Pub Date : 2023-01-01DOI: 10.14744/lhhs.2023.50002
Dilek Konukbay
Introduction: Nurses have important ethical and legal responsibilities regarding the prevention, diagnosis, and treat-ment of child abuse and neglect (CAN). This study was conducted to examine nursing students’ levels of diagnosing the symptoms and risks of CAN. Methods: This descriptive study was conducted with 324 nursing students studying at the nursing faculty of a university between April and May 2019. A “Student Information Form” and the “Scale of Diagnosing Symptoms and Risks of CAN” were used for data collection. Results: Participating in the study the mean age was 20.3±1.5. There was a statistically significant difference between being a 4 th grader, receiving training on CAN, encountering a case or suspicion of CAN, and being aged 20 and over, and the mean score on the scale of diagnosing symptoms and risks of CAN (p<0.05). Discussion and Conclusion: In this study, it was determined that the level of knowledge of nursing students about defining the symptoms and risks of CAN was not sufficient. It is seen that receiving education on CAN positively affects the ability to identify the symptoms and risks of CAN.
{"title":"Examining Nursing Students’ Levels of Diagnosing Symptoms and Risks of Child Abuse and Neglect","authors":"Dilek Konukbay","doi":"10.14744/lhhs.2023.50002","DOIUrl":"https://doi.org/10.14744/lhhs.2023.50002","url":null,"abstract":"Introduction: Nurses have important ethical and legal responsibilities regarding the prevention, diagnosis, and treat-ment of child abuse and neglect (CAN). This study was conducted to examine nursing students’ levels of diagnosing the symptoms and risks of CAN. Methods: This descriptive study was conducted with 324 nursing students studying at the nursing faculty of a university between April and May 2019. A “Student Information Form” and the “Scale of Diagnosing Symptoms and Risks of CAN” were used for data collection. Results: Participating in the study the mean age was 20.3±1.5. There was a statistically significant difference between being a 4 th grader, receiving training on CAN, encountering a case or suspicion of CAN, and being aged 20 and over, and the mean score on the scale of diagnosing symptoms and risks of CAN (p<0.05). Discussion and Conclusion: In this study, it was determined that the level of knowledge of nursing students about defining the symptoms and risks of CAN was not sufficient. It is seen that receiving education on CAN positively affects the ability to identify the symptoms and risks of CAN.","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14744/lhhs.2023.10101
Tarkan Özdemir
Introduction: Chronic obstructive pulmonary disease (COPD) is one of the most important morbidity and mortality reasons worldwide. The purpose of our study is to evaluate physician-diagnosed COPD epidemiology according to age groups. Methods: ICD10 J44.0-9 diagnoses codes in the database of Turkish Social Security Institution between 2007 and 2016 was checked through. Distribution of COPD through age groups (40–49, 50–59, 60–69, 70–79, and 80 years and older) among male and female population still alive in 2016 was calculated. Results: 56.7% of 3,168,459 patients with average age of 62.53±15.07 were males. It was determined that 3.2% prevalence in female age group of 40–49 increased up to 23.1% in the age of 80+, 4.2% prevalence in male age group of 40–49 increased up to 35.3% in the age of 80+. In total, it increased from 3.7% to 27.7% in the same group of ages. Rate of the patients between the ages of 40–69 was calculated as 66% of the total number of patients. Discussion and Conclusion: As a result, physician-diagnosed COPD prevalence in Türkiye has an increasing trend by age both in male and female population. One out of each four individuals over the age of 80 years is diagnosed with COPD. Such an evaluation shows that COPD is more frequently in older ages. However, it is not correct to limit COPD as an advanced age disease, since the majority of the patient population is 70 years and under.
{"title":"Physician-Diagnosed Chronic Obstructive Pulmonary Disease Prevalence According to Age Groups in Türkiye","authors":"Tarkan Özdemir","doi":"10.14744/lhhs.2023.10101","DOIUrl":"https://doi.org/10.14744/lhhs.2023.10101","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (COPD) is one of the most important morbidity and mortality reasons worldwide. The purpose of our study is to evaluate physician-diagnosed COPD epidemiology according to age groups. Methods: ICD10 J44.0-9 diagnoses codes in the database of Turkish Social Security Institution between 2007 and 2016 was checked through. Distribution of COPD through age groups (40–49, 50–59, 60–69, 70–79, and 80 years and older) among male and female population still alive in 2016 was calculated. Results: 56.7% of 3,168,459 patients with average age of 62.53±15.07 were males. It was determined that 3.2% prevalence in female age group of 40–49 increased up to 23.1% in the age of 80+, 4.2% prevalence in male age group of 40–49 increased up to 35.3% in the age of 80+. In total, it increased from 3.7% to 27.7% in the same group of ages. Rate of the patients between the ages of 40–69 was calculated as 66% of the total number of patients. Discussion and Conclusion: As a result, physician-diagnosed COPD prevalence in Türkiye has an increasing trend by age both in male and female population. One out of each four individuals over the age of 80 years is diagnosed with COPD. Such an evaluation shows that COPD is more frequently in older ages. However, it is not correct to limit COPD as an advanced age disease, since the majority of the patient population is 70 years and under.","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14744/lhhs.2023.10001
Ümit Atasever
Introduction: Studies have found that sexual minorities, including gay and bisexual men, have more mental health problems than the heterosexual population. The aim of this study is to examine the prevalence of depression in gay and bisexual men and its relationship with some socio-demographic variables. Methods: Participants were recruited from groups on social media such as “Facebook,” “Instagram,” and an LGBT app. Only homosexual and bisexual men were included in the study. Each participant completed the personal information form and the Beck Depression Inventory. Results: It was found that 28.7% of the 418 homosexual and bisexual men included in the study had mild depression, 29.7% had moderate depression, and 9.1% had severe depression. No statistically significant difference was found between the depression rates of homosexual and bisexual men. Discussion and Conclusion: At the end of the study, it was determined that the rate of depression in homosexual and bisexual men was higher than in the general population. Smoking, alcohol, and substance abuse rates are also higher in this group than in the general population. The limitations of this study are that only gay and bisexual men were included in the study, and there was no control group.
{"title":"Investigation of Depression Level and Its Relationship with Some Sociodemographic Characteristics in Homosexual and Bisexual Men","authors":"Ümit Atasever","doi":"10.14744/lhhs.2023.10001","DOIUrl":"https://doi.org/10.14744/lhhs.2023.10001","url":null,"abstract":"Introduction: Studies have found that sexual minorities, including gay and bisexual men, have more mental health problems than the heterosexual population. The aim of this study is to examine the prevalence of depression in gay and bisexual men and its relationship with some socio-demographic variables. Methods: Participants were recruited from groups on social media such as “Facebook,” “Instagram,” and an LGBT app. Only homosexual and bisexual men were included in the study. Each participant completed the personal information form and the Beck Depression Inventory. Results: It was found that 28.7% of the 418 homosexual and bisexual men included in the study had mild depression, 29.7% had moderate depression, and 9.1% had severe depression. No statistically significant difference was found between the depression rates of homosexual and bisexual men. Discussion and Conclusion: At the end of the study, it was determined that the rate of depression in homosexual and bisexual men was higher than in the general population. Smoking, alcohol, and substance abuse rates are also higher in this group than in the general population. The limitations of this study are that only gay and bisexual men were included in the study, and there was no control group.","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14744/lhhs.2023.12011
Suna Kavurgacı
article
{"title":"The Success of Noninvasive Mechanical Ventilation in Relation with Concomitant Disorders in Copd Patients with Acute Hypercapnic Respiratory Failure","authors":"Suna Kavurgacı","doi":"10.14744/lhhs.2023.12011","DOIUrl":"https://doi.org/10.14744/lhhs.2023.12011","url":null,"abstract":"article","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14744/lhhs.2023.40001
Ahmet Turan Kaya
Introduction: The aim of the study was to investigate associations between hepatosteatosis (HS) with computed tomography severity score (CT-SS) and survival of coronavirus disease 2019 (COVID-19) patients attending the hospital. Methods: Our study was a retrospective analysis of 435 reverse transcription polymerase-chain reaction-positive COVID-19 patients (aged ≥ 18 years) who attended our hospital between September and December 2021. The patient’s chest CT parenchymal findings and CT-SSs were reported. For quantitative analysis, HS was defined if hep-atic-to-splenic attenuation ratio (CTL/S)<1. In very fatty livers, we defined the hyperdense appearance of vascular structures compared to liver parenchyma as “pseudocontrast sign (PCS).” We divided patients into three groups based on the hepatic attenuation comparison of vascular attenuation. Group 1: no HS, Group 2: HS without PCS, and Group 3: HS with PCS. Results: 210/435 (48.3%) patients were included in Group 1, 184/435 (42.3%) in Group 2, and 41/435 (9.4%) in Group 3. The Mean CTL/S of Group 3 was 0.56±0.14, which was significantly lower than the other two groups (p<0.001). There was a very significant (p<0.001) negative correlation between CT-SS and CTL/S. There was no significant difference between HS groups with intensive care unit (ICU) admission (p=0.27) and mortality (p=0.64). In multivariate Cox regression analysis, HS with PCS was an 11-fold (p<0.001) risk factor for shortening the time from hospital admission to death and 3-fold (p=0.035) for shortening the time from ICU admission to death. Discussion and Conclusion: In our study, HS with the PCS was significantly associated with CT-SS but not with overall mortality. Consequently, this sign may be an independent indicator of shorter survival times among patients who died. However, multicenter studies are needed in a large patient population.
{"title":"Hepatosteatosis Patients with Pseudocontrast Sign in COVID-19: Relationships with Disease Severity and Survival Times","authors":"Ahmet Turan Kaya","doi":"10.14744/lhhs.2023.40001","DOIUrl":"https://doi.org/10.14744/lhhs.2023.40001","url":null,"abstract":"Introduction: The aim of the study was to investigate associations between hepatosteatosis (HS) with computed tomography severity score (CT-SS) and survival of coronavirus disease 2019 (COVID-19) patients attending the hospital. Methods: Our study was a retrospective analysis of 435 reverse transcription polymerase-chain reaction-positive COVID-19 patients (aged ≥ 18 years) who attended our hospital between September and December 2021. The patient’s chest CT parenchymal findings and CT-SSs were reported. For quantitative analysis, HS was defined if hep-atic-to-splenic attenuation ratio (CTL/S)<1. In very fatty livers, we defined the hyperdense appearance of vascular structures compared to liver parenchyma as “pseudocontrast sign (PCS).” We divided patients into three groups based on the hepatic attenuation comparison of vascular attenuation. Group 1: no HS, Group 2: HS without PCS, and Group 3: HS with PCS. Results: 210/435 (48.3%) patients were included in Group 1, 184/435 (42.3%) in Group 2, and 41/435 (9.4%) in Group 3. The Mean CTL/S of Group 3 was 0.56±0.14, which was significantly lower than the other two groups (p<0.001). There was a very significant (p<0.001) negative correlation between CT-SS and CTL/S. There was no significant difference between HS groups with intensive care unit (ICU) admission (p=0.27) and mortality (p=0.64). In multivariate Cox regression analysis, HS with PCS was an 11-fold (p<0.001) risk factor for shortening the time from hospital admission to death and 3-fold (p=0.035) for shortening the time from ICU admission to death. Discussion and Conclusion: In our study, HS with the PCS was significantly associated with CT-SS but not with overall mortality. Consequently, this sign may be an independent indicator of shorter survival times among patients who died. However, multicenter studies are needed in a large patient population.","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14744/lhhs.2023.70003
Ayşegül Yılmaz
Introduction: Various studies have demonstrated a clear link between mucosa-adherent Escherichia coli and colorectal cancer (CRC). This in silico study aims to identify commonly differentially expressed genes in CRC cells treated with distinct E. coli strains, regardless of their pathogenicity. Methods: The raw data from the GEO database were normalized with the Affy package in the R software. We used computational methods (limma analysis, linear regression analysis, hierarchical clustering, and gene set enrichment analysis) to identify the transcriptome alterations induced by E. coli O:157.H7 and E. coli K-12 strains. Results: Out of the 80 genes that were significantly differentially expressed in both E. coli-treated groups, only three genes (HIST1H4E, JUN, and TMEM267) demonstrated a high correlation (r>0.9) with the incubation time. TMEM267 is downregulated as the incubation time increases whereas HIST1H4E and JUN become upregulated. In addition, we determined nine common genesets that were significantly enriched in the Caco2 cell line after treatment either with E.coli O:157.H7 or K-12 strains. Discussion and Conclusion: In this study, the changes in gene expressions resulting from the treatment of colon cancer cells with different E. coli strains were investigated. These findings highlight the potential impact of E. coli on cancer development and suggest that certain genes may play a role in mediating the effects of E. coli in the context of CRC. Further research is warranted to elucidate the underlying mechanisms and specific pathways involved in the interactions between E. coli and cancer cells.
{"title":"Unraveling the Influence of Escherichia coli Strains on Gene Expression in Colorectal Cancer Cells through in Silico Analysis","authors":"Ayşegül Yılmaz","doi":"10.14744/lhhs.2023.70003","DOIUrl":"https://doi.org/10.14744/lhhs.2023.70003","url":null,"abstract":"Introduction: Various studies have demonstrated a clear link between mucosa-adherent Escherichia coli and colorectal cancer (CRC). This in silico study aims to identify commonly differentially expressed genes in CRC cells treated with distinct E. coli strains, regardless of their pathogenicity. Methods: The raw data from the GEO database were normalized with the Affy package in the R software. We used computational methods (limma analysis, linear regression analysis, hierarchical clustering, and gene set enrichment analysis) to identify the transcriptome alterations induced by E. coli O:157.H7 and E. coli K-12 strains. Results: Out of the 80 genes that were significantly differentially expressed in both E. coli-treated groups, only three genes (HIST1H4E, JUN, and TMEM267) demonstrated a high correlation (r>0.9) with the incubation time. TMEM267 is downregulated as the incubation time increases whereas HIST1H4E and JUN become upregulated. In addition, we determined nine common genesets that were significantly enriched in the Caco2 cell line after treatment either with E.coli O:157.H7 or K-12 strains. Discussion and Conclusion: In this study, the changes in gene expressions resulting from the treatment of colon cancer cells with different E. coli strains were investigated. These findings highlight the potential impact of E. coli on cancer development and suggest that certain genes may play a role in mediating the effects of E. coli in the context of CRC. Further research is warranted to elucidate the underlying mechanisms and specific pathways involved in the interactions between E. coli and cancer cells.","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134884181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/lhhs.2022.20001
A. Yozgat
{"title":"Screening of Patients for COVID-19 Infecton Before Endoscopic Procedures","authors":"A. Yozgat","doi":"10.14744/lhhs.2022.20001","DOIUrl":"https://doi.org/10.14744/lhhs.2022.20001","url":null,"abstract":"","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129825605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/lhhs.2022.50005
E. Avcı
{"title":"What are the parameters that can affect bowel preparation?","authors":"E. Avcı","doi":"10.14744/lhhs.2022.50005","DOIUrl":"https://doi.org/10.14744/lhhs.2022.50005","url":null,"abstract":"","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129863840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/lhhs.2021.70007
K. Yalçın, M. B. Küçükay, A. Koşar
Introduction: Obesity is one of the most critical health problems in the world. Obesity is in the etiology of various chronic diseases, thus causes mortality and morbidity. Especially in recent studies, 25 hydroxyvitamin D3 (25-OH D3) deficiency has been associated with many different diseases and became a significant health problem. Although studies are suggesting an association between obesity and 25-OH D3 deficiency, there is no consensus yet. This study investigates the relationship between 25-OH D3 levels and blood glucose level and body mass index in non-obese and non-diabetic women. Methods: In this study, the data of female patients aged between 18–84 years, who were applied to the internal med- icine outpatient clinic between 2016 and 2018 and whose heights and weights were recorded, were retrospectively analyzed. The study included 201 female patients. Results: There was a negative correlation revealed between vitamin D levels and body mass index (r=0.222, p<0.01). Discussion and Conclusion: According to these results, 25-OH D3 deficiency should be considered in patients with a high body mass index.
{"title":"The Relationship between Vitamin D Levels and Body Mass Index and Fasting Blood Glucose in Non-Obese Non-Diabetic Women","authors":"K. Yalçın, M. B. Küçükay, A. Koşar","doi":"10.14744/lhhs.2021.70007","DOIUrl":"https://doi.org/10.14744/lhhs.2021.70007","url":null,"abstract":"Introduction: Obesity is one of the most critical health problems in the world. Obesity is in the etiology of various chronic diseases, thus causes mortality and morbidity. Especially in recent studies, 25 hydroxyvitamin D3 (25-OH D3) deficiency has been associated with many different diseases and became a significant health problem. Although studies are suggesting an association between obesity and 25-OH D3 deficiency, there is no consensus yet. This study investigates the relationship between 25-OH D3 levels and blood glucose level and body mass index in non-obese and non-diabetic women. Methods: In this study, the data of female patients aged between 18–84 years, who were applied to the internal med- icine outpatient clinic between 2016 and 2018 and whose heights and weights were recorded, were retrospectively analyzed. The study included 201 female patients. Results: There was a negative correlation revealed between vitamin D levels and body mass index (r=0.222, p<0.01). Discussion and Conclusion: According to these results, 25-OH D3 deficiency should be considered in patients with a high body mass index.","PeriodicalId":187470,"journal":{"name":"Lokman Hekim Health Sciences","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133656115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/lhhs.2021.80003
Dilek Yazıcıoğlu Cezayir
Correspondence: Taylan Altıparmak, M.D. Gazi Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Ankara, Turkey E-mail: tayalt@hotmail.com Submitted: 12.08.2021 Accepted: 20.10.2021 Cite this article as: Yazıcıoğlu Cezayir D, İrkeç C, Altıparmak T, Tural R, Altan N. The Possible Role of Apelin and Sirtuin 1 in Migraine Pathogenesis. Lokman Hekim Health Sci 2021;1(2):66–69. Copyright 2021 Lokman Hekim Health Sciences OPEN ACCESS This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). BRIEF REPORT Our study presented as a poster and only of the abstract section in PACTRIMS 2017. 67 Yazıcıoğlu Cezayir et al.; Apelin and Sirtuin 1 in Migraine Pathogenesis / doi: 10.14744/lhhs.2021.80003 of several organs. It is a key regulator in a normal glucolipid metabolism, also playing a potential role in obesity, insulin resistance, controlling water, and food intake.[5] Whether migraine creates a neurodegenerative process remains a controversial subject; we hypothesize that apelin and SIRT1 molecules may have a possible role in this pathogenesis. Materials and Methods Study Design and Data Analysis Thirty patients were accepted in this study who had applied to Gazi University, Faculty of Medicine, Neurology Department between 2014 and 2015 years. Patients have been diagnosed as having migraine according to The International Classification of Headache Disorders, 3rd edition beta version (ICHD–III beta), and patients who had systemic comorbidity especially inflammatory conditions, obesity, and severe cardiac pathologies were excluded from this study. In the migraine group, 22 patients had episodic migraine and 8 had chronic migraine. Four patients had migraines with aura, and 26 had migraines without aura. Furthermore, 12 patients were in an attack period, and 18 were in an attack-free period at the time blood samples were obtained. All patients with migraine with aura were also in the episodic migraine group. The mean disease duration of the patients after diagnosis was 5.6 years. At the time of sampling, all patients have received treatment. The treatment that had been received by chronic migraine patients were amitriptyline, propranolol, duloxetine, topiramate, nonsteroidal anti-inflammatory drugs, and triptans; and the treatments received by episodic patients who had less than three attacks in a month were only nonsteroidal anti-inflammatory drugs and triptans. Furthermore, 20 healthy volunteers, with similar age and gender compared to the migraine group, were included in this study as a control group. The study was approved by the ethics committee of Keçiören Training and Research Hospital (No. 891 dated 24.06.2015). All individuals who were included in the study were informed about the study and their written consents were obtained. Experimental Procedure Ten cubic centimeters (cc) peripheric blood samples were obtained from patients and healthy volunteers. Serum parts were separated by centrifugation at
通讯:Taylan Altıparmak, M.D. Gazi Üniversitesi Tıp fak ltesi, Nöroloji Anabilim dalyi, Ankara，土耳其E-mail: tayalt@hotmail.com提交时间:12.08.2021接收时间:20.10.2021引用本文为:Yazıcıoğlu Cezayir D， İrkeç C, Altıparmak T, Tural R, Altan N. Apelin和Sirtuin 1在偏头痛发病中的可能作用。中华体检学杂志，2011;1(2):66-69。版权所有2021 Lokman Hekim Health Sciences OPEN ACCESS这是一篇基于CC BY-NC许可(http://creativecommons.org/licenses/by-nc/4.0/)的开放获取文章。我们的研究仅作为PACTRIMS 2017的摘要部分的海报发表。67 Yazıcıoğlu Cezayir等;Apelin和Sirtuin 1在偏头痛发病机制中的作用[doi: 10.14744/lhhs.2021.80003]它是正常糖脂代谢的关键调节因子，在肥胖、胰岛素抵抗、控制水分和食物摄入方面也起着潜在的作用。[5]偏头痛是否造成神经退行性过程仍然是一个有争议的话题;我们推测apelin和SIRT1分子可能在这一发病机制中起作用。材料与方法研究设计与数据分析本研究纳入了2014 - 2015年在加齐大学医学院神经内科申请的30例患者。根据国际头痛疾病分类第三版beta版(ICHD-III beta版)诊断为偏头痛的患者，以及有全身合并症，特别是炎症、肥胖和严重心脏病变的患者被排除在本研究之外。在偏头痛组，22名患者患有发作性偏头痛，8名患者患有慢性偏头痛。有先兆偏头痛4例，无先兆偏头痛26例。此外，在采集血样时，12名患者处于发作期，18名患者处于无发作期。所有先兆偏头痛患者也属于发作性偏头痛组。确诊后患者的平均病程为5.6年。抽样时，所有患者均已接受治疗。慢性偏头痛患者接受的治疗有阿米替林、心得安、度洛西汀、托吡酯、非甾体抗炎药和曲坦类药物;一个月内发作少于三次的发作性患者只接受非甾体类抗炎药和曲坦类药物的治疗。此外，20名年龄和性别与偏头痛组相似的健康志愿者被纳入本研究作为对照组。本研究已获得Keçiören培训与研究医院伦理委员会(2015年6月24日第891号)批准。所有参与研究的人都被告知了这项研究，并获得了他们的书面同意。实验方法:取患者和健康志愿者外周血10立方厘米(cc)。分离血清部分，在3000 rpm下离心5分钟。血清样品保存在- 70°C以待分析。采用ELISA技术定量测定血清SIRT1和apelin。将含有SIRT1和apelin抗体的标准培养基稀释后，将血清样品加入孔中，室温孵育2.5 h，洗涤，再与生物素抗体孵育1 h。洗涤后，加入链亲和素，静置45 h，再次洗涤，一步试剂(上海生物测定技术实验室®Human SIRT1 and apelin Kit);(中国)，孵育30分钟。分光光度法测定SIRT - 1和apelin的浓度。采用酶联免疫吸附测定仪测定450 nm处吸光度值。采用IBM SPSS 21.0统计软件包进行数据分析。数据分析采用描述性统计方法(频率、百分比、中位数、最小-最大值)，定性数据比较采用chissquared和Fisher’s and Yates Chi-square (c2)。依从性通过数据的正态分布Kolmogorov-Smirnov和Shapiro-Wilk检验进行评估。概率(p)值小于0.05为显著性。
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