Pub Date : 2021-06-01DOI: 10.23736/S0026-4946.19.05530-0
S. Savasta, Francesco Bassanese, Chiara Hruby, T. Foiadelli, B. Siri, Viviana Gori, M. Votto, C. Tinelli, G. Marseglia
BACKGROUND Ehlers-Danlos syndrome is part of connective tissue disorders and is characterized by skin hyperextensibility, joint hypermobility, easy bruising and other severe manifestations such as epilepsy, pneumothorax, arterial rupture and bowel perforation. In 2017 a new classification was published, indicating major and minor criteria for each form of EDS. Further reports in the past years tried to determine whether or not the absence of lingual frenulum should be included in minor criteria for the diagnosis of EDS, but a consensus has still not been reached. The aim of this study is to assess the clinical relevance of lingual frenulum absence, evaluating its prevalence in a cohort of EDS pediatric patients and comparing it to a group of controls. METHODS Patients with Ehlers-Danlos syndrome were observed at our Department of Pediatrics of Policlinico S.Matteo in Pavia, Italy. Each patient underwent clinical examination of the oral cavity, and controls were chosen among patients referred to our Department. RESULTS Thirty-three over 40 patients showed absence of lingual frenulum and 3 of them showed frenulum hypoplasia. Absence or hypoplasia of lingual frenulum showed a prevalence of 90% in our population, whereas only 3/170 controls (1.8%), had lingual frenulum absence. Overall, absence of the lingual frenulum showed a sensibility of 90% and a specificity of 98.2% in our population. CONCLUSIONS In agreement with other authors, we believe that the absence of lingual frenulum should be included in the minor diagnostic criteria for Ehlers-Danlos Syndrome.
{"title":"Absence of lingual frenulum in children with Ehlers-Danlos Syndrome: a retrospective study of forty cases and literature review of a twenty years long debate.","authors":"S. Savasta, Francesco Bassanese, Chiara Hruby, T. Foiadelli, B. Siri, Viviana Gori, M. Votto, C. Tinelli, G. Marseglia","doi":"10.23736/S0026-4946.19.05530-0","DOIUrl":"https://doi.org/10.23736/S0026-4946.19.05530-0","url":null,"abstract":"BACKGROUND\u0000Ehlers-Danlos syndrome is part of connective tissue disorders and is characterized by skin hyperextensibility, joint hypermobility, easy bruising and other severe manifestations such as epilepsy, pneumothorax, arterial rupture and bowel perforation. In 2017 a new classification was published, indicating major and minor criteria for each form of EDS. Further reports in the past years tried to determine whether or not the absence of lingual frenulum should be included in minor criteria for the diagnosis of EDS, but a consensus has still not been reached. The aim of this study is to assess the clinical relevance of lingual frenulum absence, evaluating its prevalence in a cohort of EDS pediatric patients and comparing it to a group of controls.\u0000\u0000\u0000METHODS\u0000Patients with Ehlers-Danlos syndrome were observed at our Department of Pediatrics of Policlinico S.Matteo in Pavia, Italy. Each patient underwent clinical examination of the oral cavity, and controls were chosen among patients referred to our Department.\u0000\u0000\u0000RESULTS\u0000Thirty-three over 40 patients showed absence of lingual frenulum and 3 of them showed frenulum hypoplasia. Absence or hypoplasia of lingual frenulum showed a prevalence of 90% in our population, whereas only 3/170 controls (1.8%), had lingual frenulum absence. Overall, absence of the lingual frenulum showed a sensibility of 90% and a specificity of 98.2% in our population.\u0000\u0000\u0000CONCLUSIONS\u0000In agreement with other authors, we believe that the absence of lingual frenulum should be included in the minor diagnostic criteria for Ehlers-Danlos Syndrome.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49385937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.23736/S0026-4946.19.05658-5
Shaoqiong Sun, Xueqin Liao, Qiujie Wang, Chaofan Xie, Bin Yang, Dan Wu
{"title":"The effectiveness of indoor children's play center in relieving preoperative anxiety in paediatric surgical patients.","authors":"Shaoqiong Sun, Xueqin Liao, Qiujie Wang, Chaofan Xie, Bin Yang, Dan Wu","doi":"10.23736/S0026-4946.19.05658-5","DOIUrl":"https://doi.org/10.23736/S0026-4946.19.05658-5","url":null,"abstract":"","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42503832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.23736/S2724-5276.16.04297-3
Z. Önal, L. Soydan, B. Karadaş, T. Gürbüz, C. Nuhoglu, M. Şimşek
BACKGROUND It is important how to evaluate chronic cervical lymphadenopathies and when to perform excisional biopsy in children. We tried to analyze the usefulness of clinical and ultrasonographic findings in order to differentiate malign lymphadenopathies from benign ones. METHODS This prospective study included 100 children who had cervical lymphadenopathies, larger than 1. 5 cm for 4 weeks duration at least. Children were between 2 and 14 years old, the mean age was 6.88±3.38 years. They were examined by clinical symptoms and ultrasonographic appearances. Persistent lymphadenopathies were evaluated by excisional biopsy. RESULTS Cervical lymhadenopathies of 80 children with well clinical symptoms decreased and resolved within 10 weeks durations. Their ultrasonographic findings revealed regular margins, ovoid shapes and getting smaller than 1. 5 cm. The remaining 20 children persisting longer than 10 weeks at the same size, with worrisome clinical symptoms and susceptible ultrasonographic findings (round shapes, irregular margins) underwent excisional biopsy. According to the biopsy results, five had tubercular lymphadenopathies, three had Hodgkin'slenfoma, two had acute lymphoblastic leukemia. CONCLUSIONS Chronic cervical lymphadenopathies can persist up to 10 weeks, althoughthey are reactive and benign.
{"title":"Management of chronic cervical lymphadenopathy in children","authors":"Z. Önal, L. Soydan, B. Karadaş, T. Gürbüz, C. Nuhoglu, M. Şimşek","doi":"10.23736/S2724-5276.16.04297-3","DOIUrl":"https://doi.org/10.23736/S2724-5276.16.04297-3","url":null,"abstract":"BACKGROUND It is important how to evaluate chronic cervical lymphadenopathies and when to perform excisional biopsy in children. We tried to analyze the usefulness of clinical and ultrasonographic findings in order to differentiate malign lymphadenopathies from benign ones. METHODS This prospective study included 100 children who had cervical lymphadenopathies, larger than 1. 5 cm for 4 weeks duration at least. Children were between 2 and 14 years old, the mean age was 6.88±3.38 years. They were examined by clinical symptoms and ultrasonographic appearances. Persistent lymphadenopathies were evaluated by excisional biopsy. RESULTS Cervical lymhadenopathies of 80 children with well clinical symptoms decreased and resolved within 10 weeks durations. Their ultrasonographic findings revealed regular margins, ovoid shapes and getting smaller than 1. 5 cm. The remaining 20 children persisting longer than 10 weeks at the same size, with worrisome clinical symptoms and susceptible ultrasonographic findings (round shapes, irregular margins) underwent excisional biopsy. According to the biopsy results, five had tubercular lymphadenopathies, three had Hodgkin'slenfoma, two had acute lymphoblastic leukemia. CONCLUSIONS Chronic cervical lymphadenopathies can persist up to 10 weeks, althoughthey are reactive and benign.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":"73 1","pages":"167-172"},"PeriodicalIF":2.6,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48980493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0026-4946.17.04791-0
S. Yum, C. Moon, Y. Youn, I. Sung
BACKGROUND The aim of this study was to elucidate the specific clinical characteristics associated with abnormal brain magnetic resonance image(MRI) findings in hypoxic ischemic encephalopathy(HIE) infants in order to discern how to predict poorer outcomes more accurately. METHODS A retrospective data analysis of HIE infants admitted to the neonatal intensive care unit of a tertiary hospital was performed. Baseline perinatal information and physical and neurological findings were compared in HIE infants according to the presence of abnormal brain MRI findings. RESULTS A total of 69 infants were enrolled in the study. Of these, 48(69.6%) infants received therapeutic hypothermia, and 60(87.0%) infants presented abnormal findings on brain MRI. Decreased muscle tone and lower Apgar scores were more often observed in infants with abnormal MRI results(p<0.05). The presence of hypotonia and 1- and 5-minute Apgar scores equal to or less than the yielded cut-off values(5.5 and 7.5, respectively)were associated with a 7.23-, 9.14-, 9.78-fold increased risk of having abnormal brain MRI results. CONCLUSIONS As muscle tone and Apgar scores were associated with abnormal brain MRI findings in HIE infants, these clinical characteristics may serve as early indicators of poor neurodevelopmental outcomes and signal the need for special attention and in-depth follow-up by MRI.
{"title":"Clinical characteristics predicting abnormal brain magnetic resonance image findings in hypoxic-ischemic encephalopathy infants.","authors":"S. Yum, C. Moon, Y. Youn, I. Sung","doi":"10.23736/S0026-4946.17.04791-0","DOIUrl":"https://doi.org/10.23736/S0026-4946.17.04791-0","url":null,"abstract":"BACKGROUND\u0000The aim of this study was to elucidate the specific clinical characteristics associated with abnormal brain magnetic resonance image(MRI) findings in hypoxic ischemic encephalopathy(HIE) infants in order to discern how to predict poorer outcomes more accurately.\u0000\u0000\u0000METHODS\u0000A retrospective data analysis of HIE infants admitted to the neonatal intensive care unit of a tertiary hospital was performed. Baseline perinatal information and physical and neurological findings were compared in HIE infants according to the presence of abnormal brain MRI findings.\u0000\u0000\u0000RESULTS\u0000A total of 69 infants were enrolled in the study. Of these, 48(69.6%) infants received therapeutic hypothermia, and 60(87.0%) infants presented abnormal findings on brain MRI. Decreased muscle tone and lower Apgar scores were more often observed in infants with abnormal MRI results(p<0.05). The presence of hypotonia and 1- and 5-minute Apgar scores equal to or less than the yielded cut-off values(5.5 and 7.5, respectively)were associated with a 7.23-, 9.14-, 9.78-fold increased risk of having abnormal brain MRI results.\u0000\u0000\u0000CONCLUSIONS\u0000As muscle tone and Apgar scores were associated with abnormal brain MRI findings in HIE infants, these clinical characteristics may serve as early indicators of poor neurodevelopmental outcomes and signal the need for special attention and in-depth follow-up by MRI.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48333061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0026-4946.19.05582-8
R. Mormile
{"title":"Childhood brain cancer risk from early life exposure to hyperinsulinemia in offspring of diabetic mothers: the exception that proves the rule?","authors":"R. Mormile","doi":"10.23736/S0026-4946.19.05582-8","DOIUrl":"https://doi.org/10.23736/S0026-4946.19.05582-8","url":null,"abstract":"","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":"1 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41974695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S2724-5276.16.04274-X
P. Boran, Selin Yıldırım, E. Karakoc‐Aydiner, I. Ogulur, A. Ozen, G. Haklar, A. Koc, T. Akkoç, I. Barlan
AIM The immunomodulatory effects of vitamin B12 deficiency in children have not yet been established in the literature. In the current study, the effects of vitamin B12 on the immune system in asymptomatic and otherwise healthy infants have been studied. METHODS The study was conducted at Marmara University, "well-child" outpatient clinic. Vitamin B12 level was measured in a cohort of 611 healthy term infants, followed regularly for at least 6 months. Immunoglobulin measurements, lymphocyte subset analysis, cytokine production analysis, lymphocyte proliferation assays and evaluation of lymphocyte apoptosis were performed in a subset of 60 infants. RESULTS In this cohort, one out of three babies displayed vitamin B12 deficiency. The percentage of CD4+CD25+ regulatory T cells (Tregs) was lower in vitamin B12 deficient babies than in controls. Although the percentage of Tregs increased after treatment, the change was not significant. There was no difference of cytokine levels between vitamin B12 deficient and control groups. However, proinflammatory cytokines were reduced after treatment. No significant difference was observed for immunoglobulins, early apoptosis and lymphocyte proliferation. CONCLUSION Vitamin B12 deficiency is an underestimated health problem among the developing countries. The clinical consequences of the decreased percentage of Tregs associated with vitamin B12 deficiency, and reduction of proinflammatory cytokines after vitamin supplementation needs to be further studied, especially in terms of emerging allergies, autoimmune disorders and anti-inflammatory effects.
{"title":"Vitamin B12 deficiency among asymptomatic healthy infants: its impact on the immune system.","authors":"P. Boran, Selin Yıldırım, E. Karakoc‐Aydiner, I. Ogulur, A. Ozen, G. Haklar, A. Koc, T. Akkoç, I. Barlan","doi":"10.23736/S2724-5276.16.04274-X","DOIUrl":"https://doi.org/10.23736/S2724-5276.16.04274-X","url":null,"abstract":"AIM\u0000The immunomodulatory effects of vitamin B12 deficiency in children have not yet been established in the literature. In the current study, the effects of vitamin B12 on the immune system in asymptomatic and otherwise healthy infants have been studied.\u0000\u0000\u0000METHODS\u0000The study was conducted at Marmara University, \"well-child\" outpatient clinic. Vitamin B12 level was measured in a cohort of 611 healthy term infants, followed regularly for at least 6 months. Immunoglobulin measurements, lymphocyte subset analysis, cytokine production analysis, lymphocyte proliferation assays and evaluation of lymphocyte apoptosis were performed in a subset of 60 infants.\u0000\u0000\u0000RESULTS\u0000In this cohort, one out of three babies displayed vitamin B12 deficiency. The percentage of CD4+CD25+ regulatory T cells (Tregs) was lower in vitamin B12 deficient babies than in controls. Although the percentage of Tregs increased after treatment, the change was not significant. There was no difference of cytokine levels between vitamin B12 deficient and control groups. However, proinflammatory cytokines were reduced after treatment. No significant difference was observed for immunoglobulins, early apoptosis and lymphocyte proliferation.\u0000\u0000\u0000CONCLUSION\u0000Vitamin B12 deficiency is an underestimated health problem among the developing countries. The clinical consequences of the decreased percentage of Tregs associated with vitamin B12 deficiency, and reduction of proinflammatory cytokines after vitamin supplementation needs to be further studied, especially in terms of emerging allergies, autoimmune disorders and anti-inflammatory effects.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47810172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S2724-5276.16.04621-1
P. Ferrara, F. Ianniello, V. Bianchi, F. Quintarelli, Michela Cammerata, Enrica Quattrocchi, G. Terranova, G. Miggiano, M. Casale
BACKGROUND To demonstrate whether supplementation of vitamin C has a beneficial effect in the prevention of recurrent respiratory tract infections (RTIs) in children. Moreover, we evaluate the main risk factors that predispose to the development of this disease. METHODS Sixty children have been enrolled in the study and randomized into two groups: the control group (G1 n = 33) and the group at risk of recurrent RTIs (G2 n = 27). To G2 group was administered every day 100% orange juice with the content of vitamin C 70 mg. RESULTS Significant reduction in the incidence rate of RTIs (episodes pre-treatment: 182-6.75 episodes/child, after-treatment: 71-2.62 episodes/child, P <0.05), were observed in G2 group. CONCLUSIONS The administration of vitamin C had a beneficial effect in our group of children with recurrent RTIs, reducing the number of infective episodes.
背景:为了证明补充维生素C是否对预防儿童复发性呼吸道感染(RTIs)有有益作用。此外，我们评估了主要的危险因素，易导致这种疾病的发展。方法60名儿童被纳入研究，随机分为两组:对照组(G1 n = 33)和RTIs复发危险组(G2 n = 27)。G2组每天给予含维生素C 70 mg的100%橙汁。结果G2组RTIs发生率显著降低(治疗前182 ~ 6.75次/例，治疗后71 ~ 2.62次/例，P <0.05)。结论在本组复发性呼吸道感染患儿中给予维生素C治疗有良好效果，可减少感染发作次数。
{"title":"Beneficial therapeutic effects of vitamin C on recurrent respiratory tract infections in children: preliminary data.","authors":"P. Ferrara, F. Ianniello, V. Bianchi, F. Quintarelli, Michela Cammerata, Enrica Quattrocchi, G. Terranova, G. Miggiano, M. Casale","doi":"10.23736/S2724-5276.16.04621-1","DOIUrl":"https://doi.org/10.23736/S2724-5276.16.04621-1","url":null,"abstract":"BACKGROUND\u0000To demonstrate whether supplementation of vitamin C has a beneficial effect in the prevention of recurrent respiratory tract infections (RTIs) in children. Moreover, we evaluate the main risk factors that predispose to the development of this disease.\u0000\u0000\u0000METHODS\u0000Sixty children have been enrolled in the study and randomized into two groups: the control group (G1 n = 33) and the group at risk of recurrent RTIs (G2 n = 27). To G2 group was administered every day 100% orange juice with the content of vitamin C 70 mg.\u0000\u0000\u0000RESULTS\u0000Significant reduction in the incidence rate of RTIs (episodes pre-treatment: 182-6.75 episodes/child, after-treatment: 71-2.62 episodes/child, P <0.05), were observed in G2 group.\u0000\u0000\u0000CONCLUSIONS\u0000The administration of vitamin C had a beneficial effect in our group of children with recurrent RTIs, reducing the number of infective episodes.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47195994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0026-4946.18.05062-4
M. L. Santos, T. B. Simões, L. A. Monteiro, J. Novaes, H. M. Fernandes
BACKGROUND The aim of the current study is to analyze the longitudinal effects of certain biopsychosocial variables (socioeconomic status, body mass index (BMI), body image and well-being (QL)), measured at three different menarche stages (S1: before menarche, S2: soon after menarche, and S3: one year after S2), on physical activity and inactivity levels in early adolescence. METHODS The sample comprised 136 Brazilian teenagers (10-13 years old), showing BMI 18.98 kg/m2 at the initial assessment, who voluntarily participated in the study. Data concerning the following variables were collected in 2010 (S1), 2011 (S2) and 2012 (S3): family income (FI) (socioeconomic anamnesis), BMI (body mass and height), well-being (Autoquestionnaire Qualité de Vie Enfant Imagé) and body image (Body Shape Questionnaire). The physical activity and inactivity levels were measured in S3, only, through the International Physical Activity Questionnaire. The Pearson's correlation and the longitudinal path analysis technique were used to statistically analyze the data. RESULTS The main results indicated that just family income and BMI, measured soon after menarche (S2), showed significant effect on physical activity and inactivity levels. More specifically, family income has positively influenced (β = 0.25) physical inactivity levels and negatively influenced (β = -0.14) moderate physical activity levels, whereas BMI has positively influenced (β = 0.15) walking levels and negatively influenced (β = -0.13) vigorous physical activity levels. CONCLUSIONS These results suggest that the body image and well-being perceived by the teenagers at different menarche stages are not determining factors of their physical activity levels in early adolescence. On the other hand, the effects of socioeconomic status and body mass index on early adolescent girls' physical activity and inactivity levels depend on the assessment period.
背景:本研究的目的是分析在三个不同的初潮阶段(S1:初潮前，S2:初潮后不久，S3:初潮后一年)测量的某些生物心理社会变量(社会经济地位，体重指数(BMI)，身体形象和幸福感(QL))对青春期早期身体活动和不活动水平的纵向影响。方法136名自愿参加研究的巴西青少年(10-13岁)，初始评估时BMI为18.98 kg/m2。2010年(S1)、2011年(S2)和2012年(S3)收集了以下变量的数据:家庭收入(FI)(社会经济记忆)、BMI(体重和身高)、幸福感(Autoquestionnaire qualit de Vie Enfant image1)和身体形象(body Shape Questionnaire)。通过国际身体活动问卷，仅在S3中测量了身体活动和不活动水平。采用Pearson相关和纵向路径分析技术对数据进行统计分析。结果主要结果表明，家庭收入和初潮后测量的身体质量指数(BMI)对身体活动和不活动水平有显著影响。更具体地说，家庭收入对不运动水平有正面影响(β = 0.25)，对中等运动水平有负面影响(β = -0.14)，而BMI对步行水平有正面影响(β = 0.15)，对剧烈运动水平有负面影响(β = -0.13)。结论不同月经初潮阶段青少年的身体形象和幸福感不是青少年早期体育活动水平的决定因素。另一方面，社会经济地位和身体质量指数对青春期早期女孩身体活动和不活动水平的影响取决于评估期。
{"title":"Longitudinal effects of biopsychosocial variables on physical activity after menarche.","authors":"M. L. Santos, T. B. Simões, L. A. Monteiro, J. Novaes, H. M. Fernandes","doi":"10.23736/S0026-4946.18.05062-4","DOIUrl":"https://doi.org/10.23736/S0026-4946.18.05062-4","url":null,"abstract":"BACKGROUND\u0000The aim of the current study is to analyze the longitudinal effects of certain biopsychosocial variables (socioeconomic status, body mass index (BMI), body image and well-being (QL)), measured at three different menarche stages (S1: before menarche, S2: soon after menarche, and S3: one year after S2), on physical activity and inactivity levels in early adolescence.\u0000\u0000\u0000METHODS\u0000The sample comprised 136 Brazilian teenagers (10-13 years old), showing BMI 18.98 kg/m2 at the initial assessment, who voluntarily participated in the study. Data concerning the following variables were collected in 2010 (S1), 2011 (S2) and 2012 (S3): family income (FI) (socioeconomic anamnesis), BMI (body mass and height), well-being (Autoquestionnaire Qualité de Vie Enfant Imagé) and body image (Body Shape Questionnaire). The physical activity and inactivity levels were measured in S3, only, through the International Physical Activity Questionnaire. The Pearson's correlation and the longitudinal path analysis technique were used to statistically analyze the data.\u0000\u0000\u0000RESULTS\u0000The main results indicated that just family income and BMI, measured soon after menarche (S2), showed significant effect on physical activity and inactivity levels. More specifically, family income has positively influenced (β = 0.25) physical inactivity levels and negatively influenced (β = -0.14) moderate physical activity levels, whereas BMI has positively influenced (β = 0.15) walking levels and negatively influenced (β = -0.13) vigorous physical activity levels.\u0000\u0000\u0000CONCLUSIONS\u0000These results suggest that the body image and well-being perceived by the teenagers at different menarche stages are not determining factors of their physical activity levels in early adolescence. On the other hand, the effects of socioeconomic status and body mass index on early adolescent girls' physical activity and inactivity levels depend on the assessment period.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48672385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-13DOI: 10.23736/S0026-4946.20.06083-1
M. Giovannini, T. Oranges, F. Portelli, A. Bassi, F. Pedaci, L. Lodi, C. Azzari, C. Filippeschi
{"title":"A rare case of pediatric linear syringocystadenoma papilliferum of the chest.","authors":"M. Giovannini, T. Oranges, F. Portelli, A. Bassi, F. Pedaci, L. Lodi, C. Azzari, C. Filippeschi","doi":"10.23736/S0026-4946.20.06083-1","DOIUrl":"https://doi.org/10.23736/S0026-4946.20.06083-1","url":null,"abstract":"","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42025914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-13DOI: 10.23736/S0026-4946.20.06177-0
Xue Ma, Fengxue Wang, Shule Zhang, Guimei Li
Background: Craniopharyngioma is a relatively common congenital intracranial tumour for children. But only few available studies focused on the endocrine evaluation before diagnosis and post-operative endocrine evaluations of children with craniopharyngioma.
Aim: This study aims to aid in the early diagnosis of craniopharyngioma (CP) and follow-up post-operative children suffered from craniopharyngioma.
Methods: Craniopharyngioma patients, as the CP group (n = 50), and healthy children, as the control group (n = 30), the symptoms and pituitary hormone levels were reviewed and investigated.
Results: The pre-operative levels of peak of GH, IGF-1, FT4, ACTH, COR and PRL of CP patients were significantly lower than those of the control group (all the P ≤ 0.001). Levels of pituitary-hormones after surgery were significantly lower than both those before surgery and those of the control group (all the P ≤ 0.001). HGH treatment could significantly improve the growth velocity of post-operative children (3.8 ± 1.5 cm/year vs 13.0 ± 3.4 cm/year for males, P ≤ 0.001; 4.0 ± 1.3 cm/year vs 12.7 ± 1.8 cm/year for females, P ≤ 0.001).
Conclusions: Children presenting with endocrine disturbance symptoms combined with pituitary hormone deficits should be assessed by MRI to exclude craniopharyngioma earlier. Also, long-term follow-up study was very essential to craniopharyngioma survivors.
背景：颅咽管瘤是一种比较常见的儿童先天性颅内肿瘤。目的：本研究旨在帮助早期诊断颅咽管瘤（CP），并对颅咽管瘤患儿进行术后随访：方法：以颅咽管瘤患者为CP组（50人），以健康儿童为对照组（30人），回顾并调查其症状和垂体激素水平：结果：CP患者术前GH、IGF-1、FT4、ACTH、COR和PRL的峰值水平明显低于对照组（P均≤0.001）。术后垂体激素水平明显低于术前和对照组（P均≤0.001）。HGH治疗可明显改善术后儿童的生长速度（男性3.8±1.5厘米/年 vs 13.0±3.4厘米/年，P≤0.001；女性4.0±1.3厘米/年 vs 12.7±1.8厘米/年，P≤0.001）：结论：儿童出现内分泌紊乱症状并伴有垂体激素缺乏时，应进行磁共振成像评估，以尽早排除颅咽管瘤。此外，长期随访研究对颅咽管瘤幸存者也非常重要。
{"title":"Early diagnosis and post-operative follow-up of 50 Chinese children with craniopharyngioma.","authors":"Xue Ma, Fengxue Wang, Shule Zhang, Guimei Li","doi":"10.23736/S0026-4946.20.06177-0","DOIUrl":"10.23736/S0026-4946.20.06177-0","url":null,"abstract":"<p><strong>Background: </strong>Craniopharyngioma is a relatively common congenital intracranial tumour for children. But only few available studies focused on the endocrine evaluation before diagnosis and post-operative endocrine evaluations of children with craniopharyngioma.</p><p><strong>Aim: </strong>This study aims to aid in the early diagnosis of craniopharyngioma (CP) and follow-up post-operative children suffered from craniopharyngioma.</p><p><strong>Methods: </strong>Craniopharyngioma patients, as the CP group (n = 50), and healthy children, as the control group (n = 30), the symptoms and pituitary hormone levels were reviewed and investigated.</p><p><strong>Results: </strong>The pre-operative levels of peak of GH, IGF-1, FT4, ACTH, COR and PRL of CP patients were significantly lower than those of the control group (all the P ≤ 0.001). Levels of pituitary-hormones after surgery were significantly lower than both those before surgery and those of the control group (all the P ≤ 0.001). HGH treatment could significantly improve the growth velocity of post-operative children (3.8 ± 1.5 cm/year vs 13.0 ± 3.4 cm/year for males, P ≤ 0.001; 4.0 ± 1.3 cm/year vs 12.7 ± 1.8 cm/year for females, P ≤ 0.001).</p><p><strong>Conclusions: </strong>Children presenting with endocrine disturbance symptoms combined with pituitary hormone deficits should be assessed by MRI to exclude craniopharyngioma earlier. Also, long-term follow-up study was very essential to craniopharyngioma survivors.</p>","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38813982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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