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Coexistence of a primary ALK-positive and MET14 exon skipping mutation double-fusion in one patient with NSCLC and response to crizotinib: A case report and literature review. 原发性alk阳性和MET14外显子跳跃突变双融合共存1例非小细胞肺癌患者对克唑替尼的反应:病例报告和文献综述
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047628
Ke Xu, Minghui Wang, Jijing Zhao, Xiaofeng Xu, Meijun Song

Rationale: Lung cancer exhibits one of the highest incidence and fatality rates globally. With the advancement of next-generation sequencing testing techniques, double or multiple gene driver mutations have been identified in certain patients.

Patient concerns: A 78-year-old female presented with a chest shadow.

Diagnoses: In this case of lung adenocarcinoma, second-generation sequencing revealed a co-occurrence of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase and MET exon 14 skipping mutation.

Interventions: Crizotinib was administered orally on August 31, 2022, resulting in a partial response and progression-free survival for a duration of 8 months. After 8 months of treatment, the patient's disease progressed, after which the treatment dose of crizotinib was increased; the patient's condition improved again.

Outcomes: Over 4 months of increased-dose oral crizotinib treatment, the patient achieved durable partial response, with significant reduction in tumor burden and without new metastases.

Lessons: This report supports crizotinib can provide potential benefit for anaplastic lymphoma kinase/MET14 co-mutated lung adenocarcinoma patients, but sufficient cases and further research are needed to confirm and explore the possible mechanisms involved.

理由:肺癌是全球发病率和死亡率最高的疾病之一。随着新一代测序检测技术的进步,在某些患者中发现了双重或多重基因驱动突变。患者关注:78岁女性,胸部阴影。诊断:在这个肺腺癌病例中,第二代测序显示棘皮细胞微管相关蛋白样4-间变性淋巴瘤激酶和MET外显子14跳变共同发生。干预措施:于2022年8月31日口服克唑替尼,导致部分缓解和8个月的无进展生存期。治疗8个月后,患者病情进展,随后加大克唑替尼治疗剂量;病人的病情又好转了。结果:在4个月的增加剂量口服克唑替尼治疗后,患者获得了持久的部分缓解,肿瘤负担显著减轻,无新的转移。结论:本报告支持克唑替尼可为间变性淋巴瘤激酶/MET14共突变肺腺癌患者提供潜在的益处,但需要足够的病例和进一步的研究来证实和探索可能的机制。
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引用次数: 0
Investigating the efficacy and safety of the 755-nm picosecond alexandrite laser in treating nevus of Ota: A systematic review and meta-analysis. 研究755 nm皮秒翠绿宝石激光治疗太田痣的疗效和安全性:系统回顾和荟萃分析。
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047692
Mishari Tariq Alrubaiaan, Ahmed Hisham Almajed, Saif Alagha, Futun Abdulhadi Alsallom, Latifah Albrahim, Khalid Nabil Nagshabandi, Lamia Alakrash

Background: The nevus of Ota is an uncommon pigmentary skin condition that causes bluish-gray pigmentation and is traditionally treated with a Q-switched laser. Emerging evidence suggests that the 755-nanometer picosecond alexandrite laser is a safe and effective therapeutic option. We sought to determine the overall effectiveness and safety profile of the 755-nanometer (nm) picosecond alexandrite laser for managing nevus of Ota.

Methods: We reviewed 6 databases for studies that addressed the safety as well as efficacy profile of the 755-nm picosecond alexandrite laser for nevus of Ota. Ten studies, including 558 individuals with nevus of Ota, were included. The main outcomes were the rate of excellent clinical response and reported side effects encompassing erythema as well as post-inflammatory pigmentary alterations, including both hyperpigmentation and hypopigmentation. Review Manager Version 5.4 and Comprehensive Meta-Analysis v3 software were used for data analysis.

Results: The pooled excellent clinical response rate for the 755-nm picosecond alexandrite laser was found to be 36.8% (95% confidence interval [24.4-51.2%], P = .642). Post-inflammatory hyperpigmentation and hypopigmentation were each observed in 20.6% and 12.2% of the cases (P-value < .001), respectively. Post-inflammatory erythema, assessed in 2 studies (n = 23), demonstrated a pooled prevalence of 45.2% (95% confidence interval: 12.9-82.2%).

Conclusion: The 755-nm picosecond alexandrite laser demonstrated moderate effectiveness and a favorable safety profile in the treatment of nevus of Ota. Pigmentary complications occurred at relatively low rates across the included studies. Further high-quality prospective and randomized controlled trials are required to confirm long-term effectiveness and safety.

背景:太田痣是一种罕见的色素皮肤状况,引起蓝灰色色素沉着,传统上用调q激光治疗。越来越多的证据表明,755纳米皮秒的翠绿宝石激光是一种安全有效的治疗选择。我们试图确定755纳米(nm)皮秒亚历山大变石激光治疗太田痣的总体有效性和安全性。方法:我们回顾了6个数据库,研究了755 nm皮秒翠绿宝石激光治疗太田痣的安全性和有效性。纳入了10项研究,包括558名太田痣患者。主要结果是良好的临床反应率和报道的副作用,包括红斑和炎症后色素改变,包括色素沉着和色素沉着减少。采用Review Manager Version 5.4和Comprehensive Meta-Analysis v3软件进行数据分析。结果:755 nm皮秒紫翠绿宝石激光综合临床优良率为36.8%(95%可信区间[24.4 ~ 51.2%],P = .642)。结论:755 nm皮秒翠绿宝石激光治疗太田痣疗效中等,安全性较好。在纳入的研究中,色素并发症的发生率相对较低。需要进一步的高质量前瞻性和随机对照试验来确认长期有效性和安全性。
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引用次数: 0
The risk factors associated with pulmonary hypertension in patients with left heart diseases. 左心病患者肺动脉高压的相关危险因素
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047799
Kaina Wang, Jin Fan, Ling Mei

Pulmonary hypertension (PH) is an important reason for morbidity and mortality in patients with left heart disease (LHD). LHD is one the most common cause of PH in the elderly. Few studies have reported risk factors in patients with PH accompanied with LHD. To identify associated risk factors with PH in patients with LHD in elderly. A total of 411 aged male patients (>60 years) with LHDs were enrolled in this trail. Pulmonary artery systolic pressure (PASP), heart chamber diameters, and left ventricular functions were evaluated by transthoracic echocardiography. Patients were classified as PH group (n = 211) and non-PH group (n = 200) according to their PASP. Clinical history was collected from medical recordings. Independent associated factors for PH were identified by Logistic regression analysis. Compared with non-PHs, PH patients were more likely to have atrial fibrillation (AF; 21% vs 9.4%, P < .01), left atrial enlargement (39.25 ± 4.96 mm vs 36.94 ± 3.16 mm, P < .01), and reduced left ventricular ejection fraction (LVEF; 58.97 ± 6.51% vs 61.15 ± 4.72%, P < .01). Multivariate logistic regression analysis showed that AF, larger left atrial diameter, lower LVEF was independently associated with the presence of PH in patients with LHDs. In patients with PH, the PASP and left atrial diameter were all related to the number of co-morbidities (P < .05). AF, left atrial enlargement, and decreased LVEF are associated with the presence of PH in patients with LHDs. Well control of comorbidities and underlying heart diseases, prevention or treatment of AF may play key roles in the management of PH in patients with LHDs.

肺动脉高压(PH)是左心疾病(LHD)患者发病和死亡的重要原因。LHD是老年人PH最常见的病因之一。很少有研究报道PH伴LHD患者的危险因素。目的:探讨老年LHD患者PH的相关危险因素。共有411例老年男性lhd患者(年龄在60岁至60岁之间)参加了这项试验。经胸超声心动图评估肺动脉收缩压(PASP)、心室直径和左心室功能。根据患者的PASP分为PH组(211例)和非PH组(200例)。从医疗记录中收集临床病史。通过Logistic回归分析确定PH的独立相关因素。与非小灵通患者相比,PH患者更容易发生心房颤动(AF; 21% vs 9.4%, P
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引用次数: 0
Association of dietary n-3 and n-6 polyunsaturated fatty acid intake and n-6/n-3 ratio with high-frequency hearing loss: A cross-sectional study. 膳食中n-3和n-6多不饱和脂肪酸摄入量和n-6/n-3比值与高频听力损失的关系:一项横断面研究
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047745
Zhaocha Gao, Qiufang Zhang, Yunbing Dai, Congcong Lv, Jianmin Qu, Yungang Wu, Xue Zhang

Although polyunsaturated fatty acids (PUFAs) are recognized for their beneficial impact on human health, evidence regarding their association with high-frequency hearing loss (HFHL) remains limited. This study aimed to examine the association between the dietary intake of n - 3 and n - 6 PUFAs, dietary n - 6/n - 3 PUFA ratio, and HFHL. In this cross-sectional study, data were obtained from 2 cycles of the National Health and Nutrition Examination Survey 2011 to 2012 and 2015 to 2016. Multivariable logistic regression models were used to assess the associations of dietary n - 3 and n - 6 PUFA intake and the dietary n - 6/n - 3 PUFA ratio with HFHL. Restricted cubic spline (RCS) analyses were performed to evaluate potential dose-response relationships. Stratification and sensitivity analyses were conducted to evaluate the robustness of the findings. A total of 6454 adults aged 30 to 69 years were included (mean [standard deviation age, 49.2 [11.4] years; 50.9% women), among whom 44.7% had HFHL. After full adjustment, higher dietary intake of both n - 3 and n - 6 PUFAs was associated with lower odds of HFHL (adjusted odds ratio, 0.93; 95% confidence interval [CI], 0.87-0.99 for n - 3 PUFAs; and 0.90; 95% CI, 0.81-0.99 for n - 6 PUFAs). RCS analyses demonstrated a linear inverse dose-response relationship (all P for nonlinearity > 0.05). Subgroup and sensitivity analyses generally supported the robustness of these associations; no significant interactions were observed for n - 3 PUFAs. For n - 6 PUFAs, a significant interaction was detected in the race/ethnicity subgroup (interaction P < .001), whereas interactions were not significant in other subgroups. Dietary n - 3 and n - 6 PUFA intake and HFHL among adults in the United States aged 30-69 years were negatively associated. This finding could have significant implications for further research on modifying dietary patterns to address HFHL.

尽管多不饱和脂肪酸(PUFAs)被认为对人类健康有益,但关于其与高频听力损失(HFHL)之间关系的证据仍然有限。本研究旨在探讨膳食中n - 3和n - 6 PUFA的摄入量、膳食中n - 6/n - 3 PUFA比例与HFHL之间的关系。在本横断面研究中,数据来自2011 - 2012年和2015 - 2016年两个周期的国家健康与营养检查调查。采用多变量logistic回归模型评估膳食n - 3和n - 6 PUFA摄入量以及膳食n - 6/n - 3 PUFA比例与HFHL的关系。采用限制性三次样条(RCS)分析评价潜在的剂量-反应关系。进行分层和敏感性分析以评估研究结果的稳健性。共纳入6454名30 ~ 69岁的成年人(平均[标准差年龄,49.2[11.4]岁,50.9%为女性),其中44.7%患有HFHL。经过全面调整后,较高的膳食摄入n - 3和n - 6 PUFAs与HFHL的发生率较低相关(调整后的优势比为0.93;n - 3 PUFAs的95%可信区间[CI]为0.87-0.99;n - 6 PUFAs的95%可信区间为0.90;0.81-0.99)。RCS分析显示,剂量-反应呈线性反比关系(非线性均为P < 0.05)。亚组和敏感性分析通常支持这些关联的稳健性;n - 3 PUFAs未观察到显著的相互作用。对于n - 6 pufa,在种族/民族亚组中检测到显著的相互作用(相互作用P
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引用次数: 0
Association of preoperative frailty and prognostic nutritional index with postoperative delirium in elderly gastric cancer patients: A single-center observational study. 老年胃癌患者术前虚弱和预后营养指数与术后谵妄的关系:一项单中心观察研究。
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047826
Dongxu Sun, Jinguang Zhang, Zhilin Chen, Junmei Zhao, Jianlei Ge, Rui Liu

gastric cancer (GC) is a common malignancy in the elderly, and postoperative delirium (POD) is one of its significant complications, severely affecting postoperative recovery and quality of life. This study aims to explore the association of preoperative Modified Frailty Index (mFI)-assessed frailty and Prognostic Nutritional Index (PNI) with POD in elderly GC patients. A total of 164 elderly GC surgery patients were included in this study. Frailty was assessed using mFI, and PNI was calculated based on serum albumin levels and peripheral blood lymphocyte count. Multivariable logistic regression analysis was used to evaluate the association of frailty and PNI with POD, and the accuracy of both in predicting POD was analyzed using receiver operating characteristic curves. Additionally, the nonlinear relationship between PNI and POD was assessed using restricted cubic splines. Compared with the non-POD group, the POD group had older age, higher proportions of frailty (mFI ≥3), alcohol consumption history, intraoperative blood loss (≥200 mL), and longer surgical duration (≥3 hours). Furthermore, the levels of albumin, hemoglobin, lymphocytes, and PNI were lower in the POD group. In multivariable logistic regression analysis, frail patients had a 4.660 times higher risk of POD (P = .003), and for every 1 standard deviation increase in PNI, the risk of POD decreased by 36.2% (P <.001). The relationship between PNI and POD exhibited a significant nonlinear association (P = .004). The area under the curve of PNI was 0.884, which was superior to that of frailty (0.694, P <.001). Frailty and PNI are important predictive factors for POD in elderly GC patients.

胃癌(GC)是老年人常见的恶性肿瘤,术后谵妄(POD)是其重要并发症之一,严重影响术后恢复和生活质量。本研究旨在探讨术前改良衰弱指数(mFI)评估的衰弱和预后营养指数(PNI)与老年GC患者POD的关系。本研究共纳入164例老年GC手术患者。用mFI评估虚弱程度,根据血清白蛋白水平和外周血淋巴细胞计数计算PNI。采用多变量logistic回归分析评估虚弱和PNI与POD的相关性,并利用受试者工作特征曲线分析两者预测POD的准确性。此外,PNI和POD之间的非线性关系被评估使用限制三次样条。与非POD组相比,POD组年龄更大、虚弱比例(mFI≥3)、有饮酒史、术中出血量(≥200 mL)、手术时间更长(≥3小时)。此外,POD组白蛋白、血红蛋白、淋巴细胞和PNI水平均较低。在多变量logistic回归分析中,体弱患者发生POD的风险高出4.660倍(P =。PNI每增加1个标准差,POD的风险降低36.2% (P
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引用次数: 0
Evaluation of the usability of YouTube videos as educational materials in improving patients' metered dose inhaler use skills: A cross-sectional study. 评价YouTube视频作为教育材料在提高患者计量吸入器使用技能方面的可用性:一项横断面研究。
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047786
Canan Arslan, Hicran Yildiz

This study aimed to analyze the quality, reliability, and content of YouTube videos related to the use technique of metered dose inhalers (MDIs). Considering the increasing use of digital platforms for health education, it is important to evaluate the accuracy and educational value of such online resources. This descriptive and cross-sectional study evaluated 377 YouTube videos retrieved through a systematic search. The video selection process was monitored using the PRISMA flow diagram according to predefined inclusion and exclusion criteria. The videos' content, quality, and reliability were assessed using the Modified DISCERN tool, Global Quality Scale, Patient Education Materials Assessment Tool, and a checklist containing MDI use steps. Statistical analyses were conducted to determine associations between evaluation scores and video characteristics. A total of 12 YouTube videos on MDI use were analyzed. Of these, 33.3% were uploaded in 2022, and 66.7% were produced by associations or unions in the health sector. The mean interaction index was 0.53 ± 0.32, and the Video Power Index was 0.08 ± 0.15. The mean reliability level of the videos was 2.91 ± 0.75, quality level 4.16 ± 0.76, understandability level 80.83 ± 18.75, actionability level 81.66 ± 18.16, information level 77.00 ± 15.06, and information accuracy level 76.25 ± 15.80. YouTube videos on MDI use were largely adequate in terms of content but demonstrated some deficiencies in reliability. It is recommended that digital health information be produced under professional supervision and in collaboration with health authorities to ensure accuracy and trustworthiness.

本研究旨在分析与计量吸入器(MDIs)使用技术相关的YouTube视频的质量、可靠性和内容。考虑到越来越多地使用数字平台进行健康教育,评估此类在线资源的准确性和教育价值非常重要。这项描述性和横断面研究评估了通过系统搜索检索到的377个YouTube视频。使用PRISMA流程图根据预定义的纳入和排除标准监控视频选择过程。使用改进的DISCERN工具、全球质量量表、患者教育材料评估工具和包含MDI使用步骤的检查表对视频的内容、质量和可靠性进行评估。进行统计分析以确定评价分数与视频特征之间的关联。总共分析了12个有关MDI使用的YouTube视频。其中,33.3%是在2022年上传的,66.7%是由卫生部门的协会或工会制作的。平均相互作用指数为0.53±0.32,视像功率指数为0.08±0.15。视频的平均信度水平为2.91±0.75,质量水平为4.16±0.76,可理解性水平为80.83±18.75,可操作性水平为81.66±18.16,信息水平为77.00±15.06,信息准确性水平为76.25±15.80。关于MDI使用的YouTube视频在内容方面基本上是足够的,但在可靠性方面显示出一些不足。建议在专业监督下并与卫生当局合作制作数字卫生信息,以确保准确性和可信度。
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引用次数: 0
Temporal trends in mortality from pneumonia and obstructive sleep apnea in the United States (1999-2020): Insights from CDC WONDER. 美国肺炎和阻塞性睡眠呼吸暂停死亡率的时间趋势(1999-2020):来自CDC WONDER的见解
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047827
Khawar Ali, Muhammad Talha, Muhammad Abdullah Mohsin, Syed Muhammad Salman Hassan, Kashf Younas, Zainab Kalsoom, Muhammad Ali, Muddassir Khalid

Pneumonia is a significant cause of mortality in the United States. In the same way, obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder that can disrupt the normal respiratory function through intermittent hypoxia, systemic inflammation, and impaired airway clearance. Data suggest that OSA may increase the chances of having pneumonia and can make the outcomes worse. To describe temporal trends and demographic patterns in mortality among US adults with pneumonia and coexisting OSA from 1999 to 2020. We performed a retrospective analysis by population using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research multiple-cause-of-death database from 1999 to 2020. Pneumonia deaths were identified by International Classification of Diseases, Tenth Revision codes J09-J18, and OSA by International Classification of Diseases, Tenth Revision code G47.3. We have calculated age-adjusted mortality rates (AAMR) per 100,000 population. Joinpoint Regression Software was used to estimate annual percent change and average annual percent change with confidence intervals of 95%. This study complies with the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. A total of 13,496 deaths from pneumonia and OSA in US adults aged ≥ 25 were identified during this study period-males exhibited higher mortality than females (AAMR: 0.38 vs 0.21). The total deaths in males were 8046, consisting 59.63% of the overall total deaths, while total deaths in females were 5450, consisting 40.38% of the overall total deaths. The AAMR rose from 0.09 in 1999 to 0.86 in 2020 (average annual percent change: 7.3307%, 95% confidence interval: 3.93-10.84). Between 1999 and 2020, mortality related to pneumonia among the patients with OSA increased significantly in the US, with significant demographic and geographic variations. There was a significant increase in death in male population 2018 onwards. These findings emphasize the need for better screening and management of OSA in populations that are at risk for pneumonia.

在美国,肺炎是导致死亡的一个重要原因。同样,阻塞性睡眠呼吸暂停(OSA)是一种常见的与睡眠有关的呼吸障碍,它可以通过间歇性缺氧、全身性炎症和气道清除受损来破坏正常的呼吸功能。数据显示,阻塞性睡眠呼吸暂停可能会增加患肺炎的机会,并可能使结果更糟。描述1999年至2020年美国成人肺炎合并阻塞性睡眠呼吸暂停患者死亡率的时间趋势和人口统计学模式。我们使用疾病控制和预防中心广泛的流行病学研究多死因在线数据数据库,从1999年到2020年对人群进行了回顾性分析。肺炎死亡由《国际疾病分类》第十次修订代码J09-J18确定,OSA由《国际疾病分类》第十次修订代码G47.3确定。我们计算了每10万人的年龄调整死亡率。使用Joinpoint回归软件估计年变化百分比和平均年变化百分比,置信区间为95%。本研究符合《加强流行病学观察性研究报告指南》。在这项研究期间,美国年龄≥25岁的成年人中,共有13496人死于肺炎和OSA,男性的死亡率高于女性(AAMR: 0.38 vs 0.21)。男性总死亡人数为8046人,占总死亡人数的59.63%;女性总死亡人数为5450人,占总死亡人数的40.38%。AAMR从1999年的0.09上升到2020年的0.86(年均变化百分比为7.3307%,95%可信区间为3.93 ~ 10.84)。1999年至2020年间,美国OSA患者肺炎相关死亡率显著上升,且存在显著的人口统计学和地理差异。2018年以来,男性人口的死亡率显著增加。这些发现强调了在肺炎风险人群中更好地筛查和管理阻塞性睡眠呼吸暂停的必要性。
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引用次数: 0
Clinical application of acupuncture myofascial trigger points in the treatment of postherpetic neuralgia and analysis of influencing factors. 针刺肌筋膜触发点治疗带状疱疹后神经痛的临床应用及影响因素分析。
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047783
Haixia Bi, Chengcai Luo, Binbin Bu

To evaluate the therapeutic efficacy of myofascial trigger point acupuncture combined with gabapentinoids compared with gabapentinoid therapy alone in patients with postherpetic neuralgia, and to identify clinical factors influencing treatment response. A total of 494 patients with postherpetic neuralgia were randomly assigned to receive either gabapentinoids alone (control group, n = 247) or combined myofascial trigger point acupuncture and gabapentinoids (experimental group, n = 247). Pain intensity was assessed using the Numerical Rating Scale (NRS) at baseline, week 3, and week 6, and changes from baseline (ΔNRS) were calculated to reflect short-term pain improvement. Regression analyses were performed to identify prognostic factors associated with the magnitude of pain reduction rather than to estimate causal treatment effects. Both groups improved significantly, but the experimental group showed greater pain reduction at week 3 and week 6 (P < .001). Multivariate analysis revealed that older age and higher body mass index were independently associated with poorer treatment response at both time points, while pain location was associated with variability in pain reduction at week 6 (patients with thoracic [chest/back] pain showed the greatest improvement). Myofascial trigger point acupuncture combined with gabapentinoids may provide additional short-term pain relief compared with pharmacological therapy alone, with thoracic pain showing the most favorable response; however, baseline imbalance and the absence of sham control limit causal inference. Age and body mass index were associated with poorer efficacy, highlighting the need for individualized strategies. Longer-term randomized trials, including an acupuncture-only arm and multidimensional pain assessments, are warranted to confirm and extend these findings.

评价肌筋膜触发点针刺联合加巴喷丁类与单独加巴喷丁类治疗带状疱疹后神经痛的疗效,并探讨影响治疗效果的临床因素。494例带状疱疹后神经痛患者随机分为单纯加巴喷丁类药物治疗组(对照组,n = 247)和肌筋膜触发点针刺联合加巴喷丁类药物治疗组(实验组,n = 247)。在基线、第3周和第6周使用数值评定量表(NRS)评估疼痛强度,并计算基线变化(ΔNRS)以反映短期疼痛改善。进行回归分析以确定与疼痛减轻程度相关的预后因素,而不是评估因果治疗效果。两组均有明显改善,但实验组在第3周和第6周疼痛减轻幅度更大(P
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引用次数: 0
Red blood cell distribution width/albumin ratio (RAR): A novel predictor of retinal vein occlusion in the Turkish population (STROBE). 红细胞分布宽度/白蛋白比(RAR):一个新的预测视网膜静脉闭塞在土耳其人口(STROBE)。
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047804
Mustafa Yildirim, Mert Bilgili, Kamber Kaşali, Büşra Medetoğlu, Elif Temur

The purpose of this study was to assess how the red cell distribution width (RDW)-albumin ratio (RAR), an indicator of nutrition, oxidative stress, and inflammation, relates to the severity of retinal vein occlusion (RVO). 55 patients with RVO who presented to the Ophthalmology Polyclinic of Atatürk University Research Hospital between January 2025 and April 2025 and 30 healthy controls were evaluated. While 37 of the patient group had branch RVO (BRVO), 18 had central RVO (CRVO). Fundus fluorescein angiography was used to differentiate between ischemic and non-ischemic retinal vein occlusion in the patient group. All patients underwent comprehensive physical examinations, which included a thorough medical history and laboratory assessments such as complete blood count parameters, hemogram, RDW, and serum albumin levels. When the demographic and biochemical characteristics of the participants were compared by gender, no statistically significant differences were found between the groups. Similarly, although albumin levels and the RDW/albumin ratio (RAR) showed differences between the groups, these differences were not statistically significant (P = .108 and P = .109, respectively). RDW-CV values showed a statistically significant difference between the groups (P = .006). It was observed that RDW-CV values were significantly higher in the ischemic occlusion group. Although albumin levels differed between the groups, this difference was not statistically significant (P = .118). However, a significant difference in the RDW/albumin ratio (RAR) was observed between the groups (P = .016). This difference was found to be due to the comparison between the control group and the ischemic occlusion group, where RAR values were higher in the ischemic group. RAR demonstrates a significant association with RVO and offers a simple, cost-effective, safe, and readily available laboratory marker for assessing RVO severity. It can be considered that especially ischemic type RVO may be associated with high RAR level.

本研究的目的是评估红细胞分布宽度(RDW)-白蛋白比(RAR)(营养、氧化应激和炎症的指标)与视网膜静脉闭塞(RVO)严重程度的关系。研究评估了2025年1月至2025年4月期间在atatatrk大学研究医院眼科综合诊所就诊的55例RVO患者和30名健康对照者。其中分支RVO (BRVO) 37例,中枢性RVO (CRVO) 18例。眼底荧光素血管造影用于区分患者组缺血性和非缺血性视网膜静脉闭塞。所有患者都进行了全面的体格检查,包括全面的病史和实验室评估,如全血细胞计数参数、血象、RDW和血清白蛋白水平。当按性别比较参与者的人口学和生化特征时,组间没有发现统计学上的显著差异。同样,尽管白蛋白水平和RDW/白蛋白比(RAR)在两组之间存在差异,但这些差异无统计学意义(P =。108, P =。109年,分别)。RDW-CV值组间差异有统计学意义(P = 0.006)。观察到缺血闭塞组RDW-CV值明显升高。尽管两组间白蛋白水平存在差异,但差异无统计学意义(P = 0.118)。然而,两组之间的RDW/白蛋白比率(RAR)差异有统计学意义(P = 0.016)。发现这一差异是由于对照组和缺血性闭塞组的比较,缺血性闭塞组的RAR值更高。RAR显示与RVO有显著关联,为评估RVO严重程度提供了一种简单、经济、安全且易于获得的实验室标记物。可以认为,特别是缺血性RVO可能与高RAR水平有关。
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引用次数: 0
Causal association between rheumatoid arthritis and interstitial lung disease: A two-sample bidirectional Mendelian randomization study. 类风湿关节炎和间质性肺疾病之间的因果关系:一项双样本双向孟德尔随机研究
IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-20 DOI: 10.1097/MD.0000000000047542
Jinxiang Peng, Haozhu Chen, Jinmei Tan, Zhuang Chen, Feng Wu

Epidemiological observations suggest a potential causal relationship between rheumatoid arthritis (RA) and interstitial lung disease (ILD), and vice versa. Alternatively, this association could be due to simple co-occurrence of RA and ILD resulting from shared population genetic or environmental risk factors. However, the causal nature of this relationship remains uncertain. This study aims to investigate the genetic causality between RA and ILD. Two-sample bidirectional Mendelian randomization (MR) was employed to test the causal effects of RA on ILD and ILD on RA, utilizing genome-wide association studies for ILD and RA. Data statistics were collected from public data sets. Relevant single nucleotide polymorphisms were selected through quality control steps in the meta-analysis results of genome-wide association studies. Two-sample bidirectional MR analysis was conducted to assess the causal relationship between the 2 conditions. The main MR analyses utilized methods such as inverse variance weighting, weighted median, and MR-Egger regression. Sensitivity analyses, including MR-Egger, leave-one-out, MR pleiotropy tests, and heterogeneity tests, were performed to evaluate heterogeneity and pleiotropy. In the European population, the risk of ILD was found to be increased by RA (odds ratio = 1.272, 95% confidence interval: 1.186-1.363, P < .001). Conversely, ILD was associated with an increased risk of RA (odds ratio = 1.111, 95% confidence interval: 1.008-1.223, P = .033). These findings highlight a potential genetic link between rheumatoid arthritis and interstitial lung disease and may inform future research regarding potential screening strategies in genetically susceptible individuals.

流行病学观察表明类风湿关节炎(RA)和间质性肺疾病(ILD)之间存在潜在的因果关系,反之亦然。或者,这种关联可能是由于共同的群体遗传或环境风险因素导致RA和ILD的简单共同发生。然而,这种关系的因果性质仍然不确定。本研究旨在探讨类风湿关节炎与ILD之间的遗传因果关系。采用双样本双向孟德尔随机化(MR),利用ILD和RA的全基因组关联研究,检验RA对ILD和ILD对RA的因果关系。数据统计从公共数据集中收集。在全基因组关联研究的meta分析结果中,通过质量控制步骤选择相关的单核苷酸多态性。进行双样本双向磁共振分析,以评估两种情况之间的因果关系。主要的MR分析采用了方差反加权、加权中位数和MR- egger回归等方法。敏感性分析,包括MR- egger、留一检验、MR多效性检验和异质性检验,用于评估异质性和多效性。在欧洲人群中,发现RA增加了ILD的风险(优势比= 1.272,95%可信区间:1.186-1.363,P
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