with an asthma exacerbation in Vietnam. Methods: A cross-sectional study was conducted at Children’s Hospital 1, Ho Chi Minh City (HCMC). Children who were aged 3 to 15 and admitted to the hospital with moderate or severe asthma exacerbation were recruited to the study. Data was collected from interviews and medical records. SPT was used to identify aeroallergen sensitization. The association between school-age, living area, and passive smoking with the odds of aeroallergen sensitization was assessed using a multivariable logistic regression. Results: The prevalence of aeroallergen sensitization was 82.6% and this figure in school-age children was higher than that in preschool-age ones (93.8% vs 72.1%, p=0.001). School-age, living in HCMC, and passive smoking significantly increased the odds of aeroallergen sensitization in asthmatic children with adjusted OR [95%CI] as 6.9 [2.1-23.3], 4.1 [1.5-11.5], and 2.9 [1.0-8.4], respectively. Asthmatic children with aeroallergen sensitization required more hours to resolve an asthma exacerbation than those without (22.4 vs 15.2, p=0.006). Conclusion: Aeroallergen sensitization was common in hospitalized children with moderate or severe asthma exacerbation. It is necessary to establish environmental policy and screening practices of aeroallergen sensitization to improve the quality of asthma management for Vietnamese children.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135159965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect Of Continuously Dutasteride Monotherapy on The Expression Of Protein Kinase C-Alpha Enzyme In BPH Model Of Wistar Strain Rattus Novergicus Rat. 持续使用度他雄胺单药对Wistar种大鼠良性前列腺增生模型中蛋白激酶C-α酶表达的影响

Q2 Medicine

Medicinski arhiv

Pub Date : 2023-01-01 DOI: 10.5455/medarh.2023.77.202-206

Besut Daryanto, I Gusti Lanang Andi Suharibawa, Athaya Febriantyo Purnomo, Pradana Nurhadi, Viera Wardhani

Background: Benign prostate hyperplasia (BPH) is frequently found in the elderly and significantly impacts the quality of life. One of the risk factors that induce BPH is the androgen hormone. One of the effective medications in reducing the severity of Lower Urinary Tract Symptoms caused by BPH is the α-adrenergic receptor 5α-reductase inhibitor.

Objective: The study aims to see the effect of long-term dutasteride on the expression of the PKC-α enzyme in prostatic stromal tissue in the BPH Model of Wistar strain Rattus norvegicus rats.

Method: This study was an experimental, post-test-only, control group design that used randomization in sample selection. The objective is to measure the expression of PKC-α enzyme from prostate tissue of an adult male Wistar Strain of Rattus Novergicus rat that was given testosterone to induce BPH and given dutasteride in 1,3 and 6 days continuously. Data is shown in mean±SD, and all of the data were analyzed using the software SPSS 21st version with the One Way ANOVA Statistical method after fulfilling the normality test and variant homogeneity test. Data analysis with confidence rate 95% and a=0,05.

Results: There was a decrease of PKC-α enzyme and prostate weight in dutasteride monotherapy in 1,3,6 days compared to the positive control, and the lowest value was on the sixth day (SD ± 2876.8). There was a constant decrease of PKC-α enzyme from the first day until the sixth day.

Conclusion: In conclusion, long-term dutasteride monotherapy could significantly decrease the level of PKC-α enzyme. There was no upregulation of the PKC-α enzyme in the long term of dutasteride monotherapy.

背景：良性前列腺增生症（BPH）常见于老年人，严重影响他们的生活质量。诱发良性前列腺增生症的风险因素之一是雄性激素。α-肾上腺素能受体 5α 还原酶抑制剂是减轻良性前列腺增生症引起的下尿路症状的有效药物之一：本研究旨在观察长期服用度他雄胺对前列腺增生模型Wistar株Rattus norvegicus大鼠前列腺基质组织中PKC-α酶表达的影响：本研究采用随机抽样的实验、后测、对照组设计。研究目的是测量成年雄性 Wistar 株大鼠前列腺组织中 PKC-α 酶的表达情况，该大鼠服用睾酮诱导前列腺增生，并连续服用 1、3 和 6 天度他雄胺。数据以均数±SD 表示，所有数据均在满足正态性检验和变异同质性检验后使用 SPSS 21st 版软件进行单因素方差分析。数据分析置信度为 95%，a=0.05：与阳性对照组相比，度他雄胺单药治疗 1、3、6 天后 PKC-α 酶和前列腺重量均有所下降，最低值出现在第 6 天（SD ± 2876.8）。从第一天到第六天，PKC-α酶持续下降：结论：总之，长期服用度他雄胺单药可显著降低PKC-α酶的水平。结论：长期使用度他雄胺单药治疗可明显降低PKC-α酶的水平，长期使用度他雄胺单药治疗也不会导致PKC-α酶上调。

{"title":"The Effect Of Continuously Dutasteride Monotherapy on The Expression Of Protein Kinase C-Alpha Enzyme In BPH Model Of Wistar Strain Rattus Novergicus Rat.","authors":"Besut Daryanto, I Gusti Lanang Andi Suharibawa, Athaya Febriantyo Purnomo, Pradana Nurhadi, Viera Wardhani","doi":"10.5455/medarh.2023.77.202-206","DOIUrl":"10.5455/medarh.2023.77.202-206","url":null,"abstract":"Background: Benign prostate hyperplasia (BPH) is frequently found in the elderly and significantly impacts the quality of life. One of the risk factors that induce BPH is the androgen hormone. One of the effective medications in reducing the severity of Lower Urinary Tract Symptoms caused by BPH is the α-adrenergic receptor 5α-reductase inhibitor.Objective: The study aims to see the effect of long-term dutasteride on the expression of the PKC-α enzyme in prostatic stromal tissue in the BPH Model of Wistar strain Rattus norvegicus rats.Method: This study was an experimental, post-test-only, control group design that used randomization in sample selection. The objective is to measure the expression of PKC-α enzyme from prostate tissue of an adult male Wistar Strain of Rattus Novergicus rat that was given testosterone to induce BPH and given dutasteride in 1,3 and 6 days continuously. Data is shown in mean±SD, and all of the data were analyzed using the software SPSS 21st version with the One Way ANOVA Statistical method after fulfilling the normality test and variant homogeneity test. Data analysis with confidence rate 95% and a=0,05.Results: There was a decrease of PKC-α enzyme and prostate weight in dutasteride monotherapy in 1,3,6 days compared to the positive control, and the lowest value was on the sixth day (SD ± 2876.8). There was a constant decrease of PKC-α enzyme from the first day until the sixth day.Conclusion: In conclusion, long-term dutasteride monotherapy could significantly decrease the level of PKC-α enzyme. There was no upregulation of the PKC-α enzyme in the long term of dutasteride monotherapy.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/fc/medarch-77-202.PMC10495133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10229900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of Cyclophilin and Phospholipase Enzyme in Women Infected with Toxoplasmosis. 女性弓形虫感染中亲环蛋白和磷脂酶的测定。

Q2 Medicine

Medicinski arhiv

Pub Date : 2022-12-01 DOI: 10.5455/medarh.2022.76.443-446

Noor Abdul Redah Al-Kremy, Maher Ali Al-Qrashy

Background: Toxoplasma gondii, a protozoan parasite with a worldwide distribution, is considered to infect one-third of all humans. many species. The intracellular parasite Toxoplasma gondii causes toxoplasmosis. Numerous physiological abnormalities are documented in toxoplasmosis-infected women.

Objective: This study aims to demonstrate the connection between cyclophilins, the phospholipase enzyme, and latent toxoplasmosis.

Methods: The research was carried out between January 2022 and June 2022. out of 150 patients had blood samples drawn, 250 had serum samples drawn from women with toxoplasma gondi infection, and 50 had healthy samples drawn from Hila city, Iraq. To exclude subjects who had any medical disorders, information from the subjects was gathered via an interviewer-managed questionnaire. ELISA was used to examine the serum. Results: About 250 samples from women with infertility were infected with Toxoplasma gondii overall (24%) Enzyme-Linked Immunosorbent Assay was utilized to evaluate the levels of phospholipase and cyclophilin, while automated VIDAS family instruments were employed to determine the qualitative and quantitative anti-Toxoplasma-IgG-tests (ELISA). Since there was a substantial difference in the statistical analysis and a significant difference in the cyclophilin protein, parasite infection changed the quantity of the enzyme phospholipase.

Conclusion: This study put forth the theory that toxoplasmosis infection. Our investigation showed that patients with toxoplasma Gondi infection had higher levels of cyclophilins and phospholipase than control subjects.

背景:刚地弓形虫是一种分布在世界各地的原生动物寄生虫，被认为感染了三分之一的人类。许多物种。细胞内寄生虫刚地弓形虫引起弓形虫病。感染弓形虫的妇女有许多生理异常记录。目的:研究亲环蛋白、磷脂酶与潜伏性弓形虫病之间的关系。方法:研究时间为2022年1月~ 2022年6月。在150名患者中抽取了血液样本，250名患者抽取了刚地弓形虫感染妇女的血清样本，50名患者抽取了伊拉克希拉市的健康样本。为了排除有任何医学障碍的受试者，通过访谈者管理的问卷收集了受试者的信息。ELISA法检测血清。结果:总共有250例不孕妇女感染弓形虫(占24%)，采用酶联免疫吸附法检测磷脂酶和亲环蛋白水平，采用全自动VIDAS家族仪器检测弓形虫igg抗体(ELISA)的定性和定量。由于统计分析差异较大，亲环蛋白差异显著，因此寄生虫感染改变了磷脂酶的数量。结论:本研究提出了弓形虫病感染的理论。我们的调查显示，刚地弓形虫感染患者的亲环蛋白和磷脂酶水平高于对照组。

{"title":"Estimation of Cyclophilin and Phospholipase Enzyme in Women Infected with Toxoplasmosis.","authors":"Noor Abdul Redah Al-Kremy, Maher Ali Al-Qrashy","doi":"10.5455/medarh.2022.76.443-446","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.443-446","url":null,"abstract":"Background: Toxoplasma gondii, a protozoan parasite with a worldwide distribution, is considered to infect one-third of all humans. many species. The intracellular parasite Toxoplasma gondii causes toxoplasmosis. Numerous physiological abnormalities are documented in toxoplasmosis-infected women.Objective: This study aims to demonstrate the connection between cyclophilins, the phospholipase enzyme, and latent toxoplasmosis.Methods: The research was carried out between January 2022 and June 2022. out of 150 patients had blood samples drawn, 250 had serum samples drawn from women with toxoplasma gondi infection, and 50 had healthy samples drawn from Hila city, Iraq. To exclude subjects who had any medical disorders, information from the subjects was gathered via an interviewer-managed questionnaire. ELISA was used to examine the serum. Results: About 250 samples from women with infertility were infected with Toxoplasma gondii overall (24%) Enzyme-Linked Immunosorbent Assay was utilized to evaluate the levels of phospholipase and cyclophilin, while automated VIDAS family instruments were employed to determine the qualitative and quantitative anti-Toxoplasma-IgG-tests (ELISA). Since there was a substantial difference in the statistical analysis and a significant difference in the cyclophilin protein, parasite infection changed the quantity of the enzyme phospholipase.Conclusion: This study put forth the theory that toxoplasmosis infection. Our investigation showed that patients with toxoplasma Gondi infection had higher levels of cyclophilins and phospholipase than control subjects.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/65/medarch-76-443.PMC10019867.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9515058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Contributes to Palliative Care Practice in Cancer Patients in Indonesia. 什么有助于姑息治疗实践在印度尼西亚的癌症患者。

Q2 Medicine

Medicinski arhiv

Pub Date : 2022-12-01 DOI: 10.5455/medarh.2022.76.464-468

Sry Suryani Widjaja, Rusdiana Rusdiana, Vito Filbert Jayalie, Rina Amelia

Background: Palliative care has an important role in cancer treatment. It has been established in Indonesia for years, however, palliative care does not give significant improvements which may due to the numerous components of palliative care.

Objective: This research aims to identify factors affecting palliative care in Indonesia.

Methods: This article is a literature review which was conducted through a systematic search from four online databases: Cochrane, Pubmed, Embase, EbscoHOST. The search revealed 45 studies then selected using PRISMA 2020 algoritm, leaving 8 studies to be analyzed. The factors affecting palliative care in Indonesia were then grouped into three points of view: the patients and caregiver; healthcare provider, further divided into healthcare personnel and system; as well as healthcare system. By knowing these factors it is expected that we can achieve optimal implementation palliative care in Indonesia, especially in cancer patient.

Results: The factors influencing palliative care in Indonesia can be grouped into patients, healthcare provider and healthcare system.

Conclusion: Palliative care improvement in Indonesia can be enhanced to achieve optimal implementation in cancer treatment.

背景:姑息治疗在癌症治疗中具有重要作用。它已经在印度尼西亚建立了多年，然而，姑息治疗并没有带来显著的改善，这可能是由于姑息治疗的众多组成部分。目的:本研究旨在确定影响印尼姑息治疗的因素。方法:系统检索Cochrane、Pubmed、Embase、EbscoHOST四个在线数据库进行文献综述。搜索结果显示，使用PRISMA 2020算法选择了45项研究，剩下8项研究有待分析。在印度尼西亚，影响姑息治疗的因素分为三个方面:患者和护理人员;医疗保健提供者，又分为医疗保健人员和医疗保健系统;还有医疗系统。通过了解这些因素，预计我们可以在印度尼西亚实现最佳实施姑息治疗，特别是在癌症患者中。结果:影响印尼姑息治疗的因素可分为患者、医疗服务提供者和医疗体系三个方面。结论:印尼的姑息治疗可以得到改善，以实现癌症治疗的最佳实施。

{"title":"What Contributes to Palliative Care Practice in Cancer Patients in Indonesia.","authors":"Sry Suryani Widjaja, Rusdiana Rusdiana, Vito Filbert Jayalie, Rina Amelia","doi":"10.5455/medarh.2022.76.464-468","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.464-468","url":null,"abstract":"Background: Palliative care has an important role in cancer treatment. It has been established in Indonesia for years, however, palliative care does not give significant improvements which may due to the numerous components of palliative care.Objective: This research aims to identify factors affecting palliative care in Indonesia.Methods: This article is a literature review which was conducted through a systematic search from four online databases: Cochrane, Pubmed, Embase, EbscoHOST. The search revealed 45 studies then selected using PRISMA 2020 algoritm, leaving 8 studies to be analyzed. The factors affecting palliative care in Indonesia were then grouped into three points of view: the patients and caregiver; healthcare provider, further divided into healthcare personnel and system; as well as healthcare system. By knowing these factors it is expected that we can achieve optimal implementation palliative care in Indonesia, especially in cancer patient.Results: The factors influencing palliative care in Indonesia can be grouped into patients, healthcare provider and healthcare system.Conclusion: Palliative care improvement in Indonesia can be enhanced to achieve optimal implementation in cancer treatment.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f1/e5/medarch-76-464.PMC10019868.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9515061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nurses' Knowledge and Practices Regarding the Prevention of Deep Vein Thrombosis in Saudi Arabia: Descriptive Cross-Sectional Study. 沙特阿拉伯护士预防深静脉血栓形成的知识与实践:描述性横断面研究。

Q2 Medicine

Medicinski arhiv

Pub Date : 2022-12-01 DOI: 10.5455/medarh.2022.76.447-453

Hessa Abdulatif Alyousef, Sahar Elmetwally A Badawi, Yasser A Elghoneimy, Rana Ali Alameri, Abdulwahab Meteb Almutairi

Background: Deep venous thrombosis (DVT) is a prevalent fatal problem and a major cause of avoidable death among morbid hospitalized patients. It is estimated that up to 900,000 people in the United States are affected each year. Additionally, around 60,000 to 100,000 Americans die annually of DVT.

Objective: To assess studied nurses' knowledge and practice regarding Deep venous thrombosis prevention.

Methods: A descriptive cross-sectional research design was used in this study at King Fahad Hospital of the University in the Kingdom of Saudi Arabia, using a self-administered questionnaire. A total of 67 nurses from medical and surgical units were included in the study. Data were coded and analyzed using SPSS 23.0 version.

Results: According to the results, the knowledge and practice of nurses were found to be high. Total knowledge score regarding prevention of deep venous thrombosis (72.8±9.6), regarding studied nurses, score for each subcategory: general knowledge category (70.6±15.5), deep venous thrombosis risk factors category (66.5±13.1), and deep venous thrombosis prevention category (90.1±10.5). in addition, a statically significance association between nurses' years of experience (p=0.026), previous Deep venous thrombosis education (p=0.012), and total knowledge score regarding the prevention of deep venous thrombosis. Concerning the self-reported practice, the majority of the studied nurses have shown a very high practice score. Yet, there was no statically significant association between the sociodemographic characteristic and practice. Furthermore, a positive association between total knowledge and reported practice score but statically insignificant (p=0.075).

Conclusion: Based on the result of the study, most of the studied nurses' level of knowledge and practice concerning the prevention of deep vein thrombosis ranged between high and very high.

背景:深静脉血栓形成(DVT)是一种常见的致命问题，也是病态住院患者可避免死亡的主要原因。据估计，美国每年有多达90万人受到影响。此外，每年约有6万至10万美国人死于深静脉血栓。目的:了解护理人员预防深静脉血栓形成的知识和实践情况。方法:本研究在沙特阿拉伯王国法赫德国王大学医院采用描述性横断面研究设计，采用自我管理问卷。共有67名来自内科和外科科室的护士参与了研究。采用SPSS 23.0对数据进行编码和分析。结果:调查结果显示，护理人员的知识和实践水平较高。受访护士预防深静脉血栓形成知识总分(72.8±9.6)分:一般知识总分(70.6±15.5)分、深静脉血栓形成危险因素总分(66.5±13.1)分、深静脉血栓形成预防总分(90.1±10.5)分。此外，护士工作年限(p=0.026)、既往深静脉血栓教育(p=0.012)与深静脉血栓预防知识总分之间存在统计学意义。在自述实践方面，大多数被研究护士的实践得分都很高。然而，在社会人口学特征和实践之间没有统计学上显著的联系。此外，总知识与报告的实践得分呈正相关，但统计学上不显著(p=0.075)。结论:根据研究结果，大部分受访护士对预防深静脉血栓形成的知识和实践水平在高到很高之间。

{"title":"Nurses' Knowledge and Practices Regarding the Prevention of Deep Vein Thrombosis in Saudi Arabia: Descriptive Cross-Sectional Study.","authors":"Hessa Abdulatif Alyousef, Sahar Elmetwally A Badawi, Yasser A Elghoneimy, Rana Ali Alameri, Abdulwahab Meteb Almutairi","doi":"10.5455/medarh.2022.76.447-453","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.447-453","url":null,"abstract":"Background: Deep venous thrombosis (DVT) is a prevalent fatal problem and a major cause of avoidable death among morbid hospitalized patients. It is estimated that up to 900,000 people in the United States are affected each year. Additionally, around 60,000 to 100,000 Americans die annually of DVT.Objective: To assess studied nurses' knowledge and practice regarding Deep venous thrombosis prevention.Methods: A descriptive cross-sectional research design was used in this study at King Fahad Hospital of the University in the Kingdom of Saudi Arabia, using a self-administered questionnaire. A total of 67 nurses from medical and surgical units were included in the study. Data were coded and analyzed using SPSS 23.0 version.Results: According to the results, the knowledge and practice of nurses were found to be high. Total knowledge score regarding prevention of deep venous thrombosis (72.8±9.6), regarding studied nurses, score for each subcategory: general knowledge category (70.6±15.5), deep venous thrombosis risk factors category (66.5±13.1), and deep venous thrombosis prevention category (90.1±10.5). in addition, a statically significance association between nurses' years of experience (p=0.026), previous Deep venous thrombosis education (p=0.012), and total knowledge score regarding the prevention of deep venous thrombosis. Concerning the self-reported practice, the majority of the studied nurses have shown a very high practice score. Yet, there was no statically significant association between the sociodemographic characteristic and practice. Furthermore, a positive association between total knowledge and reported practice score but statically insignificant (p=0.075).Conclusion: Based on the result of the study, most of the studied nurses' level of knowledge and practice concerning the prevention of deep vein thrombosis ranged between high and very high.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/d0/medarch-76-447.PMC10019885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Intensity of Vimentin Immuno-expression in Young Women with Triple Negative Breast Cancer and Its Cliniocopathological Parameters. 年轻女性三阴性乳腺癌中波形蛋白免疫表达强度与临床病理参数的相关性

Q2 Medicine

Medicinski arhiv

Pub Date : 2022-12-01 DOI: 10.5455/medarh.2022.76.454-457

Fitriani Lumongga, Ridha Dharmajaya, Kamal Basri Siregar, Delyuzar, Diah Rini Handjari, Nelva Karmila Jusuf, Delfitri Munir, Asrul

Background: Young breast cancer patients (≤40 years) have different unifying oncogenic signaling pathways when compared to older people. Vimentin is a filament intermediate. Vimentin expression has an important role in epithelial-to-mesenchymal transition (EMT) and cancer progression.

Objective: The aim of this study was to assess the correlation between vimentin intensity and clinicopathological parameters in patients with triple negative breast cancer aged 40 years.

Methods: Samples were taken from 45 paraffin blocks of patients with young woman with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.

Results: Samples were taken from paraffin blocks of patients with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.

Conclusion: This study shows that vimentin intensity is strongly associated with tumor progression, tumor mass size and tumor invasion so that it can be used as a prognostic factor in young triple negative breast cancer patients.

背景:年轻乳腺癌患者(≤40岁)与老年人相比具有不同的统一致癌信号通路。维明蛋白是一种长丝中间体。Vimentin表达在上皮-间质转化(EMT)和癌症进展中起重要作用。目的:本研究的目的是评估40岁三阴性乳腺癌患者波形蛋白强度与临床病理参数的相关性。方法:取45例符合入选标准的年轻女性三阴性浸润性乳腺癌NOS型患者石蜡切片，应用vimentin进行免疫组化检查。采用ImageJ分析评估波形蛋白强度。结果:取符合入选标准的三阴性浸润性乳腺癌NOS型患者石蜡块标本，用vimentin进行免疫组化检查。采用ImageJ分析评估波形蛋白强度。结论:本研究表明，vimentin强度与肿瘤进展、肿瘤体积大小和肿瘤侵袭程度密切相关，可作为年轻三阴性乳腺癌患者的预后因素。

{"title":"Correlation Between Intensity of Vimentin Immuno-expression in Young Women with Triple Negative Breast Cancer and Its Cliniocopathological Parameters.","authors":"Fitriani Lumongga, Ridha Dharmajaya, Kamal Basri Siregar, Delyuzar, Diah Rini Handjari, Nelva Karmila Jusuf, Delfitri Munir, Asrul","doi":"10.5455/medarh.2022.76.454-457","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.454-457","url":null,"abstract":"Background: Young breast cancer patients (≤40 years) have different unifying oncogenic signaling pathways when compared to older people. Vimentin is a filament intermediate. Vimentin expression has an important role in epithelial-to-mesenchymal transition (EMT) and cancer progression.Objective: The aim of this study was to assess the correlation between vimentin intensity and clinicopathological parameters in patients with triple negative breast cancer aged 40 years.Methods: Samples were taken from 45 paraffin blocks of patients with young woman with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.Results: Samples were taken from paraffin blocks of patients with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.Conclusion: This study shows that vimentin intensity is strongly associated with tumor progression, tumor mass size and tumor invasion so that it can be used as a prognostic factor in young triple negative breast cancer patients.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/1f/medarch-76-454.PMC10019877.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9144543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COVID-19 Vaccinations: Medical, Ethical and Legal Aspects. COVID-19疫苗接种:医学、伦理和法律方面。

Q2 Medicine

Medicinski arhiv

Pub Date : 2022-12-01 DOI: 10.5455/medarh.2022.76.413-418

Farouq Ahmad Faleh Alazzam, Hisham Jadallah Mansour Shakatreh, Zaid Ibrahim Yousef Gharaibeh, Khaled Khalaf Abed Rabbo Aldrou, Ahed J Alkhatib

Background: Following the consideration of COVID-19 as pandemic by the World Health Organization (WHO), developing new vaccinations against COVID-19 was the dream of humanity. Leading companies competed to achieve this task. Several vaccinations have been developed relatively quickly.

Objective: The aim of the present study was to review the literature regarding medical, ethical, and legal aspects of COVID-19 vaccination.

Methods: Literature was reviewed regarding various issues of COVID-19 vaccinations.

Results and discussion: The main findings showed that a dilemma exists in literature regarding the ethics in general in keeping the rights of individuals to retain their rights to receive the vaccine and considering receiving the vaccination as compulsory.

Conclusion: As the disease has become pandemic with high mortality rates, keeping the safety of the community has received the priority on individual rights, and many countries considered compulsory vaccinations.

背景:继世界卫生组织(WHO)将COVID-19列为大流行之后，开发新型疫苗是人类的梦想。领先的公司竞相完成这项任务。几种疫苗的开发相对较快。目的:本研究的目的是回顾有关COVID-19疫苗接种的医学、伦理和法律方面的文献。方法:查阅有关COVID-19疫苗接种各种问题的文献。结果和讨论:主要发现表明，文献中存在着一个两难的问题，即在保持个人保留其接种疫苗的权利和将接种疫苗视为强制性的问题上，存在着一般伦理问题。结论:由于该疾病已成为高死亡率的大流行病，保持社区安全已成为个人权利的优先事项，许多国家考虑强制接种疫苗。

{"title":"COVID-19 Vaccinations: Medical, Ethical and Legal Aspects.","authors":"Farouq Ahmad Faleh Alazzam, Hisham Jadallah Mansour Shakatreh, Zaid Ibrahim Yousef Gharaibeh, Khaled Khalaf Abed Rabbo Aldrou, Ahed J Alkhatib","doi":"10.5455/medarh.2022.76.413-418","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.413-418","url":null,"abstract":"Background: Following the consideration of COVID-19 as pandemic by the World Health Organization (WHO), developing new vaccinations against COVID-19 was the dream of humanity. Leading companies competed to achieve this task. Several vaccinations have been developed relatively quickly.Objective: The aim of the present study was to review the literature regarding medical, ethical, and legal aspects of COVID-19 vaccination.Methods: Literature was reviewed regarding various issues of COVID-19 vaccinations.Results and discussion: The main findings showed that a dilemma exists in literature regarding the ethics in general in keeping the rights of individuals to retain their rights to receive the vaccine and considering receiving the vaccination as compulsory.Conclusion: As the disease has become pandemic with high mortality rates, keeping the safety of the community has received the priority on individual rights, and many countries considered compulsory vaccinations.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/99/medarch-76-413.PMC10019883.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9499442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0