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Developmental and behavioral profile in a domestic adoptees sample: a new challenge for the pediatrician. 国内被收养儿童的发育和行为特征:对儿科医生的新挑战。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-10-01 DOI: 10.23736/S0026-4946.16.04767-8
P. Ferrara, C. Cutrona, C. Guadagno, M. Amato, A. Sbordone, R. Sacco, G. Bona
BACKGROUNDThe aim of this study is to investigate the changes of developmental and behavioral profile in a domestic adoptees sample.METHODSThirty-six domestic adoptive families were recruited, resulting in a sample of 39 children. Families were sent a general questionnaire for collecting data related to the children demographic variables, infant's background (time spent in institutional care, age at adoption), children's health status and anthropometric measures at T0, T1, T2, and T3. Moreover, the Infant Behavior Questionnaire-Revised Very Short Form and a modified version of parent-report of Child Behavior Checklist were used to assess temperament and to detect behavioral problems.RESULTSAs regards the psychopathological evaluation, behavior problems were more common in older children, especially among girls. In particular they exhibited a higher frequency of internalizing problems versus externalizing.CONCLUSIONSChildren in foster care suffer discontinuity of care that negatively affects their emotional and physical development. It is important for pediatricians to be aware of the special needs of adopted children, providing adequate support to adoptive families.
本研究的目的是探讨国内被收养儿童的发展和行为特征的变化。方法收集国内36个收养家庭,共39名儿童。向家庭发送一份普通问卷,以收集与儿童人口统计变量、婴儿背景(在机构护理的时间、收养年龄)、儿童健康状况和T0、T1、T2和T3时的人体测量值相关的数据。此外,还采用《婴儿行为问卷-修订极简表》和《儿童行为检查表家长报告》进行气质评估和行为问题检测。结果在心理病理评价中,行为问题在年龄较大的儿童中更为常见,尤其是女孩。特别是,他们表现出更频繁的内化问题而不是外化问题。结论寄养儿童的照料不连续性对其情感和身体发育有负面影响。对儿科医生来说,了解收养儿童的特殊需要,为收养家庭提供足够的支持是很重要的。
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引用次数: 0
Pidotimod in allergic diseases. 匹多莫德治疗过敏性疾病。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-10-01 Epub Date: 2020-07-29 DOI: 10.23736/S0026-4946.20.05967-8
Sara Manti, Giuseppe F Parisi, Maria Papale, Salvatore Leonardi

The rising incidence of allergic disease requires more specific, effective and safe therapeutic strategies. In this regard, several kinds of biologically active substances, commonly known as immunostimulants, have been introduced for the prevention and treatment of allergic diseases in pediatric population. Among the heterogeneous group of biologically active molecules to date available, pidotimod (Axil, Valeas S.p.A, Milan) is proved to be able to ameliorate both innate and adaptive immunity and enhances the immune system properties often impaired in patients with allergic disorders.

过敏性疾病的发病率不断上升,需要更具体、有效和安全的治疗策略。在这方面,已经引入了几种生物活性物质,通常称为免疫刺激剂,用于预防和治疗儿科人群的过敏性疾病。在迄今为止可获得的异质性生物活性分子中,匹多莫德(Axil, Valeas S.p.A, Milan)被证明能够改善先天和适应性免疫,并增强过敏性疾病患者经常受损的免疫系统特性。
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引用次数: 2
What's new about etiopathogenesis of musculoskeletal injuries in adolescent athletes? 青少年运动员肌肉骨骼损伤的发病机制有什么新进展?
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-10-01 DOI: 10.23736/S0026-4946.20.05944-7
M. Turati, Linda Boerci, M. Piatti, N. Zanchi, G. Zatti, F. Accadbled, M. Bigoni
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引用次数: 11
Covid-19 and kawasaki disease: is there a need for revising treatment guidelines? 新冠肺炎和川崎病:是否需要修订治疗指南?
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-10-01 DOI: 10.23736/S0026-4946.20.05914-9
R. Mormile
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引用次数: 0
Canned tuna tolerance in children with IgE-mediated fish allergy: an allergological and nutritional view. ige介导的鱼类过敏儿童对金枪鱼罐头的耐受性:过敏学和营养学观点。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-10-01 Epub Date: 2020-07-20 DOI: 10.23736/S0026-4946.20.05972-1
Luca Pecoraro, Laura Tenero, Angelo Pietrobelli, Luca Dalle Carbonare, Sarah Czernin, Kurt Widhalm, Alberto Alvarez-Perea, Giorgio Piacentini

Scientific research, diagnostic tools and clinical experience have shown that children suffering from IgE-mediated fish allergy do not need to follow a strict exclusion diet. In fact, they could tolerate some species of fish, which could be reintroduced in the diet by verifying their tolerance with an oral food challenge in a clinical setting. Consequently, it is possible to look a new insight on diagnosis and management of IgE-mediated fish allergy in children, considering the use of canned tuna in clinical settings. Authors performed a literature search through the Cochrane Library and Medline/PubMed databases. All quantitative and qualitative pediatric studies involving diagnosis and management of IgE-mediated fish allergy and the use of canned tuna in clinical settings were considered. Articles related to allergological and nutritional features of fish, and especially canned tuna, were selected. This research was conducted on May 2020. Canned tuna shows peculiar allergological and nutritional characteristics. Relating to allergy, canning process, characterized by cooking the fish under pressure for a time equal to about 7 hours, can lead a conformational change in parvalbumin, making it less allergenic. In terms of nutrition, canned tuna contains B, D and A vitamins and, above all, omega-3 fatty acids and shows a favourable and significantly sustainable nutritional profile. Lower allergenicity, adequate nutritional value and its rich availability in markets at reasonable costs, could make the use of canned tuna as a solution with an excellent risk/benefit ratio in the field of IgE-mediated fish allergy.

科学研究、诊断工具和临床经验表明,患有ige介导的鱼类过敏的儿童不需要遵循严格的排他性饮食。事实上,它们可以耐受某些鱼类,通过在临床环境中通过口服食物挑战验证它们的耐受性,可以将这些鱼类重新引入饮食中。因此,考虑到在临床环境中使用罐装金枪鱼,有可能对儿童ige介导的鱼类过敏的诊断和管理有新的见解。作者通过Cochrane图书馆和Medline/PubMed数据库进行了文献检索。所有涉及ige介导的鱼类过敏的诊断和管理以及在临床环境中使用罐装金枪鱼的定量和定性儿科研究都被考虑在内。有关鱼类,特别是金枪鱼罐头的过敏和营养特性的文章被选中。这项研究是在2020年5月进行的。金枪鱼罐头具有特殊的过敏和营养特性。与过敏有关,罐头加工的特点是在压力下烹饪鱼大约7小时,可以导致小蛋白的构象变化,使其不那么容易引起过敏。在营养方面,罐装金枪鱼含有维生素B、D和A,尤其是ω -3脂肪酸,显示出有利的和显著可持续的营养状况。金枪鱼罐头具有较低的致敏性、充足的营养价值和丰富的市场供应,价格合理,可以作为ige介导的鱼类过敏领域的一种具有良好风险/效益比的解决方案。
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引用次数: 1
Clinical features and physiotherapy management for Covid-19 in children. 儿童新冠肺炎的临床特点和理疗管理。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-10-01 DOI: 10.23736/S0026-4946.20.06100-9
Paulo Magalhães, F. Lanza, Bárbara Bernardo Figueirêdo
BACKGROUNDCOVID-19 has quickly become a worldwide threat to health, travel, and commerce. Studies adressing the clinical-functional presentation of viral infection and physiotherapy management in children are scarce. The purpose statement was to provide current perspectives on the physiotherapy interventions for managing children based on COVID-19 evidences.METHODSIn this review, databases were searched between 1th January and 26 th March 2020. The following descriptors were considered: (novel coronavirus); (novel corona virus); Coronavirus; (corona vírus); 2019-nCoV; nCovor; COVID-19; SARSCoV-2; in the electronic databases National Library of Medicine (PubMed/Medline), Scientific Electronic Library Online (SciELO) and Physiotherapy Evidence Database (PEDro). The results were described through the International Classification of Functioning, Disability and Health.RESULTS16 papers were included in this review. COVID-19 seems to lead to restriction of participation and interfere in tasks, such as recreation and leisure activities, respiratory muscle function and exercise tolerance. Personal protective equipments and contact precautions are important part of treatment. Effective oxygen therapy should be given immediately in presence of hypoxia. Nasal high-flow oxygen therapy, non-invasive ventilation, lung-protective ventilation strategies and prone position, should be undertaken when necessary under appropriate conditions. Airway clearance techniques should be administered only strictly needed and early activities must be encouraged.CONCLUSIONSPotential physiotherapy interventions for children with COVID-19/SARS-CoV-2 consist on ventilatory management, airway clearance techniques and early activities and mobilization.
背景冠状病毒-19已迅速成为全球范围内对健康、旅行和商业的威胁。关于儿童病毒感染的临床功能表现和物理治疗管理的研究很少。目的陈述是根据新冠肺炎的证据,提供当前对儿童物理治疗干预措施的看法。方法在本综述中,对2020年1月1日至3月26日期间的数据库进行了检索。考虑了以下描述:(新型冠状病毒);(新型冠状病毒);冠状病毒;(电晕病毒);2019新型冠状病毒nCovor;2019冠状病毒疾病严重急性呼吸系统综合征冠状病毒2型;在国家医学图书馆(PubMed/Medline)、在线科学电子图书馆(SciELO)和物理治疗证据数据库(PEDro)的电子数据库中。结果通过国际功能、残疾和健康分类进行了描述。结果本综述共收录论文16篇。新冠肺炎似乎会限制参与并干扰娱乐和休闲活动、呼吸肌肉功能和运动耐受性等任务。个人防护装备和接触预防措施是治疗的重要组成部分。缺氧时应立即给予有效的氧气治疗。必要时应在适当的条件下进行鼻腔高流量氧气治疗、无创通气、肺部保护性通气策略和俯卧位。只有在严格需要的情况下才能使用气道清除技术,并且必须鼓励早期活动。结论针对新冠肺炎/严重急性呼吸系统综合征冠状病毒2型儿童的潜在物理治疗干预措施包括通气管理、气道清除技术以及早期活动和动员。
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引用次数: 2
Salbutamol combined with budesonide in treatment of pediatric bronchial asthma and its effect on eosinophils. 沙丁胺醇联合布地奈德治疗小儿支气管哮喘及其对嗜酸性粒细胞的影响。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-09-22 DOI: 10.23736/S0026-4946.20.06003-X
Suihua Li, Qing-xiu Mei, D. Qian, Xianghong Huang, C. Fan, J. Quan
BACKGROUNDTo investigate and discuss the salbutamol combined with budesonide in treatment of pediatric bronchial asthma (BA) and its effect on eosinophils (EOS).METHODS98 BA children admitted and treated in our hospital from July 2016 to June 2017 were collected and divided into control group (n=49) and observation group (n=49) according to random number table. The children in control group were treated with budesonide and those in observation group were treated with salbutamol combined with budesonide. The clinical efficacy, pulmonary functions and levels of T-lymphocyte subsets [including cluster of differentiation 3 (CD3)+, CD4+, CD8+ and CD4+/CD8+] in the immune system between two groups were compared after the treatment; the levels of eosinophil cationic protein (ECP) and eotaxin in the children were compared before the treatment and at 1, 4 and 8 weeks after the treatment; the changes in EOS counts in blood and induced sputum of the children before and after the treatment were compared, and the EOS apoptosis rate was compared at 1, 4 and 8 weeks after the treatment.RESULTSThe effective rate of treatment in observation group was significantly higher than that in control group (p<0.05). After the treatment, the indexes of pulmonary function in observation group were obviously better than those in control group (p<0.05). Compared with those in control group, the levels of CD3+, CD4+ and CD4+/CD8+ of the children in observation group were elevated remarkably, while the CD8+ level was lowered (p<0.05). The levels of ECP and eotaxin in the two groups were decreased after the treatment compared with those before the treatment, and the levels in observation group were superior to those in control group (p<0.05). After the treatment, the EOS counts of the both groups of children were lower than those before the treatment, and the decrease in observation group was more notable than that in control group. At 1, 4 and 8 weeks after the treatment, the EOS apoptosis rate in observation group was obviously higher than that in control group (p<0.05).CONCLUSIONSThe treatment of salbutamol combined with budesonide for pediatric BA has significant therapeutic effects; it can restore the pulmonary functions rapidly and improve the immunity of the lung, reduce the levels of eotaxin, ECP and EOS of the child patients and promote EOS apoptosis.
背景探讨沙丁胺醇联合布地奈德治疗小儿支气管哮喘(BA)及其对嗜酸性粒细胞(EOS)的影响。方法收集2016年7月至2017年6月在我院住院治疗的BA患儿98例,按随机数表分为对照组(n=49)和观察组(n=49%)。对照组用布地奈德治疗,观察组用沙丁胺醇联合布地奈德。比较两组治疗后的临床疗效、肺功能和免疫系统中T淋巴细胞亚群[包括分化簇3(CD3)+、CD4+、CD8+和CD4+/CD8+]水平;比较治疗前和治疗后1、4和8周儿童嗜酸性粒细胞阳离子蛋白(ECP)和嗜酸性粒素水平;比较治疗前后儿童血液和诱导痰中EOS计数的变化,并比较治疗后1、4和8周EOS凋亡率。结果观察组治疗有效率明显高于对照组(p<0.05),治疗后肺功能指标明显优于对照组(p<0.05),治疗后两组儿童ECP和eotaxin水平均较治疗前下降,观察组优于对照组(p<0.05),观察组下降幅度明显大于对照组。治疗后1、4、8周,观察组EOS凋亡率明显高于对照组(p<0.05)。结论沙丁胺醇联合布地奈德治疗小儿BA疗效显著;它能迅速恢复肺功能,提高肺部免疫力,降低儿童eotaxin、ECP和EOS水平,促进EOS凋亡。
{"title":"Salbutamol combined with budesonide in treatment of pediatric bronchial asthma and its effect on eosinophils.","authors":"Suihua Li, Qing-xiu Mei, D. Qian, Xianghong Huang, C. Fan, J. Quan","doi":"10.23736/S0026-4946.20.06003-X","DOIUrl":"https://doi.org/10.23736/S0026-4946.20.06003-X","url":null,"abstract":"BACKGROUND\u0000To investigate and discuss the salbutamol combined with budesonide in treatment of pediatric bronchial asthma (BA) and its effect on eosinophils (EOS).\u0000\u0000\u0000METHODS\u000098 BA children admitted and treated in our hospital from July 2016 to June 2017 were collected and divided into control group (n=49) and observation group (n=49) according to random number table. The children in control group were treated with budesonide and those in observation group were treated with salbutamol combined with budesonide. The clinical efficacy, pulmonary functions and levels of T-lymphocyte subsets [including cluster of differentiation 3 (CD3)+, CD4+, CD8+ and CD4+/CD8+] in the immune system between two groups were compared after the treatment; the levels of eosinophil cationic protein (ECP) and eotaxin in the children were compared before the treatment and at 1, 4 and 8 weeks after the treatment; the changes in EOS counts in blood and induced sputum of the children before and after the treatment were compared, and the EOS apoptosis rate was compared at 1, 4 and 8 weeks after the treatment.\u0000\u0000\u0000RESULTS\u0000The effective rate of treatment in observation group was significantly higher than that in control group (p<0.05). After the treatment, the indexes of pulmonary function in observation group were obviously better than those in control group (p<0.05). Compared with those in control group, the levels of CD3+, CD4+ and CD4+/CD8+ of the children in observation group were elevated remarkably, while the CD8+ level was lowered (p<0.05). The levels of ECP and eotaxin in the two groups were decreased after the treatment compared with those before the treatment, and the levels in observation group were superior to those in control group (p<0.05). After the treatment, the EOS counts of the both groups of children were lower than those before the treatment, and the decrease in observation group was more notable than that in control group. At 1, 4 and 8 weeks after the treatment, the EOS apoptosis rate in observation group was obviously higher than that in control group (p<0.05).\u0000\u0000\u0000CONCLUSIONS\u0000The treatment of salbutamol combined with budesonide for pediatric BA has significant therapeutic effects; it can restore the pulmonary functions rapidly and improve the immunity of the lung, reduce the levels of eotaxin, ECP and EOS of the child patients and promote EOS apoptosis.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2020-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47295158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Henoch-Schönlein purpura in Saudi Arabia the characteristics and rare vital organ involvement: a literature review. 沙特阿拉伯过敏性紫癜的特点和罕见的重要器官受累:文献综述。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-09-22 DOI: 10.23736/S0026-4946.20.05962-9
Ashwaq Al E'ed
Henoch-Schönlein purpura (HSP) is the most common small vessel vasculitis in children with an annual incidence of between 10 and 30 per 100,000. It is an inflammation that affects many organs primarily in the skin, gastrointestinal (GI) tract, musculoskeletal, also vital organs like kidneys and lungs which may lead to chronic kidney disease and pulmonary hemorrhage. In this review, we are showing the characteristics of Saudi patients with HSP and the relation with preceding infections, gender, and seasonal variations in addition to the common and most severe systemic involvements. We found cases that were challenging to diagnose and others with unfortunate fetal complications.
过敏性紫癜(HSP)是儿童最常见的小血管血管炎,年发病率在十万分之10到30之间。这是一种炎症,主要影响皮肤、胃肠道、肌肉骨骼以及肾脏和肺部等重要器官,可能导致慢性肾脏疾病和肺出血。在这篇综述中,我们展示了沙特HSP患者的特征,以及与既往感染、性别和季节变化的关系,以及常见和最严重的全身性受累。我们发现了一些难以诊断的病例和其他不幸的胎儿并发症。
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引用次数: 0
Associations between sleep difficulty and school, sports and traffic injuries in early adolescents: a population-based study in north-eastern France. 早期青少年睡眠困难与学校、运动和交通伤害之间的关系:法国东北部一项基于人群的研究。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-09-22 DOI: 10.23736/S0026-4946.20.05779-5
Kénora Chau
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引用次数: 0
Nutritional characteristics of patients with functional constipation aged 4 years and older. 4岁及以上功能性便秘患者的营养特征。
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2020-09-01 DOI: 10.23736/S0026-4946.20.05978-2
Gulnar Agakisiyeva, D. Yıldırım, Hayriye Hizarcioglu-Gulsen, Ersin Gumus, A. Karhan, E. Karabulut, H. Ozen, H. Demir, İ. Saltık-Temizel
BACKGROUNDDietary modifications may have role in prevention and treatment of functional constipation. Macronutrient, extra fluid, and fibre intake have been evaluated and the results are conflicting. The aim of our study was to define the nutritional features associated with functional constipation aged 4 years and older.METHODSThis is a cross-sectional descriptive study. Forty-one patients with functional constipation and 55 age-gender matched controls between 4-18 years old were enrolled. Demographic data, duration of breast-feeding, defecation pattern in the first year of life, physical activity, socioeconomic parameters, and anthropometric measurements were noted. Mean daily macronutrient and micronutrient consumption from the 5-day dietary records were calculated by Nutrition Information System - BEBIS 7.2 version.RESULTSThere were no differences between two groups in energy, water, protein, and fibre consumption. However, in 4-7 years old constipated female and male group, the percentage of carbohydrate was higher (p=0.010, p=0.049, respectively) but fat was lower (p=0.011, p=0.032, respectively). All patients except 4-7 years old boys of both groups got less energy than the reference values. The mean daily protein intake was higher than required in the 4-7 years old constipated and control groups. There was no significant difference in fibre consumption between groups. Breastfeeding >18 months was more common in controls (p=0.039). The constipated group used the squatting toilet more frequently (p=0.002). Lower family income (p<0.001) and parental education levels (p<0.001) were associated with FC.CONCLUSIONSDietary habits may be a risk factor for functional constipation, especially, in rapid growth period.
背景饮食调整可能在预防和治疗功能性便秘方面发挥作用。对大量营养素、额外液体和纤维的摄入进行了评估,结果相互矛盾。我们研究的目的是确定与4岁及以上功能性便秘相关的营养特征。方法本研究为横断面描述性研究。41名功能性便秘患者和55名4-18岁年龄性别匹配的对照组被纳入研究。记录了人口统计学数据、母乳喂养的持续时间、出生第一年的排便模式、体力活动、社会经济参数和人体测量。根据营养信息系统-BEBIS 7.2版计算5天饮食记录中的平均每日常量营养素和微量营养素消耗量。结果两组在能量、水分、蛋白质和纤维消耗方面没有差异。然而,在4-7岁便秘的女性和男性组中,碳水化合物的百分比较高(分别为p=0.010,p=0.049),但脂肪的百分比较低(分别为0.011,p=0.032)。除4-7岁男孩外,两组患者的能量均低于参考值。4-7岁便秘组和对照组的平均每日蛋白质摄入量高于所需。各组间纤维消耗量无显著差异。母乳喂养>18个月在对照组中更常见(p=0.039)。便秘组更频繁地使用蹲便器(p=0.002)。较低的家庭收入(p<0.001)和父母教育水平(p<0.001)与FC有关。结论饮食习惯可能是功能性便秘的危险因素,尤其是在快速生长期。
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引用次数: 0
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Minerva pediatrica
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