Pub Date : 2026-02-05DOI: 10.23736/S0375-9393.26.19496-6
Saad A Moharam, Mohammed S Elsharkawy, Shaimaa W Zahra, Khaled Hamama, Amgad Elshikh, Mohamed E Mahmoud, Ahmed S Elsaily, Hatem F Elfatah, Fatma S Shalan
Background: Postoperative nausea and vomiting (PONV) remain a significant clinical challenge in pediatric squint surgeries, with potential serious complications. This randomized controlled trial aimed to evaluate the efficacy of preoperative ondansetron lozenges in preventing PONV among pediatric patients undergoing squint surgeries.
Methods: Eighty pediatric patients (aged 4-15 years) undergoing squint surgeries were randomly assigned to two equal groups: Group S received 4 mg ondansetron lozenge for two hours preoperatively, while Group C served as the control.
Results: The ondansetron lozenge group demonstrated significantly lower PONV incidence (22.5% vs. 52.5%, P=0.006, with relative risk (RR) of 0.43 (95% CI 0.22:0.82), with reduced severity across 0-2-, 2-12-, and 12-24-hour intervals. Time to onset of emesis was prolonged (269.11±214.87 vs. 115.24±65.68, P=0.005), and the oculocardiac reflex incidence was reduced (12.5% vs. 37.5%, P=0.018). Parental satisfaction was significantly higher in the Ondansetron group (8.95±1.38 vs. 7.83±1.99, P=0.004).
Conclusions: Preoperative ondansetron lozenges effectively reduce PONV incidence, severity, and complications in pediatric squint surgery, suggesting a promising prophylactic intervention.
背景：在儿童斜视手术中，术后恶心和呕吐（PONV）仍然是一个重要的临床挑战，具有潜在的严重并发症。本随机对照试验旨在评估术前昂丹司琼含片预防斜视手术儿童患者PONV的疗效。方法：80例4 ~ 15岁儿童斜视手术患者随机分为两组：S组术前给予昂丹司琼含片4 mg，疗程2小时；C组为对照组。结果：昂丹司琼含片组PONV发病率显著降低(22.5% vs. 52.5%， P=0.006，相对危险度（RR）为0.43 (95% CI 0.22:0.82)，在0-2小时、2-12小时和12-24小时的时间段内严重程度均有所降低。呕吐发生时间延长（269.11±214.87比115.24±65.68，P=0.005），心房反射发生率降低（12.5%比37.5%，P=0.018）。昂丹司琼组家长满意度显著高于对照组（8.95±1.38比7.83±1.99，P=0.004）。结论：术前使用昂丹司琼含片可有效降低小儿斜视手术中PONV的发生率、严重程度和并发症，是一种很有前景的预防干预措施。
{"title":"Preoperative ondansetron lozenge for prevention of postoperative nausea and vomiting in pediatrics undergoing squint surgeries: a randomized controlled trial.","authors":"Saad A Moharam, Mohammed S Elsharkawy, Shaimaa W Zahra, Khaled Hamama, Amgad Elshikh, Mohamed E Mahmoud, Ahmed S Elsaily, Hatem F Elfatah, Fatma S Shalan","doi":"10.23736/S0375-9393.26.19496-6","DOIUrl":"https://doi.org/10.23736/S0375-9393.26.19496-6","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting (PONV) remain a significant clinical challenge in pediatric squint surgeries, with potential serious complications. This randomized controlled trial aimed to evaluate the efficacy of preoperative ondansetron lozenges in preventing PONV among pediatric patients undergoing squint surgeries.</p><p><strong>Methods: </strong>Eighty pediatric patients (aged 4-15 years) undergoing squint surgeries were randomly assigned to two equal groups: Group S received 4 mg ondansetron lozenge for two hours preoperatively, while Group C served as the control.</p><p><strong>Results: </strong>The ondansetron lozenge group demonstrated significantly lower PONV incidence (22.5% vs. 52.5%, P=0.006, with relative risk (RR) of 0.43 (95% CI 0.22:0.82), with reduced severity across 0-2-, 2-12-, and 12-24-hour intervals. Time to onset of emesis was prolonged (269.11±214.87 vs. 115.24±65.68, P=0.005), and the oculocardiac reflex incidence was reduced (12.5% vs. 37.5%, P=0.018). Parental satisfaction was significantly higher in the Ondansetron group (8.95±1.38 vs. 7.83±1.99, P=0.004).</p><p><strong>Conclusions: </strong>Preoperative ondansetron lozenges effectively reduce PONV incidence, severity, and complications in pediatric squint surgery, suggesting a promising prophylactic intervention.</p>","PeriodicalId":18522,"journal":{"name":"Minerva anestesiologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.23736/S0375-9393.26.19865-4
Çağdaş Baytar, Özcan Pişkin
{"title":"Beyond analgesia: successful anesthetic management of total implantable venous access port implantation with serratus posterior superior intercostal plane block in a high-risk cardiac patient.","authors":"Çağdaş Baytar, Özcan Pişkin","doi":"10.23736/S0375-9393.26.19865-4","DOIUrl":"https://doi.org/10.23736/S0375-9393.26.19865-4","url":null,"abstract":"","PeriodicalId":18522,"journal":{"name":"Minerva anestesiologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intravenous anesthesia using remimazolam for a patient with Brugada Syndrome.","authors":"Shingo Kawashima, Atsushi Kobayashi, Tetsuro Kimura, Hiroyuki Kinoshita","doi":"10.23736/S0375-9393.25.19592-8","DOIUrl":"https://doi.org/10.23736/S0375-9393.25.19592-8","url":null,"abstract":"","PeriodicalId":18522,"journal":{"name":"Minerva anestesiologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.23736/S0375-9393.25.19722-8
Volkan Özen, Engin I Turan, Bahadir Çiftçi, Selçuk Alver, Ayça S Şahin
{"title":"A new frontier in pediatric regional anesthesia: quadroiliac plane block for nephrectomy analgesia.","authors":"Volkan Özen, Engin I Turan, Bahadir Çiftçi, Selçuk Alver, Ayça S Şahin","doi":"10.23736/S0375-9393.25.19722-8","DOIUrl":"https://doi.org/10.23736/S0375-9393.25.19722-8","url":null,"abstract":"","PeriodicalId":18522,"journal":{"name":"Minerva anestesiologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.23736/S0375-9393.25.19490-X
Eralp Cevikkalp, Emre Ulusoy, Merve Karakaya, Mursel Ekinci, Mustafa Dikici
{"title":"Serratus posterior superior intercostal block as a component of multimodal analgesia in thoracotomy.","authors":"Eralp Cevikkalp, Emre Ulusoy, Merve Karakaya, Mursel Ekinci, Mustafa Dikici","doi":"10.23736/S0375-9393.25.19490-X","DOIUrl":"https://doi.org/10.23736/S0375-9393.25.19490-X","url":null,"abstract":"","PeriodicalId":18522,"journal":{"name":"Minerva anestesiologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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