Pub Date : 2024-06-17eCollection Date: 2024-01-01DOI: 10.1080/12298093.2024.2362497
Abdelbagi Elfadil, Karem Ibrahem
Candida ranks as among the most frequently encountered fungal infections that associated with high morbidity and mortality. Quinoxaline derivatives are a group of small molecules that showed a promising antimicrobial activity. This study aimed to investigate the fungicidal effects of 3-hydrazinoquinoxaline-2-thiol against Candida in comparison with Amphotericin B in vitro as a reference. Also, we aim to assess the efficacy of 3-hydrazinoquinoxaline-2-thiol in vivo using mice oral candidiasis model. Fifty-six Candida isolates were subjected to susceptibility testing by broth microdilution method for 3-hydrazinoquinoxaline-2-thiol and Amphotericin B. Therefore, Minimal inhibitory concentrations (MIC) were assessed and compared. The oral candidiasis mice model was used to evaluate the activity of 3-hydrazinoquinoxaline-2-thiol in vivo. Microbiological evaluation of progression and ELISA were used in this study. 3-hydrazinoquinoxaline-2-thiol was more effective than Amphotericin B against most clinical isolates of Candida albicans. Higher effectiveness was seen against Candida glabrata and Candida parapsilosis isolates. However, the efficiency against Candida tropicalis isolates varies. 3-hydrazinoquinoxaline-2-thiol was also effective against Pichia kudriavzevii and Clavispora lusitaniae. 3-hydrazinoquinoxaline-2-thiol showed a good efficacy in mice model against C. albicans cells ATCC 10231. 3-hydrazinoquinoxaline-2-thiol has shown promising antifungal and anti-inflammatory activity against different Candida species. More tests and experiments are needed.
念珠菌是最常见的真菌感染之一，发病率和死亡率都很高。喹喔啉衍生物是一类具有良好抗菌活性的小分子。本研究旨在研究 3- 肼基喹喔啉-2-硫醇对念珠菌的杀菌效果，并将其与两性霉素 B 作为参照物进行体外比较。此外，我们还利用小鼠口腔念珠菌病模型评估 3- 肼基喹喔啉-2-硫醇在体内的疗效。我们采用肉汤微稀释法对 56 株念珠菌分离株进行了 3-肼基喹喔啉-2-硫醇和两性霉素 B 的药敏试验，并对最低抑菌浓度（MIC）进行了评估和比较。口腔念珠菌病小鼠模型用于评估 3- 肼基喹喔啉-2-硫醇的体内活性。本研究采用了微生物学进展评估和酶联免疫吸附试验。与两性霉素 B 相比，3-肼基喹喔啉-2-硫醇对大多数临床分离的白色念珠菌更有效。3-肼基喹啉-2-硫醇对白念珠菌大多数临床分离株的疗效优于两性霉素 B，而对光滑念珠菌和副丝状念珠菌分离株的疗效更高。但对热带念珠菌分离株的疗效则各不相同。3-肼基喹喔啉-2-硫醇对 Pichia kudriavzevii 和 Clavispora lusitaniae 也有效。在小鼠模型中，3-肼基喹喔啉-2-硫醇对白僵菌细胞 ATCC 10231 有很好的疗效。3- 肼基喹喔啉-2-硫醇对不同的念珠菌具有良好的抗真菌和抗炎活性。还需要进行更多的测试和实验。
{"title":"Antifungal Activity of 3-Hydrazinoquinoxaline-2-Thiol, a Novel Quinoxaline Derivative against Candida Species.","authors":"Abdelbagi Elfadil, Karem Ibrahem","doi":"10.1080/12298093.2024.2362497","DOIUrl":"10.1080/12298093.2024.2362497","url":null,"abstract":"<p><p><i>Candida</i> ranks as among the most frequently encountered fungal infections that associated with high morbidity and mortality. Quinoxaline derivatives are a group of small molecules that showed a promising antimicrobial activity. This study aimed to investigate the fungicidal effects of 3-hydrazinoquinoxaline-2-thiol against <i>Candida</i> in comparison with Amphotericin B <i>in vitro</i> as a reference. Also, we aim to assess the efficacy of 3-hydrazinoquinoxaline-2-thiol <i>in vivo</i> using mice oral candidiasis model. Fifty-six <i>Candida</i> isolates were subjected to susceptibility testing by broth microdilution method for 3-hydrazinoquinoxaline-2-thiol and Amphotericin B. Therefore, Minimal inhibitory concentrations (MIC) were assessed and compared. The oral candidiasis mice model was used to evaluate the activity of 3-hydrazinoquinoxaline-2-thiol <i>in vivo</i>. Microbiological evaluation of progression and ELISA were used in this study. 3-hydrazinoquinoxaline-2-thiol was more effective than Amphotericin B against most clinical isolates of <i>Candida albicans</i>. Higher effectiveness was seen against <i>Candida glabrata</i> and <i>Candida parapsilosis</i> isolates. However, the efficiency against <i>Candida tropicalis</i> isolates varies. 3-hydrazinoquinoxaline-2-thiol was also effective against <i>Pichia kudriavzevii</i> and <i>Clavispora lusitaniae</i>. 3-hydrazinoquinoxaline-2-thiol showed a good efficacy in mice model against <i>C. albicans</i> cells ATCC 10231. 3-hydrazinoquinoxaline-2-thiol has shown promising antifungal and anti-inflammatory activity against different <i>Candida</i> species. More tests and experiments are needed.</p>","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17eCollection Date: 2024-01-01DOI: 10.1080/12298093.2024.2360750
Atul Kumar Bhardwaj, K K Chandra, Rajesh Kumar
Entisol soil is hard and compact in nature, rendering it high in bulk density, which influences root penetration adversely and thereby poor plant growth. In this experiment, used seven treatments in different combination in normal soil, were used as growth media for the Terminalia arjuna seedling. T3 (60% entisol) found the best as it gave the highest biomass in the species regardless of arbuscular mycorrhizal fungi (AMF) treatment. AMF treatment enhanced the growth and biomass of plants significantly in all the given treatments. AMF colonization observed a maximum in tertiary roots. T1 (100% entisol soil) exhibited the highest degree of AMF colonization in tertiary roots, resulting in the highest mycorrhiza dependency of plants for this soil. The addition of normal soil to entisol soil was found to decrease the bulk density, resulting in increased root diameter, and T3 plants exhibited the highest biomass and AMF compatibility for T. arjuna species. The T. arjuna plant's growth and biomass responded positively to AMF in all types of treatments. The plant's growth and biomass were highest in the T3 treatment, which had a bulk density of 1.50 g/cm3. In this study, we combined the entisol with mycorrhizal inoculation of the nursery growing medium to promote plant growth and biomass, improve the plant's ability to hold water and absorb nutrients, and lower the entisol's bulk density. The T. arjuna (Roxb) plant responds very favorably to mycorrhiza inoculation in nursery conditions with the entisol growth medium.
{"title":"Inoculants of Arbuscular Mycorrhizal Fungi Influence Growth and Biomass of <i>Terminalia arjuna</i> under Amendment and Anamendment Entisol.","authors":"Atul Kumar Bhardwaj, K K Chandra, Rajesh Kumar","doi":"10.1080/12298093.2024.2360750","DOIUrl":"10.1080/12298093.2024.2360750","url":null,"abstract":"<p><p>Entisol soil is hard and compact in nature, rendering it high in bulk density, which influences root penetration adversely and thereby poor plant growth. In this experiment, used seven treatments in different combination in normal soil, were used as growth media for the <i>Terminalia arjuna</i> seedling. T3 (60% entisol) found the best as it gave the highest biomass in the species regardless of arbuscular mycorrhizal fungi (AMF) treatment. AMF treatment enhanced the growth and biomass of plants significantly in all the given treatments. AMF colonization observed a maximum in tertiary roots. T1 (100% entisol soil) exhibited the highest degree of AMF colonization in tertiary roots, resulting in the highest mycorrhiza dependency of plants for this soil. The addition of normal soil to entisol soil was found to decrease the bulk density, resulting in increased root diameter, and T3 plants exhibited the highest biomass and AMF compatibility for <i>T. arjuna</i> species. The <i>T. arjuna</i> plant's growth and biomass responded positively to AMF in all types of treatments. The plant's growth and biomass were highest in the T3 treatment, which had a bulk density of 1.50 g/cm<sup>3</sup>. In this study, we combined the entisol with mycorrhizal inoculation of the nursery growing medium to promote plant growth and biomass, improve the plant's ability to hold water and absorb nutrients, and lower the entisol's bulk density. The <i>T. arjuna</i> (Roxb) plant responds very favorably to mycorrhiza inoculation in nursery conditions with the entisol growth medium.</p>","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-12DOI: 10.1080/12298093.2024.2360748
Jung-Min Lee, Ahn-Heum Eom
{"title":"Effects of Black and White Mulch on Mycelial Growth of\u0000 Tuber\u0000 Species in Korean Field Environment","authors":"Jung-Min Lee, Ahn-Heum Eom","doi":"10.1080/12298093.2024.2360748","DOIUrl":"https://doi.org/10.1080/12298093.2024.2360748","url":null,"abstract":"","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.1080/12298093.2024.2341492
K. A. Schoder, J. Krümpel, Joachim Müller, Andreas Lemmer
{"title":"Effects of Environmental and Nutritional Conditions on Mycelium Growth of Three Basidiomycota","authors":"K. A. Schoder, J. Krümpel, Joachim Müller, Andreas Lemmer","doi":"10.1080/12298093.2024.2341492","DOIUrl":"https://doi.org/10.1080/12298093.2024.2341492","url":null,"abstract":"","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140657793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1080/12298093.2024.2333611
Anthony Buaya, Marco Thines
There is increasing evidence that holocarpic oomycetes, i.e., those converting their entire vegetative thallus into zoospores upon maturation, are a phylogenetically diverse group in both freshwate...
{"title":"Miracula polaris – A New Species of Miracula from the East Fjords of Iceland","authors":"Anthony Buaya, Marco Thines","doi":"10.1080/12298093.2024.2333611","DOIUrl":"https://doi.org/10.1080/12298093.2024.2333611","url":null,"abstract":"There is increasing evidence that holocarpic oomycetes, i.e., those converting their entire vegetative thallus into zoospores upon maturation, are a phylogenetically diverse group in both freshwate...","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140600957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The fungal strain designated as KNUF-21-020, belonging to the genus Triangularia, was isolated from a soil sample collected in the Chungnam province, Korea. Phylogenetic analyses based on the conca...
{"title":"Triangularia manubriata sp. Nov.: A Novel Fungal Species Belonging to the Family Podosporaceae Isolated from Soil in Korea","authors":"Seong-Keun Lim, Gwang-Jae Lim, Jin-Sil Choi, Seung-Yeol Lee, Hee-Young Jung","doi":"10.1080/12298093.2024.2326240","DOIUrl":"https://doi.org/10.1080/12298093.2024.2326240","url":null,"abstract":"The fungal strain designated as KNUF-21-020, belonging to the genus Triangularia, was isolated from a soil sample collected in the Chungnam province, Korea. Phylogenetic analyses based on the conca...","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140197696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-13DOI: 10.1080/12298093.2024.2324575
Yeon Jae Choi, Hyerang Eom, Jiyeon Park, Jelyn Park, Seoyoung Cheon, Hyeon-Su Ro
145 fungal isolates were obtained from three sampling sites situated within the Nam River basin, located in the southern region of South Korea. Through ITS sequence analysis, the fungal isolates we...
从位于韩国南部地区南江流域的三个采样点获得了 145 株真菌分离物。通过 ITS 序列分析，我们对这些真菌分离物进行了...
{"title":"Fungal Diversity in Nam River and Their Biodegradative Activities","authors":"Yeon Jae Choi, Hyerang Eom, Jiyeon Park, Jelyn Park, Seoyoung Cheon, Hyeon-Su Ro","doi":"10.1080/12298093.2024.2324575","DOIUrl":"https://doi.org/10.1080/12298093.2024.2324575","url":null,"abstract":"145 fungal isolates were obtained from three sampling sites situated within the Nam River basin, located in the southern region of South Korea. Through ITS sequence analysis, the fungal isolates we...","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140126340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-09DOI: 10.1080/12298093.2024.2322211
Moonil Son
In filamentous fungi, vegetative cell fusion occurs within and between individuals. These fusions of growing hyphae (anastomosis) from two individuals produce binucleated cells with mixed cytoplasm...
{"title":"A Story Between s and S: [Het-s] Prion of the Fungus Podospora anserina","authors":"Moonil Son","doi":"10.1080/12298093.2024.2322211","DOIUrl":"https://doi.org/10.1080/12298093.2024.2322211","url":null,"abstract":"In filamentous fungi, vegetative cell fusion occurs within and between individuals. These fusions of growing hyphae (anastomosis) from two individuals produce binucleated cells with mixed cytoplasm...","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140072112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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