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End-To-Side Venous Anastomosis in Head and Neck Free Flap Reconstruction: A Systematic Review and Meta-Analysis 端侧静脉吻合在头颈部游离皮瓣重建中的应用:系统回顾和meta分析
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-21 DOI: 10.1002/micr.70148
Andrea Costantino, Daniel Uralov, Bianca Maria Festa, Uthman Alamoudi, Mario Alessandri-Bonetti, Claudio Sampieri, Gabriele Molteni, Raul Pellini, J. Scott Magnuson, Armando De Virgilio

Purpose

We performed a systematic review and meta-analysis to evaluate the outcomes of end-to-side (ETS) anastomosis to the internal jugular vein (IJV) in head and neck free flap reconstruction. Postoperative outcomes of ETS were compared to the conventional end-to-end (ETE) technique.

Methods

A comprehensive electronic search was performed on PubMed/MEDLINE, Scopus, and Google Scholar databases. Odds ratios (ORs) were calculated with their 95% confidence intervals (CIs) for each study comparing the two groups (ETS vs. ETE).

Results

A total of 9645 patients undergoing 9663 head and neck free flap reconstructions (ETS, N = 2618; ETE, N = 7045) were included from 45 studies. The ETS technique showed an overall free flap failure rate of 2.5% (95% CI: 1.9–3.2). The pooled venous thrombosis rate was 3.8% (95% CI: 2.5–5.8), while the reoperation rate was 5.6% (95% CI: 2.7–11.5). No significant difference was found for the free flap failure rate (OR = 1.35, 95% CI: 0.77–2.36), venous thrombosis rate (OR = 0.93, 95% CI: 0.48–1.82) and reoperation rate (OR = 0.83, 95% CI: 0.42–1.63) when comparing the two groups.

Conclusion

This study demonstrates that ETS venous anastomoses offer excellent outcomes, with safety and efficacy comparable to ETE anastomoses. Both techniques can be successfully employed depending on individual patient anatomy and surgeon experience.

目的对头颈部游离皮瓣重建中颈内静脉端侧吻合的效果进行系统回顾和meta分析。将ETS的术后结果与传统的端到端(ETE)技术进行比较。方法对PubMed/MEDLINE、Scopus和谷歌Scholar数据库进行全面的电子检索。比较两组(ETS与ETE)的每项研究,计算比值比(ORs)及其95%置信区间(CIs)。结果45项研究共纳入9645例接受9663例头颈部游离皮瓣重建的患者(ETS, N = 2618; ETE, N = 7045)。ETS技术显示游离皮瓣整体失败率为2.5% (95% CI: 1.9-3.2)。合并静脉血栓发生率为3.8% (95% CI: 2.5 ~ 5.8),再手术率为5.6% (95% CI: 2.7 ~ 11.5)。两组游离瓣失败率(OR = 1.35, 95% CI: 0.77 ~ 2.36)、静脉血栓形成率(OR = 0.93, 95% CI: 0.48 ~ 1.82)、再手术率(OR = 0.83, 95% CI: 0.42 ~ 1.63)比较差异无统计学意义。结论ETS静脉吻合术具有良好的疗效,其安全性和有效性可与ETE吻合术相媲美。这两种技术都可以成功地应用,这取决于个体患者的解剖结构和外科医生的经验。
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引用次数: 0
Negative Pressure Wound Therapy in Free Flap Reconstruction: A Systematic Review and Meta-Analysis 负压伤口治疗在游离皮瓣重建:系统回顾和荟萃分析。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-19 DOI: 10.1002/micr.70144
Kazuho Kawashima, Ali Esmaeili

Background

Despite extensive research on negative pressure wound therapy (NPWT), its impact on immediate post-operative application in free flap reconstruction remains underexplored. The objective of this systematic review and meta-analysis is to evaluate the efficacy of NPWT compared with conventional wound therapy (CWT) in post-operative management of free flap, focusing on flap survival, complication rates, and flap size.

Methods

Searches were carried out in CENTRAL, Medline, and Embase. All prospective or retrospective clinical studies examining the effect of immediate post-operative application of NPWT after free flap reconstruction were considered for the review. No restrictions were placed on the date of publication but only papers written in English were included.

Results

13 studies were included in the review, with 6 studies eligible for the meta-analysis. A total of 321 free flaps were included in the pooled analysis. NPWT reduced overall complication rates compared with CWT (OR 0.34, 95% CI 0.13 to 0.88, p = 0.03, n = 240) and also resulted in a statistically significant reduction in flap size (SMD −1.54, 95% CI ‒2.48 to −0.54, p = 0.002, n = 43). However, there was no significant difference in flap survival rates (OR 2.34, 95% CI 0.77 to 7.09, p = 0.13, n = 252).

Conclusion

NPWT appears to offer benefits over CWT in reducing complications and flap size, but precautions should be taken in interpreting these results. Further high-quality randomized controlled trials are required to validate these findings.

背景:尽管对负压创面治疗(NPWT)进行了广泛的研究,但其对术后立即应用于游离皮瓣重建的影响仍未得到充分探讨。本系统综述和荟萃分析的目的是评估NPWT与传统伤口治疗(CWT)在游离皮瓣术后处理中的疗效,重点是皮瓣存活率、并发症发生率和皮瓣大小。方法:在CENTRAL、Medline和Embase中进行检索。所有前瞻性或回顾性的临床研究均考虑了游离皮瓣重建后立即应用NPWT的效果。对发表日期没有限制,但只包括用英文写的论文。结果:13项研究纳入综述,其中6项研究符合meta分析。共有321个自由皮瓣被纳入汇总分析。与CWT相比,NPWT降低了总并发症发生率(OR 0.34, 95% CI 0.13 ~ 0.88, p = 0.03, n = 240),且皮瓣大小减少具有统计学意义(SMD -1.54, 95% CI -2.48 ~ -0.54, p = 0.002, n = 43)。但两组皮瓣存活率无显著差异(OR 2.34, 95% CI 0.77 ~ 7.09, p = 0.13, n = 252)。结论:NPWT在减少并发症和皮瓣大小方面似乎比CWT有优势,但在解释这些结果时应采取预防措施。需要进一步的高质量随机对照试验来验证这些发现。
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引用次数: 0
Hybrid Total Achilles Tendon Reconstruction Combining Acellular Dermal Matrix Placement and Free Latissimus Dorsi Flap Coverage: A Report of Two Cases 脱细胞真皮基质植入与游离背阔肌瓣覆盖复合全跟腱重建2例报告。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-19 DOI: 10.1002/micr.70146
Beniamino Brunetti, Chiara Camilloni, Matteo Pazzaglia, Valeria Petrucci, Marco Morelli Coppola, Rosa Salzillo, Stefania Tenna, Irene Giovanna Aprile, Marco Germanotta, Sergio Valeri, Mauro Barone, Paolo Persichetti

Reconstruction of complex Achilles tendon defects involving both the tendon and the overlying soft tissues represents a challenging scenario for plastic surgeons. In this report, we present an innovative technique of hybrid total Achilles tendon reconstruction combining acellular dermal matrix placement to restore the full-thickness continuity of the tendon and free latissimus dorsi (LD) flap coverage to allow graft integration and simultaneously resurface the soft tissue defect, ultimately leading to lower limb salvage. Between August 2023 and February 2024 two patients received microsurgical hybrid reconstruction of complex defects, measuring 10 × 10 cm and 17 × 14 cm, respectively, involving the lower third of the leg and the Achilles tendon region, due to trauma with multiple previous failed surgeries and sarcoma resection. The full-thickness continuity of the tendon was reconstructed by use of an XCM BIOLOGIC Tissue Matrix (DePuy Synthes, Johnson & Johnson), measuring 6 and 10 cm long, respectively, folded in a three-layered tridimensional structure to recreate the shape and function of a new tendon. Subsequently, a free myo-cutaneous LD flap, was used to wrap and revascularize the neo-tendon and resurface the soft tissue defect. In both patients the flaps healed uneventfully, and neo-tendon integration was documented by MRI examination. The follow-up was uneventful. Long-term functional evaluation showed almost normal tendon excursion with both patients walking without assistance. The proposed hybrid approach may be a good alternative and innovative solution for the reconstruction of complex Achilles tendon defects consequent to trauma or oncological resection. Such results are more than promising for future studies on large series of patients.

复杂跟腱缺损的重建涉及到跟腱和其上的软组织,这对整形外科医生来说是一个具有挑战性的场景。在这篇报道中,我们提出了一种创新的混合全跟腱重建技术,结合脱细胞真皮基质放置来恢复跟腱的全层连续性和游离背阔肌(LD)皮瓣覆盖,使移植物融合,同时使软组织缺损重新出现,最终导致下肢保留。在2023年8月至2024年2月期间,两名患者接受了复杂缺陷的显微外科混合重建,分别为10 × 10 cm和17 × 14 cm,涉及小腿的下三分之一和跟腱区域,由于多次手术失败和肉瘤切除的创伤。使用XCM BIOLOGIC组织基质(DePuy Synthes, Johnson & Johnson)重建肌腱的全层连续性,分别为6和10厘米长,折叠成三层三维结构,以重建新肌腱的形状和功能。随后,一个游离的肌皮LD皮瓣被用来包裹和重建新肌腱和软组织缺损的表面。两例患者皮瓣均顺利愈合,MRI检查证实新肌腱融合。接下来的事情平淡无奇。长期功能评估显示,两名患者在没有辅助的情况下行走,肌腱偏移几乎正常。所提出的混合入路可能是创伤或肿瘤切除后复杂跟腱缺损重建的一个很好的替代和创新的解决方案。这样的结果对于未来对大量患者的研究是非常有希望的。
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引用次数: 0
MicroRAG: Development of a Novel Artificial Intelligence Retrieval-Augmented Generation Model for Microsurgery Clinical Decision Support MicroRAG:用于显微外科临床决策支持的新型人工智能检索-增强生成模型的开发。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-14 DOI: 10.1002/micr.70138
Berk B. Ozmen, Nishant Singh, Kavach Shah, Ibrahim Berber, Damanjit Singh, Eugene Pinsky, Steven A. Schulz, Sarah N. Bishop, Steven Bernard, Risal S. Djohan, Graham S. Schwarz

Background

Microsurgical decision-making requires integration of diverse patient-specific factors, advanced surgical techniques, and dynamic intraoperative insights. While artificial intelligence (AI), large language models (LLMs), and retrieval-augmented generation (RAG) models have advanced significantly in various fields, no AI-driven clinical decision support systems currently exist for microsurgery. We developed MicroRAG, the first AI-powered clinical decision support system specifically designed for microsurgery, capable of instantly providing evidence-based recommendations by searching and synthesizing the entire microsurgical literature.

Methods

We developed an AI clinical decision support system integrating 4876 peer-reviewed microsurgical publications (2000–2024) using advanced retrieval-augmented generation (RAG) technology. The system processes clinical queries through hierarchical document clustering and provides real-time, evidence-based recommendations with direct literature citations. We evaluated system performance using 10 standardized clinical scenarios covering common microsurgical decisions, measuring answer relevancy, faithfulness to source literature, and clinical accuracy.

Results

MicroRAG demonstrated exceptional performance with an average answer relevancy score of 0.953 (range: 0.857–1.000) and faithfulness score of 0.907 (range: 0.676–1.000). G-Eval correctness averaged 0.88 with Semantic Evaluation Metrics showing an average similarity score of 0.75 and confidence score of 0.80. The system successfully provided comprehensive, immediately actionable guidance for complex scenarios including free flap monitoring protocols, vascular complication management, and surgical technique selection. All responses were grounded in peer-reviewed literature with direct citations.

Conclusion

MicroRAG represents a technological innovation in microsurgical practice, providing instant access to evidence-based recommendations that typically require hours of literature review. By delivering comprehensive, literature-grounded guidance in real-time, this system has the potential to standardize best practices, reduce decision-making uncertainty, and ultimately improve patient outcomes across all levels of surgical experience.

背景:显微外科手术决策需要综合不同的患者特异性因素、先进的手术技术和动态的术中洞察。虽然人工智能(AI)、大型语言模型(llm)和检索增强生成(RAG)模型在各个领域取得了显著进展,但目前还没有人工智能驱动的显微外科临床决策支持系统。我们开发了MicroRAG,这是第一个专门为显微外科设计的人工智能临床决策支持系统,能够通过搜索和综合整个显微外科文献,即时提供基于证据的建议。方法:我们采用先进的检索增强生成(RAG)技术开发了一个人工智能临床决策支持系统,该系统集成了4876篇同行评审的显微外科出版物(2000-2024)。该系统通过分层文档聚类处理临床查询,并提供实时的、基于证据的建议和直接的文献引用。我们使用涵盖常见显微外科决策的10个标准化临床场景来评估系统性能,测量答案的相关性、对源文献的忠实度和临床准确性。结果:MicroRAG表现出优异的表现,平均答案相关性得分为0.953(范围:0.857-1.000),忠实度得分为0.907(范围:0.676-1.000)。G-Eval正确性平均为0.88,Semantic Evaluation Metrics显示平均相似度得分为0.75,置信度得分为0.80。该系统成功地为包括自由皮瓣监测方案、血管并发症管理和手术技术选择在内的复杂情况提供了全面、即时可操作的指导。所有的回答都是基于直接引用的同行评议文献。结论:MicroRAG代表了显微外科实践中的一项技术创新,提供了即时获取基于证据的建议,而通常需要数小时的文献回顾。通过提供全面的、基于文献的实时指导,该系统有可能标准化最佳实践,减少决策的不确定性,并最终改善各级手术经验的患者预后。
{"title":"MicroRAG: Development of a Novel Artificial Intelligence Retrieval-Augmented Generation Model for Microsurgery Clinical Decision Support","authors":"Berk B. Ozmen,&nbsp;Nishant Singh,&nbsp;Kavach Shah,&nbsp;Ibrahim Berber,&nbsp;Damanjit Singh,&nbsp;Eugene Pinsky,&nbsp;Steven A. Schulz,&nbsp;Sarah N. Bishop,&nbsp;Steven Bernard,&nbsp;Risal S. Djohan,&nbsp;Graham S. Schwarz","doi":"10.1002/micr.70138","DOIUrl":"10.1002/micr.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Microsurgical decision-making requires integration of diverse patient-specific factors, advanced surgical techniques, and dynamic intraoperative insights. While artificial intelligence (AI), large language models (LLMs), and retrieval-augmented generation (RAG) models have advanced significantly in various fields, no AI-driven clinical decision support systems currently exist for microsurgery. We developed MicroRAG, the first AI-powered clinical decision support system specifically designed for microsurgery, capable of instantly providing evidence-based recommendations by searching and synthesizing the entire microsurgical literature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed an AI clinical decision support system integrating 4876 peer-reviewed microsurgical publications (2000–2024) using advanced retrieval-augmented generation (RAG) technology. The system processes clinical queries through hierarchical document clustering and provides real-time, evidence-based recommendations with direct literature citations. We evaluated system performance using 10 standardized clinical scenarios covering common microsurgical decisions, measuring answer relevancy, faithfulness to source literature, and clinical accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MicroRAG demonstrated exceptional performance with an average answer relevancy score of 0.953 (range: 0.857–1.000) and faithfulness score of 0.907 (range: 0.676–1.000). G-Eval correctness averaged 0.88 with Semantic Evaluation Metrics showing an average similarity score of 0.75 and confidence score of 0.80. The system successfully provided comprehensive, immediately actionable guidance for complex scenarios including free flap monitoring protocols, vascular complication management, and surgical technique selection. All responses were grounded in peer-reviewed literature with direct citations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>MicroRAG represents a technological innovation in microsurgical practice, providing instant access to evidence-based recommendations that typically require hours of literature review. By delivering comprehensive, literature-grounded guidance in real-time, this system has the potential to standardize best practices, reduce decision-making uncertainty, and ultimately improve patient outcomes across all levels of surgical experience.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18600,"journal":{"name":"Microsurgery","volume":"45 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined Nerve Grafting and Myoelectric Orthosis Bionic Approach (MOBA) for Functional Restoration After Pan-Plexus Injury 神经移植联合肌电矫形仿生入路用于泛神经丛损伤后功能恢复。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-14 DOI: 10.1002/micr.70145
Y. Jost, S. Benner, B. Benecken, B. Zimmerlein, C. Hirche, A. A. Maldonado

A variety of approaches have been described to obtain a rudimentary grasp following traumatic pan-plexus injury in the adult. The aim of this report is to present a novel reconstructive algorithm based on the combination of reconstructive surgery and the fitting of a myoelectric orthosis (Myoelectric Orthosis Bionic Approach [MOBA]), to gain grasp function after a pan-plexus injury. A 44-year-old patient presented with a pan-plexus injury after a heavy branch fell on his right shoulder during forestry operations. After 5 months without spontaneous recovery, the patient underwent a brachial plexus exploration with intraoperative neuromonitoring, neurolysis of the C5 root and the upper trunk, and spinal accessory nerve transfer to the musculocutaneous nerve using a sural nerve graft. The myoelectric orthosis was initially employed for rehabilitation purposes, with a cutaneous electromyography (EMG) sensor positioned over the trapezius muscle to activate elbow flexion. Six months after the surgery, the patient presented Grade M1 pectoral muscle contraction, strong enough to be detected by cutaneous EMG. A second separate EMG sensor was placed over the pectoralis muscle to activate the finger flexion. As soon as the patient achieved Grade M2 active elbow bending (biceps muscle) with reinnervation signs at EMG, the sensor over the trapezius muscle was transferred to the biceps muscle to augment elbow bending. One year after surgery, the patient presented with active elbow bending (biceps muscle Grade M4), and finger flexion and extension using the myoelectric orthosis through the pectoral electrical signal, being able to hold and open. In addition, the patient presented Grade S2 proprioception and sensation in all fingers. This new treatment algorithm for pan-plexus injuries is further discussed. We believe the MOBA should be considered as an alternative treatment protocol after a pan-plexus injury.

各种方法已被描述,以获得一个基本的掌握创伤性泛神经丛损伤后,在成人。本报告的目的是提出一种基于重建手术和肌电矫形器(myoelectric orthosis Bionic Approach [MOBA])拟合的新型重建算法,以获得泛神经丛损伤后的抓握功能。一名44岁的病人在林业作业中,一根沉重的树枝落在他的右肩后,出现了泛神经丛损伤。5个月后,患者未自行恢复,术中神经监测下行臂丛探查,C5根和上干神经松解术,腓肠神经移植物将脊髓副神经转移至肌皮神经。肌电矫形器最初用于康复目的,在斜方肌上放置一个皮肤肌电(EMG)传感器来激活肘关节屈曲。术后6个月,患者出现M1级胸肌收缩,强度足以通过皮肤肌电图检测到。另一个单独的肌电图传感器放置在胸肌上,以激活手指屈曲。一旦患者达到M2级活动肘关节屈曲(二头肌)并在肌电图上有再神经支配的迹象,斜方肌上的传感器就被转移到二头肌上以增强肘关节屈曲。术后1年,患者出现肘关节主动弯曲(肱二头肌等级M4),通过胸电信号使用肌电矫形器进行手指屈伸,能够握住并打开。此外,患者所有手指均有S2级本体感觉和感觉。进一步讨论了这种新的泛神经丛损伤治疗算法。我们认为MOBA可以作为泛神经丛损伤后的一种替代治疗方案。
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引用次数: 0
Diagnostic Accuracy of Artificial Intelligence Models for Predicting Postoperative Complications Following Free Flap Reconstruction: A Systematic Review and Meta-Analysis 人工智能模型预测游离皮瓣重建术后并发症的诊断准确性:系统回顾和荟萃分析。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-13 DOI: 10.1002/micr.70143
Ramin Shekouhi, Hassan Darabi, Harvey Chim

Introduction

To systematically evaluate the diagnostic performance of artificial intelligence (AI) models in predicting postoperative complications following flap surgery, and to compare the efficacy of different input modalities used in model training.

Methods

A comprehensive literature search was conducted across PubMed, Embase, Scopus, and Web of Science to identify studies utilizing AI for flap monitoring and postoperative complication prediction. A total of 12 studies comprising 18,520 patients and 32,148 input data points were included. Pooled sensitivity, specificity, likelihood ratios, and SROC curves were calculated using a bivariate random-effects model.

Results

The meta-analysis revealed a pooled sensitivity of 78.0% [95% CI: 0.54–0.91] and a pooled specificity of 88.0% [95% CI: 0.76–0.94]. The positive and negative likelihood ratios were 6.36 [95% CI: 2.54–15.91] and 0.25 [95% CI: 0.10–0.64], respectively. The area under the SROC curve was 0.91 [95% CI: 0.88–0.93], indicating excellent overall diagnostic performance.

Conclusion

AI models, particularly those incorporating photographic data and deep learning models, demonstrate high diagnostic accuracy and hold promise as adjunct tools for postoperative flap monitoring.

前言:系统评估人工智能(AI)模型在预测皮瓣术后并发症方面的诊断性能,并比较不同输入方式在模型训练中的效果。方法:通过PubMed、Embase、Scopus和Web of Science进行文献检索,找出利用人工智能进行皮瓣监测和术后并发症预测的研究。总共纳入了12项研究,包括18,520名患者和32148个输入数据点。采用双变量随机效应模型计算合并敏感性、特异性、似然比和SROC曲线。结果:荟萃分析显示,合并敏感性为78.0% [95% CI: 0.54-0.91],合并特异性为88.0% [95% CI: 0.76-0.94]。阳性和阴性似然比分别为6.36 [95% CI: 2.54-15.91]和0.25 [95% CI: 0.10-0.64]。SROC曲线下面积为0.91 [95% CI: 0.88-0.93],总体诊断效果良好。结论:人工智能模型,特别是结合摄影数据和深度学习模型的人工智能模型,具有较高的诊断准确性,有望成为术后皮瓣监测的辅助工具。
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引用次数: 0
The Proximal Fibula Bone Flap for Complex Maxillary Reconstruction: Anatomic Evaluation and a Case Report 腓骨近端骨瓣用于复杂上颌重建:解剖学评价及1例报告。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-13 DOI: 10.1002/micr.70149
Farooq Shahzad, Evan Matros

Background

Total maxillectomy defects that involve both the supra- and infra-structure pose a reconstructive challenge. Accurate reconstruction of the orbital rim and alveolus is needed for orbital floor reconstruction and dental implant placement. The fibula is the workhorse flap for osseous craniofacial reconstruction. The distal fibula is harvested as vascularized bone while the proximal fibula is typically discarded after separating it from the pedicle. We evaluated the vascular anatomy of the proximal fibular segment for potential use as a separate bone flap.

Methods

The anatomy of the peroneal vessels was studied in clinical cases and with computed tomographic angiograms. The branches of the proximal peroneal artery and vein were dissected during routine fibula flap harvest in 25 patients. Lower extremity computed tomographic angiograms of 100 limbs were also studied. We reconstructed a hemi-maxillectomy defect resulting from resection of salivary gland adenocarcinoma in a 69-year-old female, with a vascularized bone flap supplied by this proximal peroneal branch. The conventional fibula bone flap based on the peroneal vessels was used for alveolar reconstruction and the proximal fibula based on the proximal peroneal branch was used for inferior orbital rim reconstruction as a flow-through flap anastomosed to the distal end of the peroneal vessels. A polytetrafluoroethylene-titanium implant was used to recreate the orbital floor.

Results

In all fibula flap dissections and radiographic studies, a perforating branch of the peroneal vessels was seen supplying the proximal part of the fibula. The patient's postoperative course was uneventful, and adjuvant radiation was administered. At a follow-up of 1 year 3 months, the patient had excellent globe position, normal vision, and a moderate contour depression of the right cheek.

Conclusions

The proximal fibula bone is consistently supplied by a branch of the peroneal vessels and can thus be harvested as a vascularized perforator bone flap.

背景:上颌全切除术的缺陷,包括上和基础结构构成了重建的挑战。眶底重建及植牙安置需要准确重建眶缘及牙槽。腓骨是骨性颅面重建的主要皮瓣。远端腓骨作为带血管的骨切除,而近端腓骨通常在与椎弓根分离后被丢弃。我们评估了腓骨近段的血管解剖作为一个单独的骨瓣的潜在用途。方法:结合临床病例和计算机断层血管摄影对腓血管进行解剖研究。在常规腓骨皮瓣切除过程中,对25例腓骨近端动脉和静脉分支进行了解剖。同时对100例下肢计算机断层血管造影进行了研究。我们重建了一名69岁女性因切除唾液腺腺癌而导致的半上颌切除缺损,其血管化骨瓣由腓近侧分支提供。以腓骨近支为基础的腓骨近段皮瓣与腓骨远端血管吻合,用于眶下缘重建,以腓骨近端支为基础的腓骨近段皮瓣用于眶下缘重建。使用聚四氟乙烯-钛植入物重建眶底。结果:在所有腓骨皮瓣解剖和影像学研究中,腓骨血管的穿支供应腓骨近端。患者术后过程平稳,并给予辅助放疗。随访1年3个月,患者眼球位置良好,视力正常,右脸颊轮廓凹陷中度。结论:腓骨近端由腓血管分支持续供应,因此可以作为带血管的穿支骨瓣切除。
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引用次数: 0
Associations Between Fracture Characteristics and Surgical Outcomes in Distal Digit Replantation of Tamai Zones 1–2 Tamai 1-2区远端手指再植骨折特征与手术结果的关系。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-12 DOI: 10.1002/micr.70142
Takashi Kageyama, Yuki Shiko, Maiko Osawa, Yohei Kawasaki, Toko Miyazaki, Hayahito Sakai, Reiko Tsukuura, Takumi Yamamoto

Background

Although numerous risk factors were reported for the failure of digit replantation, there was a lack of studies investigating the association between replantation outcomes and fracture characteristics. The purpose of this study was to evaluate the survival rate and functional outcomes of distal digit replantation based on the fracture patterns.

Methods

We retrospectively reviewed patients with Tamai zones I–II amputated digits who underwent replantation between 2018 and 2022. The fracture characteristics of the distal phalanx were compared to outcomes, including the survival rate, Disabilities of the Arm, Shoulder, and Hand (DASH) scores, and range of motion (ROM) of the distal interphalangeal (DIP) joint. Additionally, we compared the diagnostic performance of our proposed FIVE criteria with the mechanism of injury (MOI) and other prognostic factors in predicting replantation failure.

Results

51 digits from 48 patients, including 38 males, met the inclusion criteria. The overall survival rate was 29/51 digits (56.9%), consisting of 18/39 digits (46.2%) in crush-degloving injuries and 11/12 digits (91.7%) in sharp-cut injuries. Comminution of fractures significantly worsened the survival rate (10% vs. 69.7%; p = 0.002), while tuft fractures also significantly deteriorated the survival rate (34.8% vs. 75.0%; p = 0.005). Crush-degloving injuries significantly decreased the survival rate (p = 0.007). The FIVE criteria demonstrated relatively overall superior diagnostic performance for replantation failure, showing the highest accuracy (83.7%), specificity (89.7%), and positive predictive value (83.3%) compared to other indicators. The ROM of the DIP joint significantly worsened in high-energy fractures (p = 0.027) and subzone 4 digits (p = 0.012). DASH scores significantly deteriorated in high-energy fractures (p = 0.003), subzone 4 digits (p = 0.013), and base fractures (p = 0.036).

Conclusion

In Tamai zones 1–2, comprehensive evaluations of high-risk fracture patterns, MOI, and venous anastomosis can be a useful tool for more reliable prediction of replantation failure and functional outcomes.

背景:尽管报道了许多导致手指再植失败的危险因素,但缺乏关于再植结果与骨折特征之间关系的研究。本研究的目的是评估基于骨折类型的远端手指再植的存活率和功能结果。方法:回顾性分析2018年至2022年间接受Tamai I-II区断指再植的患者。将远端指骨骨折特征与预后进行比较,包括生存率、臂、肩和手的残疾(DASH)评分和远端指间关节(DIP)的活动范围(ROM)。此外,我们将我们提出的五个诊断标准与损伤机制(MOI)和其他预测再植失败的预后因素进行了比较。结果:48例患者51指符合纳入标准,其中男性38例。总生存率为29/51指(56.9%),其中挤压脱手套伤18/39指(46.2%),锐切伤11/12指(91.7%)。骨折粉碎显著降低生存率(10% vs. 69.7%, p = 0.002),簇状骨折也显著降低生存率(34.8% vs. 75.0%, p = 0.005)。挤压脱手套损伤显著降低生存率(p = 0.007)。与其他指标相比,FIVE标准对再植失败的诊断表现出相对总体的优势,显示出最高的准确性(83.7%)、特异性(89.7%)和阳性预测值(83.3%)。高能骨折(p = 0.027)和4指亚区骨折(p = 0.012)中DIP关节的ROM明显恶化。高能骨折(p = 0.003)、4趾亚区(p = 0.013)和基底骨折(p = 0.036)的DASH评分明显恶化。结论:在Tamai 1-2区,综合评估高危骨折类型、MOI和静脉吻合可以更可靠地预测再植失败和功能结局。
{"title":"Associations Between Fracture Characteristics and Surgical Outcomes in Distal Digit Replantation of Tamai Zones 1–2","authors":"Takashi Kageyama,&nbsp;Yuki Shiko,&nbsp;Maiko Osawa,&nbsp;Yohei Kawasaki,&nbsp;Toko Miyazaki,&nbsp;Hayahito Sakai,&nbsp;Reiko Tsukuura,&nbsp;Takumi Yamamoto","doi":"10.1002/micr.70142","DOIUrl":"10.1002/micr.70142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although numerous risk factors were reported for the failure of digit replantation, there was a lack of studies investigating the association between replantation outcomes and fracture characteristics. The purpose of this study was to evaluate the survival rate and functional outcomes of distal digit replantation based on the fracture patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed patients with Tamai zones I–II amputated digits who underwent replantation between 2018 and 2022. The fracture characteristics of the distal phalanx were compared to outcomes, including the survival rate, Disabilities of the Arm, Shoulder, and Hand (DASH) scores, and range of motion (ROM) of the distal interphalangeal (DIP) joint. Additionally, we compared the diagnostic performance of our proposed FIVE criteria with the mechanism of injury (MOI) and other prognostic factors in predicting replantation failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>51 digits from 48 patients, including 38 males, met the inclusion criteria. The overall survival rate was 29/51 digits (56.9%), consisting of 18/39 digits (46.2%) in crush-degloving injuries and 11/12 digits (91.7%) in sharp-cut injuries. Comminution of fractures significantly worsened the survival rate (10% vs. 69.7%; <i>p</i> = 0.002), while tuft fractures also significantly deteriorated the survival rate (34.8% vs. 75.0%; <i>p</i> = 0.005). Crush-degloving injuries significantly decreased the survival rate (<i>p</i> = 0.007). The FIVE criteria demonstrated relatively overall superior diagnostic performance for replantation failure, showing the highest accuracy (83.7%), specificity (89.7%), and positive predictive value (83.3%) compared to other indicators. The ROM of the DIP joint significantly worsened in high-energy fractures (<i>p</i> = 0.027) and subzone 4 digits (<i>p</i> = 0.012). DASH scores significantly deteriorated in high-energy fractures (<i>p</i> = 0.003), subzone 4 digits (<i>p</i> = 0.013), and base fractures (<i>p</i> = 0.036).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In Tamai zones 1–2, comprehensive evaluations of high-risk fracture patterns, MOI, and venous anastomosis can be a useful tool for more reliable prediction of replantation failure and functional outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18600,"journal":{"name":"Microsurgery","volume":"45 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bloodletting Therapy Using Subcutaneous Heparin and Controlled Scarification for Venous Insufficiency in Free Flap Reconstruction 游离皮瓣重建中静脉功能不全的皮下肝素放血和控制性割伤治疗。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-12 DOI: 10.1002/micr.70147
Can Ege Yalcin, Berrak Karatan, Anil Demiroz

Background

Venous congestion is a significant complication in microsurgical reconstruction and may persist despite surgical revision attempts, as demonstrated in our clinical experience. In cases where repeated surgical interventions are either not feasible or unsuccessful, alternative methods like bloodletting therapy using subcutaneous heparin injection may be beneficial.

Methods

This descriptive, retrospective report evaluated six patients who underwent microsurgical tissue transfers between 2019 and 2025 and developed refractory venous congestion. Patients were managed with a standardized protocol involving a single subcutaneous injection of 10 IU heparin administered into the congested flap zone at initiation. Dermal windows measuring approximately 2 × 5 mm were created and during follow-up, heparin-soaked gauze pads (1000 IU heparin in sterile saline) were applied over the dermal windows to sustain bleeding. If bleeding diminished, windows were gently enlarged or new sites were created.

Results

The mean age of the six patients was 30.8 years (range 12–63). Total flap survival was achieved in three patients (50%), partial loss in two patients (33%), and marginal loss in one patient (17%). Treatment duration ranged from 3 to 10 days, with a mean transfusion requirement of 1.8 units per patient (Range 0–6 units).

Conclusion

Subcutaneous heparin combined with controlled scarification represents a safe, practical, and potentially effective method to manage persistent venous congestion when surgical revision is unsuccessful or contraindicated. Future prospective studies are warranted to better define its role and optimize outcomes.

背景:根据我们的临床经验,静脉充血是显微外科重建的重要并发症,尽管外科翻修尝试,静脉充血仍可能持续存在。在反复手术治疗不可行或不成功的情况下,皮下注射肝素的放血治疗等替代方法可能是有益的。方法:本描述性回顾性报告评估了2019年至2025年期间接受显微手术组织转移并出现难治性静脉充血的6例患者。患者采用标准化方案进行管理,包括在开始时将10 IU肝素单次皮下注射到充血皮瓣区域。创建约2 × 5mm的真皮窗口,在随访期间,将肝素浸泡的纱布垫(1000 IU肝素在无菌生理盐水中)涂在真皮窗口上以维持出血。如果出血减少,就轻轻地扩大窗户或新建场地。结果:6例患者平均年龄30.8岁(范围12-63岁)。3例(50%)患者皮瓣完全存活,2例(33%)患者皮瓣部分消失,1例(17%)患者皮瓣边缘消失。治疗时间从3天到10天不等,每位患者平均输血需要量为1.8个单位(范围0-6个单位)。结论:皮下肝素联合控制性割伤是一种安全、实用、潜在有效的方法,可用于治疗手术翻修不成功或有禁忌的持续性静脉充血。未来的前瞻性研究有必要更好地确定其作用并优化结果。
{"title":"Bloodletting Therapy Using Subcutaneous Heparin and Controlled Scarification for Venous Insufficiency in Free Flap Reconstruction","authors":"Can Ege Yalcin,&nbsp;Berrak Karatan,&nbsp;Anil Demiroz","doi":"10.1002/micr.70147","DOIUrl":"10.1002/micr.70147","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Venous congestion is a significant complication in microsurgical reconstruction and may persist despite surgical revision attempts, as demonstrated in our clinical experience. In cases where repeated surgical interventions are either not feasible or unsuccessful, alternative methods like bloodletting therapy using subcutaneous heparin injection may be beneficial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This descriptive, retrospective report evaluated six patients who underwent microsurgical tissue transfers between 2019 and 2025 and developed refractory venous congestion. Patients were managed with a standardized protocol involving a single subcutaneous injection of 10 IU heparin administered into the congested flap zone at initiation. Dermal windows measuring approximately 2 × 5 mm were created and during follow-up, heparin-soaked gauze pads (1000 IU heparin in sterile saline) were applied over the dermal windows to sustain bleeding. If bleeding diminished, windows were gently enlarged or new sites were created.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of the six patients was 30.8 years (range 12–63). Total flap survival was achieved in three patients (50%), partial loss in two patients (33%), and marginal loss in one patient (17%). Treatment duration ranged from 3 to 10 days, with a mean transfusion requirement of 1.8 units per patient (Range 0–6 units).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Subcutaneous heparin combined with controlled scarification represents a safe, practical, and potentially effective method to manage persistent venous congestion when surgical revision is unsuccessful or contraindicated. Future prospective studies are warranted to better define its role and optimize outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18600,"journal":{"name":"Microsurgery","volume":"45 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salvage Reconstruction With Recycled Flap Pedicles in Head-and-Neck Surgery: A Report of Two Cases 再生皮瓣蒂在头颈部手术中的挽救性重建:附2例报告。
IF 1.7 3区 医学 Q3 SURGERY Pub Date : 2025-11-05 DOI: 10.1002/micr.70141
Akatsuki Kondo, Hiroki Umezawa, Marie Taga, Rei Ogawa

Free-flap reconstruction of head-and-neck defects is often complicated by a vessel-depleted neck after prior surgery or radiotherapy. Conventional alternatives—such as using contralateral vessels, distant recipient vessels, or interpositional vein grafts—are technically demanding and associated with additional risks. We present two salvage reconstructions in which the vascular pedicle of a previously transferred free flap was reused as recipient vessels when standard options were unavailable. A 79-year-old man developed exposure of a titanium mandibular plate 6 years after mandibular resection reconstructed with a free anterolateral thigh (ALT) flap. Preoperative ultrasonography and contrast-enhanced computed tomography confirmed patency of the ALT flap pedicle despite dense fibrosis. After removal of the exposed plate, the pedicle was carefully dissected, and a scapular osteocutaneous flap (9 × 12 cm skin, 2.5 × 11 cm bone) was anastomosed to the lateral circumflex femoral artery and vein of the existing pedicle. Both flaps survived, and postoperative cholecystitis was managed conservatively. In another case, a 63-year-old man with a history of reconstruction using a free ALT flap for recurrent temporal meningioma developed another recurrence 2 years later. Imaging confirmed patency of the previous pedicle. During salvage surgery, the pedicle was dissected, and a free rectus-abdominis flap (9 × 20 cm) was harvested. Arterial anastomosis was performed to the artery of the previous ALT pedicle, and venous drainage was established directly into the internal jugular vein due to insufficient pedicle vein caliber. Intraoperative indocyanine green fluorescence angiography confirmed flap perfusion, and both flaps healed uneventfully. These cases show that reusing the vascular pedicle of a prior free flap may provide a practical salvage option in vessel-depleted necks. Careful preoperative imaging, intraoperative assessment of flap viability, and meticulous microsurgical technique are essential for success. This approach suggests that pedicle reuse may simplify salvage reconstruction while preserving previously transferred flaps when conventional recipient vessels are unavailable.

头颈部缺损的自由皮瓣重建常因先前手术或放疗后颈部血管衰竭而复杂化。传统的替代方法,如使用对侧血管、远端受体血管或间置静脉移植,在技术上要求很高,并且有额外的风险。我们提出了两种打捞重建,其中先前转移的自由皮瓣的血管蒂在标准选择不可用时被重用为受体血管。一名79岁男性在用游离大腿前外侧皮瓣重建下颌骨切除6年后出现钛下颌骨板外露。术前超声检查和增强计算机断层扫描证实,尽管有致密纤维化,但ALT皮瓣蒂通畅。取出暴露钢板后,仔细解剖椎弓根,将9 × 12 cm皮肤,2.5 × 11 cm骨的肩胛骨皮瓣与现有椎弓根的旋股外侧动脉和静脉吻合。两个皮瓣存活,术后胆囊炎得到保守治疗。另一例患者为63岁男性,曾行游离ALT皮瓣重建颞叶脑膜瘤,2年后再次复发。影像学证实前椎弓根通畅。在抢救手术中,切除蒂,收获游离腹直肌皮瓣(9 × 20 cm)。对原ALT蒂动脉进行动脉吻合,因蒂静脉口径不足,直接建立静脉引流至颈内静脉。术中吲哚菁绿荧光血管造影证实皮瓣灌注,两个皮瓣均顺利愈合。这些病例表明,重新使用先前自由皮瓣的血管蒂可能为血管衰竭的颈部提供实用的挽救选择。仔细的术前影像,术中评估皮瓣的生存能力和细致的显微手术技术是成功的关键。该方法表明,当传统的受体血管不可用时,蒂重复使用可以简化修复重建,同时保留先前转移的皮瓣。
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引用次数: 0
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Microsurgery
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