Pub Date : 2024-07-02DOI: 10.1016/j.mehy.2024.111420
Xu Sun , Zengding Zhou , Yao Li , Feng Guo , Lei Yi
Micro-vascular hyperpermeability is often induced by the extensive burns and subsequent sepsis, and the most common clinical complication is acute lung injury (ALI), which is mortal and is the focus of our attention when treating large-area burns. We found that elderly patients have increased lung vascular permeability after extensive burns and the incidence of ALI is heavier than that of young people, which may be related to multiple underlying diseases in the elderly. Interestingly, some female patients who have total ovariectomy in the past also suffered more severe pulmonary vascular endothelial injury and ALI after extensive burns. So simple osteoporosis might have direct relationship with lung microvascular barrier disruption and the development of ALI under sepsis. In the clinic work, we found that Osteoporosis might exacerbate the lung edema after extensive burns. Additionally, by establishing the mice osteoporosis model and performing LPS in vivo to induce the sepsis-associated ALI model, we found that sepsis induced more severe ALI in the osteoporosis mice. Thus, we hypothesized that osteoporosis-mediated osteoclast activation might pre-stimulated pulmonary micro-endothelium and aggravate sepsis-induced endothelial injury and ALI by osteoclast exosomes.
大面积烧伤及随后的脓毒症往往会诱发微血管高通透性,临床上最常见的并发症是急性肺损伤(ALI),这是致命的,也是我们治疗大面积烧伤时关注的重点。我们发现,老年患者大面积烧伤后肺血管通透性增加,ALI的发生率高于年轻人,这可能与老年人多种基础疾病有关。有趣的是,一些过去接受过全卵巢切除术的女性患者在大面积烧伤后也会出现更严重的肺血管内皮损伤和ALI。因此,单纯性骨质疏松症可能与肺微血管屏障破坏和脓毒症下的 ALI 发生有直接关系。在临床工作中,我们发现骨质疏松症可能会加重大面积烧伤后的肺水肿。此外,通过建立小鼠骨质疏松症模型和体内 LPS 诱导败血症相关 ALI 模型,我们发现败血症在骨质疏松症小鼠中诱发了更严重的 ALI。因此,我们推测骨质疏松症介导的破骨细胞活化可能会预先刺激肺微内皮,并通过破骨细胞外泌体加重脓毒症诱导的内皮损伤和 ALI。
{"title":"Osteoclast exosomes pre-stimulate pulmonary endothelial cells to aggravate sepsis-induced acute lung injury","authors":"Xu Sun , Zengding Zhou , Yao Li , Feng Guo , Lei Yi","doi":"10.1016/j.mehy.2024.111420","DOIUrl":"10.1016/j.mehy.2024.111420","url":null,"abstract":"<div><p>Micro-vascular hyperpermeability is often induced by the extensive burns and subsequent sepsis, and the most common clinical complication is acute lung injury (ALI), which is mortal and is the focus of our attention when treating large-area burns. We found that elderly patients have increased lung vascular permeability after extensive burns and the incidence of ALI is heavier than that of young people, which may be related to multiple underlying diseases in the elderly. Interestingly, some female patients who have total ovariectomy in the past also suffered more severe pulmonary vascular endothelial injury and ALI after extensive burns. So simple osteoporosis might have direct relationship with lung microvascular barrier disruption and the development of ALI under sepsis. In the clinic work, we found that Osteoporosis might exacerbate the lung edema after extensive burns. Additionally, by establishing the mice osteoporosis model and performing LPS in vivo to induce the sepsis-associated ALI model, we found that sepsis induced more severe ALI in the osteoporosis mice. Thus, we hypothesized that osteoporosis-mediated osteoclast activation might pre-stimulated pulmonary micro-endothelium and aggravate sepsis-induced endothelial injury and ALI by osteoclast exosomes.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"191 ","pages":"Article 111420"},"PeriodicalIF":2.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parkinson’s disease (PD) is one of the most common diseases of the central nervous system. This disease stems from damage to the dopaminergic neurons in the substantia nigra (SN). Patients with PD experience a spectrum of motor and non-motor symptoms. Common motor symptoms comprise bradykinesia, stiffness, and resting tremors. Alongside these primary motor symptoms, patients often deal with non-motor issues such as depression, anxiety, and cognitive impairment. For years, drugs such as L-Dopa and other medications have been used to alleviate the symptoms of this disease. However, prolonged use of these medications may lead to serious health complications such as impulsive and compulsive behaviors, hallucinations or delusions, and dyskinesia. Additionally, deep brain stimulation of the SN and stem cell therapy represent relatively novel and experimental treatment approaches for PD, each with its limitations. As an alternative approach, we propose the implantation of sinoatrial node-like pacemaker cells (SANLPCs) in the SN of the brain in PD patients. SANLPCs are engineered to generate continuous action potentials. Our hypothesis posits that implanting SANLPCs in the SN could result in sustained stimulation of the cells within the SN pars compacta, thereby potentially enhancing dopamine production. We anticipate that this innovative intervention may pave the way for more targeted and effective treatments for individuals afflicted with PD.
{"title":"Implanting sinoatrial node-like pacemaker cells into the substantia nigra of the brain as a novel therapeutic approach for Parkinson’s disease","authors":"Mohammad Saleh Ranaiy , Hamed Ghazvini , Seyedeh Masoumeh Seyedhosseini Tamijani , Rezvan Yazdian-Robati , Naghmeh Ahmadiankia , Raheleh Rafaiee","doi":"10.1016/j.mehy.2024.111419","DOIUrl":"https://doi.org/10.1016/j.mehy.2024.111419","url":null,"abstract":"<div><p>Parkinson’s disease (PD) is one of the most common diseases of the central nervous system. This disease stems from damage to the dopaminergic neurons in the substantia nigra (SN). Patients with PD experience a spectrum of motor and non-motor symptoms. Common motor symptoms comprise bradykinesia, stiffness, and resting tremors. Alongside these primary motor symptoms, patients often deal with non-motor issues such as depression, anxiety, and cognitive impairment. For years, drugs such as L-Dopa and other medications have been used to alleviate the symptoms of this disease. However, prolonged use of these medications may lead to serious health complications such as impulsive and compulsive behaviors, hallucinations or delusions, and dyskinesia. Additionally, deep brain stimulation of the SN and stem cell therapy represent relatively novel and experimental treatment approaches for PD, each with its limitations. As an alternative approach, we propose the implantation of sinoatrial node-like pacemaker cells (SANLPCs) in the SN of the brain in PD patients. SANLPCs are engineered to generate continuous action potentials. Our hypothesis posits that implanting SANLPCs in the SN could result in sustained stimulation of the cells within the SN pars compacta, thereby potentially enhancing dopamine production. We anticipate that this innovative intervention may pave the way for more targeted and effective treatments for individuals afflicted with PD.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111419"},"PeriodicalIF":2.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mehy.2024.111418
Hla Myat Mo Mo , Jong Han Lee
Muscle atrophy represents a multifaceted and intricate syndrome characterized by the reduction in both mass and strength of skeletal muscles, leading to muscle dysfunction and weakness. Its potential causes encompass aging, denervation, disuse, and various diseases. One well-known pharmacological agent for glycemic control in diabetes patients is the glucagon-like peptide-1 receptor (GLP-1R) agonist. Our recent research findings have shown that compounds such as exendin-4 (Ex-4) or dulaglutide can effectively mitigate muscle atrophy in dexamethasone (Dex)-induced cellular and animal models as well as chronic kidney disease (CKD) and rodent sarcopenia models. However, it’s noteworthy that these agents may concurrently induce a decrease in body weight following administration, posing challenges when considering them as potential treatments for muscle atrophy in cachectic and sarcopenic conditions. Ghrelin, being the sole circulating orexigenic hormone known to be associated with growth hormone release, offers a potential solution to counterbalance the appetite-inhibiting effect of GLP-1R agonists. Additionally, ghrelin enhanced muscle anabolism and exerted protective effects for muscle atrophy. Therefore, combination of a GLP-1R agonist and a ghrelin analogue emerges as a synergistic therapeutic approach to effectively combat muscle atrophy.
{"title":"The synergistic potential of GLP-1R agonist dulaglutide and ghrelin receptor analogue anamorelin in ameliorating muscle atrophy","authors":"Hla Myat Mo Mo , Jong Han Lee","doi":"10.1016/j.mehy.2024.111418","DOIUrl":"https://doi.org/10.1016/j.mehy.2024.111418","url":null,"abstract":"<div><p>Muscle atrophy represents a multifaceted and intricate syndrome characterized by the reduction in both mass and strength of skeletal muscles, leading to muscle dysfunction and weakness. Its potential causes encompass aging, denervation, disuse, and various diseases. One well-known pharmacological agent for glycemic control in diabetes patients is the glucagon-like peptide-1 receptor (GLP-1R) agonist. Our recent research findings have shown that compounds such as exendin-4 (Ex-4) or dulaglutide can effectively mitigate muscle atrophy in dexamethasone (Dex)-induced cellular and animal models as well as chronic kidney disease (CKD) and rodent sarcopenia models. However, it’s noteworthy that these agents may concurrently induce a decrease in body weight following administration, posing challenges when considering them as potential treatments for muscle atrophy in cachectic and sarcopenic conditions. Ghrelin, being the sole circulating orexigenic hormone known to be associated with growth hormone release, offers a potential solution to counterbalance the appetite-inhibiting effect of GLP-1R agonists. Additionally, ghrelin enhanced muscle anabolism and exerted protective effects for muscle atrophy. Therefore, combination of a GLP-1R agonist and a ghrelin analogue emerges as a synergistic therapeutic approach to effectively combat muscle atrophy.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111418"},"PeriodicalIF":2.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mehy.2024.111416
Michael Ott , Ursula Werneke
Metformin is a biguanide antidiabetic and a first-line therapy for type-2 diabetes mellitus. It is highly effective, cheap, and easily available since taken in tablet form. Metformin-associated lactic acidosis (MALA) is a serious adverse event with high mortality. It is currently treated with bicarbonate and haemodialysis. The mechanism by which metformin can precipitate lactic acidosis remains subject to debate. Lactic acidosis has also been reported in thiamine (vitamin B1) deficiency. Thiamine deficiency results in a switch from aerobic to anaerobic metabolism with accumulation of lactate. MALA and thiamine-associated lactic acidosis are usually considered separate entities. Both, thiamine and metformin are competitive substrates of the organ cation and thiamine transporters. This way, metformin could cause thiamine deficiency in liver cells. We hypothesize that MALA may be treatable with thiamine. High-dose intravenous thiamine treatment is used routinely for the treatment of Wernicke’s encephalopathy and is regarded as safe. Thiamine has been reported to have improved MALA in four cases, who had been refractory to haemodialysis. Thiamine is widely available, easy to administer, and cheap. Thiamine could already be given while waiting for dialysis. Above all, thiamine could prove life-saving in the treatment of MALA in clinical settings in which dialysis is not available.
二甲双胍是一种双胍类抗抑郁药,是治疗 2 型糖尿病的一线药物。二甲双胍是一种双胍类抗糖尿病药物,是治疗 2 型糖尿病的一线药物。二甲双胍相关性乳酸酸中毒(MALA)是一种严重的不良反应,死亡率很高。目前的治疗方法是使用碳酸氢盐和血液透析。二甲双胍导致乳酸酸中毒的机制仍有争议。硫胺素(维生素 B1)缺乏症也有乳酸酸中毒的报道。硫胺素缺乏会导致有氧代谢转为无氧代谢,乳酸蓄积。MALA和硫胺素相关性乳酸酸中毒通常被认为是两个不同的实体。硫胺素和二甲双胍都是器官阳离子和硫胺素转运体的竞争性底物。因此,二甲双胍可能会导致肝细胞硫胺素缺乏。我们推测,硫胺素可以治疗 MALA。大剂量静脉注射硫胺素是治疗韦尼克脑病的常规方法,被认为是安全的。据报道,硫胺素改善了四例血液透析治疗无效的 MALA 患者的病情。硫胺素供应广泛、易于使用且价格低廉。在等待透析期间就可以服用硫胺素。最重要的是,在无法进行透析的临床环境中,硫胺素可用于治疗MALA,从而挽救患者的生命。
{"title":"Metformin-associated lactic acidosis may be treatable with thiamine","authors":"Michael Ott , Ursula Werneke","doi":"10.1016/j.mehy.2024.111416","DOIUrl":"https://doi.org/10.1016/j.mehy.2024.111416","url":null,"abstract":"<div><p>Metformin is a biguanide antidiabetic and a first-line therapy for type-2 diabetes mellitus. It is highly effective, cheap, and easily available since taken in tablet form. Metformin-associated lactic acidosis (MALA) is a serious adverse event with high mortality. It is currently treated with bicarbonate and haemodialysis. The mechanism by which metformin can precipitate lactic acidosis remains subject to debate. Lactic acidosis has also been reported in thiamine (vitamin B1) deficiency. Thiamine deficiency results in a switch from aerobic to anaerobic metabolism with accumulation of lactate. MALA and thiamine-associated lactic acidosis are usually considered separate entities. Both, thiamine and metformin are competitive substrates of the organ cation and thiamine transporters. This way, metformin could cause thiamine deficiency in liver cells. We hypothesize that MALA may be treatable with thiamine. High-dose intravenous thiamine treatment is used routinely for the treatment of Wernicke’s encephalopathy and is regarded as safe. Thiamine has been reported to have improved MALA in four cases, who had been refractory to haemodialysis. Thiamine is widely available, easy to administer, and cheap. Thiamine could already be given while waiting for dialysis. Above all, thiamine could prove life-saving in the treatment of MALA in clinical settings in which dialysis is not available.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111416"},"PeriodicalIF":2.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0306987724001592/pdfft?md5=15ab6e6ca33ec4c3f8c320c99c10bf60&pid=1-s2.0-S0306987724001592-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mehy.2024.111412
Pilar García-Peñarrubia
Despite significant advances in transplantation medicine, allograft rejection remains a major challenge in clinical practice. The preexistence of alloreactive lymphocytes is a primary cause of allograft rejection. The forthcoming challenges in clinical transplantation will involve the suppression or eradication of allospecific memory T cells. Viral infections and allograft rejection interact in multiple ways that can compromise the survival of transplanted organs. Evidence is currently accumulating on the incorporation of HLA antigens and other host cell plasma membrane molecules into the viral envelope. A consequence of the viral envelope displaying the HLA signature acquired from the plasma membrane of infected cells is that when virions are transmitted to the next host, the newly infected person became exposed to allogeneic molecules stimulating alloimmunity and generating memory to alloantigens. Thus, successive exposure to viral infections throughout life could potentially contribute to the development of alloimmunity and the generation of numerous clones of memory alloreactive lymphocytes. In this paper a novel hypothesis is developed on the potential role and mechanisms of alloresponse induced by human spread of enveloped viruses. As this hypothesis could aid in the knowledge of preexisting alloreactivity, additional research into the intricacies of virion-incorporated host cell proteins is necessary. A deeper understanding of this dynamic interaction will help promote advances in the long-term acceptance of transplants.
尽管移植医学取得了重大进展,但异体移植排斥反应仍然是临床实践中的一大挑战。异体反应性淋巴细胞的预先存在是异体移植排斥反应的主要原因。临床移植即将面临的挑战包括抑制或消除异体特异性记忆 T 细胞。病毒感染和异体移植排斥反应以多种方式相互作用,可能会影响移植器官的存活。目前有越来越多的证据表明,HLA 抗原和其他宿主细胞质膜分子被纳入病毒包膜。病毒包膜显示从感染细胞质膜上获得的 HLA 标志的一个后果是,当病毒传播到下一个宿主时,新感染者会接触到异体分子,从而刺激异体免疫并产生对异体抗原的记忆。因此,一生中连续接触病毒感染有可能导致异体免疫的发展,并产生大量记忆性异体反应淋巴细胞克隆。本文就人类传播包膜病毒诱导异体反应的潜在作用和机制提出了一个新的假设。由于这一假说有助于了解预先存在的异反应,因此有必要对病毒结合宿主细胞蛋白的复杂性进行更多研究。加深对这种动态相互作用的理解将有助于促进对移植的长期接受。
{"title":"A novel hypothesis on mechanisms and potential role of host cell membrane proteins incorporated into the viral envelope in alloreactivity","authors":"Pilar García-Peñarrubia","doi":"10.1016/j.mehy.2024.111412","DOIUrl":"https://doi.org/10.1016/j.mehy.2024.111412","url":null,"abstract":"<div><p>Despite significant advances in transplantation medicine, allograft rejection remains a major challenge in clinical practice. The preexistence of alloreactive lymphocytes is a primary cause of allograft rejection. The forthcoming challenges in clinical transplantation will involve the suppression or eradication of allospecific memory T cells. Viral infections and allograft rejection interact in multiple ways that can compromise the survival of transplanted organs. Evidence is currently accumulating on the incorporation of HLA antigens and other host cell plasma membrane molecules into the viral envelope. A consequence of the viral envelope displaying the HLA signature acquired from the plasma membrane of infected cells is that when virions are transmitted to the next host, the newly infected person became exposed to allogeneic molecules stimulating alloimmunity and generating memory to alloantigens. Thus, successive exposure to viral infections throughout life could potentially contribute to the development of alloimmunity and the generation of numerous clones of memory alloreactive lymphocytes. In this paper a novel hypothesis is developed on the potential role and mechanisms of alloresponse induced by human spread of enveloped viruses. As this hypothesis could aid in the knowledge of preexisting alloreactivity, additional research into the intricacies of virion-incorporated host cell proteins is necessary<strong>.</strong> A deeper understanding of this dynamic interaction will help promote advances in the long-term acceptance of transplants.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111412"},"PeriodicalIF":2.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-30DOI: 10.1016/j.mehy.2024.111413
Caglar Berkel
{"title":"Potential regulation of certain genes at the transcription level for ferroptosis evasion in triple-negative breast cancer (TNBC): A hypothesis","authors":"Caglar Berkel","doi":"10.1016/j.mehy.2024.111413","DOIUrl":"https://doi.org/10.1016/j.mehy.2024.111413","url":null,"abstract":"","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111413"},"PeriodicalIF":2.1,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-26DOI: 10.1016/j.mehy.2024.111409
B.-A. Hagiu
In oncological patients, whole body vibration (WBV) can be used to reduce cancer therapy-related morbidities, including in the case of intensive/high-dose chemotherapy. Based on the fact that WBV has the unique effect among physical exercises of intensifying blood circulation in the splanchnic territory, the medical hypothesis can be formulated according to which this type of training performed immediately after or ideally during intravenous chemotherapy would enhance the effectiveness of drug therapy due to the increase in the rate of distribution. This effect, which can benefit especially patients with abdominal tumors, may also allow the reduction of doses, thus reducing the probability of the occurrence of adverse reactions. Testing the hypothesis is possible on experimental animals, but for the organization of the research protocol, it must be taken into account that mechanical vibrations can destroy tumor cells by their own action, by influencing mesenchymal stem cells or by stimulating the secretion of irisin. Research on experimental animals is also necessary to discern whether mechanical vibrations do not affect the treatment of tumors with stem cells or do not decrease anti-tumor immunity.
{"title":"Can whole body vibration enhance chemotherapy?","authors":"B.-A. Hagiu","doi":"10.1016/j.mehy.2024.111409","DOIUrl":"https://doi.org/10.1016/j.mehy.2024.111409","url":null,"abstract":"<div><p>In oncological patients, whole body vibration (WBV) can be used to reduce cancer therapy-related morbidities, including in the case of intensive/high-dose chemotherapy. Based on the fact that WBV has the unique effect among physical exercises of intensifying blood circulation in the splanchnic territory, the medical hypothesis can be formulated according to which this type of training performed immediately after or ideally during intravenous chemotherapy would enhance the effectiveness of drug therapy due to the increase in the rate of distribution. This effect, which can benefit especially patients with abdominal tumors, may also allow the reduction of doses, thus reducing the probability of the occurrence of adverse reactions. Testing the hypothesis is possible on experimental animals, but for the organization of the research protocol, it must be taken into account that mechanical vibrations can destroy tumor cells by their own action, by influencing mesenchymal stem cells or by stimulating the secretion of irisin. Research on experimental animals is also necessary to discern whether mechanical vibrations do not affect the treatment of tumors with stem cells or do not decrease anti-tumor immunity.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111409"},"PeriodicalIF":2.1,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25DOI: 10.1016/j.mehy.2024.111410
Rodrigo Rodrigues
{"title":"Eccentric training for people with post-COVID condition: A hypothesis to consider?","authors":"Rodrigo Rodrigues","doi":"10.1016/j.mehy.2024.111410","DOIUrl":"https://doi.org/10.1016/j.mehy.2024.111410","url":null,"abstract":"","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111410"},"PeriodicalIF":2.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-14DOI: 10.1016/j.mehy.2024.111397
Ju Tian , Huimin You , Jing Ding , Dandan Shi , Chenyan Long , Yanting li , Zhijun Luo , Xiaoying He
Atherosclerosis and wound healing are complex pathophysiological processes involving multiple cell types, including endothelial cells and platelets. Endothelial-to-mesenchymal transition (EndMT) involves the transformation of endothelial cells into mesenchymal cells. This transition serves as a critical mechanism in vascular remodeling, essential for both atherosclerosis pathogenesis and wound healing. On the other hand, epithelial-to-mesenchymal transition (EMT), which involves the transformation of epithelial cells into mesenchymal cells, is crucial for wound healing. Platelets are known to release various growth factors and cytokines which are integral to wound healing and tissue repair, although their direct role in the modulation of EndMT and EMT remains unclear. However, a few studies have shown a potential mechanistic link between platelet activity and these cellular transitions. Since EndMT and EMT play a critical role in vascular remodeling and tissue repair, respectively, it is plausible that these processes are modulated by platelets, which are known for their dynamic and context-dependent release of growth factors and cytokines. Therefore, we postulate that platelets significantly impact the progression of atherosclerosis through the modulation of EndMT, and that of wound healing through the regulation of both EndMT and EMT. The influence of platelets on these processes can have both beneficial and detrimental effects. This hypothesis represents a significant advance in our understanding of the complex interplay between platelets, cellular phenotype, and disease pathophysiology. Elucidating the specific mechanisms by which platelets modulate EMT and EndMT could pave the way for innovative therapeutic strategies that harness the body’s innate capacity for repair and regeneration, thereby enhancing clinical outcomes for these conditions.
{"title":"Platelets could be key regulators of epithelial/endothelial-to- mesenchymal transition in atherosclerosis and wound healing","authors":"Ju Tian , Huimin You , Jing Ding , Dandan Shi , Chenyan Long , Yanting li , Zhijun Luo , Xiaoying He","doi":"10.1016/j.mehy.2024.111397","DOIUrl":"10.1016/j.mehy.2024.111397","url":null,"abstract":"<div><p>Atherosclerosis and wound healing are complex pathophysiological processes involving multiple cell types, including endothelial cells and platelets. Endothelial-to-mesenchymal transition (EndMT) involves the transformation of endothelial cells into mesenchymal cells. This transition serves as a critical mechanism in vascular remodeling, essential for both atherosclerosis pathogenesis and wound healing. On the other hand, epithelial-to-mesenchymal transition (EMT), which involves the transformation of epithelial cells into mesenchymal cells, is crucial for wound healing. Platelets are known to release various growth factors and cytokines which are integral to wound healing and tissue repair, although their direct role in the modulation of EndMT and EMT remains unclear. However, a few studies have shown a potential mechanistic link between platelet activity and these cellular transitions. Since EndMT and EMT play a critical role in vascular remodeling and tissue repair, respectively, it is plausible that these processes are modulated by platelets, which are known for their dynamic and context-dependent release of growth factors and cytokines.<!--> <!-->Therefore, we postulate that platelets significantly impact the progression of atherosclerosis through the modulation of EndMT, and that of wound healing through the regulation of both EndMT and EMT. The influence of platelets on these processes can have both beneficial and detrimental effects. This hypothesis represents a significant advance in our understanding of the complex interplay between platelets, cellular phenotype, and disease pathophysiology. Elucidating the specific mechanisms by which platelets modulate EMT and EndMT could pave the way for innovative therapeutic strategies that harness the body’s innate capacity for repair and regeneration, thereby enhancing clinical outcomes for these conditions.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111397"},"PeriodicalIF":2.1,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.1016/j.mehy.2024.111405
Jovana Paunovic Pantic , Svetlana Valjarevic , Jelena Cumic , Igor Pantic
We hypothesize that the Gray-Level Co-occurrence Matrix (GLCM) and the Run-Length Matrix (RLM) techniques can effectively quantify discrete changes in EEG signals, and that the features extracted from these matrices can be utilized to train a Random Forest (RF) model. Our contribution includes the development of a robust code in sci-kit learn for a hypothetical model that, after adequate training and testing, could be used to detect and remove artifacts as well as differentiate between physiological and pathological EEG signals. Moreover, our approach envisions the RF model as a powerful tool capable of differentiating between normal and abnormal EEG signals. This approach could lead to the development of more potent AI tools that enhance clinical decision-making in neurology and psychiatry.
{"title":"AI-enhanced EEG signal interpretation: A novel approach using texture analysis with random forests","authors":"Jovana Paunovic Pantic , Svetlana Valjarevic , Jelena Cumic , Igor Pantic","doi":"10.1016/j.mehy.2024.111405","DOIUrl":"10.1016/j.mehy.2024.111405","url":null,"abstract":"<div><p>We hypothesize that the Gray-Level Co-occurrence Matrix (GLCM) and the Run-Length Matrix (RLM) techniques can effectively quantify discrete changes in EEG signals, and that the features extracted from these matrices can be utilized to train a Random Forest (RF) model. Our contribution includes the development of a robust code in sci-kit learn for a hypothetical model that, after adequate training and testing, could be used to detect and remove artifacts as well as differentiate between physiological and pathological EEG signals. Moreover, our approach envisions the RF model as a powerful tool capable of differentiating between normal and abnormal EEG signals. This approach could lead to the development of more potent AI tools that enhance clinical decision-making in neurology and psychiatry.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111405"},"PeriodicalIF":2.1,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}