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Immediate Versus Delayed Grafting: Re-Evaluating Graft Timing in Microsurgical Reconstruction 即刻与延迟移植:显微外科重建中移植时机的再评估
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-08-12 DOI: 10.1002/micr.70105
Georgios Karamitros, William C. Lineaweaver
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引用次数: 0
Optimizing Fingertip Reconstruction: A Comparative Analysis of Reverse Homodigital Island and Digital Artery Perforator Flaps 优化指尖重建:反向同指岛皮瓣与指动脉穿支皮瓣的对比分析
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-08-01 DOI: 10.1002/micr.70101
Yusuke Miyashima, Hiroyuki Gotani, Mitsuhiro Okada, Yoshitaka Tanaka, Hirohisa Yagi, Kosuke Saito, Kotaro Okamoto, Hidetomi Terai

Background

Fingertip amputations are a common form of hand trauma and often require soft tissue reconstruction when replantation is not feasible. The reverse homodigital island flap (RHI) and the digital artery perforator flap (DAP) are two widely used techniques for fingertip reconstruction; however, direct comparisons of their clinical outcomes remain limited.

Methods

This retrospective study analyzed 39 patients who underwent either RHI (n = 20) or DAP (n = 19) procedures for fingertip injuries. Patients with thumb injuries, multiple finger injuries, or insufficient follow-up data were excluded. Postoperative management included flap monitoring, limb elevation, and early rehabilitation. Outcomes assessed included flap survival, operative time, hospital stay, functional recovery, and complications such as flap congestion, necrosis, and nail deformities.

Results

No significant differences were found in baseline characteristics or affected digits. The RHI group mainly involved Ishikawa subzone II injuries with avulsion patterns, while the DAP group had predominantly subzone I crush injuries. Distal phalanx bone defect length was comparable between groups. Both RHI and DAP demonstrated high flap survival rates, with no cases of major necrosis. The mean operative time was significantly shorter in the DAP group (68 min) compared to the RHI group (101 min, p < 0.001). Similarly, the hospital stay was shorter in the DAP group (13 days) than in the RHI group (18 days, p < 0.05). While both flaps achieved good functional and sensory recovery, the DAP group exhibited a lower secondary procedure rate (21.1%) compared to the RHI group (70%, p < 0.002). However, nail deformities, particularly claw deformities, were more frequently observed in the DAP group (47.4%).

Conclusion

The DAP flap offers a shorter operative time, faster recovery, and a lower secondary procedure rate, making it a preferable option for functional reconstruction. In contrast, although the RHI flap requires a longer treatment period, it may provide superior esthetic outcomes.

指尖截肢是手部创伤的常见形式,当再植不可行时,通常需要软组织重建。逆行同指岛状皮瓣(RHI)和指动脉穿支皮瓣(DAP)是目前广泛应用于指端重建的两种技术。然而,对其临床结果的直接比较仍然有限。方法回顾性分析39例接受RHI (n = 20)或DAP (n = 19)手术治疗指尖损伤的患者。排除拇指损伤、多指损伤或随访资料不足的患者。术后处理包括皮瓣监测、肢体抬高和早期康复。评估的结果包括皮瓣存活、手术时间、住院时间、功能恢复和并发症,如皮瓣充血、坏死和指甲畸形。结果两组患者的基线特征及患指无明显差异。RHI组以石川II亚区损伤为主,伴有撕脱伤,DAP组以I亚区挤压伤为主。组间远端指骨缺损长度具有可比性。RHI和DAP均表现出较高的皮瓣存活率,无大坏死病例。DAP组的平均手术时间(68分钟)明显短于RHI组(101分钟,p < 0.001)。同样,DAP组的住院时间(13天)短于RHI组(18天,p < 0.05)。虽然两个皮瓣都获得了良好的功能和感觉恢复,但与RHI组(70%,p < 0.002)相比,DAP组的二次手术率(21.1%)较低。然而,在DAP组中,指甲畸形,尤其是爪畸形更为常见(47.4%)。结论DAP皮瓣手术时间短,恢复快,二次手术率低,是功能重建的较好选择。相比之下,虽然RHI皮瓣需要更长的治疗时间,但它可以提供更好的美学效果。
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引用次数: 0
Machine Learning-Based Flap Takeback Prediction Modeling: Theory for a Real-Time, Patient-Specific Postoperative Flap Monitoring and Alert System 基于机器学习的皮瓣回收预测模型:一个实时的、患者特异性的术后皮瓣监测和警报系统的理论
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-07-31 DOI: 10.1002/micr.70100
Olachi O. Oleru, Kim-Anh-Nhi Nguyen, Peter Taub, Arash Kia

Background

Postoperative free flap monitoring is crucial yet taxing, requiring frequent and often subjective assessments to detect early signs of compromise. The present study aims to develop a machine learning model to predict the risk of flap take-back reoperation due to arterial and/or venous compromise, as a basis for real-time risk monitoring and alerts.

Methods

This retrospective cohort study utilized patient data from a New York City hospital system from 2019 to 2024. Adult patients undergoing free flap reconstruction were included. Data from electronic medical records (EMRs) included demographic and clinical variables. The primary outcome was flap takeback, defined as urgent or emergent microvascular exploration or revision surgery during the same admission. A random forest model was developed and trained on the data with oversampling to balance the training set. Model performance was evaluated using AUROC, sensitivity, specificity, accuracy, and precision.

Results

The study included 458 patient encounters, with a flap takeback rate of 6.1%. The final model achieved a train AUROC of 0.99 and a test AUROC of 0.86. Sensitivity and specificity on the test set were 75% and 78%, respectively, with 78% accuracy. Key predictors included skin integrity, pulse, and diastolic blood pressure.

Conclusions

The machine learning model accurately predicts free flap takeback, offering a proactive approach to postoperative monitoring. Integrating this model into EMR platforms can provide real-time early warning systems (EWS), enhancing early detection and intervention for flap compromise. Future research should validate the model across diverse settings.

术后游离皮瓣监测是至关重要的,但也很费力,需要经常进行主观评估,以发现早期损伤的迹象。本研究旨在开发一种机器学习模型,以预测由于动脉和/或静脉妥协而导致皮瓣收回再手术的风险,作为实时风险监测和警报的基础。方法本回顾性队列研究利用2019年至2024年纽约市医院系统的患者数据。包括接受游离皮瓣重建的成年患者。来自电子病历(emr)的数据包括人口统计学和临床变量。主要结局是皮瓣收回,定义为同一入院期间紧急或紧急微血管探查或翻修手术。建立了一个随机森林模型,并在过采样数据上进行训练,以平衡训练集。采用AUROC、敏感性、特异性、准确性和精密度评估模型性能。结果共纳入458例患者,皮瓣回收率为6.1%。最终模型的训练AUROC为0.99,测试AUROC为0.86。检测集的敏感性和特异性分别为75%和78%,准确率为78%。关键的预测指标包括皮肤完整性、脉搏和舒张压。结论机器学习模型能准确预测游离皮瓣的恢复,为术后监测提供了积极的方法。将该模型集成到EMR平台中,可以提供实时预警系统(EWS),提高襟翼受损的早期发现和干预能力。未来的研究应该在不同的环境下验证这个模型。
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引用次数: 0
Free Chain-Linked Fillet Flaps From a Contralateral Chopart Amputation for Reconstruction of an Extensive Lower Extremity Defect: A Case Report and Literature Review 游离链链带瓣对侧截肢重建大面积下肢缺损1例报告及文献复习
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-07-31 DOI: 10.1002/micr.70102
Keisuke Shimbo, Yuki Aoki, Tatsuhiko Saiki

Free fillet flap reconstruction transfers composite tissue from an unsalvageable limb to repair a separate defect. We report a case of free fillet flaps based on the posterior tibial artery (PTA) and anterior tibial artery (ATA). A 41-year-old man was crushed under a truck; his right leg suffered an open tibia and fibula fracture (Gustilo IIIB) with extensive soft tissue loss, while his left foot was amputated at the tarsal level. He initially underwent Chopart-level amputation of the left limb, which was subsequently revised to a below-knee amputation. Two free fillet flaps were harvested from the amputated limb: one based on the PTA (15 × 13 cm) and the other based on the ATA (20 × 8 cm). Two chain-linked fillet flaps via flow-through anastomosis were used to cover the soft tissue defect exposing the right tibia. Postoperatively, partial necrosis occurred in the ATA-based fillet flap, which healed after reoperation. The patient regained mobility with a prosthesis. Free chain-linked fillet flaps harvested from a limited amputation segment are a feasible and useful option for reconstructing complex soft tissue defects without additional donor site morbidity.

游离片瓣重建将复合组织从无法修复的肢体转移到修复单独的缺陷。我们报告一例基于胫骨后动脉(PTA)和胫骨前动脉(ATA)的游离腓骨瓣。一名41岁的男子被一辆卡车压死;右腿胫骨和腓骨开放性骨折(Gustilo IIIB),伴有大面积软组织丢失,左脚跗骨水平截肢。患者最初接受左下肢肖邦级截肢,随后改为膝以下截肢。从断肢上取下2个游离片状皮瓣:一个基于PTA (15 × 13 cm),另一个基于ATA (20 × 8 cm)。采用两条链链吻合的鱼片瓣覆盖暴露右侧胫骨的软组织缺损。术后,以ata为基础的骨片瓣出现部分坏死,再手术后愈合。病人用假体恢复了活动能力。从有限的截肢节段中获取的游离链连接片瓣是重建复杂软组织缺损的可行和有用的选择,而不会增加供体部位的发病率。
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引用次数: 0
Fasciocutaneous Vascularized Lymph Node Transfer for Head and Neck Lymphedema: A Case Report 筋膜皮带血管化淋巴结转移治疗头颈部淋巴水肿1例报告
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-07-30 DOI: 10.1002/micr.70098
Hamzah Almadani, Hosung Rhyu, Andrew Cantor, Philip S. Brazio

Head and neck lymphedema is a common complication of head and neck cancer treatment. Lymphovenous bypass is a promising surgical treatment but may not be an option for all patients after radiotherapy due to the obliteration of local lymphatic targets for bypass. We aim to present vascularized lymph node transfer (VLNT) as a solution to this problem. We report the case of a 38-year-old patient with Stage 2 face and neck lymphedema after treatment for T4aN1oral squamous cell carcinoma, who had no targets for lymphovenous bypass. The patient was treated with a 6 by 14 cm fasciocutaneous VLNT based on the left superficial circumflex iliac artery and vein, to the right facial vein and facial artery. The patient was given a low-dose heparin infusion, placed in a head bolster to prevent neck rotation, and discharged with low-dose aspirin. 4.5 months after free flap reconstruction, the patient underwent revision of the flap including indocyanine green lymphatic mapping, thinning with lymph-sparing liposuction, and re-advancement with Z-plasty for contour. At 11 months, the patient experienced a reduction of swelling, improvement of symptoms, and no further need for compression and manual lymphatic drainage. The area of greatest mobility impairment was resurfaced with flap skin, improving subjective tightness. Indocyanine green imaging at 4 months and 11 months revealed linear lymphatics traversing from the facial skin into the flap. Facial dermal thickness on ultrasound decreased from 1.43 to 1.09 mm between 4 and 11 months postoperatively. Fasciocutaneous VLNT has the potential to restore lymphatic drainage, improving swelling and tightness for patients with head and neck lymphedema who do not have lymphatic targets for bypass. Future studies on head and neck lymphedema should routinely employ ultrasound measurement of dermal thickness as an objective measure.

头颈部淋巴水肿是头颈部肿瘤治疗的常见并发症。淋巴静脉旁路是一种很有前途的手术治疗方法,但可能不是所有放疗后的患者都可以选择,因为旁路治疗会阻塞局部淋巴目标。我们的目的是提出血管化淋巴结转移(VLNT)作为解决这个问题的方法。我们报告一例38岁的患者,在接受t4an1口腔鳞状细胞癌治疗后出现2期面部和颈部淋巴水肿,没有淋巴静脉旁路治疗的目标。患者行6 × 14 cm筋膜皮VLNT,以左旋髂浅动脉和静脉为基础,至右面静脉和面动脉。患者给予低剂量肝素输注,放置在头枕中以防止颈部旋转,出院时给予低剂量阿司匹林。游离皮瓣重建4.5个月后,患者对皮瓣进行翻修,包括吲哚菁绿淋巴标图,保留淋巴吸脂减薄,z形成形术进行轮廓再推进。11个月时,患者肿胀减轻,症状改善,不再需要按压和手动淋巴引流。活动障碍最大的区域用皮瓣皮肤重铺,改善主观松紧度。4个月和11个月的吲哚菁绿成像显示线性淋巴管从面部皮肤进入皮瓣。术后4 ~ 11个月,超声显示面部真皮厚度由1.43 mm降至1.09 mm。筋膜皮VLNT有可能恢复淋巴引流,改善头颈部淋巴水肿患者的肿胀和紧致,这些患者没有淋巴旁路目标。未来头颈部淋巴水肿的研究应常规采用超声测量皮肤厚度作为客观测量。
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引用次数: 0
Segmental Cylindrical Gracilis Free Flap for Dead Space Obliteration in Chronic Midfoot Osteomyelitis Secondary to Ballistic Injury: A Case Report 节段性圆柱股薄肌游离皮瓣治疗弹道伤继发慢性足中部骨髓炎1例
IF 1.5 3区 医学 Q3 SURGERY Pub Date : 2025-07-27 DOI: 10.1002/micr.70097
Erkan Sabri Ertaş

Chronic osteomyelitis of the midfoot, particularly following high-energy trauma such as a landmine injury, presents a formidable challenge due to the region's limited soft tissue envelope, complex anatomy, and the critical need for effective and durable dead space obliteration. While various flap options have been described, there remains no consensus on the optimal approach for managing deep defects in the midfoot, especially in cases complicated by prior surgical procedures. We present the case of a 23-year-old male who developed chronic midfoot osteomyelitis following a landmine explosion. Despite multiple debridements, targeted antibiotic therapy, and initial soft tissue coverage with an anterolateral thigh (ALT) flap, a persistent 6 × 5 cm (30 cm3) dead space remained, consistent with a Cierny–Mader type III-A classification. A segmentally harvested gracilis muscle flap was designed and sculpted to conform to the dimensions of the cavity, then inset into the defect. Microvascular end-to-side anastomosis was performed to the anterior tibial artery and two accompanying veins, and the flap was covered with a split-thickness skin graft. The postoperative course was uneventful at the recipient site. Mild serous drainage from the donor site, attributed to fat necrosis, resolved completely with conservative elastic compression therapy. At 12-month follow-up, the patient remained infection-free, was fully ambulatory without assistance, and imaging confirmed complete obliteration of the dead space. This case suggests that a segmentally harvested gracilis muscle flap may offer a viable, anatomically conforming single-stage option for managing complex midfoot osteomyelitis in selected patients. In individuals with prior treatment failure, this approach may help reduce surgical burden, enhance infection control, and support not only physical but also psychological recovery through resolution of a prolonged disease course.

由于足中部软组织包膜有限,解剖结构复杂,并且迫切需要有效和持久的死区清除,因此慢性骨髓炎,特别是在高能创伤(如地雷伤害)之后,提出了一个巨大的挑战。虽然已经描述了各种皮瓣的选择,但对于处理足中部深度缺损的最佳方法仍然没有共识,特别是在先前外科手术复杂的情况下。我们提出的情况下,一个23岁的男性谁发展慢性足中部骨髓炎后地雷爆炸。尽管进行了多次清创,靶向抗生素治疗,并初步用大腿前外侧(ALT)皮瓣覆盖软组织,但仍存在持续的6 × 5 cm (30 cm3)死腔,符合cierney - mader III-A型分类。设计并雕刻出符合腔体尺寸的节段性股薄肌瓣,然后插入缺损。对胫骨前动脉及两条伴行静脉端侧吻合,皮瓣上覆盖裂厚皮片。术后过程在受体部位平安无事。由脂肪坏死引起的供体部位轻度浆液性引流,经保守弹性压迫治疗完全解决。在12个月的随访中,患者无感染,无需辅助即可完全走动,影像学证实死腔完全闭塞。本病例提示节段性股薄肌瓣可为特定患者治疗复杂的足中骨髓炎提供可行的、符合解剖结构的单阶段选择。对于先前治疗失败的个体,这种方法可以帮助减轻手术负担,加强感染控制,并通过解决延长的疾病过程,不仅支持身体恢复,也支持心理恢复。
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引用次数: 0
Outcomes of Parascapular Free Flap in Reconstructive Microsurgery: A Systematic Review and Meta-Analysis 肩胛旁游离皮瓣在显微外科重建中的效果:系统回顾和荟萃分析
IF 1.5 3区 医学 Q3 SURGERY Pub Date : 2025-07-25 DOI: 10.1002/micr.70099
Agustin N. Posso, Audrey Mustoe, Maria J. Escobar-Domingo, Charlotte Thomas, Jade E. Smith, Jose Foppiani, Dorien I. Schonebaum, Noelle Garbaccio, Samuel J. Lin, Bernard T. Lee

Introduction

The parascapular free flap (PFF), primarily harvested as a fasciocutaneous flap, is perfused by the parascapular branch of the circumflex scapular artery. Its anatomy enables modification and combination with other flaps. However, its use in reconstructive microsurgery has not been comprehensively characterized. This systematic review and meta-analysis aim to assess the key features and outcomes of the PFF.

Methods

The study protocol followed the PRISMA guidelines. Multiple online databases were used to identify articles published through 2024. Studies including patients who underwent PFF procedures were eligible. A two-stage screening process was conducted for study selection. Data extraction focused on the primary outcome (failure rate), secondary outcomes (other complications), and additional information. An analysis of pooled data was performed to evaluate rates of complications.

Results

Eighty-four articles were included in this review. A total of 647 patients and 664 PFFs were identified; among these, 57.38% were harvested solely as PFFs, while 42.62% involved combinations with other free flaps. The predominant recipient site was the head and neck, accounting for 72.52% of cases. The leading indications were malignancy (28.64%), post-burn scarring (17.35%), and trauma (13.26%). Meta-analysis of the primary outcome revealed no heterogeneity across the studies (I2 = 0.00%; Q statistic 17.50, p = 0.56), with a pooled failure rate of 0.99% (95% CI: 0%–2.63%). Other complication rates included partial necrosis (2.09%, 95% CI: 0%–5.45%), hematoma (5.18%, 95% CI: 1.34%–10.63%), wound dehiscence (5.98%, 95% CI: 0.38%–15.47%), infection (0.86%, 95% CI: 0.00%–3.97%), and venous thrombosis (1.57%, 95% CI: 0.00%–4.95%).

Conclusion

The PFF is a versatile and reliable option in reconstructive microsurgery, offering low failure rates and minimal complications. Its applicability across various anatomical regions and indications makes it an invaluable option for microsurgeons.

肩胛旁自由皮瓣(PFF)主要作为筋膜皮瓣,由旋肩胛动脉的肩胛旁分支灌注。它的解剖结构可以修饰和与其他皮瓣结合。然而,其在重建显微外科中的应用尚未得到全面的描述。本系统综述和荟萃分析旨在评估PFF的主要特征和结果。方法研究方案遵循PRISMA指南。多个在线数据库用于识别到2024年出版的文章。包括接受PFF手术的患者的研究是合格的。通过两阶段筛选过程进行研究选择。数据提取侧重于主要结果(失败率)、次要结果(其他并发症)和其他信息。对合并数据进行分析以评估并发症的发生率。结果共纳入84篇文献。共发现647例患者和664例pff;其中,单独作为游离皮瓣收获的占57.38%,与其他游离皮瓣组合收获的占42.62%。主要受累部位为头颈部,占72.52%。主要指征为恶性肿瘤(28.64%)、烧伤后瘢痕(17.35%)和创伤(13.26%)。对主要结局的荟萃分析显示,各研究间无异质性(I2 = 0.00%;Q统计量为17.50,p = 0.56),合并失败率为0.99% (95% CI: 0% ~ 2.63%)。其他并发症发生率包括部分坏死(2.09%,95% CI: 0% ~ 5.45%)、血肿(5.18%,95% CI: 1.34% ~ 10.63%)、创面裂开(5.98%,95% CI: 0.38% ~ 15.47%)、感染(0.86%,95% CI: 0.00% ~ 3.97%)、静脉血栓形成(1.57%,95% CI: 0.00% ~ 4.95%)。结论PFF在显微重建手术中是一种功能齐全、可靠的选择,失败率低,并发症少。它适用于各种解剖区域和适应症,使其成为显微外科医生的宝贵选择。
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引用次数: 0
Reconstruction of Bilateral Paranasal Skin and Soft Tissue Defects Using a Free Bilobed Thoracoacromial Artery Perforator Flap Following Multiple Cutaneous Squamous Cell Carcinomas Resection: A Case Report and Literature Review 双叶胸肩峰动脉穿支皮瓣重建双侧鼻旁皮肤及软组织缺损:1例报告及文献复习
IF 1.5 3区 医学 Q3 SURGERY Pub Date : 2025-07-25 DOI: 10.1002/micr.70094
Shu-qing Huang, Xin Zhou, Tong-chun Mao, Rong-shuai Yan, Xiang Li, Zhi-bin Yang, Ze-yuan Lei

In recent years, the thoracoacromial artery perforator (TAAP) flap has emerged as a promising option for the reconstruction of facial defects, typically utilized in the form of a pedicled flap. However, there remains relatively limited experience in using a free TAAP to repair facial defects. This case describes the first application of a free bilobed TAAP for one-stage reconstruction of multiple facial defects after resecting cutaneous squamous cell carcinomas (cSCC). The patient was a 76-year-old man who noticed progressive enlargement of two black neoplasms around the left and right nose for over 1 year and 3 months, respectively. A preoperative biopsy confirmed both lesions as cSCC. During surgery, two skin and soft tissue defects, measuring approximately 6.5 cm × 3.0 cm and 3.5 cm × 2.0 cm, were left in the bilateral paranasal regions after the removal of tumors. A free bilobed TAAP flap of the appropriate size was designed and harvested to repair these defects. The postoperative course was uneventful, and the patient recovered without complications. Good esthetic and functional outcomes were achieved during a 14-month follow-up period. This report suggests that a free bilobed TAAP flap may be an option for reconstructing multiple facial defects caused by trauma, tumor resection, or other lesions.

近年来,胸肩峰动脉穿支皮瓣(TAAP)已成为重建面部缺损的一种很有前途的选择,通常以带蒂皮瓣的形式使用。然而,使用游离TAAP修复面部缺损的经验仍然相对有限。本病例描述了在皮肤鳞状细胞癌(cSCC)切除后,首次应用游离双叶TAAP进行一期面部多处缺损重建。患者是一名76岁的男性,他注意到左右鼻子周围的两个黑色肿瘤进行性扩大,分别超过1年和3个月。术前活检证实两个病变为cSCC。术中在双侧鼻副区切除肿瘤后留下约6.5 cm × 3.0 cm和3.5 cm × 2.0 cm的两个皮肤软组织缺损。我们设计并收获了一个大小合适的游离双叶TAAP皮瓣来修复这些缺陷。术后过程顺利,患者恢复无并发症。在14个月的随访期间,获得了良好的美学和功能结果。本报告提示,游离双叶TAAP皮瓣可能是重建外伤、肿瘤切除或其他病变引起的面部多处缺损的一种选择。
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引用次数: 0
Tactile Sensory Recovery in Neurotized Versus Non-Neurotized Autologous Breast Reconstruction: A Systematic Review and Meta-Analysis 神经化与非神经化自体乳房重建的触觉恢复:系统回顾和荟萃分析
IF 1.5 3区 医学 Q3 SURGERY Pub Date : 2025-07-18 DOI: 10.1002/micr.70096
Alejandra Aristizábal, Harrison Herrera, Joseph M. Escandón, Pedro Ciudad, Gabriel del Corral, Rahim Nazerali, Andres Mascaro, Oscar J. Manrique

Background

Tactile sensory recovery in autologous breast reconstruction (ABR) has been shown to prevent injuries and improve quality of life. However, the studies comparing neurotized versus non-neurotized outcomes are still controversial due to methodological heterogeneity. This review uses consistent and objective outcomes to evaluate the current evidence's qualitative characteristics and quantitative tactile sensory recovery.

Methods

We conducted a systematic electronic literature search from database inception through 10 February 2024, of the following databases: PubMed, Ovid MEDLINE, Embase, SCOPUS, and CINAHL to identify all studies reporting outcomes of tactile sensory recovery using the Semmes-Weinstein Measuring scale in free-flap ABR comparing neurotization versus non-neurotization. The SWM scale score, demographic characteristics, and surgical features were extracted from each study. Due to the data heterogeneity within the studies, we transformed the data into means and pooled the qualitative information.

Results

We identified 264 articles. After thorough screening, 12 fulfilled the inclusion criteria and were included in the qualitative synthesis. Finally, 7 were quantitatively analyzed with a total of 251 breasts that underwent ABR with free flap neurotization and 244 breasts without neurotization. This revealed a mean SWM score difference of −0.67 and a significant p-value < 0.05. A subgroup DIEP flap analysis performed for 177 neurotized compared to 175 non-eurotized flaps yielded a significant mean difference of −0.86 p < 0.05. There were no significant differences between groups in age (48.8 vs. 49.8, p = 0.5), history of chemotherapy (72 vs. 74, p = 0.91), radiotherapy (61 vs. 56, p = 0.84), or follow-up time (21.85 vs. 25.09 months, p = < 0.05) that could have influenced tactile sensory recovery.

Conclusion

Neurotization in free-flap ABR could allow better tactile sensory recovery than the spontaneous sensation gained without it. The additional surgical time required for coaptation is short, and no studies have reported associated complications, making it a safe procedure that can potentially improve patients´ quality of life. Nonetheless, higher-quality studies, such as randomized control trials with standardized sensation testing and more rigorous methodologies, are needed before making final clinical recommendations.

背景自体乳房再造术(ABR)中触觉感觉恢复已被证明可以预防损伤和提高生活质量。然而,由于方法的异质性,比较神经化与非神经化结果的研究仍然存在争议。本综述使用一致和客观的结果来评估当前证据的定性特征和定量触觉感觉恢复。方法从数据库建立到2024年2月10日,我们对以下数据库进行了系统的电子文献检索:PubMed、Ovid MEDLINE、Embase、SCOPUS和CINAHL,以确定所有使用Semmes-Weinstein自由皮瓣ABR测量量表比较神经化和非神经化的触觉感觉恢复结果的研究。从每项研究中提取SWM量表评分、人口统计学特征和手术特征。由于研究中数据的异质性,我们将数据转化为均值并汇集定性信息。结果共鉴定264篇。经彻底筛选,12例符合纳入标准,纳入定性综合。最后,定量分析了7个乳房,共251个乳房进行了ABR自由皮瓣神经化和244个乳房未神经化。结果显示,SWM平均评分差异为- 0.67,p值为0.05。对177个神经化皮瓣与175个非神经化皮瓣进行亚组DIEP分析,平均差异为- 0.86 p < 0.05。年龄(48.8个月对49.8个月,p = 0.5)、化疗史(72个月对74个月,p = 0.91)、放疗史(61个月对56个月,p = 0.84)、随访时间(21.85个月对25.09个月,p = < 0.05)对触觉感觉恢复的影响均无显著差异。结论游离皮瓣ABR的神经化治疗比不神经化治疗能更好地恢复触觉。适应所需的额外手术时间很短,并且没有相关并发症的研究报告,使其成为一种安全的手术,可以潜在地改善患者的生活质量。然而,在做出最终的临床建议之前,需要更高质量的研究,如标准化感觉测试的随机对照试验和更严格的方法。
{"title":"Tactile Sensory Recovery in Neurotized Versus Non-Neurotized Autologous Breast Reconstruction: A Systematic Review and Meta-Analysis","authors":"Alejandra Aristizábal,&nbsp;Harrison Herrera,&nbsp;Joseph M. Escandón,&nbsp;Pedro Ciudad,&nbsp;Gabriel del Corral,&nbsp;Rahim Nazerali,&nbsp;Andres Mascaro,&nbsp;Oscar J. Manrique","doi":"10.1002/micr.70096","DOIUrl":"https://doi.org/10.1002/micr.70096","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tactile sensory recovery in autologous breast reconstruction (ABR) has been shown to prevent injuries and improve quality of life. However, the studies comparing neurotized versus non-neurotized outcomes are still controversial due to methodological heterogeneity. This review uses consistent and objective outcomes to evaluate the current evidence's qualitative characteristics and quantitative tactile sensory recovery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic electronic literature search from database inception through 10 February 2024, of the following databases: PubMed, Ovid MEDLINE, Embase, SCOPUS, and CINAHL to identify all studies reporting outcomes of tactile sensory recovery using the Semmes-Weinstein Measuring scale in free-flap ABR comparing neurotization versus non-neurotization. The SWM scale score, demographic characteristics, and surgical features were extracted from each study. Due to the data heterogeneity within the studies, we transformed the data into means and pooled the qualitative information.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 264 articles. After thorough screening, 12 fulfilled the inclusion criteria and were included in the qualitative synthesis. Finally, 7 were quantitatively analyzed with a total of 251 breasts that underwent ABR with free flap neurotization and 244 breasts without neurotization. This revealed a mean SWM score difference of −0.67 and a significant <i>p</i>-value &lt; 0.05. A subgroup DIEP flap analysis performed for 177 neurotized compared to 175 non-eurotized flaps yielded a significant mean difference of −0.86 <i>p</i> &lt; 0.05. There were no significant differences between groups in age (48.8 vs. 49.8, <i>p</i> = 0.5), history of chemotherapy (72 vs. 74, <i>p</i> = 0.91), radiotherapy (61 vs. 56, <i>p</i> = 0.84), or follow-up time (21.85 vs. 25.09 months, <i>p</i> = &lt; 0.05) that could have influenced tactile sensory recovery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Neurotization in free-flap ABR could allow better tactile sensory recovery than the spontaneous sensation gained without it. The additional surgical time required for coaptation is short, and no studies have reported associated complications, making it a safe procedure that can potentially improve patients´ quality of life. Nonetheless, higher-quality studies, such as randomized control trials with standardized sensation testing and more rigorous methodologies, are needed before making final clinical recommendations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18600,"journal":{"name":"Microsurgery","volume":"45 5","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Vasopressors on Microvascular Free Flap Perfusion in Head and Neck Reconstruction 血管加压剂对头颈部重建微血管游离皮瓣灌注的影响
IF 1.5 3区 医学 Q3 SURGERY Pub Date : 2025-07-14 DOI: 10.1002/micr.70095
Mark Ooms, Philipp Winnand, Marius Heitzer, Nils Vohl, Marie Katz, Johannes Bickenbach, Frank Hölzle, Ali Modabber

Introduction

The use of vasopressors in microvascular head and neck reconstruction is still controversial in view of its potentially negative influence on microvascular flap perfusion, which is crucial for flap viability and commonly used as a parameter in flap monitoring. The aim of this study was to investigate the influence of vasopressors on microvascular free flap perfusion.

Materials and Methods

Perfusion measurement data recorded intraoperatively and postoperatively using the Oxygen-2-see (O2C) analysis system in 274 patients undergoing microvascular head and neck reconstruction with fasciocutaneous free flaps (FFFs) or perforator free flaps (PFFs) between 2011 and 2020 were analyzed retrospectively. Vasopressor dose and perfusion parameters, such as flap blood flow, hemoglobin concentration, and hemoglobin oxygen saturation, as well as flap flow conductance (calculated as the ratio of flap blood flow and mean arterial blood pressure), were tested for associations.

Results

Intraoperative hemoglobin oxygen saturation and postoperative flap blood flow were negatively associated with vasopressor dose in PFFs (r = −0.307, p < 0.001; r = −0.211, p = 0.012, respectively). Both associations remained in multivariable analysis (p = 0.002; p = 0.022, respectively). Postoperative flap flow conductance was negatively associated with vasopressor dose in PFFs (r = −0.232, p = 0.008). This association remained in multivariable analysis (p = 0.023).

Conclusion

The use of vasopressors influences microvascular free flap perfusion in PFFs in terms of intraoperative hemoglobin oxygen saturation, postoperative flap blood flow, and postoperative flap flow conductance. This suggests that the use of vasopressors in PFFs may be an adjustable variable for controlling flap perfusion and should be considered a confounding variable during flap monitoring based on flap perfusion.

血管加压剂在微血管头颈部重建中的应用仍存在争议,因为它可能对微血管皮瓣灌注产生负面影响,而微血管皮瓣灌注对皮瓣的存活至关重要,通常被用作皮瓣监测的参数。本研究旨在探讨血管加压剂对游离皮瓣微血管灌注的影响。材料与方法回顾性分析2011年至2020年274例应用筋膜皮自由皮瓣(FFFs)或穿支自由皮瓣(PFFs)行微血管头颈部重建术的患者术中及术后氧-2-see (O2C)分析系统记录的灌注测量数据。检测血管加压剂剂量和血流灌注参数,如皮瓣血流量、血红蛋白浓度、血红蛋白氧饱和度,以及皮瓣血流导度(以皮瓣血流量与平均动脉血压之比计算)的相关性。结果术中血红蛋白氧饱和度和术后皮瓣血流量与pff血管加压剂剂量呈负相关(r = - 0.307, p < 0.001;R = - 0.211, p = 0.012)。在多变量分析中,这两种关联仍然存在(p = 0.002;P = 0.022)。pff术后皮瓣血流导度与血管加压剂剂量呈负相关(r = - 0.232, p = 0.008)。这种关联在多变量分析中仍然存在(p = 0.023)。结论血管加压药物的使用对pff微血管自由皮瓣灌注的影响包括术中血红蛋白氧饱和度、术后皮瓣血流量和皮瓣血流导度。这表明血管加压剂在pff中的应用可能是控制皮瓣灌注的可调节变量,在基于皮瓣灌注的皮瓣监测中应被视为混杂变量。
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引用次数: 0
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Microsurgery
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