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Isomeric oxabenzochrysenones from Musa acuminata and Wachendorfia thyrsiflora. 荆芥和荆芥的异分异构体草苯并蒽酮。
Pub Date : 2002-10-01 DOI: 10.1080/10575630290033079
Stefan Opitz, Felipe Otálvaro, Fernando Echeverri, Winston Quiñones, Bernd Schneider

Two new oxabenzochrysenones (naphthoxanthenones), representing phenylphenalenone-related natural products, were isolated from Musa acuminata and Wachendorfia thyrsiflora.

摘要从针叶Musa acuminata和Wachendorfia thyrsiflora中分离到两个新的苯苯并蒽酮类化合物(oxabenzochrysenones)。
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引用次数: 19
Partial synthesis of 23-hydroxyursolic acid isolated from medicinal plants of the Rubiaceae family. 从茜草科药用植物中分离出的 23-羟基熊果酸的部分合成。
Pub Date : 2002-08-01 DOI: 10.1080/10575630290020622
Lothar Bore, Tadashi Honda, Gordon W Gribble

23-Hydroxyursolic acid (2), previously isolated from medicinal plants of the Rubiaceae family, was synthesized in ten steps via methyl 23-hydroxy-3-oxours-12-en-28-oate (5) from commercially available ursolic acid (6).

以前从茜草科药用植物中分离出的 23-羟基熊果酸(2)是通过 23-hydroxy-3-oxours-12-en-28-oate (5) 从市售熊果酸(6)中分十步合成的。
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引用次数: 7
New Triterpenoids from the Orchids Scaphyglottis Livida and Nidema Boothii 兰科植物黄花兰科植物和凤仙花兰科植物的新三萜类化合物
Pub Date : 2002-01-01 DOI: 10.1080/10575630290019967
S. Estrada, L. Acevedo, Mitzi Rodriguez, R. Toscano, R. Mata
Two new triterpenoids, nidemin ( 1 ), a modified lanostane, and 9,19-cyclolanosta-24,24-dimethyl-25-en-3 -yl trans - p -hydroxycinnamate ( 2 ) have been isolated from the orchids Nidema boothii and Scaphyglottis livida , respectively. The isolates were characterized by spectral methods. The structure of nidemin ( 1 ) was unambiguously confirmed by X-ray analysis.
从兰科植物Nidema boothii和Scaphyglottis livida中分别分离到两个新的三萜:nidemin(1)、一个修饰的lanostane和9,19- cycloolanosta -24,24-dimethyl-25-en-3 -yl trans - p -hydroxycinnamate(2)。用波谱法对分离物进行了鉴定。x射线分析明确证实了nidemin(1)的结构。
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引用次数: 17
An in vitro screening method for DNA cytosine-C5-methylase inhibitor DNA胞嘧啶- c5 -甲基化酶抑制剂的体外筛选方法
Pub Date : 2002-01-01 DOI: 10.1080/1057563029001/4809
T. Tamura, Atsushi Kataoka, Lidan Shu, Akihiko Ashida, Hidehiko Tanaka, K. Inagaki
A specific inhibitor of DNA cytosine C5-methylases would be useful for studying genomic imprinting, X-chromosome inactivation, carcinogenesis, and regulation of tissue-specific gene expression, for these physiological phenomena appears to be regulated through DNA methylation in promoter sequences. This paper reports a novel convenient in vitro assay method for screening DNA cytosine C5-methylase inhibitor. Our method uses a commercially available Hae III methylase (cytosine C5 methylase), its corresponding Hae III endonuclease, and u DNA as their substrate.
DNA胞嘧啶c5甲基化酶的特异性抑制剂将有助于研究基因组印迹、x染色体失活、癌变和组织特异性基因表达的调控,因为这些生理现象似乎是通过启动子序列中的DNA甲基化来调节的。本文报道了一种新的体外筛选DNA胞嘧啶c5 -甲基化酶抑制剂的简便方法。我们的方法使用市售的Hae III甲基化酶(胞嘧啶C5甲基化酶),其相应的Hae III内切酶和u DNA作为底物。
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引用次数: 4
Two New Cyclic Bis(Bibenzyl)s, Isoriccardinquinone A and B from the Liverwort Marchantia Paleacea 两个新环双(联苯基)s,异烟基红醌A和B
Pub Date : 2002-01-01 DOI: 10.1080/10575630290004242
M. So, W. Chan, P. Xia, Yu-xin Cui
From the 95% ethanol extract of the Hong Kong liverwort, Marchantia paleacea , guided by bioactivity directed isolation, two novel isoriccardinquinones A and B were obtained together with previously known marchantin C, isoriccardin C and phenanthrene derivative, 2-hydroxy-3,7-dimethoxyphenanthrene. The structures of the new compounds were established by high field spectroscopic methods, including 2D NMR techniques.
采用生物活性定向分离的方法,从香港肝草(Marchantia paleacea)的95%乙醇提取物中分离得到两个新的异山芹红醌A和B,以及已知的山芹素C、异山芹素C和菲衍生物2-羟基-3,7-二甲氧基菲。新化合物的结构通过高场光谱方法确定,包括二维核磁共振技术。
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引用次数: 15
Extraction Studies of Tabernanthe Iboga and Voacanga Africana 山核桃和非洲山核桃的提取研究
Pub Date : 2002-01-01 DOI: 10.1080/1057563029001/4881
Christopher Jenks
The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it. Ibogaine is used experimentally to interrupt drug addiction and allow therapeutic intervention, but is currently unaffordable to doctors in less economically developed countries. To meet this need, an extraction of alkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar and ammonia, and was successfully applied to related alkaloids from Voacanga africana bark also. The alkaloids were converted to their hydrochlorides and purified, and the minor alkaloids were recovered.
烟叶根皮以烟叶碱为主要生物碱,是烟叶碱的重要来源。伊博加因在实验中被用于中断药物成瘾并允许治疗干预,但目前经济欠发达国家的医生负担不起。为了满足这一需求,我们优化并简化了提取木耳根皮中生物碱的工艺,只使用稀释的醋和氨水,并成功地应用于木耳根皮中相关生物碱的提取。将生物碱转化为氢氯化物并提纯,回收少量生物碱。
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引用次数: 44
Marruboside, a New Phenylethanoid Glycoside from Marrubium Vulgare L 一种来自凡士林的新型苯乙醇苷
Pub Date : 2002-01-01 DOI: 10.1080/10575630290013576
S. Sahpaz, T. Hennebelle, F. Bailleul
A new phenylethanoid glycoside, marruboside, has been isolated from the aerial parts of Marrubium vulgare L. Its structure was established as 3,4-dihydroxy- g -phenylethoxy- O- [ g - d -apiofuranosyl-(1 M 2)- f - l -rhamnopyranosyl-(1 M 3)]-[ g - d -apiofuranosyl-(1 M 6)]-4- O -caffeoyl- g - d -glucopyranoside, on the basis of spectroscopic evidence.
从马鲁比姆(Marrubium vulgare l .)的地上部分分离得到一种新的苯乙醇苷——马鲁糖苷,通过波谱分析确定其结构为3,4-二羟基-g -苯乙氧基- O- [g -d - apiofuransyl -(1 m2)- f - 1 -鼠李糖吡喃基-(1 m3)]-[g -d - apiofuransyl -(1 m3)]-4- O-咖啡基-g -d -glucopyranoside。
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引用次数: 29
New Triterpenoids from the Leaves of Abrus Precatorius 标题青花蒿叶中的新三萜类化合物
Pub Date : 2002-01-01 DOI: 10.1080/10575630290020596
Nam-Cheol Kim, Darrick S. H. L. Kim, A. Kinghorn
Three new ( 1-3 ) triterpenoids and one known ( 4 ) triterpenoid were isolated from an acid hydrolyzed methanol-soluble extract of the leaves of Abrus precatorius . Their structures were identified as (20 S ,22 S )-3 g ,22-dihydroxycucurbita-5(10),24-diene-26,29-dioic acid i -lactone ( 1 ), 3- O -[6'-methyl- g - d -glucuronopyranosyl]-3 g ,22 g -dihydroxyolean-12-en-29-oic acid methyl ester ( 2 ), 3- O - g - d -glucuronopyranosylsophoradiol methyl ester ( 3 ), and sophoradiol ( 4 ) by spectroscopic techniques including 2D NMR.
从Abrus precatorius叶片的醇溶性酸水解提取物中分离到3个新的(1-3)三萜和1个已知的(4)三萜。通过二维核磁共振等波谱技术鉴定其结构为(20 S,22 S)-3 g,22-二羟基葫芦-5(10),24-二烯-26,29-二酸i -内酯(1),3- O -[6'-甲基-g -d -葡萄糖醛酸-葡萄糖醛酸甲酯]-3 g,22 g -二羟基烯-12-烯-29-葡萄糖醛酸甲酯(2),3- O -g -d -葡萄糖醛酸-葡萄糖醛酸甲酯(3)和槐二醇(4)。
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引用次数: 22
A New Approach for Asymmetric Synthesis of (R)-3-Methylpyrrolidine Alkaloids from (S)-Malic Acid (S)-苹果酸不对称合成(R)-3-甲基吡咯烷生物碱的新方法
Pub Date : 2002-01-01 DOI: 10.1080/1057563029001/4854
Xiao Zheng, Pei‐Qiang Huang, Yuanping Ruan, A. Lee, W. Chan
Diastereoselective methylation of dimethyl (S)-malate 7, followed by two, three-step reductive de-hydroxylation procedures afforded dimethyl (R)-2-methylsuccinate 11 in 80.2% e.e. and 84.7% e.e., respectively. The latter compound was further transformed into the natural enantiomers of the ant venom alkaloids (R)-leptothoracine 1 and (R)-3-methyl-N-(2-phenylethyl)-pyrrolidine 2.
二甲基(S)-苹果酸酯7的非对映选择性甲基化,然后是两步、三步还原去羟基化过程,分别在80.2% e.e.和84.7% e.e.得到二甲基(R)-2-甲基琥珀酸酯11。后一种化合物进一步转化为蚂蚁毒液生物碱(R)- lepto胸碱1和(R)-3-甲基- n -(2-苯乙基)-吡咯烷2的天然对映体。
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引用次数: 4
A Novel Cacalolide from Psacalium Decompositum 一种新的仙人掌碱类化合物
Pub Date : 2002-01-01 DOI: 10.1080/10575630290020532
R. Reyes‐Chilpa, M. Jiménez-Estrada, Marcia V Godínez, S. Hernández-Ortega, M. Campos, E. Bejar
A new cacalolide sesquiterpenoid, named as Romo-A, was isolated from the roots of Psacalium decompositum , Asteraceae, a Mexican medicinal shrub with antidiabetic properties. Its structure was elucidated by NMR, MS, IR, UV, and confirmed by X-ray diffraction studies.
从具有抗糖尿病作用的墨西哥药用灌木石蒜科(Asteraceae)石蒜科(sacalium decomposum)的根中分离到一种新的仙人掌碱倍半萜,命名为Romo-A。其结构经核磁共振、质谱、红外、紫外、x射线衍射确证。
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引用次数: 2
期刊
Natural Product Letters
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