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Electrocatalytic advancements with trimetallic nanoparticles: design strategies and roadmap 三金属纳米粒子的电催化进展:设计策略和路线图。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-17 DOI: 10.1039/D5NA00936G
Sonali Garg, Aafreen Nakai, Rijo Rajeev, Anitha Varghese and Manvinder Kaur

Trimetallic nanoparticles (TMNPs) have emerged as a versatile class of nanomaterials whose multifunctional and synergistic properties surpass those of mono- and bimetallic systems. This review examines the recent advancements in TMNP synthesis, bridging conventional top-down techniques with state-of-the-art bottom-up strategies that provide precise control over atomic ordering while addressing concerns related to sustainability. This review provides a systematic discussion of the structural and synthetic innovations resulting in their rapid adoption in electrochemical applications, including fuel cells, oxygen and hydrogen electrocatalysis, supercapacitors, and electrochemical sensing. Particular emphasis on the influence of interfacial and compositional engineering in TMNPs, ameliorating superior catalytic activity and stability over conventional catalysts, has been comprehensively highlighted. Finally, key challenges, including scalability, long-term stability, biocompatibility, and miniaturization, have been outlined for future opportunities for designing sustainable, application-oriented TMNPs. By linking fundamental structure–property relationships with electrochemical performance, this review contributes a unified framework for fabricating next-generation TMNPs towards energy conversion, catalysis, and advanced sensing applications.

三金属纳米粒子(TMNPs)是一种多功能的纳米材料,其多功能和协同性能超过了单金属和双金属体系。本文综述了TMNP合成的最新进展,将传统的自上而下的技术与最先进的自下而上的策略连接起来,在解决与可持续性相关的问题的同时,提供对原子顺序的精确控制。这篇综述系统地讨论了结构和合成方面的创新,这些创新导致了它们在电化学应用中的迅速采用,包括燃料电池、氧和氢电催化、超级电容器和电化学传感。特别强调了界面和组成工程对TMNPs的影响,改善了比传统催化剂更好的催化活性和稳定性。最后,概述了未来设计可持续的、面向应用的TMNPs的关键挑战,包括可扩展性、长期稳定性、生物相容性和小型化。通过将基本的结构-性质关系与电化学性能联系起来,本综述为制造面向能量转换、催化和高级传感应用的下一代TMNPs提供了统一的框架。
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引用次数: 0
Dual functionality of silver- and bismuth-based molybdenum disulfide multiple phases towards effective oxygen evolution reaction and dye degradation 银基和铋基二硫化钼多相双官能团对有效析氧反应和染料降解的影响。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-17 DOI: 10.1039/D5NA00763A
Asma Asmat, Sobia Dilpazir, Muhammd Imran, Sawaira Moeen, Anwar Ul-Hamid, Ghafar Ali and Muhammad Ikram

The engineering of two-dimensional (2D) layered materials through metallic and non-metallic doping has proven to be an intriguing strategy for achieving efficient water oxidation and high catalytic activities. The current study reveals the fabrication of a novel bifunctional Ag/Bi-doped MoS2 catalyst with a fixed concentration (2 wt%) of bismuth (Bi) and varying concentrations (1 and 3 wt%) of silver (Ag) as dopants in MoS2 (host) using a facile hydrothermal strategy. The Bi-doped MoS2 catalyst with 3 wt% Ag exhibited an excellent catalytic activity of 99.57% for the elimination of RhB dye from water and flexibility in a wide pH range, signifying its catalytic dye-degradation potential in diverse pH environments. Additionally, the bifunctional catalyst demonstrated an outstanding electrocatalytic OER performance, requiring an overpotential of only 192 mV to reach a current density of 10 mA cm−2 and a small Tafel slope of 65.3 mV dec−1.

通过金属和非金属掺杂的二维(2D)层状材料工程已被证明是实现高效水氧化和高催化活性的有趣策略。目前的研究揭示了一种新型双功能银/双掺杂MoS2催化剂的制备,该催化剂采用固定浓度(2 wt%)的铋(Bi)和不同浓度(1和3 wt%)的银(Ag)作为MoS2(宿主)的掺杂剂,使用简单的水热策略。银质量分数为3 wt%的双掺杂MoS2催化剂对水中RhB染料的降解活性为99.57%,且在较宽的pH范围内具有一定的灵活性,表明其在不同pH环境下具有催化降解染料的潜力。此外,双功能催化剂表现出出色的电催化OER性能,只需要192 mV的过电位就可以达到10 mA cm-2的电流密度和65.3 mV dec1的小Tafel斜率。
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引用次数: 0
Sodium cholate orchestrated synthesis of silver deposited camphorsulphonic acid doped rodlike polypyrrole architecture for asymmetric supercapacitor applications 在不对称超级电容器应用中,胆酸钠协调合成银沉积樟脑磺酸掺杂棒状聚吡咯结构。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-17 DOI: 10.1039/D5NA00792E
Arpita Adhikari, Monojit Mondal, Dipankar Singha, Souvik Das, Samparka Sanyal, Pradip Kar, Malay Kumar Rana, Tarun Kanti Bhattacharyya and Basudev Lahiri

An asymmetric supercapacitor (ASC) was developed using camphorsulphonic acid (CSA)-doped polypyrrole (PPY) nanorods as the positive electrode and activated carbon as the negative electrode. The CSA doping and rod-like morphology enhanced the conductivity and electrochemical activity of PPY. Density functional theory (DFT) analysis revealed that CSA significantly lowers the HOMO–LUMO energy gaps of pyrrole oligomers, particularly with increasing chain length, indicating improved electronic properties favorable for charge storage. Electrochemical testing showed that the pristine CSA-doped PPY electrode exhibited a moderate specific capacitance of 180 F g−1 at 2 mV s−1, which decreased at higher scan rates. However, after silver nanoparticle deposition on the PPY surface, it displayed a highly reversible and rectangular-type cyclic voltammetry (CV) profile, indicating ideal capacitive behavior, with a specific capacity of 527.28 F g−1 at a scan rate of 2 mV s−1. This enhancement was attributed to the strong interaction between silver and the CSA-doped PPY nanorods, which synergistically improved the capacitive performance. The energy density value obtained from the Ragone plot was 12.57 Wh kg−1. These findings demonstrated the potential of metal-doped conductive polymers for high-performance supercapacitor applications. For real-time evaluation, cyclic voltammetry (CV) and galvanostatic charge–discharge (GCD) tests were performed on the assembled asymmetric supercapacitor (ASC). The ASC employed an Ag-deposited, CSA-doped polypyrrole (PPY) positive electrode and a biowaste-derived activated porous carbon negative electrode. The device delivered a specific capacitance of 208.88 F g−1 at 2 mA cm−2, with corresponding gravimetric energy and power densities of 41.78 Wh kg−1 and 886.89 W kg−1, respectively.

以樟脑磺酸(CSA)掺杂聚吡咯(PPY)纳米棒为正极,活性炭为负极,研制了一种不对称超级电容器(ASC)。CSA掺杂和棒状形貌增强了PPY的电导率和电化学活性。密度泛函理论(DFT)分析表明,CSA显著降低了吡咯低聚物的HOMO-LUMO能隙,特别是随着链长的增加,表明CSA改善了有利于电荷存储的电子性质。电化学测试表明,原始的csa掺杂PPY电极在2 mV s-1下的比电容为180 F -1,随着扫描速率的提高而降低。然而,银纳米颗粒沉积在PPY表面后,显示出高度可逆的矩形型循环伏安曲线,表明理想的电容行为,在扫描速率为2 mV s-1时,比容量为527.28 gf -1。这种增强归因于银与csa掺杂的PPY纳米棒之间的强相互作用,协同提高了电容性能。Ragone图得到的能量密度值为12.57 Wh kg-1。这些发现证明了金属掺杂导电聚合物在高性能超级电容器中的应用潜力。为了实时评估,对组装的非对称超级电容器(ASC)进行了循环伏安(CV)和恒流充放电(GCD)测试。ASC采用银沉积、csa掺杂的聚吡咯(PPY)正极和生物废物衍生的多孔活性炭负极。该器件在2 mA cm-2下的比电容为208.88 F -1,相应的重量能量和功率密度分别为41.78 Wh kg-1和886.89 W kg-1。
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引用次数: 0
Two-dimensional Fe-MOF and bimetallic NiFe-MOFs with different Ni : Fe ratios for superior electrochemical performance in supercapacitor applications 具有不同Ni: Fe比的二维Fe- mof和双金属Ni - mof在超级电容器中具有优异的电化学性能。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-17 DOI: 10.1039/D5NA00246J
Hanaa A. Mohamedien, Abeer Enaiet Allah, Soha M. Kamal and Fatma Mohamed

Supercapacitors (SCs) are garnering significant attention owing to their remarkable power density. Transition-metal-based MOFs have abundant valence states, which contribute to their superior stability, high energy density, and high power density. In this study, monometallic Fe-BDC MOF and bimetallic NiFe-BDC MOFs were synthesized with different molar ratios and examined for their application in supercapacitors. SEM-coupled EDX, BET, and XRD analyses were performed to determine their morphologies and microstructures. The electrodes were evaluated through cyclic voltammetry (CV), galvanostatic charge/discharge (GCD), and electrochemical impedance spectroscopy (EIS) measurements in a 1 M KOH aqueous electrolyte. The Ni10Fe1-BDC MOF electrode exhibited the highest capacitance (918.75 F g−1) at 4 A g−1 due to its fast ion transport and low electrical resistance, resulting from its spherical structure. The Ni10Fe1-BDC MOF//Ni10Fe1-BDC MOF symmetric supercapacitor accomplished a high energy density of 106.42 Wh kg−1 at a power density of 3720 W kg−1 and exhibited a high rate capability of 137.73% after 2000 cycles, indicating its potential in supercapacitor applications.

超级电容器(SCs)因其卓越的功率密度而备受关注。过渡金属基mof具有丰富的价态,这使得其具有优异的稳定性、高能量密度和高功率密度。本研究以不同的摩尔比合成了单金属Fe-BDC MOF和双金属Fe-BDC MOF,并考察了它们在超级电容器中的应用。sem耦合EDX, BET和XRD分析确定了它们的形貌和微观结构。在1 M KOH水溶液中,通过循环伏安法(CV)、恒流充放电法(GCD)和电化学阻抗谱(EIS)测量对电极进行了评价。Ni10Fe1-BDC MOF电极在4 A g-1时具有较高的电容量(918.75 F -1),这是由于Ni10Fe1-BDC MOF电极具有快速离子输运和低电阻的球形结构。Ni10Fe1-BDC MOF//Ni10Fe1-BDC MOF对称超级电容器在功率密度为3720 W kg-1的情况下,实现了106.42 Wh kg-1的高能量密度,循环2000次后具有137.73%的高速率容量,显示了其在超级电容器中的应用潜力。
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引用次数: 0
Plasmon-enhanced photocatalytic nanoreactors for selective inactivation of murine leukemia virus (MLV) 等离子体增强光催化纳米反应器选择性灭活小鼠白血病病毒(MLV)。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-16 DOI: 10.1039/D5NA00784D
Tianhong Ouyang, Koustav Kundu, James Hood, Baichuan Cheng, Yixin Mei, Ainsley Gray, Suryaram Gummuluru and Björn M. Reinhard

The lack of effective virucides that can eradicate viruses under mild conditions that do not harm mammalian cells or high value biologics poses risks for the food, health care, and pharmaceutical industries. Here, we examine plasmonic nanoreactors that contain the photocatalyst [Ru(bpy)3]2+ localized in the evanescent electric (E-) field of a silver nanoparticle (AgNP) as a selective virucide. The AgNP is passivated by a lipid coating and functionalized with annexin V to target and bind enveloped viruses with surface-exposed phosphatidylserine and localize the light-driven reactivity of the plasmonic nanoreactor virucide (PNV) in the proximity of the virus to enhance inactivation efficacy and minimize collateral damage. The lipid coating prevents premature Ag+ release under “dark” conditions and minimizes cytotoxicity. Upon illumination at 470 nm, plasmon-enhanced excitation of [Ru(bpy)3]2+ induces photoreactivity and generates reactive oxygen species (ROS) that damage the bound virus and increase the permeability of the lipid coating around the AgNP, facilitating the release of Ag+ ions. Using murine leukemia virus (MLV) as a model, annexin V-functionalized PNVs achieved over 85% viral inactivation after 30 minutes of illumination with 470 nm light (65 mW cm−2) at a 1 : 1 virus : PNV ratio, with no measurable cytotoxicity in mammalian host cells. These results demonstrate that PNVs combine light-activated reactivity with targeting to achieve potent, selective virucidal activity under mild conditions, paving a path to safeguarding biologics and cell cultures against viral contamination.

缺乏能够在温和条件下根除病毒而不伤害哺乳动物细胞或高价值生物制剂的有效杀菌剂,给食品、保健和制药行业带来了风险。在这里,我们研究了含有光催化剂[Ru(bpy)3]2+的等离子体纳米反应器,该催化剂定位于银纳米颗粒(AgNP)的倏逝电(E-)场中,作为选择性杀毒剂。AgNP通过脂质涂层钝化,并通过膜联蛋白V功能化,以靶向和结合表面暴露的磷脂酰丝氨酸包膜病毒,并将等离子体纳米反应器杀毒剂(PNV)的光驱动反应性定位在病毒附近,以增强灭活效果并最小化附带损伤。脂质涂层可防止银离子在“黑暗”条件下过早释放,并将细胞毒性降至最低。在470 nm的光照下,等离子体增强激发[Ru(bpy)3]2+诱导光反应性,并产生活性氧(ROS),破坏结合的病毒,增加AgNP周围脂质涂层的通透性,促进Ag+离子的释放。以小鼠白血病病毒(MLV)为模型,膜联蛋白v功能化的PNV在470 nm光(65 mW cm-2)以1:1的病毒:PNV比例照射30分钟后,达到85%以上的病毒失活,在哺乳动物宿主细胞中没有可测量的细胞毒性。这些结果表明,pnv结合了光活化反应性和靶向性,在温和条件下实现了有效的选择性杀病毒活性,为保护生物制剂和细胞培养物免受病毒污染铺平了道路。
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引用次数: 0
Microbial synthesis of bimetallic Pd–Rh and Pd–Pt nanoparticle catalysts 微生物合成双金属钯铑和钯铂纳米颗粒催化剂。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-16 DOI: 10.1039/D5NA00861A
Jinxin Xie, Christopher Egan-Morriss, Victoria S. Coker, Sam Sullivan-Allsop, Rongsheng Cai, Sarah J. Haigh and Jonathan R. Lloyd

In this study the metal-reducing bacterium, Geobacter sulfurreducens, was used to efficiently recover palladium (Pd), platinum (Pt), and rhodium (Rh) from solution via enzymatic bioreduction to form monometallic or bimetallic bio-PGM nanoparticles. Herein, we report the novel biosynthesis of bimetallic PdRh alloy nanoparticles (bio-PdRh), along with bimetallic PdPt nanoparticles (bio-PdPt). In monometallic solutions, G. sulfurreducens biosynthesised Pd(0), Pt(0), and Rh(0) nanoparticles supported at the cell surface, consistent with bioreduction by outer membrane c-type cytochromes. However, in bimetallic solutions, the cells preferentially bioreduced Pt(IV) over Pd(II), resulting in Pt-rich bio-PdPt nanoparticles and highly dispersed Pd(II) cell-surface clusters. In contrast, co-bioreduction of Pd(II) and Rh(III) led to the formation of PdRh alloy nanoparticles. We hypothesise that differences in the reduction potentials of the metal complexes were key to forming these different nanostructures. The reduction of 4-nitrophenol was used to assess bionanoparticle catalytic activity. Monometallic bio-Pt and bio-Rh displayed low activity for this reaction, whereas bio-Pd nanoparticles were highly active and gave the fastest initial reaction rate. Bimetallic bio-PdPt and bio-PdRh catalysts performed comparably to bio-Pd, using half the Pd content. This work highlights the ability of metal-reducing bacteria to synthesise functional nanocatalysts while recovering precious metals from mixed metal-containing wastewaters.

在这项研究中,金属还原细菌硫还原Geobacter sulphreducens通过酶促生物还原从溶液中有效地回收钯(Pd),铂(Pt)和铑(Rh),形成单金属或双金属生物pgm纳米颗粒。在此,我们报告了新的生物合成双金属PdRh合金纳米颗粒(bio-PdRh),以及双金属PdPt纳米颗粒(bio-PdPt)。在单金属溶液中,G.硫还原生物合成的Pd(0)、Pt(0)和Rh(0)纳米颗粒,支持在细胞表面,与外膜c型细胞色素的生物还原一致。然而,在双金属溶液中,细胞优先生物还原Pt(iv)而不是Pd(ii),从而产生富Pt的生物pdpt纳米颗粒和高度分散的Pd(ii)细胞表面团簇。相反,Pd(ii)和Rh(iii)的共生物还原导致PdRh合金纳米颗粒的形成。我们假设金属配合物还原电位的差异是形成这些不同纳米结构的关键。用4-硝基苯酚的还原反应来评价生物纳米颗粒的催化活性。单金属bio-Pt和bio-Rh在该反应中表现出较低的活性,而bio-Pd纳米颗粒则表现出较高的活性,并给出了最快的初始反应速率。双金属生物- pdpt和生物- pdrh催化剂的性能与生物-Pd相当,使用一半的Pd含量。这项工作强调了金属还原细菌合成功能性纳米催化剂的能力,同时从含金属的混合废水中回收贵金属。
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引用次数: 0
Novel biogenic silver nanoparticles produced by Enterobacter xiangfangensis Pb204 reinstate the activity of specific antibiotics against resistant ESKAPE pathogens 香方肠杆菌Pb204产生的新型生物源银纳米颗粒恢复了特异性抗生素对ESKAPE耐药病原体的活性。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-15 DOI: 10.1039/D5NA00787A
Prabhavathi Sathish Sundar, Rofhiwa Musoliwa and Kulsum Kondiah

Antimicrobial resistance (AMR) in pathogenic bacteria remains a major challenge and critical threat to the global healthcare industry, demanding alternative therapeutic strategies. Among the various nanomaterials studied, silver nanoparticles (Ag-NPs) have shown promising antibacterial properties due to their broad-spectrum activity, oligodynamic effect, and reduced possibility of inducing microbial resistance. This study investigates the antimicrobial efficacy of biogenically synthesised silver nanoparticles using a cell-free extract of Enterobacter xiangfangensis Pb204 combined with antibiotics against eight pathogenic bacterial strains, including ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.), E. coli, and Vibrio cholerae. The biogenic Ag-NPs were characterised by ultraviolet-visible (UV-Vis) spectroscopy and transmission electron microscopy (TEM) with energy-dispersive spectroscopy (EDS) analysis. Disc diffusion assays demonstrated that biogenic Ag-NPs (21 µg and 25 µg) effectively inhibited the growth of all tested pathogens. When Ag-NPs were combined with antibiotics amoxicillin/clavulanic acid (AMC), ampicillin (AMP), ciprofloxacin (CIP), meropenem (MEM), and vancomycin (VAN), most inhibition zones expanded, with the greatest synergistic effect observed in combination with vancomycin against Enterococcus faecium. These results support the potential of combined therapies using antibiotics and biogenic Ag-NPs to combat the effects of AMR in clinically significant pathogens.

致病菌的抗微生物药物耐药性(AMR)仍然是全球医疗保健行业面临的主要挑战和严重威胁,需要替代治疗策略。在研究的各种纳米材料中,银纳米颗粒(Ag-NPs)由于其广谱活性、寡动力学效应和降低诱导微生物耐药的可能性而显示出很好的抗菌性能。本研究研究了用无细胞香房肠杆菌Pb204提取物联合抗生素生物合成的银纳米颗粒对ESKAPE病原菌(粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌、肠杆菌)、大肠杆菌和霍乱弧菌等8种病原菌的抗菌效果。采用紫外可见光谱(UV-Vis)、透射电子显微镜(TEM)和能谱分析(EDS)对生物源Ag-NPs进行了表征。圆盘扩散实验表明,生物源性Ag-NPs(21µg和25µg)能有效抑制所有被试病原体的生长。Ag-NPs与阿莫西林/克拉维酸(AMC)、氨苄西林(AMP)、环丙沙星(CIP)、美罗培南(MEM)、万古霉素(VAN)等抗生素联用时,大部分抑制区扩大,其中与万古霉素联用对屎肠球菌的协同作用最大。这些结果支持使用抗生素和生物源性Ag-NPs联合治疗的潜力,以对抗AMR对临床重要病原体的影响。
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引用次数: 0
Nanoparticle-delivered miR-486-5p inhibits H2O2-induced injury in cultured endothelial and kidney tubular epithelial cells 纳米颗粒递送的miR-486-5p抑制h2o2诱导的培养内皮细胞和肾小管上皮细胞损伤。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-15 DOI: 10.1039/D5NA00581G
Ali O. Maadelat, Savindi Wehella, Adrianna Douvris, Shireesha Manturthi, Kevin D. Burns and Suresh Gadde

Acute kidney injury (AKI) is a serious condition characterized by a sudden decrease in kidney function, often leading to chronic kidney disease. Current treatment options are limited, necessitating novel therapeutic strategies. We previously showed that microRNA-486-5p (miR-486-5p) protects against AKI by regulating cell death (apoptosis) both in vitro and in vivo. However, efficient and selective delivery remains a challenge. In this study, we designed and developed nanoparticles (NPs) to encapsulate and deliver miR-486-5p to cultured endothelial and kidney tubular epithelial cells. NPs were characterized and optimized for size, polydispersity index, surface charge, and encapsulation efficiency. The stability of NPs in long-term storage and in biological solutions was confirmed. Results indicated effective cellular uptake of NPs, cargo microRNA delivery to the intracellular environment, and the absence of cytotoxicity upon NP treatment. Functional assessments showed that miR-486-5p-encapsulating lipid-polymeric hybrid NPs (HNPs) suppressed the expression of Forkhead Box Protein O1 (FOXO1), a validated target of miR-486-5p, in all cell lines investigated, suggesting effective miR-486-5p protection and transport. Both endothelial and tubular epithelial cells were significantly protected against induced apoptosis when pretreated with miR-486-5p-encapsulating HNPs. However, selective siRNA-mediated knockdown of FOXO1 did not result in injury protection, suggesting involvement of other miR-486-5p targets. Furthermore, cell injury-induced expression of inflammatory cytokines was inhibited by HNP-delivered miR-486-5p in both cell lines. These findings demonstrate the protective and anti-inflammatory effects of miR-486-5p-HNP systems in injured endothelial and tubular epithelial cells, highlighting their capacity as a potential nano-therapy for AKI and paving the way for in vivo studies and clinical applications.

急性肾损伤(AKI)是一种以肾功能突然下降为特征的严重疾病,常导致慢性肾脏疾病。目前的治疗方案是有限的,需要新的治疗策略。我们之前的研究表明,microRNA-486-5p (miR-486-5p)通过在体外和体内调节细胞死亡(凋亡)来预防AKI。然而,高效和有选择性的交付仍然是一个挑战。在这项研究中,我们设计并开发了纳米颗粒(NPs)来包裹miR-486-5p并将其递送到培养的内皮细胞和肾小管上皮细胞中。对NPs的尺寸、多分散性指数、表面电荷和包封效率进行了表征和优化。证实了NPs在长期储存和生物溶液中的稳定性。结果表明,NPs在细胞内被有效摄取,microRNA被递送到细胞内环境,并且在NP处理后没有细胞毒性。功能评估显示,miR-486-5p包封的脂质聚合物杂交NPs (HNPs)在所有被研究的细胞系中抑制了叉头盒蛋白O1 (FOXO1)的表达,FOXO1是miR-486-5p的有效靶点,表明miR-486-5p有效保护和运输。用mir -486-5p包封的HNPs预处理后,内皮细胞和小管上皮细胞都能明显地防止诱导的凋亡。然而,sirna介导的FOXO1的选择性敲低并没有导致损伤保护,这表明其他miR-486-5p靶点也参与其中。此外,在两种细胞系中,hnp传递的miR-486-5p抑制了细胞损伤诱导的炎症细胞因子的表达。这些发现证明了miR-486-5p-HNP系统对损伤的内皮细胞和小管上皮细胞的保护和抗炎作用,突出了它们作为AKI潜在纳米疗法的能力,并为体内研究和临床应用铺平了道路。
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引用次数: 0
Announcing the Nanoscale Advances Paper Prize. 宣布纳米级进展论文奖。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-12 eCollection Date: 2026-01-06 DOI: 10.1039/d5na90081f
Paul Scott, Jeremy P Allen, Yue Zhang, Dirk M Guldi

Here at Nanoscale Advances we are lucky to receive high quality research papers from across the full range of nanoscience and nanotechnology topics every year. We wanted to find a way to recognise the most significant papers published in the journal each year, judged by the expert nanoscience and nanotechnology researchers who make up our Editorial and Advisory Boards. In this article we are excited to announce the winner and runners-up of the very first Paper Prize, as well as the process that we have taken to select these excellent articles.

在这里,我们很幸运每年都能收到来自纳米科学和纳米技术主题的高质量研究论文。我们希望找到一种方法来识别每年在该杂志上发表的最重要的论文,这些论文由组成我们的编辑和顾问委员会的纳米科学专家和纳米技术研究人员评判。在这篇文章中,我们很高兴地宣布第一篇论文奖的优胜者和亚军,以及我们选择这些优秀文章的过程。
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引用次数: 0
Announcing the Nanoscale Advances Paper Prize 宣布纳米级进展论文奖。
IF 4.6 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-12 DOI: 10.1039/D5NA90081F
Paul Scott, Jeremy P. Allen, Yue Zhang and Dirk M. Guldi

Here at Nanoscale Advances we are lucky to receive high quality research papers from across the full range of nanoscience and nanotechnology topics every year. We wanted to find a way to recognise the most significant papers published in the journal each year, judged by the expert nanoscience and nanotechnology researchers who make up our Editorial and Advisory Boards. In this article we are excited to announce the winner and runners-up of the very first Paper Prize, as well as the process that we have taken to select these excellent articles.

在这里,我们很幸运每年都能收到来自纳米科学和纳米技术主题的高质量研究论文。我们希望找到一种方法来识别每年在该杂志上发表的最重要的论文,这些论文由组成我们的编辑和顾问委员会的纳米科学专家和纳米技术研究人员评判。在这篇文章中,我们很高兴地宣布第一篇论文奖的优胜者和亚军,以及我们选择这些优秀文章的过程。
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引用次数: 0
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Nanoscale Advances
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